Rubisco LSMT substrate-binding, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rubisco LSMT substrate-binding, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFL1_LEIDO

TriTrypDb:

LdBPK_300160.1 , LdCL_300006700 , LDHU3_30.0280

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFL1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0032259	methylation	2	11
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.483
CLV_C14_Caspase3-7	81	85	PF00656	0.455
CLV_MEL_PAP_1	593	599	PF00089	0.335
CLV_NRD_NRD_1	266	268	PF00675	0.465
CLV_NRD_NRD_1	28	30	PF00675	0.498
CLV_NRD_NRD_1	392	394	PF00675	0.387
CLV_NRD_NRD_1	487	489	PF00675	0.385
CLV_NRD_NRD_1	493	495	PF00675	0.370
CLV_NRD_NRD_1	535	537	PF00675	0.278
CLV_PCSK_KEX2_1	266	268	PF00082	0.465
CLV_PCSK_KEX2_1	27	29	PF00082	0.347
CLV_PCSK_KEX2_1	303	305	PF00082	0.406
CLV_PCSK_KEX2_1	487	489	PF00082	0.386
CLV_PCSK_KEX2_1	493	495	PF00082	0.371
CLV_PCSK_KEX2_1	535	537	PF00082	0.278
CLV_PCSK_KEX2_1	600	602	PF00082	0.260
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.347
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.406
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.276
CLV_PCSK_PC7_1	262	268	PF00082	0.349
CLV_PCSK_PC7_1	596	602	PF00082	0.256
CLV_PCSK_SKI1_1	130	134	PF00082	0.356
CLV_PCSK_SKI1_1	156	160	PF00082	0.630
CLV_PCSK_SKI1_1	166	170	PF00082	0.600
CLV_PCSK_SKI1_1	177	181	PF00082	0.499
CLV_PCSK_SKI1_1	237	241	PF00082	0.433
CLV_PCSK_SKI1_1	266	270	PF00082	0.372
CLV_PCSK_SKI1_1	488	492	PF00082	0.383
CLV_PCSK_SKI1_1	494	498	PF00082	0.338
DEG_APCC_DBOX_1	202	210	PF00400	0.410
DEG_APCC_DBOX_1	595	603	PF00400	0.456
DEG_APCC_DBOX_1	67	75	PF00400	0.433
DOC_CYCLIN_RxL_1	262	270	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.430
DOC_MAPK_gen_1	493	499	PF00069	0.481
DOC_MAPK_MEF2A_6	587	595	PF00069	0.481
DOC_MAPK_RevD_3	289	304	PF00069	0.378
DOC_PP1_RVXF_1	104	110	PF00149	0.387
DOC_PP1_RVXF_1	175	181	PF00149	0.462
DOC_PP1_RVXF_1	27	34	PF00149	0.351
DOC_PP1_RVXF_1	603	610	PF00149	0.318
DOC_PP2B_LxvP_1	207	210	PF13499	0.358
DOC_PP2B_LxvP_1	452	455	PF13499	0.572
DOC_PP2B_LxvP_1	497	500	PF13499	0.476
DOC_USP7_MATH_1	122	126	PF00917	0.523
DOC_USP7_MATH_1	143	147	PF00917	0.503
DOC_USP7_MATH_1	154	158	PF00917	0.629
DOC_USP7_MATH_1	199	203	PF00917	0.452
DOC_USP7_MATH_1	232	236	PF00917	0.414
DOC_USP7_MATH_1	302	306	PF00917	0.550
DOC_USP7_MATH_1	335	339	PF00917	0.504
DOC_USP7_MATH_1	340	344	PF00917	0.410
DOC_USP7_MATH_1	550	554	PF00917	0.573
DOC_WW_Pin1_4	541	546	PF00397	0.571
LIG_14-3-3_CanoR_1	166	171	PF00244	0.511
LIG_14-3-3_CanoR_1	266	276	PF00244	0.463
LIG_14-3-3_CanoR_1	57	63	PF00244	0.540
LIG_14-3-3_CterR_2	612	614	PF00244	0.392
LIG_Actin_WH2_2	586	602	PF00022	0.509
LIG_AP2alpha_2	97	99	PF02296	0.413
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BRCT_BRCA1_1	211	215	PF00533	0.421
LIG_BRCT_BRCA1_1	342	346	PF00533	0.415
LIG_BRCT_BRCA1_1	359	363	PF00533	0.208
LIG_Clathr_ClatBox_1	71	75	PF01394	0.435
LIG_deltaCOP1_diTrp_1	172	180	PF00928	0.377
LIG_EH1_1	214	222	PF00400	0.245
LIG_FHA_1	136	142	PF00498	0.383
LIG_FHA_1	276	282	PF00498	0.396
LIG_FHA_1	386	392	PF00498	0.469
LIG_FHA_1	401	407	PF00498	0.523
LIG_FHA_1	6	12	PF00498	0.616
LIG_FHA_2	167	173	PF00498	0.584
LIG_FHA_2	409	415	PF00498	0.426
LIG_FHA_2	567	573	PF00498	0.476
LIG_FHA_2	574	580	PF00498	0.446
LIG_FHA_2	59	65	PF00498	0.545
LIG_FHA_2	76	82	PF00498	0.446
LIG_LIR_Apic_2	58	63	PF02991	0.478
LIG_LIR_Gen_1	527	537	PF02991	0.464
LIG_LIR_Gen_1	78	88	PF02991	0.358
LIG_LIR_Nem_3	263	268	PF02991	0.359
LIG_LIR_Nem_3	418	423	PF02991	0.312
LIG_LIR_Nem_3	78	83	PF02991	0.343
LIG_LYPXL_yS_3	276	279	PF13949	0.311
LIG_NRBOX	235	241	PF00104	0.363
LIG_NRBOX	514	520	PF00104	0.474
LIG_SH2_CRK	223	227	PF00017	0.329
LIG_SH2_CRK	423	427	PF00017	0.307
LIG_SH2_CRK	435	439	PF00017	0.321
LIG_SH2_NCK_1	136	140	PF00017	0.407
LIG_SH2_STAP1	253	257	PF00017	0.326
LIG_SH2_STAP1	495	499	PF00017	0.367
LIG_SH2_STAT5	223	226	PF00017	0.406
LIG_SH2_STAT5	30	33	PF00017	0.389
LIG_SH3_1	536	542	PF00018	0.478
LIG_SH3_3	274	280	PF00018	0.314
LIG_SH3_3	452	458	PF00018	0.446
LIG_SH3_3	536	542	PF00018	0.478
LIG_SH3_3	92	98	PF00018	0.440
LIG_SUMO_SIM_par_1	70	75	PF11976	0.409
LIG_TRAF2_1	241	244	PF00917	0.480
LIG_TRFH_1	437	441	PF08558	0.397
LIG_TYR_ITIM	221	226	PF00017	0.389
MOD_CK1_1	190	196	PF00069	0.492
MOD_CK1_1	202	208	PF00069	0.463
MOD_CK1_1	465	471	PF00069	0.678
MOD_CK1_1	544	550	PF00069	0.494
MOD_CK1_1	565	571	PF00069	0.533
MOD_CK2_1	145	151	PF00069	0.640
MOD_CK2_1	566	572	PF00069	0.485
MOD_CK2_1	573	579	PF00069	0.449
MOD_CK2_1	58	64	PF00069	0.484
MOD_CK2_1	75	81	PF00069	0.250
MOD_Cter_Amidation	533	536	PF01082	0.207
MOD_GlcNHglycan	1	4	PF01048	0.745
MOD_GlcNHglycan	151	155	PF01048	0.621
MOD_GlcNHglycan	156	159	PF01048	0.613
MOD_GlcNHglycan	332	335	PF01048	0.509
MOD_GlcNHglycan	341	345	PF01048	0.381
MOD_GlcNHglycan	469	473	PF01048	0.683
MOD_GSK3_1	1	8	PF00069	0.631
MOD_GSK3_1	143	150	PF00069	0.599
MOD_GSK3_1	168	175	PF00069	0.494
MOD_GSK3_1	353	360	PF00069	0.430
MOD_GSK3_1	468	475	PF00069	0.696
MOD_GSK3_1	550	557	PF00069	0.479
MOD_GSK3_1	562	569	PF00069	0.432
MOD_LATS_1	164	170	PF00433	0.497
MOD_N-GLC_1	18	23	PF02516	0.410
MOD_N-GLC_1	385	390	PF02516	0.350
MOD_NEK2_1	1	6	PF00069	0.726
MOD_NEK2_1	216	221	PF00069	0.307
MOD_NEK2_1	314	319	PF00069	0.462
MOD_NEK2_1	419	424	PF00069	0.325
MOD_NEK2_2	137	142	PF00069	0.460
MOD_PIKK_1	302	308	PF00454	0.442
MOD_PKA_2	202	208	PF00069	0.461
MOD_Plk_1	260	266	PF00069	0.427
MOD_Plk_1	480	486	PF00069	0.591
MOD_Plk_1	573	579	PF00069	0.524
MOD_Plk_2-3	573	579	PF00069	0.513
MOD_Plk_2-3	75	81	PF00069	0.448
MOD_Plk_4	202	208	PF00069	0.423
MOD_Plk_4	216	222	PF00069	0.364
MOD_Plk_4	314	320	PF00069	0.372
MOD_Plk_4	550	556	PF00069	0.545
MOD_ProDKin_1	541	547	PF00069	0.571
TRG_DiLeu_BaEn_1	243	248	PF01217	0.359
TRG_DiLeu_BaEn_2	44	50	PF01217	0.522
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.468
TRG_ENDOCYTIC_2	223	226	PF00928	0.379
TRG_ENDOCYTIC_2	253	256	PF00928	0.409
TRG_ENDOCYTIC_2	276	279	PF00928	0.311
TRG_ENDOCYTIC_2	423	426	PF00928	0.310
TRG_ENDOCYTIC_2	435	438	PF00928	0.314
TRG_ENDOCYTIC_2	537	540	PF00928	0.522
TRG_ER_diArg_1	265	267	PF00400	0.458
TRG_ER_diArg_1	28	30	PF00400	0.355
TRG_ER_diArg_1	487	489	PF00400	0.477
TRG_ER_diArg_1	492	494	PF00400	0.466
TRG_ER_diArg_1	535	537	PF00400	0.446
TRG_ER_diArg_1	67	70	PF00400	0.400
TRG_NES_CRM1_1	287	299	PF08389	0.361
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B9	Leptomonas seymouri	61%	97%
A0A0S4JJX6	Bodo saltans	33%	89%
A0A1X0P2C3	Trypanosomatidae	42%	100%
A0A422N122	Trypanosoma rangeli	44%	100%
A4HHW1	Leishmania braziliensis	81%	100%
A4I511	Leishmania infantum	100%	100%
C9ZQG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B0E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q7U0	Leishmania major	93%	100%
V5AWY0	Trypanosoma cruzi	44%	100%