Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFH5_LEIDO

TriTrypDb:

LdBPK_354260.1 , LdCL_350047700 , LDHU3_35.5480

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0031410	cytoplasmic vesicle	6	5
GO:0031982	vesicle	4	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0097708	intracellular vesicle	5	5
GO:0110165	cellular anatomical entity	1	9
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A0A3Q8IFH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFH5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022607	cellular component assembly	4	5
GO:0043933	protein-containing complex organization	4	5
GO:0065003	protein-containing complex assembly	5	5
GO:0070070	proton-transporting V-type ATPase complex assembly	7	5
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	5
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	8	5
GO:0071840	cellular component organization or biogenesis	2	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.735
CLV_PCSK_KEX2_1	119	121	PF00082	0.439
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.439
CLV_PCSK_SKI1_1	116	120	PF00082	0.409
CLV_PCSK_SKI1_1	5	9	PF00082	0.435
CLV_PCSK_SKI1_1	73	77	PF00082	0.440
DEG_SCF_FBW7_1	18	24	PF00400	0.745
DEG_SCF_TRCP1_1	59	65	PF00400	0.715
DOC_CKS1_1	18	23	PF01111	0.745
DOC_MAPK_gen_1	147	157	PF00069	0.497
DOC_MAPK_MEF2A_6	151	159	PF00069	0.494
DOC_MAPK_MEF2A_6	176	184	PF00069	0.411
DOC_PP2B_LxvP_1	177	180	PF13499	0.422
DOC_PP2B_LxvP_1	9	12	PF13499	0.636
DOC_USP7_MATH_1	21	25	PF00917	0.741
DOC_USP7_MATH_1	57	61	PF00917	0.703
DOC_USP7_MATH_1	80	84	PF00917	0.672
DOC_USP7_UBL2_3	147	151	PF12436	0.611
DOC_WW_Pin1_4	17	22	PF00397	0.789
DOC_WW_Pin1_4	30	35	PF00397	0.735
DOC_WW_Pin1_4	40	45	PF00397	0.644
DOC_WW_Pin1_4	59	64	PF00397	0.735
LIG_14-3-3_CanoR_1	5	10	PF00244	0.635
LIG_EVH1_1	9	13	PF00568	0.636
LIG_FHA_1	125	131	PF00498	0.592
LIG_FHA_1	163	169	PF00498	0.297
LIG_FHA_1	4	10	PF00498	0.635
LIG_FHA_1	45	51	PF00498	0.662
LIG_FHA_1	69	75	PF00498	0.696
LIG_FHA_2	105	111	PF00498	0.625
LIG_GBD_Chelix_1	169	177	PF00786	0.304
LIG_LIR_Nem_3	202	208	PF02991	0.333
LIG_LIR_Nem_3	88	94	PF02991	0.605
LIG_NRP_CendR_1	227	230	PF00754	0.533
LIG_SH2_PTP2	154	157	PF00017	0.346
LIG_SH2_STAP1	87	91	PF00017	0.604
LIG_SH2_STAT5	154	157	PF00017	0.346
LIG_SH2_STAT5	205	208	PF00017	0.297
LIG_SH2_STAT5	85	88	PF00017	0.592
LIG_SH3_3	7	13	PF00018	0.639
LIG_TYR_ITIM	152	157	PF00017	0.346
MOD_CDK_SPK_2	40	45	PF00069	0.728
MOD_CK1_1	30	36	PF00069	0.769
MOD_CK1_1	43	49	PF00069	0.641
MOD_CK2_1	219	225	PF00069	0.684
MOD_CK2_1	48	54	PF00069	0.819
MOD_CK2_1	90	96	PF00069	0.723
MOD_GlcNHglycan	137	140	PF01048	0.416
MOD_GlcNHglycan	54	58	PF01048	0.536
MOD_GlcNHglycan	59	62	PF01048	0.459
MOD_GSK3_1	104	111	PF00069	0.527
MOD_GSK3_1	17	24	PF00069	0.740
MOD_GSK3_1	197	204	PF00069	0.382
MOD_GSK3_1	219	226	PF00069	0.693
MOD_GSK3_1	30	37	PF00069	0.747
MOD_GSK3_1	40	47	PF00069	0.738
MOD_GSK3_1	53	60	PF00069	0.716
MOD_GSK3_1	86	93	PF00069	0.630
MOD_N-GLC_1	135	140	PF02516	0.491
MOD_N-GLC_1	219	224	PF02516	0.489
MOD_NEK2_1	140	145	PF00069	0.677
MOD_NEK2_1	162	167	PF00069	0.339
MOD_NEK2_1	201	206	PF00069	0.351
MOD_NEK2_1	86	91	PF00069	0.635
MOD_PIKK_1	142	148	PF00454	0.600
MOD_PIKK_1	23	29	PF00454	0.714
MOD_PIKK_1	48	54	PF00454	0.711
MOD_PKA_2	44	50	PF00069	0.662
MOD_PKA_2	69	75	PF00069	0.698
MOD_Plk_1	104	110	PF00069	0.643
MOD_Plk_1	135	141	PF00069	0.691
MOD_Plk_1	80	86	PF00069	0.655
MOD_Plk_2-3	104	110	PF00069	0.673
MOD_Plk_4	201	207	PF00069	0.414
MOD_Plk_4	86	92	PF00069	0.590
MOD_ProDKin_1	17	23	PF00069	0.789
MOD_ProDKin_1	30	36	PF00069	0.734
MOD_ProDKin_1	40	46	PF00069	0.644
MOD_ProDKin_1	59	65	PF00069	0.734
MOD_SUMO_for_1	118	121	PF00179	0.635
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.515
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.652
TRG_ENDOCYTIC_2	154	157	PF00928	0.346
TRG_ENDOCYTIC_2	208	211	PF00928	0.445
TRG_ENDOCYTIC_2	87	90	PF00928	0.577
TRG_ENDOCYTIC_2	91	94	PF00928	0.577
TRG_ER_diLys_1	227	230	PF00400	0.674
TRG_ER_FFAT_2	117	127	PF00635	0.557
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVK4	Leptomonas seymouri	49%	100%
A0A422NK67	Trypanosoma rangeli	37%	100%
A4HN91	Leishmania braziliensis	71%	100%
A4IBV9	Leishmania infantum	97%	100%
C9ZYQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AFP6	Leishmania major	87%	100%
E9B6U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%