Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 2 |
Forrest at al. (procyclic) | no | yes: 2 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 15 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 5 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 18 |
NetGPI | no | yes: 0, no: 18 |
Related structures:
AlphaFold database: A0A3Q8IFG5
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 121 | 125 | PF00656 | 0.819 |
CLV_C14_Caspase3-7 | 130 | 134 | PF00656 | 0.822 |
CLV_C14_Caspase3-7 | 81 | 85 | PF00656 | 0.702 |
CLV_NRD_NRD_1 | 305 | 307 | PF00675 | 0.648 |
CLV_NRD_NRD_1 | 540 | 542 | PF00675 | 0.707 |
CLV_NRD_NRD_1 | 577 | 579 | PF00675 | 0.557 |
CLV_NRD_NRD_1 | 615 | 617 | PF00675 | 0.564 |
CLV_PCSK_KEX2_1 | 524 | 526 | PF00082 | 0.738 |
CLV_PCSK_KEX2_1 | 539 | 541 | PF00082 | 0.468 |
CLV_PCSK_PC1ET2_1 | 524 | 526 | PF00082 | 0.760 |
CLV_PCSK_PC1ET2_1 | 539 | 541 | PF00082 | 0.468 |
CLV_PCSK_SKI1_1 | 21 | 25 | PF00082 | 0.572 |
CLV_PCSK_SKI1_1 | 214 | 218 | PF00082 | 0.499 |
CLV_PCSK_SKI1_1 | 231 | 235 | PF00082 | 0.558 |
CLV_PCSK_SKI1_1 | 324 | 328 | PF00082 | 0.559 |
CLV_PCSK_SKI1_1 | 525 | 529 | PF00082 | 0.619 |
CLV_PCSK_SKI1_1 | 535 | 539 | PF00082 | 0.514 |
CLV_PCSK_SKI1_1 | 56 | 60 | PF00082 | 0.594 |
DEG_APCC_DBOX_1 | 353 | 361 | PF00400 | 0.668 |
DOC_MAPK_MEF2A_6 | 146 | 154 | PF00069 | 0.637 |
DOC_MAPK_MEF2A_6 | 553 | 560 | PF00069 | 0.589 |
DOC_PP1_RVXF_1 | 368 | 375 | PF00149 | 0.669 |
DOC_PP1_SILK_1 | 612 | 617 | PF00149 | 0.482 |
DOC_PP2B_LxvP_1 | 478 | 481 | PF13499 | 0.751 |
DOC_SPAK_OSR1_1 | 30 | 34 | PF12202 | 0.559 |
DOC_USP7_MATH_1 | 347 | 351 | PF00917 | 0.610 |
DOC_USP7_MATH_1 | 391 | 395 | PF00917 | 0.594 |
DOC_USP7_MATH_1 | 445 | 449 | PF00917 | 0.566 |
DOC_USP7_MATH_1 | 461 | 465 | PF00917 | 0.502 |
DOC_USP7_MATH_1 | 567 | 571 | PF00917 | 0.489 |
DOC_USP7_MATH_1 | 603 | 607 | PF00917 | 0.544 |
DOC_USP7_MATH_2 | 334 | 340 | PF00917 | 0.611 |
DOC_USP7_MATH_2 | 424 | 430 | PF00917 | 0.623 |
DOC_USP7_UBL2_3 | 255 | 259 | PF12436 | 0.538 |
DOC_USP7_UBL2_3 | 531 | 535 | PF12436 | 0.483 |
DOC_WW_Pin1_4 | 387 | 392 | PF00397 | 0.637 |
DOC_WW_Pin1_4 | 420 | 425 | PF00397 | 0.686 |
LIG_14-3-3_CanoR_1 | 265 | 270 | PF00244 | 0.616 |
LIG_14-3-3_CanoR_1 | 30 | 39 | PF00244 | 0.469 |
LIG_14-3-3_CanoR_1 | 301 | 308 | PF00244 | 0.423 |
LIG_14-3-3_CanoR_1 | 4 | 9 | PF00244 | 0.738 |
LIG_14-3-3_CanoR_1 | 415 | 421 | PF00244 | 0.645 |
LIG_14-3-3_CanoR_1 | 427 | 431 | PF00244 | 0.525 |
LIG_14-3-3_CanoR_1 | 541 | 549 | PF00244 | 0.561 |
LIG_Actin_WH2_2 | 437 | 455 | PF00022 | 0.628 |
LIG_AP2alpha_1 | 50 | 54 | PF02296 | 0.608 |
LIG_BIR_III_2 | 84 | 88 | PF00653 | 0.668 |
LIG_BRCT_BRCA1_1 | 267 | 271 | PF00533 | 0.605 |
LIG_BRCT_BRCA1_1 | 585 | 589 | PF00533 | 0.458 |
LIG_BRCT_BRCA1_1 | 63 | 67 | PF00533 | 0.560 |
LIG_CSL_BTD_1 | 388 | 391 | PF09270 | 0.625 |
LIG_EH1_1 | 608 | 616 | PF00400 | 0.518 |
LIG_FHA_1 | 143 | 149 | PF00498 | 0.668 |
LIG_FHA_1 | 201 | 207 | PF00498 | 0.458 |
LIG_FHA_1 | 264 | 270 | PF00498 | 0.624 |
LIG_FHA_1 | 53 | 59 | PF00498 | 0.621 |
LIG_FHA_1 | 592 | 598 | PF00498 | 0.448 |
LIG_FHA_2 | 30 | 36 | PF00498 | 0.603 |
LIG_FHA_2 | 469 | 475 | PF00498 | 0.744 |
LIG_GBD_Chelix_1 | 611 | 619 | PF00786 | 0.494 |
LIG_Integrin_RGD_1 | 122 | 124 | PF01839 | 0.749 |
LIG_LIR_Gen_1 | 174 | 183 | PF02991 | 0.581 |
LIG_LIR_Gen_1 | 226 | 235 | PF02991 | 0.552 |
LIG_LIR_Gen_1 | 298 | 304 | PF02991 | 0.571 |
LIG_LIR_Gen_1 | 605 | 615 | PF02991 | 0.567 |
LIG_LIR_Nem_3 | 149 | 154 | PF02991 | 0.615 |
LIG_LIR_Nem_3 | 163 | 168 | PF02991 | 0.377 |
LIG_LIR_Nem_3 | 17 | 23 | PF02991 | 0.634 |
LIG_LIR_Nem_3 | 174 | 178 | PF02991 | 0.422 |
LIG_LIR_Nem_3 | 226 | 230 | PF02991 | 0.541 |
LIG_LIR_Nem_3 | 290 | 294 | PF02991 | 0.454 |
LIG_LIR_Nem_3 | 298 | 302 | PF02991 | 0.556 |
LIG_LIR_Nem_3 | 464 | 469 | PF02991 | 0.685 |
LIG_LIR_Nem_3 | 605 | 611 | PF02991 | 0.498 |
LIG_PCNA_yPIPBox_3 | 301 | 312 | PF02747 | 0.382 |
LIG_Pex14_2 | 50 | 54 | PF04695 | 0.608 |
LIG_SH2_CRK | 165 | 169 | PF00017 | 0.577 |
LIG_SH2_CRK | 20 | 24 | PF00017 | 0.637 |
LIG_SH2_CRK | 227 | 231 | PF00017 | 0.647 |
LIG_SH2_CRK | 283 | 287 | PF00017 | 0.542 |
LIG_SH2_CRK | 291 | 295 | PF00017 | 0.448 |
LIG_SH2_CRK | 299 | 303 | PF00017 | 0.403 |
LIG_SH2_CRK | 312 | 316 | PF00017 | 0.385 |
LIG_SH2_GRB2like | 312 | 315 | PF00017 | 0.379 |
LIG_SH2_GRB2like | 542 | 545 | PF00017 | 0.532 |
LIG_SH2_SRC | 312 | 315 | PF00017 | 0.379 |
LIG_SH2_SRC | 542 | 545 | PF00017 | 0.489 |
LIG_SH2_STAP1 | 312 | 316 | PF00017 | 0.385 |
LIG_SH2_STAP1 | 469 | 473 | PF00017 | 0.700 |
LIG_SH2_STAT3 | 37 | 40 | PF00017 | 0.601 |
LIG_SH2_STAT5 | 175 | 178 | PF00017 | 0.601 |
LIG_SH2_STAT5 | 195 | 198 | PF00017 | 0.499 |
LIG_SH2_STAT5 | 283 | 286 | PF00017 | 0.566 |
LIG_SH2_STAT5 | 291 | 294 | PF00017 | 0.426 |
LIG_SH2_STAT5 | 337 | 340 | PF00017 | 0.585 |
LIG_SH2_STAT5 | 37 | 40 | PF00017 | 0.601 |
LIG_SH2_STAT5 | 432 | 435 | PF00017 | 0.670 |
LIG_SH2_STAT5 | 542 | 545 | PF00017 | 0.532 |
LIG_SH3_3 | 147 | 153 | PF00018 | 0.587 |
LIG_SH3_3 | 385 | 391 | PF00018 | 0.672 |
LIG_SH3_3 | 439 | 445 | PF00018 | 0.647 |
LIG_SH3_3 | 493 | 499 | PF00018 | 0.803 |
LIG_SH3_3 | 89 | 95 | PF00018 | 0.754 |
LIG_SUMO_SIM_anti_2 | 439 | 445 | PF11976 | 0.642 |
LIG_TRAF2_1 | 25 | 28 | PF00917 | 0.554 |
LIG_TYR_ITIM | 18 | 23 | PF00017 | 0.625 |
LIG_TYR_ITIM | 225 | 230 | PF00017 | 0.639 |
LIG_UBA3_1 | 206 | 214 | PF00899 | 0.571 |
LIG_UBA3_1 | 342 | 348 | PF00899 | 0.568 |
LIG_UBA3_1 | 572 | 579 | PF00899 | 0.464 |
LIG_UBA3_1 | 610 | 617 | PF00899 | 0.551 |
LIG_WRC_WIRS_1 | 371 | 376 | PF05994 | 0.660 |
MOD_CDK_SPxxK_3 | 420 | 427 | PF00069 | 0.686 |
MOD_CK1_1 | 250 | 256 | PF00069 | 0.593 |
MOD_CK1_1 | 300 | 306 | PF00069 | 0.615 |
MOD_CK1_1 | 364 | 370 | PF00069 | 0.609 |
MOD_CK1_1 | 414 | 420 | PF00069 | 0.666 |
MOD_CK1_1 | 516 | 522 | PF00069 | 0.737 |
MOD_CK2_1 | 29 | 35 | PF00069 | 0.600 |
MOD_CK2_1 | 387 | 393 | PF00069 | 0.440 |
MOD_CK2_1 | 420 | 426 | PF00069 | 0.565 |
MOD_CK2_1 | 452 | 458 | PF00069 | 0.405 |
MOD_CK2_1 | 468 | 474 | PF00069 | 0.714 |
MOD_GlcNHglycan | 118 | 121 | PF01048 | 0.778 |
MOD_GlcNHglycan | 127 | 130 | PF01048 | 0.756 |
MOD_GlcNHglycan | 236 | 239 | PF01048 | 0.681 |
MOD_GlcNHglycan | 241 | 245 | PF01048 | 0.660 |
MOD_GlcNHglycan | 384 | 387 | PF01048 | 0.731 |
MOD_GlcNHglycan | 393 | 396 | PF01048 | 0.383 |
MOD_GlcNHglycan | 492 | 495 | PF01048 | 0.761 |
MOD_GlcNHglycan | 517 | 521 | PF01048 | 0.786 |
MOD_GlcNHglycan | 580 | 583 | PF01048 | 0.595 |
MOD_GlcNHglycan | 585 | 588 | PF01048 | 0.545 |
MOD_GlcNHglycan | 62 | 66 | PF01048 | 0.674 |
MOD_GSK3_1 | 138 | 145 | PF00069 | 0.575 |
MOD_GSK3_1 | 196 | 203 | PF00069 | 0.549 |
MOD_GSK3_1 | 259 | 266 | PF00069 | 0.635 |
MOD_GSK3_1 | 356 | 363 | PF00069 | 0.726 |
MOD_GSK3_1 | 387 | 394 | PF00069 | 0.505 |
MOD_GSK3_1 | 426 | 433 | PF00069 | 0.632 |
MOD_GSK3_1 | 547 | 554 | PF00069 | 0.636 |
MOD_GSK3_1 | 563 | 570 | PF00069 | 0.336 |
MOD_GSK3_1 | 591 | 598 | PF00069 | 0.411 |
MOD_N-GLC_1 | 411 | 416 | PF02516 | 0.661 |
MOD_N-GLC_1 | 591 | 596 | PF02516 | 0.453 |
MOD_NEK2_1 | 105 | 110 | PF00069 | 0.647 |
MOD_NEK2_1 | 198 | 203 | PF00069 | 0.564 |
MOD_NEK2_1 | 269 | 274 | PF00069 | 0.574 |
MOD_NEK2_1 | 295 | 300 | PF00069 | 0.581 |
MOD_NEK2_1 | 360 | 365 | PF00069 | 0.700 |
MOD_NEK2_1 | 382 | 387 | PF00069 | 0.709 |
MOD_NEK2_1 | 452 | 457 | PF00069 | 0.596 |
MOD_NEK2_1 | 50 | 55 | PF00069 | 0.608 |
MOD_NEK2_1 | 572 | 577 | PF00069 | 0.542 |
MOD_NEK2_2 | 138 | 143 | PF00069 | 0.592 |
MOD_NEK2_2 | 445 | 450 | PF00069 | 0.559 |
MOD_NMyristoyl | 1 | 7 | PF02799 | 0.794 |
MOD_PIKK_1 | 200 | 206 | PF00454 | 0.548 |
MOD_PIKK_1 | 365 | 371 | PF00454 | 0.689 |
MOD_PIKK_1 | 414 | 420 | PF00454 | 0.666 |
MOD_PK_1 | 4 | 10 | PF00069 | 0.801 |
MOD_PKA_1 | 578 | 584 | PF00069 | 0.596 |
MOD_PKA_2 | 29 | 35 | PF00069 | 0.615 |
MOD_PKA_2 | 3 | 9 | PF00069 | 0.727 |
MOD_PKA_2 | 300 | 306 | PF00069 | 0.433 |
MOD_PKA_2 | 414 | 420 | PF00069 | 0.649 |
MOD_PKA_2 | 426 | 432 | PF00069 | 0.527 |
MOD_PKA_2 | 490 | 496 | PF00069 | 0.690 |
MOD_Plk_1 | 551 | 557 | PF00069 | 0.606 |
MOD_Plk_4 | 100 | 106 | PF00069 | 0.664 |
MOD_Plk_4 | 171 | 177 | PF00069 | 0.578 |
MOD_Plk_4 | 208 | 214 | PF00069 | 0.381 |
MOD_Plk_4 | 265 | 271 | PF00069 | 0.616 |
MOD_Plk_4 | 445 | 451 | PF00069 | 0.552 |
MOD_Plk_4 | 567 | 573 | PF00069 | 0.529 |
MOD_Plk_4 | 610 | 616 | PF00069 | 0.561 |
MOD_ProDKin_1 | 387 | 393 | PF00069 | 0.634 |
MOD_ProDKin_1 | 420 | 426 | PF00069 | 0.690 |
MOD_SUMO_rev_2 | 141 | 148 | PF00179 | 0.536 |
TRG_DiLeu_BaEn_2 | 584 | 590 | PF01217 | 0.492 |
TRG_DiLeu_BaLyEn_6 | 163 | 168 | PF01217 | 0.586 |
TRG_DiLeu_BaLyEn_6 | 337 | 342 | PF01217 | 0.536 |
TRG_DiLeu_BaLyEn_6 | 395 | 400 | PF01217 | 0.627 |
TRG_ENDOCYTIC_2 | 164 | 167 | PF00928 | 0.553 |
TRG_ENDOCYTIC_2 | 175 | 178 | PF00928 | 0.541 |
TRG_ENDOCYTIC_2 | 195 | 198 | PF00928 | 0.467 |
TRG_ENDOCYTIC_2 | 20 | 23 | PF00928 | 0.632 |
TRG_ENDOCYTIC_2 | 227 | 230 | PF00928 | 0.652 |
TRG_ENDOCYTIC_2 | 282 | 285 | PF00928 | 0.565 |
TRG_ENDOCYTIC_2 | 291 | 294 | PF00928 | 0.412 |
TRG_ENDOCYTIC_2 | 299 | 302 | PF00928 | 0.357 |
TRG_ENDOCYTIC_2 | 312 | 315 | PF00928 | 0.379 |
TRG_ENDOCYTIC_2 | 469 | 472 | PF00928 | 0.687 |
TRG_ER_diArg_1 | 540 | 542 | PF00400 | 0.553 |
TRG_NLS_Bipartite_1 | 524 | 543 | PF00514 | 0.708 |
TRG_NLS_MonoCore_2 | 537 | 542 | PF00514 | 0.655 |
TRG_NLS_MonoExtN_4 | 535 | 542 | PF00514 | 0.661 |
TRG_Pf-PMV_PEXEL_1 | 166 | 170 | PF00026 | 0.583 |
TRG_Pf-PMV_PEXEL_1 | 454 | 458 | PF00026 | 0.356 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A3Q8ISI8 | Leishmania donovani | 95% | 100% |
A0A3S7X4A3 | Leishmania donovani | 99% | 100% |
A4HJ70 | Leishmania braziliensis | 61% | 99% |
A4HJ71 | Leishmania braziliensis | 65% | 99% |
A4HJ73 | Leishmania braziliensis | 64% | 100% |
A4HJW7 | Leishmania braziliensis | 59% | 100% |
A4I6I2 | Leishmania infantum | 99% | 100% |
A4I6L8 | Leishmania infantum | 98% | 100% |
E8NHD1 | Leishmania infantum | 97% | 100% |
E8NHD2 | Leishmania infantum | 93% | 100% |
E8NHE7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 85% | 100% |
E8NHE8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 88% | 100% |
E9B1P3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 86% | 100% |
Q4Q6G7 | Leishmania major | 87% | 100% |
Q4Q6G8 | Leishmania major | 89% | 100% |
Q4Q6H0 | Leishmania major | 88% | 100% |
Q9BHE5 | Leishmania major | 90% | 100% |