LeishMANIAdb
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DUF4139 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4139 domain-containing protein
Gene product:
Present in the outer mitochondrial membrane proteome 37
Species:
Leishmania donovani
UniProt:
A0A3Q8IFG9_LEIDO
TriTrypDb:
LdBPK_292220.1 * , LdCL_290028200 , LDHU3_30.1300
Length:
640

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 12
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
TermNameLevelCount
GO:0005739 mitochondrion 5 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
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Expansion

Sequence features

A0A3Q8IFG9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFG9

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 120 124 PF00656 0.731
CLV_NRD_NRD_1 140 142 PF00675 0.435
CLV_NRD_NRD_1 335 337 PF00675 0.339
CLV_NRD_NRD_1 40 42 PF00675 0.393
CLV_NRD_NRD_1 597 599 PF00675 0.302
CLV_NRD_NRD_1 613 615 PF00675 0.258
CLV_NRD_NRD_1 99 101 PF00675 0.624
CLV_PCSK_KEX2_1 140 142 PF00082 0.570
CLV_PCSK_KEX2_1 217 219 PF00082 0.468
CLV_PCSK_KEX2_1 335 337 PF00082 0.327
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I3W3 Leptomonas seymouri 61% 100%
A0A0S4JNB4 Bodo saltans 22% 100%
A0A3Q8IHT6 Leishmania donovani 25% 100%
A0A3R7LIT5 Trypanosoma rangeli 32% 100%
A4HHL0 Leishmania braziliensis 78% 100%
A4I4S0 Leishmania infantum 99% 100%
A4I5C4 Leishmania infantum 24% 100%
C9ZQQ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 100%
C9ZUB2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 92%
E9AE72 Leishmania major 94% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS