DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFJ9_LEIDO

TriTrypDb:

LdBPK_301090.1 , LdCL_300016100 , LDHU3_30.1420

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFJ9

PDB structure(s): 7am2_BS

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0044183	protein folding chaperone	1	1
GO:0051082	unfolded protein binding	3	1
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.600
CLV_C14_Caspase3-7	386	390	PF00656	0.598
CLV_MEL_PAP_1	113	119	PF00089	0.350
CLV_NRD_NRD_1	115	117	PF00675	0.374
CLV_NRD_NRD_1	130	132	PF00675	0.221
CLV_NRD_NRD_1	142	144	PF00675	0.592
CLV_NRD_NRD_1	174	176	PF00675	0.753
CLV_NRD_NRD_1	196	198	PF00675	0.548
CLV_NRD_NRD_1	231	233	PF00675	0.489
CLV_NRD_NRD_1	244	246	PF00675	0.497
CLV_NRD_NRD_1	48	50	PF00675	0.724
CLV_PCSK_FUR_1	229	233	PF00082	0.495
CLV_PCSK_KEX2_1	115	117	PF00082	0.349
CLV_PCSK_KEX2_1	129	131	PF00082	0.203
CLV_PCSK_KEX2_1	142	144	PF00082	0.576
CLV_PCSK_KEX2_1	174	176	PF00082	0.752
CLV_PCSK_KEX2_1	196	198	PF00082	0.561
CLV_PCSK_KEX2_1	229	231	PF00082	0.483
CLV_PCSK_KEX2_1	244	246	PF00082	0.485
CLV_PCSK_KEX2_1	48	50	PF00082	0.724
CLV_PCSK_SKI1_1	17	21	PF00082	0.585
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DEG_SPOP_SBC_1	182	186	PF00917	0.760
DEG_SPOP_SBC_1	260	264	PF00917	0.767
DEG_SPOP_SBC_1	63	67	PF00917	0.707
DOC_CKS1_1	342	347	PF01111	0.472
DOC_PP1_SILK_1	303	308	PF00149	0.629
DOC_PP4_FxxP_1	190	193	PF00568	0.514
DOC_USP7_MATH_1	165	169	PF00917	0.725
DOC_USP7_MATH_1	260	264	PF00917	0.692
DOC_USP7_MATH_1	58	62	PF00917	0.617
DOC_USP7_MATH_1	64	68	PF00917	0.607
DOC_WW_Pin1_4	157	162	PF00397	0.764
DOC_WW_Pin1_4	19	24	PF00397	0.539
DOC_WW_Pin1_4	262	267	PF00397	0.724
DOC_WW_Pin1_4	271	276	PF00397	0.570
DOC_WW_Pin1_4	341	346	PF00397	0.467
DOC_WW_Pin1_4	364	369	PF00397	0.547
DOC_WW_Pin1_4	388	393	PF00397	0.670
DOC_WW_Pin1_4	79	84	PF00397	0.388
LIG_14-3-3_CanoR_1	115	124	PF00244	0.280
LIG_14-3-3_CanoR_1	395	400	PF00244	0.573
LIG_AP2alpha_1	211	215	PF02296	0.465
LIG_BIR_III_2	80	84	PF00653	0.388
LIG_BRCT_BRCA1_1	186	190	PF00533	0.551
LIG_CaM_IQ_9	224	240	PF13499	0.503
LIG_DLG_GKlike_1	395	403	PF00625	0.579
LIG_FHA_1	401	407	PF00498	0.586
LIG_FHA_1	64	70	PF00498	0.596
LIG_FHA_2	217	223	PF00498	0.492
LIG_FHA_2	272	278	PF00498	0.468
LIG_FHA_2	286	292	PF00498	0.465
LIG_FHA_2	342	348	PF00498	0.449
LIG_FHA_2	384	390	PF00498	0.655
LIG_FHA_2	80	86	PF00498	0.254
LIG_Integrin_RGD_1	204	206	PF01839	0.412
LIG_LIR_Apic_2	187	193	PF02991	0.516
LIG_LIR_Apic_2	418	422	PF02991	0.423
LIG_LIR_Gen_1	118	128	PF02991	0.274
LIG_LIR_Nem_3	111	117	PF02991	0.264
LIG_LIR_Nem_3	118	124	PF02991	0.288
LIG_LIR_Nem_3	325	330	PF02991	0.434
LIG_LIR_Nem_3	88	93	PF02991	0.241
LIG_Pex14_2	211	215	PF04695	0.371
LIG_SH2_CRK	198	202	PF00017	0.606
LIG_SH2_CRK	419	423	PF00017	0.433
LIG_SH2_CRK	72	76	PF00017	0.254
LIG_SH2_CRK	90	94	PF00017	0.388
LIG_SH2_SRC	376	379	PF00017	0.622
LIG_SH2_SRC	387	390	PF00017	0.553
LIG_SH2_SRC	405	408	PF00017	0.584
LIG_SH2_STAP1	25	29	PF00017	0.734
LIG_SH2_STAP1	355	359	PF00017	0.396
LIG_SH2_STAT5	405	408	PF00017	0.596
LIG_SH3_3	309	315	PF00018	0.569
LIG_SH3_3	317	323	PF00018	0.458
LIG_SH3_3	326	332	PF00018	0.343
LIG_SH3_3	334	340	PF00018	0.401
LIG_SH3_3	342	348	PF00018	0.434
LIG_TRAF2_1	82	85	PF00917	0.272
LIG_WRPW_2	330	333	PF00400	0.419
MOD_CDK_SPxxK_3	271	278	PF00069	0.499
MOD_CDK_SPxxK_3	364	371	PF00069	0.575
MOD_CDK_SPxxK_3	388	395	PF00069	0.534
MOD_CK1_1	168	174	PF00069	0.799
MOD_CK1_1	180	186	PF00069	0.669
MOD_CK1_1	262	268	PF00069	0.719
MOD_CK1_1	363	369	PF00069	0.594
MOD_CK1_1	51	57	PF00069	0.621
MOD_CK2_1	216	222	PF00069	0.548
MOD_CK2_1	285	291	PF00069	0.529
MOD_CK2_1	341	347	PF00069	0.442
MOD_CK2_1	79	85	PF00069	0.254
MOD_Cter_Amidation	172	175	PF01082	0.550
MOD_GlcNHglycan	147	150	PF01048	0.727
MOD_GlcNHglycan	168	171	PF01048	0.819
MOD_GlcNHglycan	30	33	PF01048	0.602
MOD_GlcNHglycan	395	398	PF01048	0.436
MOD_GlcNHglycan	53	56	PF01048	0.602
MOD_GlcNHglycan	60	63	PF01048	0.563
MOD_GSK3_1	153	160	PF00069	0.718
MOD_GSK3_1	17	24	PF00069	0.572
MOD_GSK3_1	176	183	PF00069	0.703
MOD_GSK3_1	256	263	PF00069	0.770
MOD_GSK3_1	28	35	PF00069	0.528
MOD_GSK3_1	353	360	PF00069	0.563
MOD_GSK3_1	363	370	PF00069	0.525
MOD_GSK3_1	391	398	PF00069	0.518
MOD_GSK3_1	44	51	PF00069	0.561
MOD_GSK3_1	58	65	PF00069	0.700
MOD_N-GLC_1	256	261	PF02516	0.745
MOD_NEK2_1	44	49	PF00069	0.600
MOD_PIKK_1	353	359	PF00454	0.618
MOD_PKA_1	115	121	PF00069	0.417
MOD_PKA_1	175	181	PF00069	0.672
MOD_PKA_1	48	54	PF00069	0.714
MOD_PKA_2	115	121	PF00069	0.417
MOD_PKA_2	165	171	PF00069	0.731
MOD_PKA_2	48	54	PF00069	0.717
MOD_PKA_2	58	64	PF00069	0.770
MOD_Plk_1	357	363	PF00069	0.608
MOD_Plk_2-3	216	222	PF00069	0.499
MOD_Plk_4	32	38	PF00069	0.518
MOD_ProDKin_1	157	163	PF00069	0.766
MOD_ProDKin_1	19	25	PF00069	0.540
MOD_ProDKin_1	262	268	PF00069	0.723
MOD_ProDKin_1	271	277	PF00069	0.557
MOD_ProDKin_1	341	347	PF00069	0.471
MOD_ProDKin_1	364	370	PF00069	0.546
MOD_ProDKin_1	388	394	PF00069	0.666
MOD_ProDKin_1	79	85	PF00069	0.388
MOD_SUMO_rev_2	213	220	PF00179	0.423
MOD_SUMO_rev_2	80	89	PF00179	0.264
TRG_ENDOCYTIC_2	121	124	PF00928	0.274
TRG_ENDOCYTIC_2	327	330	PF00928	0.440
TRG_ENDOCYTIC_2	72	75	PF00928	0.254
TRG_ENDOCYTIC_2	90	93	PF00928	0.388
TRG_ER_diArg_1	114	116	PF00400	0.417
TRG_ER_diArg_1	128	131	PF00400	0.417
TRG_ER_diArg_1	196	198	PF00400	0.562
TRG_ER_diArg_1	229	232	PF00400	0.492
TRG_ER_diArg_1	48	50	PF00400	0.729
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S6	Leptomonas seymouri	61%	100%
A0A0S4JEE6	Bodo saltans	32%	100%
A0A1X0P2B2	Trypanosomatidae	38%	100%
A0A3R7P4U9	Trypanosoma rangeli	39%	100%
A4HI58	Leishmania braziliensis	79%	99%
A4I5D4	Leishmania infantum	99%	100%
C9ZQR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B0N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7K0	Leishmania major	88%	100%
V5BPN3	Trypanosoma cruzi	34%	100%