RNA methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFH0_LEIDO

TriTrypDb:

LdBPK_321790.1 , LdCL_320023400 , LDHU3_32.2270

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFH0

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.537
CLV_C14_Caspase3-7	358	362	PF00656	0.530
CLV_C14_Caspase3-7	495	499	PF00656	0.556
CLV_C14_Caspase3-7	588	592	PF00656	0.405
CLV_C14_Caspase3-7	632	636	PF00656	0.724
CLV_NRD_NRD_1	2	4	PF00675	0.728
CLV_NRD_NRD_1	214	216	PF00675	0.532
CLV_NRD_NRD_1	31	33	PF00675	0.526
CLV_NRD_NRD_1	320	322	PF00675	0.560
CLV_NRD_NRD_1	464	466	PF00675	0.406
CLV_NRD_NRD_1	568	570	PF00675	0.538
CLV_PCSK_KEX2_1	2	4	PF00082	0.728
CLV_PCSK_KEX2_1	214	216	PF00082	0.532
CLV_PCSK_KEX2_1	31	33	PF00082	0.537
CLV_PCSK_KEX2_1	319	321	PF00082	0.570
CLV_PCSK_KEX2_1	464	466	PF00082	0.494
CLV_PCSK_KEX2_1	568	570	PF00082	0.538
CLV_PCSK_SKI1_1	106	110	PF00082	0.552
CLV_PCSK_SKI1_1	215	219	PF00082	0.521
CLV_PCSK_SKI1_1	395	399	PF00082	0.404
CLV_PCSK_SKI1_1	568	572	PF00082	0.566
DEG_Nend_UBRbox_1	1	4	PF02207	0.648
DOC_CYCLIN_RxL_1	212	222	PF00134	0.553
DOC_CYCLIN_yClb3_PxF_3	374	382	PF00134	0.515
DOC_MAPK_MEF2A_6	198	206	PF00069	0.396
DOC_PP2B_LxvP_1	12	15	PF13499	0.679
DOC_PP2B_LxvP_1	333	336	PF13499	0.627
DOC_PP2B_LxvP_1	522	525	PF13499	0.389
DOC_PP2B_LxvP_1	596	599	PF13499	0.332
DOC_USP7_MATH_1	122	126	PF00917	0.729
DOC_USP7_MATH_1	292	296	PF00917	0.399
DOC_USP7_MATH_1	350	354	PF00917	0.676
DOC_USP7_MATH_1	355	359	PF00917	0.649
DOC_USP7_MATH_1	407	411	PF00917	0.747
DOC_USP7_MATH_1	416	420	PF00917	0.739
DOC_USP7_MATH_1	472	476	PF00917	0.510
DOC_USP7_MATH_1	494	498	PF00917	0.722
DOC_USP7_MATH_1	556	560	PF00917	0.543
DOC_USP7_MATH_1	59	63	PF00917	0.345
DOC_USP7_MATH_1	96	100	PF00917	0.544
DOC_WW_Pin1_4	133	138	PF00397	0.473
DOC_WW_Pin1_4	148	153	PF00397	0.375
DOC_WW_Pin1_4	168	173	PF00397	0.310
DOC_WW_Pin1_4	242	247	PF00397	0.528
DOC_WW_Pin1_4	301	306	PF00397	0.547
DOC_WW_Pin1_4	364	369	PF00397	0.638
DOC_WW_Pin1_4	401	406	PF00397	0.560
DOC_WW_Pin1_4	419	424	PF00397	0.598
DOC_WW_Pin1_4	476	481	PF00397	0.375
DOC_WW_Pin1_4	487	492	PF00397	0.448
DOC_WW_Pin1_4	70	75	PF00397	0.543
LIG_14-3-3_CanoR_1	2	6	PF00244	0.738
LIG_14-3-3_CanoR_1	214	218	PF00244	0.494
LIG_14-3-3_CanoR_1	232	241	PF00244	0.740
LIG_14-3-3_CanoR_1	659	666	PF00244	0.342
LIG_14-3-3_CanoR_1	97	104	PF00244	0.608
LIG_Actin_WH2_2	384	402	PF00022	0.408
LIG_APCC_ABBA_1	141	146	PF00400	0.418
LIG_APCC_ABBA_1	431	436	PF00400	0.238
LIG_Clathr_ClatBox_1	173	177	PF01394	0.353
LIG_FHA_1	21	27	PF00498	0.534
LIG_FHA_1	222	228	PF00498	0.705
LIG_FHA_1	233	239	PF00498	0.577
LIG_FHA_1	260	266	PF00498	0.557
LIG_FHA_1	354	360	PF00498	0.770
LIG_FHA_1	365	371	PF00498	0.613
LIG_FHA_1	477	483	PF00498	0.416
LIG_FHA_1	58	64	PF00498	0.409
LIG_FHA_1	612	618	PF00498	0.412
LIG_GBD_Chelix_1	267	275	PF00786	0.386
LIG_HP1_1	172	176	PF01393	0.379
LIG_LIR_Apic_2	146	152	PF02991	0.470
LIG_LIR_Apic_2	475	481	PF02991	0.408
LIG_LIR_Gen_1	310	318	PF02991	0.584
LIG_LIR_Gen_1	324	333	PF02991	0.512
LIG_LIR_Nem_3	136	141	PF02991	0.501
LIG_LIR_Nem_3	147	153	PF02991	0.458
LIG_LIR_Nem_3	310	315	PF02991	0.601
LIG_LIR_Nem_3	324	328	PF02991	0.483
LIG_LIR_Nem_3	427	431	PF02991	0.477
LIG_LIR_Nem_3	457	461	PF02991	0.490
LIG_LIR_Nem_3	82	86	PF02991	0.440
LIG_REV1ctd_RIR_1	326	333	PF16727	0.465
LIG_SH2_CRK	478	482	PF00017	0.391
LIG_SH2_GRB2like	435	438	PF00017	0.329
LIG_SH2_STAP1	435	439	PF00017	0.386
LIG_SH2_STAP1	539	543	PF00017	0.481
LIG_SH2_STAT3	255	258	PF00017	0.343
LIG_SH2_STAT5	149	152	PF00017	0.563
LIG_SH2_STAT5	255	258	PF00017	0.348
LIG_SH2_STAT5	277	280	PF00017	0.360
LIG_SH2_STAT5	380	383	PF00017	0.557
LIG_SH2_STAT5	428	431	PF00017	0.366
LIG_SH2_STAT5	458	461	PF00017	0.329
LIG_SH2_STAT5	478	481	PF00017	0.416
LIG_SH2_STAT5	68	71	PF00017	0.417
LIG_SH3_3	12	18	PF00018	0.697
LIG_SH3_3	150	156	PF00018	0.642
LIG_SH3_3	251	257	PF00018	0.364
LIG_SH3_3	371	377	PF00018	0.501
LIG_SH3_3	485	491	PF00018	0.454
LIG_SH3_3	660	666	PF00018	0.362
LIG_SUMO_SIM_par_1	171	177	PF11976	0.366
LIG_WW_3	13	17	PF00397	0.571
MOD_CDK_SPK_2	364	369	PF00069	0.623
MOD_CK1_1	110	116	PF00069	0.660
MOD_CK1_1	151	157	PF00069	0.506
MOD_CK1_1	353	359	PF00069	0.564
MOD_CK1_1	419	425	PF00069	0.670
MOD_CK1_1	492	498	PF00069	0.742
MOD_CK1_1	560	566	PF00069	0.535
MOD_CK1_1	582	588	PF00069	0.520
MOD_CK1_1	62	68	PF00069	0.347
MOD_CK1_1	73	79	PF00069	0.351
MOD_CK2_1	582	588	PF00069	0.464
MOD_CK2_1	97	103	PF00069	0.571
MOD_Cter_Amidation	462	465	PF01082	0.330
MOD_GlcNHglycan	124	127	PF01048	0.689
MOD_GlcNHglycan	129	132	PF01048	0.616
MOD_GlcNHglycan	298	301	PF01048	0.674
MOD_GlcNHglycan	340	343	PF01048	0.735
MOD_GlcNHglycan	344	347	PF01048	0.740
MOD_GlcNHglycan	352	355	PF01048	0.628
MOD_GlcNHglycan	401	404	PF01048	0.432
MOD_GlcNHglycan	417	421	PF01048	0.698
MOD_GlcNHglycan	449	452	PF01048	0.393
MOD_GlcNHglycan	502	505	PF01048	0.630
MOD_GlcNHglycan	54	57	PF01048	0.396
MOD_GlcNHglycan	652	655	PF01048	0.410
MOD_GlcNHglycan	660	663	PF01048	0.371
MOD_GlcNHglycan	99	102	PF01048	0.765
MOD_GSK3_1	129	136	PF00069	0.649
MOD_GSK3_1	182	189	PF00069	0.356
MOD_GSK3_1	20	27	PF00069	0.631
MOD_GSK3_1	292	299	PF00069	0.554
MOD_GSK3_1	338	345	PF00069	0.685
MOD_GSK3_1	349	356	PF00069	0.757
MOD_GSK3_1	472	479	PF00069	0.397
MOD_GSK3_1	489	496	PF00069	0.498
MOD_GSK3_1	556	563	PF00069	0.534
MOD_GSK3_1	575	582	PF00069	0.243
MOD_GSK3_1	611	618	PF00069	0.389
MOD_GSK3_1	646	653	PF00069	0.540
MOD_N-GLC_1	110	115	PF02516	0.692
MOD_N-GLC_1	168	173	PF02516	0.416
MOD_N-GLC_1	364	369	PF02516	0.575
MOD_N-GLC_1	57	62	PF02516	0.403
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	109	114	PF00069	0.538
MOD_NEK2_1	296	301	PF00069	0.578
MOD_NEK2_1	348	353	PF00069	0.511
MOD_NEK2_1	399	404	PF00069	0.543
MOD_NEK2_1	424	429	PF00069	0.450
MOD_NEK2_1	447	452	PF00069	0.472
MOD_NEK2_1	500	505	PF00069	0.645
MOD_NEK2_1	57	62	PF00069	0.362
MOD_NEK2_2	59	64	PF00069	0.326
MOD_PIKK_1	222	228	PF00454	0.500
MOD_PIKK_1	646	652	PF00454	0.442
MOD_PKA_2	1	7	PF00069	0.761
MOD_PKA_2	213	219	PF00069	0.538
MOD_PKA_2	27	33	PF00069	0.444
MOD_PKA_2	381	387	PF00069	0.452
MOD_PKA_2	399	405	PF00069	0.556
MOD_PKA_2	658	664	PF00069	0.338
MOD_PKA_2	96	102	PF00069	0.666
MOD_Plk_1	110	116	PF00069	0.692
MOD_Plk_1	222	228	PF00069	0.602
MOD_Plk_1	539	545	PF00069	0.597
MOD_Plk_1	582	588	PF00069	0.419
MOD_Plk_4	424	430	PF00069	0.441
MOD_Plk_4	615	621	PF00069	0.347
MOD_Plk_4	73	79	PF00069	0.335
MOD_ProDKin_1	133	139	PF00069	0.470
MOD_ProDKin_1	148	154	PF00069	0.390
MOD_ProDKin_1	168	174	PF00069	0.295
MOD_ProDKin_1	242	248	PF00069	0.512
MOD_ProDKin_1	301	307	PF00069	0.549
MOD_ProDKin_1	364	370	PF00069	0.633
MOD_ProDKin_1	401	407	PF00069	0.571
MOD_ProDKin_1	419	425	PF00069	0.588
MOD_ProDKin_1	476	482	PF00069	0.375
MOD_ProDKin_1	487	493	PF00069	0.457
MOD_ProDKin_1	70	76	PF00069	0.540
TRG_DiLeu_BaEn_4	517	523	PF01217	0.370
TRG_ENDOCYTIC_2	277	280	PF00928	0.297
TRG_ENDOCYTIC_2	312	315	PF00928	0.546
TRG_ENDOCYTIC_2	325	328	PF00928	0.434
TRG_ENDOCYTIC_2	428	431	PF00928	0.494
TRG_ER_diArg_1	1	3	PF00400	0.734
TRG_ER_diArg_1	187	190	PF00400	0.550
TRG_ER_diArg_1	213	215	PF00400	0.494
TRG_ER_diArg_1	31	33	PF00400	0.516
TRG_ER_diArg_1	318	321	PF00400	0.555
TRG_ER_diArg_1	567	569	PF00400	0.455
TRG_ER_FFAT_2	146	154	PF00635	0.427
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P977	Leptomonas seymouri	48%	98%
A0A0S4IV62	Bodo saltans	36%	100%
A0A1X0NUB8	Trypanosomatidae	33%	100%
A0A3R7KBD3	Trypanosoma rangeli	37%	100%
A4HKF8	Leishmania braziliensis	72%	100%
A4I7Y6	Leishmania infantum	100%	100%
D0AA55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B2U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5A9	Leishmania major	90%	100%
V5BF12	Trypanosoma cruzi	39%	100%