Lipase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Lipase, putative

Gene product:

lipase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFI3_LEIDO

TriTrypDb:

LdBPK_312540.1 , LdCL_310033400 , LDHU3_31.4560

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 9
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IFI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFI3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004806	triglyceride lipase activity	5	10
GO:0016298	lipase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0052689	carboxylic ester hydrolase activity	4	11
GO:0004620	phospholipase activity	5	1
GO:0008970	phospholipase A1 activity	5	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	5	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	251	253	PF00675	0.521
CLV_NRD_NRD_1	364	366	PF00675	0.548
CLV_PCSK_KEX2_1	253	255	PF00082	0.521
CLV_PCSK_KEX2_1	364	366	PF00082	0.530
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.521
CLV_PCSK_SKI1_1	271	275	PF00082	0.418
DOC_CKS1_1	132	137	PF01111	0.249
DOC_MAPK_HePTP_8	212	224	PF00069	0.184
DOC_MAPK_MEF2A_6	215	224	PF00069	0.184
DOC_PP1_RVXF_1	53	60	PF00149	0.220
DOC_PP1_RVXF_1	6	13	PF00149	0.526
DOC_PP4_FxxP_1	232	235	PF00568	0.233
DOC_USP7_MATH_1	154	158	PF00917	0.277
DOC_USP7_MATH_1	303	307	PF00917	0.272
DOC_WW_Pin1_4	131	136	PF00397	0.263
DOC_WW_Pin1_4	216	221	PF00397	0.248
DOC_WW_Pin1_4	80	85	PF00397	0.267
LIG_14-3-3_CanoR_1	149	158	PF00244	0.200
LIG_14-3-3_CanoR_1	252	257	PF00244	0.256
LIG_14-3-3_CanoR_1	271	276	PF00244	0.329
LIG_14-3-3_CanoR_1	313	321	PF00244	0.355
LIG_14-3-3_CanoR_1	47	57	PF00244	0.374
LIG_deltaCOP1_diTrp_1	52	59	PF00928	0.203
LIG_eIF4E_1	173	179	PF01652	0.295
LIG_EVH1_2	269	273	PF00568	0.220
LIG_FHA_1	11	17	PF00498	0.321
LIG_FHA_1	158	164	PF00498	0.366
LIG_FHA_1	175	181	PF00498	0.321
LIG_FHA_1	95	101	PF00498	0.396
LIG_FHA_2	229	235	PF00498	0.270
LIG_FHA_2	284	290	PF00498	0.309
LIG_FHA_2	323	329	PF00498	0.392
LIG_GBD_Chelix_1	15	23	PF00786	0.208
LIG_LIR_Apic_2	130	135	PF02991	0.226
LIG_LIR_Apic_2	231	235	PF02991	0.241
LIG_LIR_Apic_2	339	343	PF02991	0.240
LIG_LIR_Gen_1	119	126	PF02991	0.290
LIG_LIR_Gen_1	153	163	PF02991	0.242
LIG_LIR_Gen_1	198	208	PF02991	0.208
LIG_LIR_Gen_1	272	282	PF02991	0.332
LIG_LIR_Gen_1	345	355	PF02991	0.343
LIG_LIR_Gen_1	83	92	PF02991	0.340
LIG_LIR_Nem_3	119	123	PF02991	0.303
LIG_LIR_Nem_3	153	158	PF02991	0.253
LIG_LIR_Nem_3	198	203	PF02991	0.304
LIG_LIR_Nem_3	272	276	PF02991	0.319
LIG_LIR_Nem_3	345	350	PF02991	0.365
LIG_LIR_Nem_3	51	57	PF02991	0.286
LIG_LIR_Nem_3	83	89	PF02991	0.359
LIG_Pex14_1	132	136	PF04695	0.194
LIG_Pex14_2	175	179	PF04695	0.152
LIG_PTB_Apo_2	125	132	PF02174	0.212
LIG_PTB_Apo_2	236	243	PF02174	0.239
LIG_SH2_CRK	120	124	PF00017	0.339
LIG_SH2_CRK	155	159	PF00017	0.327
LIG_SH2_CRK	347	351	PF00017	0.261
LIG_SH2_CRK	7	11	PF00017	0.496
LIG_SH2_GRB2like	92	95	PF00017	0.325
LIG_SH2_NCK_1	120	124	PF00017	0.349
LIG_SH2_NCK_1	340	344	PF00017	0.239
LIG_SH2_NCK_1	347	351	PF00017	0.214
LIG_SH2_STAP1	176	180	PF00017	0.243
LIG_SH2_STAP1	338	342	PF00017	0.264
LIG_SH2_STAT5	176	179	PF00017	0.311
LIG_SH2_STAT5	230	233	PF00017	0.240
LIG_SH2_STAT5	241	244	PF00017	0.241
LIG_SH2_STAT5	26	29	PF00017	0.570
LIG_SH2_STAT5	275	278	PF00017	0.304
LIG_SH2_STAT5	320	323	PF00017	0.273
LIG_SH2_STAT5	5	8	PF00017	0.582
LIG_SH2_STAT5	64	67	PF00017	0.265
LIG_SH3_2	266	271	PF14604	0.295
LIG_SH3_3	215	221	PF00018	0.367
LIG_SH3_3	263	269	PF00018	0.224
LIG_SH3_3	273	279	PF00018	0.269
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.206
LIG_SUMO_SIM_anti_2	246	251	PF11976	0.184
LIG_SUMO_SIM_par_1	225	231	PF11976	0.340
LIG_SUMO_SIM_par_1	348	353	PF11976	0.360
LIG_TRFH_1	131	135	PF08558	0.152
LIG_TRFH_1	340	344	PF08558	0.364
LIG_TYR_ITIM	100	105	PF00017	0.299
LIG_TYR_ITIM	318	323	PF00017	0.265
LIG_WRC_WIRS_1	229	234	PF05994	0.251
LIG_WW_3	268	272	PF00397	0.295
MOD_CK1_1	153	159	PF00069	0.263
MOD_CK1_1	243	249	PF00069	0.269
MOD_CK1_1	36	42	PF00069	0.427
MOD_CK1_1	80	86	PF00069	0.295
MOD_CK2_1	228	234	PF00069	0.270
MOD_CK2_1	283	289	PF00069	0.333
MOD_CK2_1	322	328	PF00069	0.342
MOD_GlcNHglycan	102	105	PF01048	0.518
MOD_GlcNHglycan	152	155	PF01048	0.370
MOD_GlcNHglycan	44	47	PF01048	0.569
MOD_GSK3_1	150	157	PF00069	0.293
MOD_GSK3_1	174	181	PF00069	0.313
MOD_GSK3_1	248	255	PF00069	0.243
MOD_GSK3_1	26	33	PF00069	0.605
MOD_GSK3_1	305	312	PF00069	0.299
MOD_GSK3_1	71	78	PF00069	0.403
MOD_N-GLC_1	243	248	PF02516	0.509
MOD_N-GLC_1	359	364	PF02516	0.608
MOD_N-GLC_1	48	53	PF02516	0.532
MOD_N-GLC_1	80	85	PF02516	0.504
MOD_N-GLC_1	93	98	PF02516	0.439
MOD_N-GLC_2	77	79	PF02516	0.402
MOD_NEK2_1	116	121	PF00069	0.281
MOD_NEK2_1	178	183	PF00069	0.261
MOD_NEK2_1	256	261	PF00069	0.277
MOD_NEK2_1	57	62	PF00069	0.264
MOD_NEK2_2	154	159	PF00069	0.270
MOD_NEK2_2	174	179	PF00069	0.300
MOD_NEK2_2	305	310	PF00069	0.276
MOD_NEK2_2	327	332	PF00069	0.317
MOD_PIKK_1	157	163	PF00454	0.180
MOD_PKA_1	252	258	PF00069	0.175
MOD_PKA_2	116	122	PF00069	0.232
MOD_PKA_2	256	262	PF00069	0.227
MOD_PKA_2	294	300	PF00069	0.224
MOD_PKA_2	312	318	PF00069	0.385
MOD_Plk_1	195	201	PF00069	0.288
MOD_Plk_1	243	249	PF00069	0.184
MOD_Plk_1	327	333	PF00069	0.272
MOD_Plk_1	359	365	PF00069	0.364
MOD_Plk_1	36	42	PF00069	0.458
MOD_Plk_2-3	228	234	PF00069	0.286
MOD_Plk_2-3	336	342	PF00069	0.300
MOD_Plk_4	11	17	PF00069	0.350
MOD_Plk_4	174	180	PF00069	0.325
MOD_Plk_4	21	27	PF00069	0.404
MOD_Plk_4	245	251	PF00069	0.249
MOD_Plk_4	305	311	PF00069	0.253
MOD_Plk_4	36	42	PF00069	0.507
MOD_ProDKin_1	131	137	PF00069	0.263
MOD_ProDKin_1	216	222	PF00069	0.248
MOD_ProDKin_1	80	86	PF00069	0.260
TRG_DiLeu_BaEn_1	164	169	PF01217	0.210
TRG_ENDOCYTIC_2	102	105	PF00928	0.316
TRG_ENDOCYTIC_2	120	123	PF00928	0.206
TRG_ENDOCYTIC_2	155	158	PF00928	0.251
TRG_ENDOCYTIC_2	176	179	PF00928	0.340
TRG_ENDOCYTIC_2	275	278	PF00928	0.320
TRG_ENDOCYTIC_2	320	323	PF00928	0.256
TRG_ENDOCYTIC_2	347	350	PF00928	0.378
TRG_ENDOCYTIC_2	64	67	PF00928	0.272
TRG_ENDOCYTIC_2	7	10	PF00928	0.603
TRG_ER_diArg_1	363	365	PF00400	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D0	Leptomonas seymouri	57%	100%
A0A0S4IJE8	Bodo saltans	34%	100%
A0A0S4J5D7	Bodo saltans	38%	100%
A0A0S4JTA1	Bodo saltans	36%	100%
A0A1X0NZH3	Trypanosomatidae	40%	87%
A0A1X0P001	Trypanosomatidae	37%	100%
A0A3Q8IG97	Leishmania donovani	32%	100%
A0A422NPJ5	Trypanosoma rangeli	36%	74%
A4HJN0	Leishmania braziliensis	60%	100%
A4HLK7	Leishmania braziliensis	36%	100%
A4I6H7	Leishmania infantum	32%	100%
A4I752	Leishmania infantum	99%	100%
B8NIB8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	28%	100%
C9ZME7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B246	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
O42815	Aspergillus tubingensis	29%	100%
O59952	Thermomyces lanuginosus	30%	100%
P19515	Rhizomucor miehei	30%	100%
P61871	Rhizopus niveus	30%	94%
P61872	Rhizopus oryzae	30%	94%
Q2UNW5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	27%	100%
Q4Q615	Leishmania major	86%	100%
Q4Q6I0	Leishmania major	33%	100%
Q9BHD5	Leishmania major	39%	100%
Q9P979	Aspergillus awamori	30%	100%
Q9XTR8	Caenorhabditis elegans	28%	100%
V5B761	Trypanosoma cruzi	42%	100%