Cytidylyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidylyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFJ1_LEIDO

TriTrypDb:

LdBPK_322200.1 , LdCL_320027400 , LDHU3_32.2740

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFJ1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015937	coenzyme A biosynthetic process	7	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033866	nucleoside bisphosphate biosynthetic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	3
GO:0004140	dephospho-CoA kinase activity	5	1
GO:0016301	kinase activity	4	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	226	228	PF00675	0.328
CLV_PCSK_SKI1_1	201	205	PF00082	0.267
CLV_PCSK_SKI1_1	26	30	PF00082	0.531
CLV_PCSK_SKI1_1	35	39	PF00082	0.683
DEG_APCC_DBOX_1	25	33	PF00400	0.547
DEG_SCF_FBW7_1	28	34	PF00400	0.577
DOC_CKS1_1	28	33	PF01111	0.569
DOC_CYCLIN_RxL_1	283	293	PF00134	0.418
DOC_MAPK_gen_1	250	259	PF00069	0.460
DOC_MAPK_MEF2A_6	250	259	PF00069	0.463
DOC_MAPK_RevD_3	215	229	PF00069	0.514
DOC_USP7_MATH_1	130	134	PF00917	0.791
DOC_USP7_MATH_1	39	43	PF00917	0.713
DOC_USP7_UBL2_3	167	171	PF12436	0.486
DOC_USP7_UBL2_3	181	185	PF12436	0.300
DOC_WW_Pin1_4	126	131	PF00397	0.784
DOC_WW_Pin1_4	27	32	PF00397	0.557
DOC_WW_Pin1_4	278	283	PF00397	0.458
DOC_WW_Pin1_4	311	316	PF00397	0.552
LIG_14-3-3_CanoR_1	216	225	PF00244	0.458
LIG_14-3-3_CanoR_1	53	63	PF00244	0.566
LIG_14-3-3_CanoR_1	78	82	PF00244	0.449
LIG_APCC_ABBA_1	153	158	PF00400	0.548
LIG_BIR_III_4	176	180	PF00653	0.496
LIG_deltaCOP1_diTrp_1	165	173	PF00928	0.487
LIG_FHA_1	204	210	PF00498	0.461
LIG_FHA_1	23	29	PF00498	0.538
LIG_FHA_1	267	273	PF00498	0.543
LIG_FHA_1	314	320	PF00498	0.529
LIG_FHA_2	78	84	PF00498	0.499
LIG_HP1_1	3	7	PF01393	0.482
LIG_IRF3_LxIS_1	95	102	PF10401	0.507
LIG_LIR_Gen_1	68	74	PF02991	0.481
LIG_LIR_LC3C_4	276	280	PF02991	0.458
LIG_LIR_Nem_3	165	169	PF02991	0.461
LIG_LIR_Nem_3	192	196	PF02991	0.496
LIG_LIR_Nem_3	68	73	PF02991	0.446
LIG_PCNA_PIPBox_1	241	250	PF02747	0.497
LIG_Rb_pABgroove_1	150	158	PF01858	0.493
LIG_SH2_CRK	184	188	PF00017	0.396
LIG_SH2_NCK_1	156	160	PF00017	0.544
LIG_SH2_PTP2	186	189	PF00017	0.460
LIG_SH2_SRC	156	159	PF00017	0.546
LIG_SH2_STAP1	156	160	PF00017	0.544
LIG_SH2_STAP1	89	93	PF00017	0.405
LIG_SH2_STAT5	186	189	PF00017	0.415
LIG_SH2_STAT5	23	26	PF00017	0.448
LIG_SH2_STAT5	70	73	PF00017	0.467
LIG_SH3_3	25	31	PF00018	0.508
LIG_SH3_3	276	282	PF00018	0.468
LIG_SH3_3	309	315	PF00018	0.552
LIG_SH3_4	181	188	PF00018	0.309
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.392
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.425
LIG_SUMO_SIM_par_1	150	158	PF11976	0.491
LIG_SUMO_SIM_par_1	2	10	PF11976	0.511
LIG_SxIP_EBH_1	97	108	PF03271	0.376
LIG_TRAF2_1	119	122	PF00917	0.749
MOD_CDK_SPxxK_3	128	135	PF00069	0.611
MOD_CK1_1	133	139	PF00069	0.729
MOD_CK1_1	223	229	PF00069	0.554
MOD_CK1_1	233	239	PF00069	0.543
MOD_CK1_1	263	269	PF00069	0.474
MOD_CK1_1	27	33	PF00069	0.517
MOD_CK1_1	281	287	PF00069	0.465
MOD_CK1_1	44	50	PF00069	0.686
MOD_CK2_1	116	122	PF00069	0.664
MOD_CK2_1	52	58	PF00069	0.547
MOD_CK2_1	77	83	PF00069	0.504
MOD_GlcNHglycan	132	135	PF01048	0.784
MOD_GlcNHglycan	197	200	PF01048	0.348
MOD_GlcNHglycan	264	268	PF01048	0.280
MOD_GlcNHglycan	295	298	PF01048	0.300
MOD_GlcNHglycan	43	46	PF01048	0.663
MOD_GlcNHglycan	63	66	PF01048	0.479
MOD_GlcNHglycan	89	92	PF01048	0.487
MOD_GSK3_1	116	123	PF00069	0.672
MOD_GSK3_1	126	133	PF00069	0.743
MOD_GSK3_1	27	34	PF00069	0.573
MOD_GSK3_1	35	42	PF00069	0.686
MOD_NEK2_1	203	208	PF00069	0.469
MOD_NEK2_1	230	235	PF00069	0.556
MOD_NEK2_1	24	29	PF00069	0.439
MOD_NEK2_1	319	324	PF00069	0.507
MOD_NEK2_1	6	11	PF00069	0.592
MOD_NEK2_1	82	87	PF00069	0.468
MOD_NEK2_1	99	104	PF00069	0.399
MOD_PIKK_1	327	333	PF00454	0.660
MOD_PKA_2	327	333	PF00069	0.649
MOD_PKA_2	52	58	PF00069	0.572
MOD_PKA_2	77	83	PF00069	0.385
MOD_Plk_1	220	226	PF00069	0.579
MOD_Plk_1	82	88	PF00069	0.502
MOD_Plk_4	220	226	PF00069	0.490
MOD_Plk_4	77	83	PF00069	0.398
MOD_ProDKin_1	126	132	PF00069	0.783
MOD_ProDKin_1	27	33	PF00069	0.568
MOD_ProDKin_1	278	284	PF00069	0.458
MOD_ProDKin_1	311	317	PF00069	0.552
TRG_ENDOCYTIC_2	184	187	PF00928	0.376
TRG_ENDOCYTIC_2	70	73	PF00928	0.445
TRG_NLS_MonoExtC_3	226	232	PF00514	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILA3	Leptomonas seymouri	59%	100%
A0A1X0NU95	Trypanosomatidae	34%	100%
A0A3R7M2F9	Trypanosoma rangeli	35%	100%
A4HKJ7	Leishmania braziliensis	75%	98%
A4I829	Leishmania infantum	99%	100%
D0AA94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q569	Leishmania major	93%	100%
V5DCC0	Trypanosoma cruzi	35%	100%