Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-CoA synthetase alpha subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFF5_LEIDO

TriTrypDb:

LdBPK_252220.1 , LdCL_250028000 , LdCL_250028100 , LDHU3_25.2690 , LDHU3_25.2700

Length:

299

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, succinyl-CoA synthetase alpha subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0009361	succinate-CoA ligase complex (ADP-forming)	5	1
GO:0032991	protein-containing complex	1	1
GO:0042709	succinate-CoA ligase complex	4	1
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0045239	tricarboxylic acid cycle enzyme complex	3	1
GO:0110165	cellular anatomical entity	1	12

Previous1 2Next

Expansion

Sequence features

A0A3Q8IFF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFF5

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006099	tricarboxylic acid cycle	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004774	succinate-CoA ligase activity	5	12
GO:0004775	succinate-CoA ligase (ADP-forming) activity	6	12
GO:0004776	succinate-CoA ligase (GDP-forming) activity	6	1
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1
GO:0016874	ligase activity	2	12
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	12

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.618
CLV_C14_Caspase3-7	90	94	PF00656	0.411
CLV_NRD_NRD_1	251	253	PF00675	0.389
CLV_NRD_NRD_1	8	10	PF00675	0.611
CLV_PCSK_KEX2_1	251	253	PF00082	0.389
CLV_PCSK_KEX2_1	8	10	PF00082	0.640
CLV_PCSK_PC7_1	4	10	PF00082	0.705
CLV_PCSK_SKI1_1	115	119	PF00082	0.461
CLV_PCSK_SKI1_1	200	204	PF00082	0.501
CLV_PCSK_SKI1_1	271	275	PF00082	0.530

Previous1 2 3 4 5…10Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JKD5	Bodo saltans	75%	100%
A0A1X0NY43	Trypanosomatidae	83%	99%
A0A3R7N4H2	Trypanosoma rangeli	80%	100%
A4HEB6	Leishmania braziliensis	96%	100%
A4I1R2	Leishmania infantum	100%	100%
B3FHT4	Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII)	68%	94%
C9ZKB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	99%
E9AXU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AXU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O08371	Rickettsia prowazekii (strain Madrid E)	66%	100%

Previous1 2 3 4 5 6 7Next