Cilia- and flagella-associated protein 157

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFG4_LEIDO

TriTrypDb:

LdCL_220012800 , LDHU3_22.0960

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.534
CLV_NRD_NRD_1	106	108	PF00675	0.720
CLV_NRD_NRD_1	170	172	PF00675	0.471
CLV_NRD_NRD_1	32	34	PF00675	0.668
CLV_NRD_NRD_1	339	341	PF00675	0.553
CLV_NRD_NRD_1	384	386	PF00675	0.563
CLV_NRD_NRD_1	84	86	PF00675	0.718
CLV_NRD_NRD_1	92	94	PF00675	0.659
CLV_PCSK_FUR_1	337	341	PF00082	0.530
CLV_PCSK_KEX2_1	106	108	PF00082	0.733
CLV_PCSK_KEX2_1	31	33	PF00082	0.664
CLV_PCSK_KEX2_1	339	341	PF00082	0.566
CLV_PCSK_KEX2_1	370	372	PF00082	0.516
CLV_PCSK_KEX2_1	383	385	PF00082	0.449
CLV_PCSK_KEX2_1	84	86	PF00082	0.717
CLV_PCSK_KEX2_1	91	93	PF00082	0.664
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.558
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.468
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.739
CLV_PCSK_PC7_1	102	108	PF00082	0.678
CLV_PCSK_SKI1_1	253	257	PF00082	0.580
CLV_PCSK_SKI1_1	367	371	PF00082	0.521
CLV_PCSK_SKI1_1	377	381	PF00082	0.479
CLV_PCSK_SKI1_1	402	406	PF00082	0.575
CLV_PCSK_SKI1_1	416	420	PF00082	0.443
CLV_PCSK_SKI1_1	56	60	PF00082	0.684
DEG_APCC_DBOX_1	170	178	PF00400	0.489
DOC_CKS1_1	130	135	PF01111	0.715
DOC_MAPK_gen_1	171	177	PF00069	0.527
DOC_MAPK_gen_1	337	346	PF00069	0.575
DOC_USP7_MATH_1	119	123	PF00917	0.616
DOC_USP7_MATH_1	213	217	PF00917	0.518
DOC_USP7_MATH_1	396	400	PF00917	0.541
DOC_WW_Pin1_4	129	134	PF00397	0.727
DOC_WW_Pin1_4	42	47	PF00397	0.635
DOC_WW_Pin1_4	48	53	PF00397	0.622
DOC_WW_Pin1_4	93	98	PF00397	0.556
LIG_14-3-3_CanoR_1	149	153	PF00244	0.437
LIG_14-3-3_CanoR_1	306	314	PF00244	0.567
LIG_14-3-3_CanoR_1	31	36	PF00244	0.673
LIG_14-3-3_CanoR_1	347	355	PF00244	0.565
LIG_14-3-3_CanoR_1	62	67	PF00244	0.700
LIG_14-3-3_CanoR_1	92	97	PF00244	0.682
LIG_APCC_ABBA_1	161	166	PF00400	0.473
LIG_APCC_ABBA_1	206	211	PF00400	0.578
LIG_APCC_ABBAyCdc20_2	160	166	PF00400	0.509
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_FHA_1	189	195	PF00498	0.573
LIG_FHA_1	347	353	PF00498	0.525
LIG_FHA_2	130	136	PF00498	0.711
LIG_FHA_2	149	155	PF00498	0.432
LIG_FHA_2	284	290	PF00498	0.615
LIG_LIR_Gen_1	146	152	PF02991	0.617
LIG_LIR_Gen_1	233	244	PF02991	0.577
LIG_LIR_Nem_3	146	150	PF02991	0.558
LIG_LIR_Nem_3	233	239	PF02991	0.560
LIG_PCNA_PIPBox_1	215	224	PF02747	0.581
LIG_RPA_C_Fungi	14	26	PF08784	0.629
LIG_SH2_NCK_1	147	151	PF00017	0.442
LIG_SH2_STAP1	136	140	PF00017	0.614
LIG_SH2_STAP1	164	168	PF00017	0.412
LIG_SH2_STAP1	209	213	PF00017	0.506
LIG_SH2_STAP1	387	391	PF00017	0.572
LIG_SH2_STAT3	266	269	PF00017	0.579
LIG_SH2_STAT5	266	269	PF00017	0.579
LIG_SH2_STAT5	428	431	PF00017	0.480
LIG_SH3_3	127	133	PF00018	0.739
LIG_SUMO_SIM_anti_2	173	181	PF11976	0.541
LIG_SUMO_SIM_par_1	173	181	PF11976	0.476
LIG_SUMO_SIM_par_1	203	212	PF11976	0.506
LIG_SUMO_SIM_par_1	324	329	PF11976	0.707
LIG_TRAF2_1	132	135	PF00917	0.627
LIG_TRAF2_1	139	142	PF00917	0.584
LIG_TRAF2_1	58	61	PF00917	0.684
MOD_CDK_SPK_2	93	98	PF00069	0.556
MOD_CDK_SPxK_1	50	56	PF00069	0.778
MOD_CDK_SPxK_1	93	99	PF00069	0.557
MOD_CK1_1	117	123	PF00069	0.719
MOD_CK1_1	198	204	PF00069	0.599
MOD_CK1_1	34	40	PF00069	0.641
MOD_CK2_1	129	135	PF00069	0.664
MOD_CK2_1	204	210	PF00069	0.587
MOD_CK2_1	283	289	PF00069	0.645
MOD_DYRK1A_RPxSP_1	42	46	PF00069	0.719
MOD_DYRK1A_RPxSP_1	93	97	PF00069	0.555
MOD_GlcNHglycan	1	4	PF01048	0.741
MOD_GlcNHglycan	108	111	PF01048	0.695
MOD_GlcNHglycan	121	124	PF01048	0.645
MOD_GlcNHglycan	215	218	PF01048	0.447
MOD_GlcNHglycan	79	82	PF01048	0.716
MOD_GlcNHglycan	87	90	PF01048	0.647
MOD_GSK3_1	102	109	PF00069	0.738
MOD_GSK3_1	117	124	PF00069	0.635
MOD_GSK3_1	194	201	PF00069	0.549
MOD_GSK3_1	373	380	PF00069	0.576
MOD_GSK3_1	56	63	PF00069	0.708
MOD_LATS_1	83	89	PF00433	0.563
MOD_N-GLC_1	117	122	PF02516	0.717
MOD_N-GLC_1	273	278	PF02516	0.526
MOD_N-GLC_1	85	90	PF02516	0.662
MOD_NEK2_1	346	351	PF00069	0.560
MOD_NEK2_1	373	378	PF00069	0.576
MOD_NEK2_2	387	392	PF00069	0.575
MOD_PIKK_1	56	62	PF00454	0.763
MOD_PK_1	204	210	PF00069	0.430
MOD_PK_1	62	68	PF00069	0.719
MOD_PKA_1	106	112	PF00069	0.713
MOD_PKA_1	253	259	PF00069	0.502
MOD_PKA_1	31	37	PF00069	0.675
MOD_PKA_1	84	90	PF00069	0.717
MOD_PKA_1	91	97	PF00069	0.655
MOD_PKA_2	106	112	PF00069	0.713
MOD_PKA_2	148	154	PF00069	0.601
MOD_PKA_2	283	289	PF00069	0.575
MOD_PKA_2	31	37	PF00069	0.675
MOD_PKA_2	317	323	PF00069	0.561
MOD_PKA_2	333	339	PF00069	0.442
MOD_PKA_2	346	352	PF00069	0.599
MOD_PKA_2	61	67	PF00069	0.727
MOD_PKA_2	84	90	PF00069	0.724
MOD_PKA_2	91	97	PF00069	0.646
MOD_Plk_1	198	204	PF00069	0.527
MOD_Plk_1	387	393	PF00069	0.574
MOD_Plk_1	85	91	PF00069	0.663
MOD_Plk_2-3	148	154	PF00069	0.541
MOD_Plk_2-3	283	289	PF00069	0.583
MOD_Plk_4	204	210	PF00069	0.562
MOD_Plk_4	261	267	PF00069	0.493
MOD_ProDKin_1	129	135	PF00069	0.722
MOD_ProDKin_1	42	48	PF00069	0.634
MOD_ProDKin_1	50	56	PF00069	0.621
MOD_ProDKin_1	93	99	PF00069	0.557
MOD_SUMO_for_1	152	155	PF00179	0.430
MOD_SUMO_for_1	20	23	PF00179	0.524
MOD_SUMO_for_1	355	358	PF00179	0.624
MOD_SUMO_for_1	409	412	PF00179	0.569
MOD_SUMO_rev_2	411	420	PF00179	0.556
TRG_DiLeu_BaEn_1	358	363	PF01217	0.569
TRG_DiLeu_BaEn_4	158	164	PF01217	0.541
TRG_DiLeu_BaEn_4	413	419	PF01217	0.613
TRG_ENDOCYTIC_2	147	150	PF00928	0.623
TRG_ENDOCYTIC_2	164	167	PF00928	0.373
TRG_ER_diArg_1	31	33	PF00400	0.664
TRG_ER_diArg_1	337	340	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I875	Leptomonas seymouri	70%	97%
A0A1X0NT91	Trypanosomatidae	35%	95%
A4HCB9	Leishmania braziliensis	72%	100%
C9ZSG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
E9AVQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	95%
Q4QBS4	Leishmania major	90%	100%