DUF4139 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 37

Species:

Leishmania donovani

UniProt:

A0A3Q8IFG9_LEIDO

TriTrypDb:

LdBPK_292220.1 , LdCL_290028200 , LDHU3_30.1300

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IFG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.731
CLV_NRD_NRD_1	140	142	PF00675	0.435
CLV_NRD_NRD_1	335	337	PF00675	0.339
CLV_NRD_NRD_1	40	42	PF00675	0.393
CLV_NRD_NRD_1	597	599	PF00675	0.302
CLV_NRD_NRD_1	613	615	PF00675	0.258
CLV_NRD_NRD_1	99	101	PF00675	0.624
CLV_PCSK_KEX2_1	140	142	PF00082	0.570
CLV_PCSK_KEX2_1	217	219	PF00082	0.468
CLV_PCSK_KEX2_1	335	337	PF00082	0.327
CLV_PCSK_KEX2_1	395	397	PF00082	0.255
CLV_PCSK_KEX2_1	40	42	PF00082	0.393
CLV_PCSK_KEX2_1	508	510	PF00082	0.284
CLV_PCSK_KEX2_1	543	545	PF00082	0.324
CLV_PCSK_KEX2_1	597	599	PF00082	0.318
CLV_PCSK_KEX2_1	613	615	PF00082	0.400
CLV_PCSK_KEX2_1	99	101	PF00082	0.608
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.450
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.255
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.306
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.301
CLV_PCSK_SKI1_1	148	152	PF00082	0.408
CLV_PCSK_SKI1_1	218	222	PF00082	0.532
CLV_PCSK_SKI1_1	224	228	PF00082	0.468
CLV_PCSK_SKI1_1	267	271	PF00082	0.616
CLV_PCSK_SKI1_1	508	512	PF00082	0.295
CLV_PCSK_SKI1_1	543	547	PF00082	0.381
CLV_PCSK_SKI1_1	86	90	PF00082	0.501
CLV_Separin_Metazoa	219	223	PF03568	0.421
DEG_APCC_DBOX_1	427	435	PF00400	0.327
DEG_APCC_DBOX_1	596	604	PF00400	0.202
DEG_Nend_UBRbox_3	1	3	PF02207	0.607
DOC_CKS1_1	356	361	PF01111	0.255
DOC_CKS1_1	47	52	PF01111	0.520
DOC_CYCLIN_RxL_1	213	225	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.386
DOC_MAPK_gen_1	148	156	PF00069	0.468
DOC_MAPK_gen_1	40	47	PF00069	0.423
DOC_MAPK_gen_1	554	563	PF00069	0.329
DOC_MAPK_gen_1	613	623	PF00069	0.425
DOC_MAPK_gen_1	99	110	PF00069	0.490
DOC_MAPK_MEF2A_6	231	240	PF00069	0.385
DOC_MAPK_MEF2A_6	616	625	PF00069	0.327
DOC_PP2B_LxvP_1	434	437	PF13499	0.314
DOC_PP2B_LxvP_1	465	468	PF13499	0.386
DOC_PP4_FxxP_1	412	415	PF00568	0.292
DOC_PP4_FxxP_1	47	50	PF00568	0.547
DOC_USP7_MATH_1	119	123	PF00917	0.764
DOC_USP7_MATH_1	12	16	PF00917	0.627
DOC_USP7_MATH_1	229	233	PF00917	0.353
DOC_USP7_MATH_1	446	450	PF00917	0.346
DOC_USP7_MATH_1	490	494	PF00917	0.404
DOC_USP7_MATH_1	501	505	PF00917	0.256
DOC_USP7_MATH_1	545	549	PF00917	0.496
DOC_USP7_MATH_1	562	566	PF00917	0.248
DOC_USP7_MATH_1	617	621	PF00917	0.327
DOC_USP7_UBL2_3	527	531	PF12436	0.354
DOC_WW_Pin1_4	243	248	PF00397	0.655
DOC_WW_Pin1_4	352	357	PF00397	0.467
DOC_WW_Pin1_4	361	366	PF00397	0.214
DOC_WW_Pin1_4	46	51	PF00397	0.500
DOC_WW_Pin1_4	572	577	PF00397	0.355
DOC_WW_Pin1_4	6	11	PF00397	0.541
LIG_14-3-3_CanoR_1	100	110	PF00244	0.534
LIG_Actin_WH2_2	255	272	PF00022	0.412
LIG_APCC_ABBA_1	471	476	PF00400	0.386
LIG_APCC_ABBA_1	583	588	PF00400	0.376
LIG_BIR_III_4	125	129	PF00653	0.591
LIG_FHA_1	105	111	PF00498	0.561
LIG_FHA_1	174	180	PF00498	0.438
LIG_FHA_1	18	24	PF00498	0.576
LIG_FHA_1	188	194	PF00498	0.444
LIG_FHA_1	256	262	PF00498	0.538
LIG_FHA_1	263	269	PF00498	0.523
LIG_FHA_1	301	307	PF00498	0.331
LIG_FHA_1	404	410	PF00498	0.362
LIG_FHA_1	424	430	PF00498	0.349
LIG_FHA_1	544	550	PF00498	0.350
LIG_FHA_2	255	261	PF00498	0.504
LIG_LIR_Apic_2	283	287	PF02991	0.285
LIG_LIR_Apic_2	46	50	PF02991	0.551
LIG_LIR_Gen_1	288	299	PF02991	0.467
LIG_LIR_Gen_1	439	450	PF02991	0.304
LIG_LIR_Gen_1	461	472	PF02991	0.338
LIG_LIR_Nem_3	288	294	PF02991	0.319
LIG_LIR_Nem_3	439	445	PF02991	0.304
LIG_LIR_Nem_3	461	467	PF02991	0.338
LIG_PDZ_Class_2	635	640	PF00595	0.434
LIG_Pex14_1	291	295	PF04695	0.302
LIG_Pex14_2	79	83	PF04695	0.482
LIG_SH2_CRK	284	288	PF00017	0.255
LIG_SH2_CRK	442	446	PF00017	0.358
LIG_SH2_GRB2like	309	312	PF00017	0.285
LIG_SH2_GRB2like	33	36	PF00017	0.404
LIG_SH2_STAP1	295	299	PF00017	0.321
LIG_SH2_STAP1	533	537	PF00017	0.310
LIG_SH2_STAT5	170	173	PF00017	0.616
LIG_SH2_STAT5	281	284	PF00017	0.275
LIG_SH2_STAT5	479	482	PF00017	0.398
LIG_SH2_STAT5	498	501	PF00017	0.209
LIG_SH2_STAT5	522	525	PF00017	0.342
LIG_SH2_STAT5	584	587	PF00017	0.337
LIG_SH3_1	270	276	PF00018	0.423
LIG_SH3_3	265	271	PF00018	0.573
LIG_SH3_3	348	354	PF00018	0.434
LIG_SH3_3	53	59	PF00018	0.531
LIG_SH3_3	573	579	PF00018	0.320
LIG_SH3_3	626	632	PF00018	0.318
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.544
LIG_SUMO_SIM_anti_2	619	625	PF11976	0.386
LIG_SUMO_SIM_par_1	104	111	PF11976	0.608
LIG_SUMO_SIM_par_1	260	265	PF11976	0.440
LIG_SUMO_SIM_par_1	606	612	PF11976	0.411
LIG_TRAF2_1	564	567	PF00917	0.313
LIG_TRFH_1	464	468	PF08558	0.386
LIG_TYR_ITIM	440	445	PF00017	0.270
MOD_CDC14_SPxK_1	575	578	PF00782	0.386
MOD_CDK_SPK_2	243	248	PF00069	0.524
MOD_CDK_SPxK_1	572	578	PF00069	0.386
MOD_CK1_1	104	110	PF00069	0.520
MOD_CK1_1	246	252	PF00069	0.640
MOD_CK1_1	355	361	PF00069	0.375
MOD_CK1_1	441	447	PF00069	0.327
MOD_CK1_1	46	52	PF00069	0.513
MOD_CK1_1	633	639	PF00069	0.506
MOD_CK2_1	174	180	PF00069	0.527
MOD_CK2_1	229	235	PF00069	0.498
MOD_CK2_1	441	447	PF00069	0.395
MOD_CK2_1	561	567	PF00069	0.301
MOD_Cter_Amidation	524	527	PF01082	0.456
MOD_GlcNHglycan	119	122	PF01048	0.791
MOD_GlcNHglycan	135	138	PF01048	0.551
MOD_GlcNHglycan	14	17	PF01048	0.523
MOD_GlcNHglycan	176	179	PF01048	0.474
MOD_GlcNHglycan	248	251	PF01048	0.723
MOD_GlcNHglycan	287	290	PF01048	0.408
MOD_GlcNHglycan	330	333	PF01048	0.303
MOD_GlcNHglycan	490	493	PF01048	0.311
MOD_GSK3_1	117	124	PF00069	0.689
MOD_GSK3_1	142	149	PF00069	0.363
MOD_GSK3_1	323	330	PF00069	0.255
MOD_N-GLC_1	207	212	PF02516	0.418
MOD_N-GLC_1	34	39	PF02516	0.386
MOD_N-GLC_1	459	464	PF02516	0.305
MOD_N-GLC_1	633	638	PF02516	0.574
MOD_NEK2_1	187	192	PF00069	0.565
MOD_NEK2_1	327	332	PF00069	0.302
MOD_NEK2_1	45	50	PF00069	0.560
MOD_NEK2_2	535	540	PF00069	0.292
MOD_PIKK_1	142	148	PF00454	0.416
MOD_PKA_1	543	549	PF00069	0.285
MOD_PKA_2	28	34	PF00069	0.440
MOD_PKA_2	535	541	PF00069	0.318
MOD_PKA_2	543	549	PF00069	0.356
MOD_Plk_1	110	116	PF00069	0.533
MOD_Plk_1	168	174	PF00069	0.518
MOD_Plk_1	323	329	PF00069	0.473
MOD_Plk_1	34	40	PF00069	0.441
MOD_Plk_1	446	452	PF00069	0.303
MOD_Plk_1	633	639	PF00069	0.510
MOD_Plk_4	28	34	PF00069	0.399
MOD_Plk_4	280	286	PF00069	0.260
MOD_Plk_4	416	422	PF00069	0.416
MOD_Plk_4	518	524	PF00069	0.438
MOD_Plk_4	633	639	PF00069	0.521
MOD_ProDKin_1	243	249	PF00069	0.661
MOD_ProDKin_1	352	358	PF00069	0.459
MOD_ProDKin_1	361	367	PF00069	0.214
MOD_ProDKin_1	46	52	PF00069	0.507
MOD_ProDKin_1	572	578	PF00069	0.355
MOD_ProDKin_1	6	12	PF00069	0.540
MOD_SUMO_for_1	216	219	PF00179	0.514
MOD_SUMO_rev_2	230	238	PF00179	0.474
MOD_SUMO_rev_2	320	325	PF00179	0.281
MOD_SUMO_rev_2	502	510	PF00179	0.303
MOD_SUMO_rev_2	78	88	PF00179	0.557
TRG_DiLeu_BaEn_1	619	624	PF01217	0.255
TRG_DiLeu_BaEn_2	469	475	PF01217	0.285
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.285
TRG_ENDOCYTIC_2	442	445	PF00928	0.318
TRG_ER_diArg_1	334	336	PF00400	0.327
TRG_ER_diArg_1	481	484	PF00400	0.250
TRG_ER_diArg_1	613	616	PF00400	0.394
TRG_NES_CRM1_1	146	158	PF08389	0.452
TRG_NLS_Bipartite_1	526	546	PF00514	0.202
TRG_NLS_MonoExtN_4	540	546	PF00514	0.377
TRG_NLS_MonoExtN_4	597	602	PF00514	0.255
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	141	146	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W3	Leptomonas seymouri	61%	100%
A0A0S4JNB4	Bodo saltans	22%	100%
A0A3Q8IHT6	Leishmania donovani	25%	100%
A0A3R7LIT5	Trypanosoma rangeli	32%	100%
A4HHL0	Leishmania braziliensis	78%	100%
A4I4S0	Leishmania infantum	99%	100%
A4I5C4	Leishmania infantum	24%	100%
C9ZQQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
C9ZUB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
E9AE72	Leishmania major	94%	100%
E9ALL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B0M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q7L0	Leishmania major	25%	100%