Aquaporin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aquaporin-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFK5_LEIDO

TriTrypDb:

LdBPK_322500.1 , LdCL_320030600 , LDHU3_32.3140

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8IFK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFK5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0015267	channel activity	4	7
GO:0022803	passive transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.230
CLV_C14_Caspase3-7	556	560	PF00656	0.775
CLV_C14_Caspase3-7	562	566	PF00656	0.699
CLV_NRD_NRD_1	164	166	PF00675	0.538
CLV_NRD_NRD_1	214	216	PF00675	0.487
CLV_NRD_NRD_1	463	465	PF00675	0.529
CLV_PCSK_KEX2_1	164	166	PF00082	0.538
CLV_PCSK_SKI1_1	155	159	PF00082	0.501
CLV_PCSK_SKI1_1	165	169	PF00082	0.437
CLV_PCSK_SKI1_1	215	219	PF00082	0.356
CLV_PCSK_SKI1_1	308	312	PF00082	0.349
CLV_PCSK_SKI1_1	340	344	PF00082	0.573
CLV_PCSK_SKI1_1	464	468	PF00082	0.482
CLV_PCSK_SKI1_1	531	535	PF00082	0.616
CLV_PCSK_SKI1_1	582	586	PF00082	0.542
DEG_Nend_UBRbox_2	1	3	PF02207	0.760
DEG_ODPH_VHL_1	436	449	PF01847	0.334
DEG_SPOP_SBC_1	143	147	PF00917	0.766
DEG_SPOP_SBC_1	506	510	PF00917	0.730
DEG_SPOP_SBC_1	583	587	PF00917	0.761
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.565
DOC_MAPK_gen_1	218	226	PF00069	0.596
DOC_MAPK_MEF2A_6	180	187	PF00069	0.622
DOC_PP2B_LxvP_1	224	227	PF13499	0.598
DOC_PP4_FxxP_1	32	35	PF00568	0.743
DOC_USP7_MATH_1	109	113	PF00917	0.630
DOC_USP7_MATH_1	129	133	PF00917	0.609
DOC_USP7_MATH_1	136	140	PF00917	0.758
DOC_USP7_MATH_1	254	258	PF00917	0.334
DOC_USP7_MATH_1	298	302	PF00917	0.491
DOC_USP7_MATH_1	345	349	PF00917	0.278
DOC_USP7_MATH_1	35	39	PF00917	0.741
DOC_USP7_MATH_1	410	414	PF00917	0.373
DOC_USP7_MATH_1	493	497	PF00917	0.709
DOC_USP7_MATH_1	506	510	PF00917	0.757
DOC_USP7_MATH_1	90	94	PF00917	0.769
DOC_WW_Pin1_4	113	118	PF00397	0.694
DOC_WW_Pin1_4	25	30	PF00397	0.686
DOC_WW_Pin1_4	49	54	PF00397	0.689
DOC_WW_Pin1_4	538	543	PF00397	0.718
DOC_WW_Pin1_4	86	91	PF00397	0.768
LIG_14-3-3_CanoR_1	101	109	PF00244	0.765
LIG_14-3-3_CanoR_1	515	519	PF00244	0.778
LIG_Actin_WH2_2	414	431	PF00022	0.291
LIG_AP2alpha_2	199	201	PF02296	0.694
LIG_BRCT_BRCA1_1	282	286	PF00533	0.328
LIG_BRCT_BRCA1_1	353	357	PF00533	0.334
LIG_BRCT_BRCA1_1	378	382	PF00533	0.491
LIG_FHA_1	166	172	PF00498	0.728
LIG_FHA_1	180	186	PF00498	0.609
LIG_FHA_1	250	256	PF00498	0.334
LIG_FHA_1	280	286	PF00498	0.317
LIG_FHA_1	322	328	PF00498	0.283
LIG_FHA_1	347	353	PF00498	0.282
LIG_FHA_1	456	462	PF00498	0.639
LIG_FHA_1	548	554	PF00498	0.712
LIG_FHA_1	584	590	PF00498	0.644
LIG_FHA_2	149	155	PF00498	0.731
LIG_FHA_2	509	515	PF00498	0.803
LIG_FHA_2	542	548	PF00498	0.692
LIG_GBD_Chelix_1	302	310	PF00786	0.278
LIG_GBD_Chelix_1	444	452	PF00786	0.437
LIG_Integrin_RGD_1	125	127	PF01839	0.417
LIG_Integrin_RGD_1	528	530	PF01839	0.498
LIG_LIR_Apic_2	31	35	PF02991	0.744
LIG_LIR_Apic_2	585	591	PF02991	0.683
LIG_LIR_Gen_1	219	227	PF02991	0.623
LIG_LIR_Gen_1	228	236	PF02991	0.571
LIG_LIR_Gen_1	238	247	PF02991	0.239
LIG_LIR_Gen_1	354	365	PF02991	0.334
LIG_LIR_Nem_3	219	224	PF02991	0.634
LIG_LIR_Nem_3	228	232	PF02991	0.578
LIG_LIR_Nem_3	238	243	PF02991	0.239
LIG_LIR_Nem_3	246	250	PF02991	0.334
LIG_LIR_Nem_3	287	291	PF02991	0.334
LIG_LIR_Nem_3	354	360	PF02991	0.334
LIG_MAD2	169	177	PF02301	0.732
LIG_NBox_RRM_1	296	306	PF00076	0.538
LIG_Pex14_2	32	36	PF04695	0.661
LIG_Pex14_2	382	386	PF04695	0.334
LIG_PTB_Apo_2	369	376	PF02174	0.334
LIG_PTB_Phospho_1	369	375	PF10480	0.334
LIG_SH2_CRK	221	225	PF00017	0.623
LIG_SH2_STAP1	181	185	PF00017	0.668
LIG_SH2_STAP1	221	225	PF00017	0.623
LIG_SH2_STAT3	375	378	PF00017	0.491
LIG_SH2_STAT5	181	184	PF00017	0.673
LIG_SH2_STAT5	239	242	PF00017	0.334
LIG_SH2_STAT5	290	293	PF00017	0.334
LIG_SH2_STAT5	318	321	PF00017	0.334
LIG_SH2_STAT5	351	354	PF00017	0.291
LIG_SH3_1	570	576	PF00018	0.715
LIG_SH3_2	573	578	PF14604	0.690
LIG_SH3_3	167	173	PF00018	0.686
LIG_SH3_3	37	43	PF00018	0.731
LIG_SH3_3	47	53	PF00018	0.658
LIG_SH3_3	570	576	PF00018	0.734
LIG_SUMO_SIM_anti_2	252	257	PF11976	0.317
LIG_SUMO_SIM_par_1	181	186	PF11976	0.669
LIG_SUMO_SIM_par_1	251	257	PF11976	0.334
LIG_SUMO_SIM_par_1	46	52	PF11976	0.661
LIG_TRAF2_1	544	547	PF00917	0.709
LIG_TRFH_1	434	438	PF08558	0.334
LIG_WRC_WIRS_1	244	249	PF05994	0.334
LIG_WRC_WIRS_1	285	290	PF05994	0.334
LIG_WRC_WIRS_1	361	366	PF05994	0.334
MOD_CDK_SPK_2	538	543	PF00069	0.757
MOD_CDK_SPxxK_3	538	545	PF00069	0.682
MOD_CK1_1	112	118	PF00069	0.702
MOD_CK1_1	141	147	PF00069	0.768
MOD_CK1_1	262	268	PF00069	0.278
MOD_CK1_1	346	352	PF00069	0.290
MOD_CK1_1	376	382	PF00069	0.489
MOD_CK1_1	393	399	PF00069	0.317
MOD_CK1_1	508	514	PF00069	0.747
MOD_CK1_1	51	57	PF00069	0.769
MOD_CK1_1	519	525	PF00069	0.832
MOD_CK1_1	566	572	PF00069	0.766
MOD_CK2_1	497	503	PF00069	0.749
MOD_CK2_1	508	514	PF00069	0.752
MOD_CK2_1	541	547	PF00069	0.695
MOD_CK2_1	574	580	PF00069	0.773
MOD_CK2_1	72	78	PF00069	0.767
MOD_CMANNOS	432	435	PF00535	0.334
MOD_Cter_Amidation	162	165	PF01082	0.537
MOD_GlcNHglycan	140	143	PF01048	0.594
MOD_GlcNHglycan	146	149	PF01048	0.520
MOD_GlcNHglycan	23	26	PF01048	0.635
MOD_GlcNHglycan	291	294	PF01048	0.307
MOD_GlcNHglycan	353	356	PF01048	0.334
MOD_GlcNHglycan	37	40	PF01048	0.501
MOD_GlcNHglycan	378	381	PF01048	0.287
MOD_GlcNHglycan	392	395	PF01048	0.317
MOD_GlcNHglycan	397	400	PF01048	0.334
MOD_GlcNHglycan	402	405	PF01048	0.491
MOD_GlcNHglycan	412	415	PF01048	0.383
MOD_GlcNHglycan	499	502	PF01048	0.513
MOD_GlcNHglycan	565	568	PF01048	0.579
MOD_GlcNHglycan	74	77	PF01048	0.615
MOD_GlcNHglycan	92	95	PF01048	0.436
MOD_GlcNHglycan	96	99	PF01048	0.491
MOD_GSK3_1	109	116	PF00069	0.735
MOD_GSK3_1	138	145	PF00069	0.779
MOD_GSK3_1	179	186	PF00069	0.649
MOD_GSK3_1	21	28	PF00069	0.720
MOD_GSK3_1	280	287	PF00069	0.296
MOD_GSK3_1	343	350	PF00069	0.293
MOD_GSK3_1	351	358	PF00069	0.289
MOD_GSK3_1	48	55	PF00069	0.824
MOD_GSK3_1	485	492	PF00069	0.674
MOD_GSK3_1	493	500	PF00069	0.661
MOD_GSK3_1	501	508	PF00069	0.667
MOD_GSK3_1	510	517	PF00069	0.728
MOD_GSK3_1	518	525	PF00069	0.662
MOD_GSK3_1	86	93	PF00069	0.721
MOD_N-GLC_1	136	141	PF02516	0.558
MOD_N-GLC_1	259	264	PF02516	0.491
MOD_N-GLC_1	468	473	PF02516	0.412
MOD_N-GLC_1	55	60	PF02516	0.447
MOD_N-GLC_1	78	83	PF02516	0.570
MOD_N-GLC_2	594	596	PF02516	0.465
MOD_NEK2_1	119	124	PF00069	0.757
MOD_NEK2_1	179	184	PF00069	0.635
MOD_NEK2_1	235	240	PF00069	0.491
MOD_NEK2_1	243	248	PF00069	0.334
MOD_NEK2_1	279	284	PF00069	0.333
MOD_NEK2_1	360	365	PF00069	0.334
MOD_NEK2_1	390	395	PF00069	0.334
MOD_NEK2_1	518	523	PF00069	0.699
MOD_NEK2_2	254	259	PF00069	0.334
MOD_PIKK_1	101	107	PF00454	0.766
MOD_PIKK_1	447	453	PF00454	0.430
MOD_PIKK_1	455	461	PF00454	0.638
MOD_PIKK_1	554	560	PF00454	0.781
MOD_PK_1	259	265	PF00069	0.291
MOD_PKA_2	100	106	PF00069	0.722
MOD_PKA_2	376	382	PF00069	0.491
MOD_PKA_2	400	406	PF00069	0.278
MOD_PKA_2	485	491	PF00069	0.705
MOD_PKA_2	504	510	PF00069	0.623
MOD_PKA_2	514	520	PF00069	0.694
MOD_PKA_2	547	553	PF00069	0.681
MOD_Plk_1	136	142	PF00069	0.766
MOD_Plk_1	259	265	PF00069	0.291
MOD_Plk_1	55	61	PF00069	0.648
MOD_Plk_4	235	241	PF00069	0.491
MOD_Plk_4	259	265	PF00069	0.291
MOD_Plk_4	280	286	PF00069	0.334
MOD_Plk_4	347	353	PF00069	0.362
MOD_Plk_4	427	433	PF00069	0.291
MOD_Plk_4	584	590	PF00069	0.621
MOD_ProDKin_1	113	119	PF00069	0.694
MOD_ProDKin_1	25	31	PF00069	0.687
MOD_ProDKin_1	49	55	PF00069	0.690
MOD_ProDKin_1	538	544	PF00069	0.714
MOD_ProDKin_1	86	92	PF00069	0.769
MOD_SUMO_for_1	157	160	PF00179	0.677
MOD_SUMO_rev_2	186	194	PF00179	0.615
MOD_SUMO_rev_2	426	431	PF00179	0.338
MOD_SUMO_rev_2	457	467	PF00179	0.635
MOD_SUMO_rev_2	577	584	PF00179	0.762
TRG_DiLeu_BaEn_1	193	198	PF01217	0.576
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.579
TRG_ENDOCYTIC_2	221	224	PF00928	0.626
TRG_ER_diArg_1	164	166	PF00400	0.678
TRG_ER_diArg_1	475	478	PF00400	0.712
TRG_ER_diArg_1	542	545	PF00400	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I348	Leptomonas seymouri	53%	98%
A4HKM9	Leishmania braziliensis	76%	100%
A4I858	Leishmania infantum	99%	100%
E9B317	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q537	Leishmania major	90%	100%