LeishMANIAdb
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DUF2040 domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF2040 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IFH1_LEIDO
TriTrypDb:
LdBPK_300580.1 , LdCL_300010900 , LDHU3_30.0760
Length:
325

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote/Amastigote: 108, 110

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IFH1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFH1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 108 112 PF00656 0.681
CLV_C14_Caspase3-7 82 86 PF00656 0.525
CLV_NRD_NRD_1 122 124 PF00675 0.598
CLV_NRD_NRD_1 132 134 PF00675 0.555
CLV_NRD_NRD_1 163 165 PF00675 0.534
CLV_NRD_NRD_1 244 246 PF00675 0.481
CLV_NRD_NRD_1 288 290 PF00675 0.598
CLV_NRD_NRD_1 89 91 PF00675 0.507
CLV_PCSK_KEX2_1 132 134 PF00082 0.503
CLV_PCSK_KEX2_1 152 154 PF00082 0.422
CLV_PCSK_KEX2_1 244 246 PF00082 0.481
CLV_PCSK_KEX2_1 288 290 PF00082 0.598
CLV_PCSK_KEX2_1 97 99 PF00082 0.716
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.485
CLV_PCSK_PC1ET2_1 152 154 PF00082 0.551
CLV_PCSK_PC1ET2_1 97 99 PF00082 0.716
CLV_PCSK_SKI1_1 278 282 PF00082 0.493
CLV_PCSK_SKI1_1 288 292 PF00082 0.429
CLV_PCSK_SKI1_1 312 316 PF00082 0.446
CLV_PCSK_SKI1_1 45 49 PF00082 0.489
CLV_PCSK_SKI1_1 92 96 PF00082 0.567
DEG_APCC_DBOX_1 301 309 PF00400 0.485
DEG_SCF_TRCP1_1 184 189 PF00400 0.494
DOC_ANK_TNKS_1 252 259 PF00023 0.542
DOC_CYCLIN_RxL_1 42 52 PF00134 0.544
DOC_MAPK_gen_1 210 219 PF00069 0.504
DOC_MAPK_gen_1 286 293 PF00069 0.447
DOC_MAPK_MEF2A_6 210 219 PF00069 0.504
DOC_MAPK_MEF2A_6 312 319 PF00069 0.472
DOC_USP7_MATH_1 243 247 PF00917 0.478
DOC_USP7_UBL2_3 191 195 PF12436 0.583
DOC_USP7_UBL2_3 265 269 PF12436 0.581
DOC_USP7_UBL2_3 88 92 PF12436 0.595
DOC_WW_Pin1_4 37 42 PF00397 0.516
LIG_14-3-3_CanoR_1 244 248 PF00244 0.472
LIG_Actin_WH2_2 65 83 PF00022 0.578
LIG_BIR_II_1 1 5 PF00653 0.534
LIG_FHA_1 18 24 PF00498 0.512
LIG_FHA_2 114 120 PF00498 0.560
LIG_FHA_2 229 235 PF00498 0.449
LIG_FHA_2 98 104 PF00498 0.701
LIG_LIR_Gen_1 143 150 PF02991 0.535
LIG_LIR_Gen_1 40 51 PF02991 0.442
LIG_LIR_Nem_3 143 148 PF02991 0.592
LIG_LIR_Nem_3 40 46 PF02991 0.441
LIG_LIR_Nem_3 49 54 PF02991 0.414
LIG_LIR_Nem_3 9 15 PF02991 0.566
LIG_PDZ_Class_3 320 325 PF00595 0.541
LIG_SH2_CRK 145 149 PF00017 0.586
LIG_SH2_STAP1 21 25 PF00017 0.520
LIG_SH2_STAP1 43 47 PF00017 0.414
LIG_SH2_STAP1 8 12 PF00017 0.490
LIG_SH2_STAT3 8 11 PF00017 0.517
LIG_SH2_STAT5 8 11 PF00017 0.458
LIG_SH3_2 260 265 PF14604 0.587
LIG_SH3_3 257 263 PF00018 0.575
LIG_SUMO_SIM_anti_2 213 219 PF11976 0.499
LIG_SUMO_SIM_anti_2 303 310 PF11976 0.404
LIG_SUMO_SIM_par_1 303 310 PF11976 0.485
LIG_SUMO_SIM_par_1 313 318 PF11976 0.475
LIG_SUMO_SIM_par_1 46 52 PF11976 0.483
LIG_TRAF2_1 116 119 PF00917 0.555
LIG_TRAF2_1 125 128 PF00917 0.479
LIG_TRAF2_1 232 235 PF00917 0.547
LIG_TRAF2_1 239 242 PF00917 0.506
LIG_UBA3_1 50 56 PF00899 0.566
LIG_WRC_WIRS_1 7 12 PF05994 0.575
MOD_CK1_1 270 276 PF00069 0.497
MOD_CK2_1 107 113 PF00069 0.593
MOD_CK2_1 228 234 PF00069 0.441
MOD_CK2_1 243 249 PF00069 0.401
MOD_CK2_1 265 271 PF00069 0.578
MOD_CK2_1 304 310 PF00069 0.532
MOD_CK2_1 46 52 PF00069 0.552
MOD_GlcNHglycan 1 4 PF01048 0.571
MOD_GlcNHglycan 106 110 PF01048 0.658
MOD_GlcNHglycan 184 187 PF01048 0.722
MOD_GlcNHglycan 203 206 PF01048 0.350
MOD_GSK3_1 182 189 PF00069 0.489
MOD_GSK3_1 224 231 PF00069 0.402
MOD_GSK3_1 261 268 PF00069 0.619
MOD_GSK3_1 33 40 PF00069 0.565
MOD_GSK3_1 52 59 PF00069 0.523
MOD_NEK2_1 182 187 PF00069 0.701
MOD_NEK2_1 32 37 PF00069 0.467
MOD_NEK2_1 46 51 PF00069 0.490
MOD_PIKK_1 270 276 PF00454 0.603
MOD_PKA_1 97 103 PF00069 0.711
MOD_PKA_2 243 249 PF00069 0.470
MOD_PKA_2 97 103 PF00069 0.641
MOD_Plk_1 270 276 PF00069 0.603
MOD_Plk_2-3 107 113 PF00069 0.681
MOD_Plk_2-3 304 310 PF00069 0.532
MOD_Plk_4 304 310 PF00069 0.430
MOD_Plk_4 46 52 PF00069 0.488
MOD_ProDKin_1 37 43 PF00069 0.507
MOD_SUMO_for_1 211 214 PF00179 0.436
MOD_SUMO_rev_2 55 65 PF00179 0.530
MOD_SUMO_rev_2 85 93 PF00179 0.588
TRG_DiLeu_BaEn_1 213 218 PF01217 0.552
TRG_DiLeu_BaEn_3 213 219 PF01217 0.472
TRG_ENDOCYTIC_2 12 15 PF00928 0.570
TRG_ENDOCYTIC_2 145 148 PF00928 0.589
TRG_ENDOCYTIC_2 43 46 PF00928 0.417
TRG_NLS_MonoExtN_4 188 194 PF00514 0.716
TRG_Pf-PMV_PEXEL_1 245 249 PF00026 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM18 Leptomonas seymouri 70% 100%
A0A422NIF5 Trypanosoma rangeli 39% 99%
A4HI07 Leishmania braziliensis 87% 100%
A4I584 Leishmania infantum 100% 100%
E9B0I1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q7Q0 Leishmania major 97% 100%
V5AS86 Trypanosoma cruzi 36% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS