Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFF3_LEIDO

TriTrypDb:

LdBPK_310840.1 , LdCL_310014200 , LDHU3_31.1240

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A0A3Q8IFF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.625
CLV_C14_Caspase3-7	62	66	PF00656	0.373
CLV_NRD_NRD_1	299	301	PF00675	0.487
CLV_NRD_NRD_1	314	316	PF00675	0.328
CLV_NRD_NRD_1	353	355	PF00675	0.311
CLV_NRD_NRD_1	411	413	PF00675	0.408
CLV_NRD_NRD_1	62	64	PF00675	0.694
CLV_PCSK_KEX2_1	299	301	PF00082	0.498
CLV_PCSK_KEX2_1	353	355	PF00082	0.329
CLV_PCSK_KEX2_1	413	415	PF00082	0.414
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.425
CLV_PCSK_PC7_1	349	355	PF00082	0.316
CLV_PCSK_SKI1_1	176	180	PF00082	0.377
CLV_PCSK_SKI1_1	276	280	PF00082	0.534
CLV_PCSK_SKI1_1	404	408	PF00082	0.399
CLV_PCSK_SKI1_1	445	449	PF00082	0.251
CLV_PCSK_SKI1_1	482	486	PF00082	0.438
CLV_PCSK_SKI1_1	522	526	PF00082	0.291
CLV_PCSK_SKI1_1	635	639	PF00082	0.335
DOC_CDC14_PxL_1	82	90	PF14671	0.286
DOC_CYCLIN_RxL_1	273	281	PF00134	0.580
DOC_MAPK_DCC_7	610	618	PF00069	0.314
DOC_MAPK_gen_1	315	323	PF00069	0.562
DOC_MAPK_MEF2A_6	518	525	PF00069	0.516
DOC_MAPK_MEF2A_6	610	618	PF00069	0.292
DOC_PP1_RVXF_1	520	526	PF00149	0.263
DOC_PP1_RVXF_1	96	103	PF00149	0.310
DOC_PP2B_LxvP_1	88	91	PF13499	0.282
DOC_PP4_FxxP_1	13	16	PF00568	0.404
DOC_PP4_FxxP_1	335	338	PF00568	0.580
DOC_PP4_FxxP_1	49	52	PF00568	0.582
DOC_USP7_MATH_1	19	23	PF00917	0.440
DOC_USP7_MATH_1	197	201	PF00917	0.744
DOC_USP7_MATH_1	241	245	PF00917	0.617
DOC_USP7_MATH_1	405	409	PF00917	0.490
DOC_USP7_MATH_1	443	447	PF00917	0.555
DOC_USP7_MATH_1	52	56	PF00917	0.586
DOC_USP7_MATH_1	576	580	PF00917	0.435
DOC_USP7_UBL2_3	147	151	PF12436	0.540
LIG_14-3-3_CanoR_1	137	143	PF00244	0.544
LIG_14-3-3_CanoR_1	182	188	PF00244	0.745
LIG_14-3-3_CanoR_1	522	528	PF00244	0.300
LIG_14-3-3_CanoR_1	98	103	PF00244	0.332
LIG_Actin_WH2_2	78	96	PF00022	0.408
LIG_APCC_ABBA_1	636	641	PF00400	0.503
LIG_APCC_ABBAyCdc20_2	635	641	PF00400	0.503
LIG_BH_BH3_1	460	476	PF00452	0.317
LIG_BIR_III_4	240	244	PF00653	0.655
LIG_BIR_III_4	575	579	PF00653	0.274
LIG_BRCT_BRCA1_1	456	460	PF00533	0.438
LIG_eIF4E_1	116	122	PF01652	0.348
LIG_eIF4E_1	631	637	PF01652	0.503
LIG_FHA_1	117	123	PF00498	0.301
LIG_FHA_1	257	263	PF00498	0.611
LIG_FHA_1	395	401	PF00498	0.472
LIG_FHA_1	432	438	PF00498	0.543
LIG_FHA_1	494	500	PF00498	0.396
LIG_FHA_1	534	540	PF00498	0.292
LIG_FHA_1	617	623	PF00498	0.401
LIG_FHA_2	1	7	PF00498	0.419
LIG_FHA_2	137	143	PF00498	0.535
LIG_FHA_2	251	257	PF00498	0.698
LIG_GBD_Chelix_1	451	459	PF00786	0.264
LIG_LIR_Apic_2	333	338	PF02991	0.566
LIG_LIR_Apic_2	46	52	PF02991	0.407
LIG_LIR_Gen_1	453	464	PF02991	0.372
LIG_LIR_Gen_1	598	608	PF02991	0.321
LIG_LIR_LC3C_4	536	540	PF02991	0.275
LIG_LIR_Nem_3	115	121	PF02991	0.366
LIG_LIR_Nem_3	141	146	PF02991	0.548
LIG_LIR_Nem_3	203	208	PF02991	0.774
LIG_LIR_Nem_3	446	451	PF02991	0.379
LIG_LIR_Nem_3	453	459	PF02991	0.348
LIG_LIR_Nem_3	598	604	PF02991	0.302
LIG_LIR_Nem_3	626	631	PF02991	0.331
LIG_NRBOX	454	460	PF00104	0.261
LIG_PCNA_PIPBox_1	367	376	PF02747	0.553
LIG_PCNA_yPIPBox_3	366	374	PF02747	0.566
LIG_PCNA_yPIPBox_3	543	553	PF02747	0.250
LIG_Pex14_2	331	335	PF04695	0.544
LIG_Pex14_2	456	460	PF04695	0.373
LIG_Pex14_2	479	483	PF04695	0.363
LIG_SH2_CRK	118	122	PF00017	0.305
LIG_SH2_CRK	371	375	PF00017	0.593
LIG_SH2_CRK	424	428	PF00017	0.596
LIG_SH2_GRB2like	134	137	PF00017	0.536
LIG_SH2_STAP1	550	554	PF00017	0.379
LIG_SH2_STAP1	601	605	PF00017	0.332
LIG_SH2_STAP1	628	632	PF00017	0.381
LIG_SH2_STAT5	118	121	PF00017	0.338
LIG_SH2_STAT5	134	137	PF00017	0.541
LIG_SH2_STAT5	138	141	PF00017	0.569
LIG_SH2_STAT5	310	313	PF00017	0.609
LIG_SH2_STAT5	355	358	PF00017	0.533
LIG_SH2_STAT5	438	441	PF00017	0.570
LIG_SH2_STAT5	463	466	PF00017	0.364
LIG_SH2_STAT5	603	606	PF00017	0.447
LIG_SH2_STAT5	631	634	PF00017	0.442
LIG_SH3_1	105	111	PF00018	0.325
LIG_SH3_2	247	252	PF14604	0.595
LIG_SH3_3	101	107	PF00018	0.308
LIG_SH3_3	206	212	PF00018	0.639
LIG_SH3_3	244	250	PF00018	0.602
LIG_SH3_3	489	495	PF00018	0.490
LIG_SUMO_SIM_anti_2	536	542	PF11976	0.275
LIG_SUMO_SIM_anti_2	551	556	PF11976	0.252
LIG_SUMO_SIM_anti_2	619	626	PF11976	0.351
LIG_SUMO_SIM_par_1	466	473	PF11976	0.372
LIG_SUMO_SIM_par_1	510	515	PF11976	0.601
LIG_SxIP_EBH_1	435	445	PF03271	0.503
LIG_TRAF2_1	415	418	PF00917	0.673
LIG_TRAF2_1	43	46	PF00917	0.472
LIG_UBA3_1	436	441	PF00899	0.445
LIG_UBA3_1	534	543	PF00899	0.295
LIG_WRC_WIRS_1	310	315	PF05994	0.428
LIG_WRC_WIRS_1	476	481	PF05994	0.499
LIG_WRC_WIRS_1	484	489	PF05994	0.421
MOD_CK1_1	123	129	PF00069	0.333
MOD_CK1_1	17	23	PF00069	0.788
MOD_CK1_1	186	192	PF00069	0.519
MOD_CK1_1	200	206	PF00069	0.539
MOD_CK1_1	446	452	PF00069	0.327
MOD_CK1_1	469	475	PF00069	0.537
MOD_CK1_1	478	484	PF00069	0.509
MOD_CK1_1	588	594	PF00069	0.394
MOD_CK2_1	250	256	PF00069	0.630
MOD_CK2_1	36	42	PF00069	0.627
MOD_CK2_1	405	411	PF00069	0.454
MOD_CK2_1	63	69	PF00069	0.469
MOD_GlcNHglycan	168	171	PF01048	0.770
MOD_GlcNHglycan	194	198	PF01048	0.743
MOD_GlcNHglycan	199	202	PF01048	0.763
MOD_GlcNHglycan	26	30	PF01048	0.662
MOD_GlcNHglycan	301	304	PF01048	0.518
MOD_GlcNHglycan	448	451	PF01048	0.426
MOD_GlcNHglycan	54	57	PF01048	0.529
MOD_GlcNHglycan	578	581	PF01048	0.455
MOD_GSK3_1	112	119	PF00069	0.521
MOD_GSK3_1	17	24	PF00069	0.575
MOD_GSK3_1	193	200	PF00069	0.770
MOD_GSK3_1	446	453	PF00069	0.402
MOD_GSK3_1	483	490	PF00069	0.353
MOD_GSK3_1	59	66	PF00069	0.596
MOD_N-GLC_1	59	64	PF02516	0.588
MOD_N-GLC_1	596	601	PF02516	0.351
MOD_N-GLC_2	585	587	PF02516	0.488
MOD_NEK2_1	11	16	PF00069	0.520
MOD_NEK2_1	301	306	PF00069	0.540
MOD_NEK2_1	430	435	PF00069	0.419
MOD_NEK2_1	437	442	PF00069	0.397
MOD_NEK2_1	454	459	PF00069	0.324
MOD_NEK2_1	475	480	PF00069	0.445
MOD_NEK2_1	483	488	PF00069	0.301
MOD_NEK2_1	503	508	PF00069	0.313
MOD_NEK2_1	59	64	PF00069	0.571
MOD_NEK2_1	623	628	PF00069	0.359
MOD_NEK2_2	372	377	PF00069	0.449
MOD_NEK2_2	443	448	PF00069	0.453
MOD_PIKK_1	195	201	PF00454	0.644
MOD_PIKK_1	503	509	PF00454	0.280
MOD_PK_1	225	231	PF00069	0.500
MOD_PK_1	63	69	PF00069	0.381
MOD_PKA_1	299	305	PF00069	0.504
MOD_PKA_1	63	69	PF00069	0.381
MOD_PKA_2	136	142	PF00069	0.392
MOD_PKA_2	299	305	PF00069	0.508
MOD_Plk_1	394	400	PF00069	0.308
MOD_Plk_1	596	602	PF00069	0.353
MOD_Plk_4	112	118	PF00069	0.467
MOD_Plk_4	120	126	PF00069	0.377
MOD_Plk_4	200	206	PF00069	0.715
MOD_Plk_4	309	315	PF00069	0.504
MOD_Plk_4	330	336	PF00069	0.442
MOD_Plk_4	450	456	PF00069	0.347
MOD_Plk_4	475	481	PF00069	0.411
MOD_Plk_4	487	493	PF00069	0.322
MOD_Plk_4	533	539	PF00069	0.348
MOD_Plk_4	623	629	PF00069	0.329
MOD_SUMO_for_1	406	409	PF00179	0.481
MOD_SUMO_rev_2	408	415	PF00179	0.537
TRG_DiLeu_BaEn_1	395	400	PF01217	0.361
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.448
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.392
TRG_ENDOCYTIC_2	118	121	PF00928	0.321
TRG_ENDOCYTIC_2	310	313	PF00928	0.522
TRG_ENDOCYTIC_2	332	335	PF00928	0.394
TRG_ENDOCYTIC_2	371	374	PF00928	0.421
TRG_ENDOCYTIC_2	463	466	PF00928	0.331
TRG_ENDOCYTIC_2	550	553	PF00928	0.426
TRG_ENDOCYTIC_2	601	604	PF00928	0.436
TRG_ENDOCYTIC_2	631	634	PF00928	0.444
TRG_ER_diArg_1	293	296	PF00400	0.651
TRG_ER_diArg_1	298	300	PF00400	0.568
TRG_ER_diArg_1	352	354	PF00400	0.361
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	36%	100%
A0A0N1HRT9	Leptomonas seymouri	38%	100%
A0A0N1P9A0	Leptomonas seymouri	31%	100%
A0A0N1PBU6	Leptomonas seymouri	35%	100%
A0A1X0P9W4	Trypanosomatidae	31%	100%
A0A3Q8ISH4	Leishmania donovani	70%	100%
A0A3S7X483	Leishmania donovani	82%	100%
A0A3S7X888	Leishmania donovani	32%	100%
A4HB26	Leishmania braziliensis	32%	100%
A4HJ59	Leishmania braziliensis	45%	100%
A4HJ60	Leishmania braziliensis	49%	97%
A4I6H4	Leishmania infantum	81%	100%
A4I6H5	Leishmania infantum	69%	96%
A4IA83	Leishmania infantum	31%	99%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	97%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q6I2	Leishmania major	65%	97%
Q4Q6I3	Leishmania major	70%	100%