Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFL4_LEIDO

TriTrypDb:

LdBPK_342070.1 , LdCL_340028400 , LDHU3_34.3490

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.561
CLV_C14_Caspase3-7	216	220	PF00656	0.545
CLV_C14_Caspase3-7	326	330	PF00656	0.634
CLV_C14_Caspase3-7	489	493	PF00656	0.629
CLV_NRD_NRD_1	34	36	PF00675	0.705
CLV_NRD_NRD_1	424	426	PF00675	0.446
CLV_NRD_NRD_1	562	564	PF00675	0.473
CLV_PCSK_KEX2_1	36	38	PF00082	0.691
CLV_PCSK_KEX2_1	424	426	PF00082	0.409
CLV_PCSK_KEX2_1	566	568	PF00082	0.500
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.691
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.440
CLV_PCSK_SKI1_1	107	111	PF00082	0.563
CLV_PCSK_SKI1_1	317	321	PF00082	0.605
CLV_PCSK_SKI1_1	349	353	PF00082	0.473
CLV_PCSK_SKI1_1	396	400	PF00082	0.514
CLV_PCSK_SKI1_1	407	411	PF00082	0.439
CLV_PCSK_SKI1_1	424	428	PF00082	0.234
CLV_PCSK_SKI1_1	519	523	PF00082	0.362
CLV_PCSK_SKI1_1	65	69	PF00082	0.515
DEG_APCC_DBOX_1	518	526	PF00400	0.426
DEG_APCC_DBOX_1	601	609	PF00400	0.467
DEG_Nend_UBRbox_3	1	3	PF02207	0.668
DEG_SPOP_SBC_1	28	32	PF00917	0.698
DEG_SPOP_SBC_1	306	310	PF00917	0.674
DOC_CDC14_PxL_1	257	265	PF14671	0.462
DOC_CKS1_1	56	61	PF01111	0.562
DOC_CYCLIN_RxL_1	314	323	PF00134	0.521
DOC_CYCLIN_RxL_1	346	353	PF00134	0.408
DOC_MAPK_gen_1	424	432	PF00069	0.333
DOC_MAPK_MEF2A_6	182	190	PF00069	0.419
DOC_MAPK_MEF2A_6	425	434	PF00069	0.330
DOC_MIT_MIM_1	178	186	PF04212	0.436
DOC_PP1_RVXF_1	422	429	PF00149	0.408
DOC_PP4_FxxP_1	21	24	PF00568	0.562
DOC_PP4_FxxP_1	537	540	PF00568	0.326
DOC_USP7_MATH_1	103	107	PF00917	0.556
DOC_USP7_MATH_1	144	148	PF00917	0.540
DOC_USP7_MATH_1	22	26	PF00917	0.719
DOC_USP7_MATH_1	28	32	PF00917	0.747
DOC_USP7_MATH_1	306	310	PF00917	0.657
DOC_USP7_MATH_1	342	346	PF00917	0.381
DOC_USP7_MATH_1	347	351	PF00917	0.446
DOC_USP7_MATH_1	382	386	PF00917	0.670
DOC_USP7_MATH_1	562	566	PF00917	0.473
DOC_USP7_MATH_1	569	573	PF00917	0.459
DOC_WW_Pin1_4	142	147	PF00397	0.576
DOC_WW_Pin1_4	320	325	PF00397	0.652
DOC_WW_Pin1_4	366	371	PF00397	0.547
DOC_WW_Pin1_4	37	42	PF00397	0.714
DOC_WW_Pin1_4	47	52	PF00397	0.662
DOC_WW_Pin1_4	55	60	PF00397	0.591
DOC_WW_Pin1_4	555	560	PF00397	0.383
DOC_WW_Pin1_4	91	96	PF00397	0.603
LIG_14-3-3_CanoR_1	122	128	PF00244	0.469
LIG_14-3-3_CanoR_1	173	178	PF00244	0.455
LIG_14-3-3_CanoR_1	467	471	PF00244	0.426
LIG_14-3-3_CanoR_1	79	84	PF00244	0.368
LIG_14-3-3_CanoR_1	87	95	PF00244	0.588
LIG_Actin_WH2_2	127	144	PF00022	0.396
LIG_Actin_WH2_2	510	525	PF00022	0.419
LIG_BIR_III_2	204	208	PF00653	0.450
LIG_BIR_III_4	499	503	PF00653	0.278
LIG_BIR_III_4	532	536	PF00653	0.385
LIG_BRCT_BRCA1_1	473	477	PF00533	0.426
LIG_BRCT_BRCA1_1	557	561	PF00533	0.361
LIG_Clathr_ClatBox_1	544	548	PF01394	0.477
LIG_deltaCOP1_diTrp_1	280	286	PF00928	0.442
LIG_FHA_1	169	175	PF00498	0.528
LIG_FHA_1	282	288	PF00498	0.434
LIG_FHA_1	341	347	PF00498	0.394
LIG_FHA_1	539	545	PF00498	0.249
LIG_FHA_1	56	62	PF00498	0.511
LIG_FHA_2	147	153	PF00498	0.708
LIG_FHA_2	173	179	PF00498	0.470
LIG_LIR_Gen_1	178	188	PF02991	0.314
LIG_LIR_Gen_1	243	252	PF02991	0.521
LIG_LIR_Gen_1	358	368	PF02991	0.554
LIG_LIR_Gen_1	541	549	PF02991	0.470
LIG_LIR_Gen_1	591	601	PF02991	0.357
LIG_LIR_Nem_3	178	183	PF02991	0.321
LIG_LIR_Nem_3	243	247	PF02991	0.482
LIG_LIR_Nem_3	358	363	PF02991	0.477
LIG_LIR_Nem_3	403	409	PF02991	0.501
LIG_LIR_Nem_3	541	545	PF02991	0.375
LIG_LIR_Nem_3	548	552	PF02991	0.423
LIG_LIR_Nem_3	568	573	PF02991	0.206
LIG_LIR_Nem_3	591	597	PF02991	0.368
LIG_Pex14_1	282	286	PF04695	0.443
LIG_Pex14_1	414	418	PF04695	0.469
LIG_Pex14_1	473	477	PF04695	0.351
LIG_PTB_Apo_2	543	550	PF02174	0.456
LIG_Rb_pABgroove_1	346	354	PF01858	0.405
LIG_SH2_CRK	418	422	PF00017	0.402
LIG_SH2_CRK	570	574	PF00017	0.464
LIG_SH2_SRC	435	438	PF00017	0.279
LIG_SH2_STAP1	437	441	PF00017	0.489
LIG_SH2_STAT3	74	77	PF00017	0.542
LIG_SH2_STAT5	140	143	PF00017	0.508
LIG_SH2_STAT5	180	183	PF00017	0.302
LIG_SH2_STAT5	265	268	PF00017	0.365
LIG_SH3_2	6	11	PF14604	0.616
LIG_SH3_3	252	258	PF00018	0.454
LIG_SH3_3	3	9	PF00018	0.809
LIG_SH3_3	391	397	PF00018	0.596
LIG_SH3_3	53	59	PF00018	0.633
LIG_TYR_ITIM	552	557	PF00017	0.264
LIG_WRC_WIRS_1	241	246	PF05994	0.460
LIG_WRC_WIRS_1	539	544	PF05994	0.249
MOD_CDK_SPxxK_3	366	373	PF00069	0.543
MOD_CK1_1	27	33	PF00069	0.729
MOD_CK1_1	309	315	PF00069	0.554
MOD_CK1_1	323	329	PF00069	0.585
MOD_CK1_1	369	375	PF00069	0.523
MOD_CK1_1	385	391	PF00069	0.649
MOD_CK1_1	445	451	PF00069	0.510
MOD_CK1_1	55	61	PF00069	0.668
MOD_CK1_1	86	92	PF00069	0.556
MOD_CK2_1	172	178	PF00069	0.487
MOD_CK2_1	310	316	PF00069	0.595
MOD_CK2_1	562	568	PF00069	0.463
MOD_CMANNOS	463	466	PF00535	0.456
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.518
MOD_DYRK1A_RPxSP_1	37	41	PF00069	0.719
MOD_GlcNHglycan	135	139	PF01048	0.575
MOD_GlcNHglycan	26	29	PF01048	0.740
MOD_GlcNHglycan	325	328	PF01048	0.546
MOD_GlcNHglycan	385	388	PF01048	0.703
MOD_GlcNHglycan	389	392	PF01048	0.652
MOD_GlcNHglycan	473	476	PF01048	0.489
MOD_GlcNHglycan	485	489	PF01048	0.560
MOD_GlcNHglycan	511	514	PF01048	0.453
MOD_GSK3_1	142	149	PF00069	0.524
MOD_GSK3_1	168	175	PF00069	0.453
MOD_GSK3_1	22	29	PF00069	0.697
MOD_GSK3_1	305	312	PF00069	0.705
MOD_GSK3_1	31	38	PF00069	0.714
MOD_GSK3_1	383	390	PF00069	0.698
MOD_GSK3_1	441	448	PF00069	0.547
MOD_GSK3_1	47	54	PF00069	0.763
MOD_GSK3_1	569	576	PF00069	0.442
MOD_GSK3_1	588	595	PF00069	0.295
MOD_GSK3_1	79	86	PF00069	0.577
MOD_NEK2_1	134	139	PF00069	0.397
MOD_NEK2_1	232	237	PF00069	0.327
MOD_NEK2_1	240	245	PF00069	0.363
MOD_NEK2_1	315	320	PF00069	0.507
MOD_NEK2_1	491	496	PF00069	0.606
MOD_NEK2_1	580	585	PF00069	0.460
MOD_NEK2_1	83	88	PF00069	0.621
MOD_NEK2_2	347	352	PF00069	0.479
MOD_PIKK_1	281	287	PF00454	0.519
MOD_PIKK_1	330	336	PF00454	0.481
MOD_PKA_1	35	41	PF00069	0.753
MOD_PKA_2	172	178	PF00069	0.487
MOD_PKA_2	466	472	PF00069	0.464
MOD_PKA_2	562	568	PF00069	0.464
MOD_PKA_2	86	92	PF00069	0.540
MOD_Plk_1	218	224	PF00069	0.399
MOD_Plk_1	232	238	PF00069	0.327
MOD_Plk_1	245	251	PF00069	0.432
MOD_Plk_1	315	321	PF00069	0.605
MOD_Plk_1	491	497	PF00069	0.473
MOD_Plk_1	547	553	PF00069	0.384
MOD_Plk_2-3	400	406	PF00069	0.430
MOD_Plk_4	123	129	PF00069	0.336
MOD_Plk_4	232	238	PF00069	0.421
MOD_Plk_4	272	278	PF00069	0.414
MOD_Plk_4	310	316	PF00069	0.620
MOD_Plk_4	79	85	PF00069	0.623
MOD_ProDKin_1	142	148	PF00069	0.584
MOD_ProDKin_1	320	326	PF00069	0.654
MOD_ProDKin_1	366	372	PF00069	0.544
MOD_ProDKin_1	37	43	PF00069	0.715
MOD_ProDKin_1	47	53	PF00069	0.659
MOD_ProDKin_1	55	61	PF00069	0.581
MOD_ProDKin_1	555	561	PF00069	0.381
MOD_ProDKin_1	91	97	PF00069	0.601
MOD_SUMO_rev_2	400	409	PF00179	0.430
MOD_SUMO_rev_2	8	18	PF00179	0.772
TRG_DiLeu_BaEn_2	13	19	PF01217	0.571
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.511
TRG_ENDOCYTIC_2	180	183	PF00928	0.302
TRG_ENDOCYTIC_2	418	421	PF00928	0.383
TRG_ENDOCYTIC_2	554	557	PF00928	0.331
TRG_ENDOCYTIC_2	570	573	PF00928	0.521
TRG_ER_diArg_1	423	425	PF00400	0.376
TRG_NES_CRM1_1	123	135	PF08389	0.399
TRG_NES_CRM1_1	178	192	PF08389	0.326
TRG_NLS_MonoExtC_3	34	39	PF00514	0.689
TRG_NLS_MonoExtC_3	562	567	PF00514	0.407
TRG_NLS_MonoExtN_4	35	40	PF00514	0.694
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGH4	Leptomonas seymouri	47%	95%
A0A1X0P9M0	Trypanosomatidae	24%	100%
A0A422P0J6	Trypanosoma rangeli	25%	100%
A4HAU2	Leishmania braziliensis	75%	100%
C9ZMM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AHT6	Leishmania infantum	99%	100%
E9B516	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2X0	Leishmania major	90%	100%
V5BKG8	Trypanosoma cruzi	26%	100%