Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IFH8_LEIDO

TriTrypDb:

LdBPK_292330.1 , LdCL_290029400 , LDHU3_29.3440

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.658
CLV_C14_Caspase3-7	5	9	PF00656	0.565
CLV_NRD_NRD_1	130	132	PF00675	0.481
CLV_NRD_NRD_1	17	19	PF00675	0.536
CLV_NRD_NRD_1	318	320	PF00675	0.678
CLV_NRD_NRD_1	328	330	PF00675	0.596
CLV_PCSK_FUR_1	70	74	PF00082	0.473
CLV_PCSK_KEX2_1	130	132	PF00082	0.481
CLV_PCSK_KEX2_1	318	320	PF00082	0.678
CLV_PCSK_KEX2_1	72	74	PF00082	0.513
CLV_PCSK_KEX2_1	87	89	PF00082	0.466
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.513
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.466
CLV_PCSK_SKI1_1	173	177	PF00082	0.462
CLV_PCSK_SKI1_1	284	288	PF00082	0.692
CLV_PCSK_SKI1_1	54	58	PF00082	0.378
CLV_PCSK_SKI1_1	73	77	PF00082	0.317
CLV_PCSK_SKI1_1	93	97	PF00082	0.320
DEG_COP1_1	255	263	PF00400	0.545
DEG_SPOP_SBC_1	332	336	PF00917	0.658
DOC_CYCLIN_yClb1_LxF_4	155	161	PF00134	0.404
DOC_MAPK_gen_1	70	77	PF00069	0.480
DOC_PP1_RVXF_1	52	58	PF00149	0.394
DOC_PP1_RVXF_1	70	77	PF00149	0.354
DOC_USP7_MATH_1	145	149	PF00917	0.345
DOC_USP7_MATH_1	189	193	PF00917	0.572
DOC_USP7_MATH_1	219	223	PF00917	0.704
DOC_USP7_MATH_1	243	247	PF00917	0.684
DOC_USP7_MATH_1	254	258	PF00917	0.553
DOC_USP7_MATH_1	271	275	PF00917	0.556
DOC_USP7_MATH_1	332	336	PF00917	0.658
DOC_USP7_UBL2_3	326	330	PF12436	0.650
DOC_WW_Pin1_4	19	24	PF00397	0.475
DOC_WW_Pin1_4	273	278	PF00397	0.670
DOC_WW_Pin1_4	287	292	PF00397	0.538
DOC_WW_Pin1_4	294	299	PF00397	0.578
DOC_WW_Pin1_4	3	8	PF00397	0.633
LIG_14-3-3_CanoR_1	249	254	PF00244	0.637
LIG_14-3-3_CanoR_1	26	32	PF00244	0.459
LIG_14-3-3_CanoR_1	264	270	PF00244	0.564
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	117	121	PF00533	0.558
LIG_BRCT_BRCA1_1	271	275	PF00533	0.655
LIG_BRCT_BRCA1_1	43	47	PF00533	0.481
LIG_Clathr_ClatBox_1	55	59	PF01394	0.447
LIG_FHA_1	297	303	PF00498	0.575
LIG_FHA_1	79	85	PF00498	0.477
LIG_FHA_2	283	289	PF00498	0.652
LIG_LIR_Gen_1	148	158	PF02991	0.350
LIG_LIR_Nem_3	148	154	PF02991	0.356
LIG_LIR_Nem_3	44	50	PF02991	0.483
LIG_SH2_CRK	201	205	PF00017	0.542
LIG_SH2_NCK_1	43	47	PF00017	0.481
LIG_SH2_SRC	201	204	PF00017	0.538
LIG_SH2_STAP1	151	155	PF00017	0.468
LIG_SH2_STAP1	43	47	PF00017	0.481
LIG_SH2_STAT5	49	52	PF00017	0.578
LIG_SH2_STAT5	80	83	PF00017	0.414
LIG_SH3_3	183	189	PF00018	0.613
LIG_SH3_3	229	235	PF00018	0.617
LIG_SH3_3	295	301	PF00018	0.693
LIG_SH3_3	307	313	PF00018	0.596
LIG_SUMO_SIM_par_1	308	315	PF11976	0.628
LIG_SUMO_SIM_par_1	35	41	PF11976	0.360
LIG_TRFH_1	292	296	PF08558	0.630
LIG_UBA3_1	36	42	PF00899	0.511
LIG_WRC_WIRS_1	157	162	PF05994	0.399
MOD_CDK_SPxxK_3	19	26	PF00069	0.597
MOD_CK1_1	2	8	PF00069	0.606
MOD_CK1_1	208	214	PF00069	0.658
MOD_CK1_1	22	28	PF00069	0.443
MOD_CK1_1	222	228	PF00069	0.546
MOD_CK1_1	248	254	PF00069	0.706
MOD_CK1_1	273	279	PF00069	0.670
MOD_CK1_1	290	296	PF00069	0.534
MOD_CK2_1	162	168	PF00069	0.416
MOD_CK2_1	27	33	PF00069	0.455
MOD_CK2_1	282	288	PF00069	0.651
MOD_GlcNHglycan	147	150	PF01048	0.456
MOD_GlcNHglycan	217	220	PF01048	0.666
MOD_GlcNHglycan	224	228	PF01048	0.574
MOD_GlcNHglycan	241	244	PF01048	0.571
MOD_GlcNHglycan	245	248	PF01048	0.621
MOD_GlcNHglycan	251	254	PF01048	0.594
MOD_GlcNHglycan	255	259	PF01048	0.552
MOD_GlcNHglycan	277	280	PF01048	0.711
MOD_GlcNHglycan	314	317	PF01048	0.654
MOD_GlcNHglycan	44	47	PF01048	0.401
MOD_GSK3_1	177	184	PF00069	0.496
MOD_GSK3_1	205	212	PF00069	0.657
MOD_GSK3_1	213	220	PF00069	0.640
MOD_GSK3_1	239	246	PF00069	0.642
MOD_GSK3_1	265	272	PF00069	0.644
MOD_GSK3_1	290	297	PF00069	0.649
MOD_GSK3_1	308	315	PF00069	0.558
MOD_N-GLC_1	332	337	PF02516	0.633
MOD_NEK2_1	1	6	PF00069	0.672
MOD_NEK2_1	143	148	PF00069	0.486
MOD_NEK2_1	171	176	PF00069	0.464
MOD_NEK2_1	217	222	PF00069	0.691
MOD_NEK2_1	269	274	PF00069	0.631
MOD_PIKK_1	219	225	PF00454	0.700
MOD_PKA_2	248	254	PF00069	0.622
MOD_PKA_2	89	95	PF00069	0.431
MOD_Plk_1	78	84	PF00069	0.516
MOD_Plk_4	156	162	PF00069	0.442
MOD_Plk_4	181	187	PF00069	0.569
MOD_Plk_4	225	231	PF00069	0.576
MOD_Plk_4	27	33	PF00069	0.460
MOD_ProDKin_1	19	25	PF00069	0.470
MOD_ProDKin_1	273	279	PF00069	0.671
MOD_ProDKin_1	287	293	PF00069	0.539
MOD_ProDKin_1	294	300	PF00069	0.577
MOD_ProDKin_1	3	9	PF00069	0.635
MOD_SUMO_for_1	95	98	PF00179	0.455
MOD_SUMO_rev_2	11	21	PF00179	0.632
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.663
TRG_ENDOCYTIC_2	151	154	PF00928	0.470
TRG_ENDOCYTIC_2	200	203	PF00928	0.608
TRG_ER_diArg_1	114	117	PF00400	0.498
TRG_ER_diArg_1	129	131	PF00400	0.426
TRG_ER_diArg_1	88	91	PF00400	0.379
TRG_ER_diLys_1	337	341	PF00400	0.552
TRG_NLS_Bipartite_1	72	91	PF00514	0.330
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHU4	Leishmania braziliensis	57%	100%
A4I4T1	Leishmania infantum	99%	100%
E9AE84	Leishmania major	89%	100%
E9ALK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%