Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFI2_LEIDO

TriTrypDb:

LdBPK_300730.1 , LdCL_300012400 , LDHU3_30.0920

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFI2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008684	2-oxopent-4-enoate hydratase activity	5	1
GO:0016829	lyase activity	2	1
GO:0016835	carbon-oxygen lyase activity	3	1
GO:0016836	hydro-lyase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	95	97	PF00675	0.459
CLV_PCSK_KEX2_1	179	181	PF00082	0.498
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.482
CLV_PCSK_SKI1_1	187	191	PF00082	0.517
CLV_PCSK_SKI1_1	221	225	PF00082	0.456
CLV_PCSK_SKI1_1	229	233	PF00082	0.442
DEG_APCC_DBOX_1	1	9	PF00400	0.666
DEG_Nend_UBRbox_1	1	4	PF02207	0.639
DOC_CKS1_1	206	211	PF01111	0.468
DOC_CKS1_1	240	245	PF01111	0.432
DOC_PP4_FxxP_1	149	152	PF00568	0.384
DOC_USP7_UBL2_3	224	228	PF12436	0.518
DOC_WW_Pin1_4	134	139	PF00397	0.440
DOC_WW_Pin1_4	205	210	PF00397	0.419
DOC_WW_Pin1_4	236	241	PF00397	0.348
LIG_14-3-3_CanoR_1	187	197	PF00244	0.519
LIG_14-3-3_CanoR_1	2	6	PF00244	0.582
LIG_14-3-3_CanoR_1	258	264	PF00244	0.468
LIG_14-3-3_CanoR_1	96	102	PF00244	0.502
LIG_BRCT_BRCA1_1	3	7	PF00533	0.524
LIG_BRCT_BRCA1_1	90	94	PF00533	0.311
LIG_deltaCOP1_diTrp_1	252	256	PF00928	0.436
LIG_FHA_1	184	190	PF00498	0.495
LIG_FHA_1	209	215	PF00498	0.427
LIG_FHA_1	258	264	PF00498	0.458
LIG_FHA_1	80	86	PF00498	0.368
LIG_FHA_2	123	129	PF00498	0.410
LIG_LIR_Gen_1	208	218	PF02991	0.457
LIG_LIR_Gen_1	260	265	PF02991	0.465
LIG_LIR_Nem_3	145	150	PF02991	0.366
LIG_LIR_Nem_3	17	21	PF02991	0.394
LIG_LIR_Nem_3	208	213	PF02991	0.448
LIG_LIR_Nem_3	252	256	PF02991	0.430
LIG_LIR_Nem_3	260	264	PF02991	0.363
LIG_LIR_Nem_3	58	64	PF02991	0.445
LIG_LYPXL_yS_3	61	64	PF13949	0.417
LIG_Pex14_2	90	94	PF04695	0.331
LIG_SH2_CRK	261	265	PF00017	0.368
LIG_SH2_STAP1	219	223	PF00017	0.371
LIG_SH2_STAP1	249	253	PF00017	0.452
LIG_SH2_STAT3	21	24	PF00017	0.497
LIG_SH2_STAT5	108	111	PF00017	0.402
LIG_SH2_STAT5	18	21	PF00017	0.334
LIG_SH3_3	237	243	PF00018	0.403
LIG_SH3_3	65	71	PF00018	0.327
LIG_SH3_3	82	88	PF00018	0.357
LIG_Sin3_3	210	217	PF02671	0.449
LIG_TRAF2_1	55	58	PF00917	0.424
LIG_TYR_ITIM	259	264	PF00017	0.412
LIG_UBA3_1	89	97	PF00899	0.419
MOD_CDK_SPK_2	236	241	PF00069	0.376
MOD_CK1_1	130	136	PF00069	0.545
MOD_CK1_1	174	180	PF00069	0.462
MOD_CK1_1	182	188	PF00069	0.447
MOD_CK1_1	239	245	PF00069	0.418
MOD_CK2_1	122	128	PF00069	0.418
MOD_GlcNHglycan	141	145	PF01048	0.465
MOD_GlcNHglycan	200	203	PF01048	0.412
MOD_GlcNHglycan	8	11	PF01048	0.597
MOD_GSK3_1	130	137	PF00069	0.449
MOD_GSK3_1	179	186	PF00069	0.437
MOD_GSK3_1	208	215	PF00069	0.369
MOD_GSK3_1	75	82	PF00069	0.473
MOD_N-GLC_1	171	176	PF02516	0.462
MOD_NEK2_1	1	6	PF00069	0.526
MOD_NEK2_1	140	145	PF00069	0.369
MOD_NEK2_1	183	188	PF00069	0.449
MOD_NEK2_1	259	264	PF00069	0.412
MOD_NEK2_1	48	53	PF00069	0.465
MOD_NEK2_1	79	84	PF00069	0.468
MOD_NEK2_1	8	13	PF00069	0.460
MOD_NEK2_2	75	80	PF00069	0.507
MOD_PIKK_1	79	85	PF00454	0.445
MOD_PK_1	97	103	PF00069	0.456
MOD_PKA_1	179	185	PF00069	0.464
MOD_PKA_2	1	7	PF00069	0.607
MOD_PKA_2	179	185	PF00069	0.464
MOD_PKA_2	257	263	PF00069	0.446
MOD_PKA_2	79	85	PF00069	0.358
MOD_PKA_2	95	101	PF00069	0.353
MOD_Plk_1	121	127	PF00069	0.499
MOD_Plk_1	171	177	PF00069	0.434
MOD_Plk_2-3	122	128	PF00069	0.510
MOD_Plk_2-3	28	34	PF00069	0.515
MOD_Plk_4	227	233	PF00069	0.404
MOD_Plk_4	259	265	PF00069	0.405
MOD_ProDKin_1	134	140	PF00069	0.438
MOD_ProDKin_1	205	211	PF00069	0.419
MOD_ProDKin_1	236	242	PF00069	0.348
MOD_SUMO_for_1	178	181	PF00179	0.421
MOD_SUMO_rev_2	110	120	PF00179	0.353
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.429
TRG_ENDOCYTIC_2	261	264	PF00928	0.357
TRG_ENDOCYTIC_2	61	64	PF00928	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W6	Leptomonas seymouri	64%	100%
A0A0S4KNC9	Bodo saltans	22%	100%
A0A1X0P382	Trypanosomatidae	39%	99%
A0A422NIG2	Trypanosoma rangeli	38%	99%
A4HI22	Leishmania braziliensis	91%	100%
A4I599	Leishmania infantum	100%	100%
C9ZQN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	99%
E9B0J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q7N7	Leishmania major	98%	100%
Q584U2	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	38%	99%
V5BC65	Trypanosoma cruzi	38%	99%