3'-nucleotidase/nuclease, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-nucleotidase/nuclease precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFH4_LEIDO

TriTrypDb:

LdBPK_312380.1 , LdCL_310031900 , LDHU3_31.4250

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 22, no: 6
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0009986	cell surface	2	1

Expansion

Sequence features

A0A3Q8IFH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFH4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	29
GO:0006259	DNA metabolic process	4	29
GO:0006308	DNA catabolic process	5	29
GO:0006725	cellular aromatic compound metabolic process	3	29
GO:0006807	nitrogen compound metabolic process	2	29
GO:0008152	metabolic process	1	29
GO:0009056	catabolic process	2	29
GO:0009057	macromolecule catabolic process	4	29
GO:0009987	cellular process	1	29
GO:0019439	aromatic compound catabolic process	4	29
GO:0034641	cellular nitrogen compound metabolic process	3	29
GO:0034655	nucleobase-containing compound catabolic process	4	29
GO:0043170	macromolecule metabolic process	3	29
GO:0044237	cellular metabolic process	2	29
GO:0044238	primary metabolic process	2	29
GO:0044248	cellular catabolic process	3	29
GO:0044260	obsolete cellular macromolecule metabolic process	3	29
GO:0044265	obsolete cellular macromolecule catabolic process	4	29
GO:0044270	cellular nitrogen compound catabolic process	4	29
GO:0046483	heterocycle metabolic process	3	29
GO:0046700	heterocycle catabolic process	4	29
GO:0071704	organic substance metabolic process	2	29
GO:0090304	nucleic acid metabolic process	4	29
GO:1901360	organic cyclic compound metabolic process	3	29
GO:1901361	organic cyclic compound catabolic process	4	29
GO:1901575	organic substance catabolic process	3	29
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006196	AMP catabolic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009123	nucleoside monophosphate metabolic process	5	1
GO:0009125	nucleoside monophosphate catabolic process	6	1
GO:0009126	purine nucleoside monophosphate metabolic process	6	1
GO:0009128	purine nucleoside monophosphate catabolic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009158	ribonucleoside monophosphate catabolic process	7	1
GO:0009161	ribonucleoside monophosphate metabolic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	1
GO:0009169	purine ribonucleoside monophosphate catabolic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046033	AMP metabolic process	7	1
GO:0046434	organophosphate catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	29
GO:0003824	catalytic activity	1	29
GO:0004518	nuclease activity	4	29
GO:0004519	endonuclease activity	5	29
GO:0005488	binding	1	29
GO:0016787	hydrolase activity	2	29
GO:0016788	hydrolase activity, acting on ester bonds	3	29
GO:0043167	ion binding	2	29
GO:0043169	cation binding	3	29
GO:0046872	metal ion binding	4	29
GO:0097159	organic cyclic compound binding	2	29
GO:1901363	heterocyclic compound binding	2	29
GO:0008252	nucleotidase activity	6	1
GO:0008254	3'-nucleotidase activity	7	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	366	368	PF00082	0.361
CLV_PCSK_KEX2_1	40	42	PF00082	0.434
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.326
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.441
CLV_PCSK_SKI1_1	185	189	PF00082	0.529
CLV_PCSK_SKI1_1	280	284	PF00082	0.421
CLV_PCSK_SKI1_1	288	292	PF00082	0.425
DEG_SCF_FBW7_1	94	100	PF00400	0.167
DOC_CKS1_1	94	99	PF01111	0.248
DOC_CYCLIN_RxL_1	2	13	PF00134	0.378
DOC_CYCLIN_RxL_1	50	61	PF00134	0.196
DOC_MAPK_gen_1	3	12	PF00069	0.401
DOC_MAPK_MEF2A_6	3	11	PF00069	0.453
DOC_MAPK_MEF2A_6	30	37	PF00069	0.344
DOC_PP1_RVXF_1	54	61	PF00149	0.178
DOC_PP4_FxxP_1	60	63	PF00568	0.274
DOC_USP7_MATH_1	131	135	PF00917	0.184
DOC_USP7_UBL2_3	271	275	PF12436	0.268
DOC_WW_Pin1_4	106	111	PF00397	0.262
DOC_WW_Pin1_4	64	69	PF00397	0.303
DOC_WW_Pin1_4	93	98	PF00397	0.250
LIG_14-3-3_CanoR_1	206	213	PF00244	0.268
LIG_Actin_WH2_2	285	300	PF00022	0.220
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_BIR_III_3	1	5	PF00653	0.408
LIG_Clathr_ClatBox_1	176	180	PF01394	0.206
LIG_FHA_1	103	109	PF00498	0.353
LIG_FHA_1	11	17	PF00498	0.445
LIG_FHA_1	111	117	PF00498	0.322
LIG_FHA_1	182	188	PF00498	0.277
LIG_FHA_1	239	245	PF00498	0.356
LIG_FHA_1	246	252	PF00498	0.306
LIG_FHA_1	336	342	PF00498	0.348
LIG_FHA_1	352	358	PF00498	0.339
LIG_FHA_1	80	86	PF00498	0.330
LIG_FHA_2	123	129	PF00498	0.240
LIG_FHA_2	228	234	PF00498	0.346
LIG_FHA_2	263	269	PF00498	0.335
LIG_FHA_2	98	104	PF00498	0.254
LIG_GBD_Chelix_1	137	145	PF00786	0.384
LIG_GBD_Chelix_1	289	297	PF00786	0.469
LIG_GBD_Chelix_1	347	355	PF00786	0.193
LIG_GBD_Chelix_1	356	364	PF00786	0.312
LIG_LIR_Apic_2	59	63	PF02991	0.274
LIG_LIR_Gen_1	210	220	PF02991	0.294
LIG_LIR_Gen_1	372	378	PF02991	0.522
LIG_LIR_Gen_1	89	99	PF02991	0.299
LIG_LIR_LC3C_4	354	357	PF02991	0.200
LIG_LIR_Nem_3	210	216	PF02991	0.305
LIG_LIR_Nem_3	368	373	PF02991	0.525
LIG_LIR_Nem_3	89	94	PF02991	0.315
LIG_NRBOX	140	146	PF00104	0.184
LIG_NRBOX	6	12	PF00104	0.540
LIG_PDZ_Class_2	373	378	PF00595	0.560
LIG_SH2_CRK	255	259	PF00017	0.239
LIG_SH2_NCK_1	373	377	PF00017	0.520
LIG_SH2_SRC	222	225	PF00017	0.349
LIG_SH2_SRC	255	258	PF00017	0.218
LIG_SH2_SRC	373	376	PF00017	0.539
LIG_SH2_STAP1	227	231	PF00017	0.293
LIG_SH2_STAP1	373	377	PF00017	0.566
LIG_SH2_STAT5	222	225	PF00017	0.277
LIG_SH2_STAT5	363	366	PF00017	0.541
LIG_SH2_STAT5	93	96	PF00017	0.229
LIG_SH2_STAT5	99	102	PF00017	0.218
LIG_SH3_3	201	207	PF00018	0.264
LIG_SH3_3	62	68	PF00018	0.245
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.436
LIG_SUMO_SIM_anti_2	140	145	PF11976	0.194
LIG_SUMO_SIM_anti_2	34	39	PF11976	0.335
LIG_SUMO_SIM_anti_2	354	359	PF11976	0.212
LIG_SUMO_SIM_par_1	100	109	PF11976	0.381
LIG_SUMO_SIM_par_1	175	181	PF11976	0.235
LIG_SUMO_SIM_par_1	8	13	PF11976	0.512
LIG_UBA3_1	305	310	PF00899	0.234
LIG_Vh1_VBS_1	340	358	PF01044	0.179
LIG_WRC_WIRS_1	57	62	PF05994	0.178
MOD_CK1_1	181	187	PF00069	0.391
MOD_CK1_1	229	235	PF00069	0.316
MOD_CK1_1	245	251	PF00069	0.173
MOD_CK1_1	301	307	PF00069	0.344
MOD_CK1_1	311	317	PF00069	0.417
MOD_CK2_1	122	128	PF00069	0.244
MOD_CK2_1	191	197	PF00069	0.335
MOD_CK2_1	229	235	PF00069	0.300
MOD_CK2_1	43	49	PF00069	0.307
MOD_GlcNHglycan	199	202	PF01048	0.552
MOD_GlcNHglycan	24	27	PF01048	0.623
MOD_GlcNHglycan	333	336	PF01048	0.549
MOD_GlcNHglycan	60	63	PF01048	0.430
MOD_GSK3_1	102	109	PF00069	0.294
MOD_GSK3_1	12	19	PF00069	0.486
MOD_GSK3_1	22	29	PF00069	0.480
MOD_GSK3_1	223	230	PF00069	0.245
MOD_GSK3_1	238	245	PF00069	0.270
MOD_GSK3_1	292	299	PF00069	0.264
MOD_GSK3_1	311	318	PF00069	0.462
MOD_GSK3_1	331	338	PF00069	0.436
MOD_GSK3_1	93	100	PF00069	0.191
MOD_N-GLC_1	293	298	PF02516	0.536
MOD_NEK2_1	10	15	PF00069	0.451
MOD_NEK2_1	122	127	PF00069	0.314
MOD_NEK2_1	16	21	PF00069	0.503
MOD_NEK2_1	223	228	PF00069	0.270
MOD_NEK2_1	292	297	PF00069	0.285
MOD_NEK2_1	43	48	PF00069	0.254
MOD_NEK2_1	58	63	PF00069	0.206
MOD_NEK2_1	70	75	PF00069	0.243
MOD_PKA_1	275	281	PF00069	0.299
MOD_PKB_1	367	375	PF00069	0.506
MOD_Plk_1	102	108	PF00069	0.239
MOD_Plk_1	223	229	PF00069	0.253
MOD_Plk_1	293	299	PF00069	0.321
MOD_Plk_2-3	102	108	PF00069	0.287
MOD_Plk_4	115	121	PF00069	0.242
MOD_Plk_4	12	18	PF00069	0.447
MOD_Plk_4	301	307	PF00069	0.340
MOD_Plk_4	351	357	PF00069	0.265
MOD_Plk_4	43	49	PF00069	0.284
MOD_ProDKin_1	106	112	PF00069	0.262
MOD_ProDKin_1	64	70	PF00069	0.303
MOD_ProDKin_1	93	99	PF00069	0.250
MOD_SUMO_rev_2	193	200	PF00179	0.278
MOD_SUMO_rev_2	267	272	PF00179	0.237
MOD_SUMO_rev_2	314	322	PF00179	0.366
MOD_SUMO_rev_2	323	333	PF00179	0.372
MOD_SUMO_rev_2	78	83	PF00179	0.268
TRG_DiLeu_BaEn_1	279	284	PF01217	0.220
TRG_ENDOCYTIC_2	213	216	PF00928	0.254
TRG_ENDOCYTIC_2	373	376	PF00928	0.551
TRG_ER_diArg_1	3	6	PF00400	0.395
TRG_NES_CRM1_1	150	164	PF08389	0.284
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8Q7	Leptomonas seymouri	36%	100%
A0A0S4JAL3	Bodo saltans	41%	100%
A0A0S4JML7	Bodo saltans	24%	100%
A0A1X0P2K7	Trypanosomatidae	44%	100%
A0A3Q8IBF6	Leishmania donovani	46%	100%
A0A3Q8IEW3	Leishmania donovani	37%	100%
A0A3Q8IK90	Leishmania donovani	63%	100%
A0A3S7X3A6	Leishmania donovani	37%	100%
A0A422N7B0	Trypanosoma rangeli	43%	100%
A4H6V5	Leishmania braziliensis	46%	100%
A4HI96	Leishmania braziliensis	34%	100%
A4HJL3	Leishmania braziliensis	76%	100%
A4I5I0	Leishmania infantum	37%	100%
A4I736	Leishmania infantum	100%	100%
C9ZQH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZQH6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZQW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AGC7	Leishmania infantum	46%	100%
E9ANW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B0S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B0S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B231	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
F4JJL0	Arabidopsis thaliana	30%	100%
F4JJL3	Arabidopsis thaliana	28%	100%
P24021	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	100%
Q4Q630	Leishmania major	93%	100%
Q4Q7F3	Leishmania major	38%	100%
Q4Q7F4	Leishmania major	39%	100%
Q4QGQ3	Leishmania major	45%	100%
Q66VY6	Leishmania major	65%	100%
Q8LDW6	Arabidopsis thaliana	27%	100%
Q9C9G4	Arabidopsis thaliana	29%	100%
Q9SXA6	Arabidopsis thaliana	27%	100%
V5B8Z9	Trypanosoma cruzi	39%	97%