Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFE8_LEIDO

TriTrypDb:

LdBPK_220390.1 , LdCL_220010200 , LDHU3_22.0700

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.579
CLV_C14_Caspase3-7	232	236	PF00656	0.780
CLV_C14_Caspase3-7	360	364	PF00656	0.609
CLV_NRD_NRD_1	153	155	PF00675	0.544
CLV_NRD_NRD_1	314	316	PF00675	0.509
CLV_NRD_NRD_1	529	531	PF00675	0.619
CLV_NRD_NRD_1	545	547	PF00675	0.720
CLV_NRD_NRD_1	86	88	PF00675	0.676
CLV_PCSK_KEX2_1	153	155	PF00082	0.544
CLV_PCSK_KEX2_1	314	316	PF00082	0.509
CLV_PCSK_KEX2_1	529	531	PF00082	0.689
CLV_PCSK_KEX2_1	545	547	PF00082	0.685
CLV_PCSK_KEX2_1	86	88	PF00082	0.676
CLV_PCSK_SKI1_1	146	150	PF00082	0.546
CLV_PCSK_SKI1_1	314	318	PF00082	0.607
CLV_PCSK_SKI1_1	55	59	PF00082	0.469
DEG_APCC_DBOX_1	145	153	PF00400	0.625
DEG_MDM2_SWIB_1	496	504	PF02201	0.540
DEG_Nend_UBRbox_3	1	3	PF02207	0.554
DEG_SCF_TRCP1_1	235	240	PF00400	0.749
DEG_SPOP_SBC_1	14	18	PF00917	0.596
DEG_SPOP_SBC_1	265	269	PF00917	0.770
DEG_SPOP_SBC_1	338	342	PF00917	0.745
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.637
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.690
DOC_MAPK_gen_1	217	227	PF00069	0.605
DOC_MAPK_gen_1	314	323	PF00069	0.481
DOC_MAPK_gen_1	86	93	PF00069	0.508
DOC_MAPK_MEF2A_6	488	496	PF00069	0.619
DOC_MAPK_RevD_3	72	87	PF00069	0.588
DOC_PP1_RVXF_1	53	59	PF00149	0.500
DOC_PP2B_LxvP_1	492	495	PF13499	0.724
DOC_PP2B_LxvP_1	537	540	PF13499	0.822
DOC_PP2B_LxvP_1	59	62	PF13499	0.511
DOC_PP4_FxxP_1	32	35	PF00568	0.510
DOC_SPAK_OSR1_1	71	75	PF12202	0.591
DOC_USP7_MATH_1	13	17	PF00917	0.576
DOC_USP7_MATH_1	159	163	PF00917	0.475
DOC_USP7_MATH_1	185	189	PF00917	0.769
DOC_USP7_MATH_1	213	217	PF00917	0.811
DOC_USP7_MATH_1	248	252	PF00917	0.671
DOC_USP7_MATH_1	257	261	PF00917	0.698
DOC_USP7_MATH_1	265	269	PF00917	0.792
DOC_USP7_MATH_1	325	329	PF00917	0.602
DOC_USP7_MATH_1	338	342	PF00917	0.569
DOC_USP7_MATH_1	343	347	PF00917	0.685
DOC_USP7_MATH_1	348	352	PF00917	0.818
DOC_USP7_MATH_1	408	412	PF00917	0.756
DOC_WW_Pin1_4	116	121	PF00397	0.674
DOC_WW_Pin1_4	190	195	PF00397	0.740
DOC_WW_Pin1_4	258	263	PF00397	0.747
DOC_WW_Pin1_4	31	36	PF00397	0.482
DOC_WW_Pin1_4	339	344	PF00397	0.698
DOC_WW_Pin1_4	367	372	PF00397	0.571
DOC_WW_Pin1_4	383	388	PF00397	0.655
DOC_WW_Pin1_4	389	394	PF00397	0.696
DOC_WW_Pin1_4	529	534	PF00397	0.602
DOC_WW_Pin1_4	554	559	PF00397	0.781
LIG_14-3-3_CanoR_1	115	120	PF00244	0.722
LIG_14-3-3_CanoR_1	124	130	PF00244	0.620
LIG_14-3-3_CanoR_1	266	271	PF00244	0.714
LIG_14-3-3_CanoR_1	287	294	PF00244	0.432
LIG_14-3-3_CanoR_1	439	448	PF00244	0.744
LIG_14-3-3_CanoR_1	482	492	PF00244	0.649
LIG_14-3-3_CanoR_1	529	533	PF00244	0.722
LIG_14-3-3_CanoR_1	569	576	PF00244	0.613
LIG_Actin_WH2_2	301	319	PF00022	0.597
LIG_Actin_WH2_2	38	54	PF00022	0.587
LIG_BIR_III_4	363	367	PF00653	0.545
LIG_BRCT_BRCA1_1	229	233	PF00533	0.710
LIG_BRCT_BRCA1_1	63	67	PF00533	0.531
LIG_CSL_BTD_1	537	540	PF09270	0.822
LIG_EH1_1	305	313	PF00400	0.584
LIG_FHA_1	175	181	PF00498	0.705
LIG_FHA_1	221	227	PF00498	0.812
LIG_FHA_1	265	271	PF00498	0.579
LIG_FHA_1	288	294	PF00498	0.564
LIG_FHA_1	515	521	PF00498	0.745
LIG_FHA_2	159	165	PF00498	0.605
LIG_FHA_2	177	183	PF00498	0.473
LIG_FHA_2	267	273	PF00498	0.696
LIG_FHA_2	508	514	PF00498	0.591
LIG_FHA_2	98	104	PF00498	0.599
LIG_LIR_Apic_2	30	35	PF02991	0.527
LIG_LIR_Gen_1	411	419	PF02991	0.755
LIG_LIR_Gen_1	77	85	PF02991	0.637
LIG_LIR_Nem_3	164	169	PF02991	0.547
LIG_LIR_Nem_3	174	178	PF02991	0.540
LIG_LIR_Nem_3	411	415	PF02991	0.670
LIG_LIR_Nem_3	463	469	PF02991	0.652
LIG_LIR_Nem_3	570	576	PF02991	0.534
LIG_LIR_Nem_3	77	83	PF02991	0.626
LIG_Pex14_2	496	500	PF04695	0.559
LIG_SH2_CRK	173	177	PF00017	0.565
LIG_SH2_NCK_1	43	47	PF00017	0.585
LIG_SH2_STAP1	43	47	PF00017	0.492
LIG_SH2_STAT5	173	176	PF00017	0.520
LIG_SH2_STAT5	307	310	PF00017	0.479
LIG_SH2_STAT5	459	462	PF00017	0.488
LIG_SH2_STAT5	563	566	PF00017	0.639
LIG_SH3_1	530	536	PF00018	0.601
LIG_SH3_3	191	197	PF00018	0.831
LIG_SH3_3	390	396	PF00018	0.668
LIG_SH3_3	462	468	PF00018	0.660
LIG_SH3_3	530	536	PF00018	0.737
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.582
LIG_SUMO_SIM_par_1	176	182	PF11976	0.670
LIG_SUMO_SIM_par_1	446	452	PF11976	0.710
LIG_WRC_WIRS_1	29	34	PF05994	0.537
MOD_CDK_SPxxK_3	193	200	PF00069	0.608
MOD_CK1_1	119	125	PF00069	0.706
MOD_CK1_1	134	140	PF00069	0.506
MOD_CK1_1	196	202	PF00069	0.817
MOD_CK1_1	207	213	PF00069	0.613
MOD_CK1_1	229	235	PF00069	0.769
MOD_CK1_1	260	266	PF00069	0.752
MOD_CK1_1	31	37	PF00069	0.597
MOD_CK1_1	339	345	PF00069	0.739
MOD_CK1_1	346	352	PF00069	0.595
MOD_CK1_1	483	489	PF00069	0.629
MOD_CK1_1	531	537	PF00069	0.718
MOD_CK1_1	541	547	PF00069	0.786
MOD_CK1_1	554	560	PF00069	0.654
MOD_CK2_1	158	164	PF00069	0.496
MOD_CK2_1	185	191	PF00069	0.795
MOD_CK2_1	266	272	PF00069	0.708
MOD_CK2_1	339	345	PF00069	0.779
MOD_CK2_1	408	414	PF00069	0.671
MOD_CK2_1	507	513	PF00069	0.528
MOD_Cter_Amidation	423	426	PF01082	0.729
MOD_GlcNHglycan	121	124	PF01048	0.772
MOD_GlcNHglycan	186	190	PF01048	0.835
MOD_GlcNHglycan	20	23	PF01048	0.743
MOD_GlcNHglycan	209	212	PF01048	0.642
MOD_GlcNHglycan	213	216	PF01048	0.613
MOD_GlcNHglycan	235	238	PF01048	0.705
MOD_GlcNHglycan	255	258	PF01048	0.705
MOD_GlcNHglycan	290	293	PF01048	0.632
MOD_GlcNHglycan	297	300	PF01048	0.557
MOD_GlcNHglycan	353	356	PF01048	0.684
MOD_GlcNHglycan	482	485	PF01048	0.637
MOD_GlcNHglycan	533	536	PF01048	0.716
MOD_GlcNHglycan	547	550	PF01048	0.656
MOD_GlcNHglycan	554	557	PF01048	0.758
MOD_GSK3_1	115	122	PF00069	0.708
MOD_GSK3_1	14	21	PF00069	0.641
MOD_GSK3_1	207	214	PF00069	0.644
MOD_GSK3_1	227	234	PF00069	0.765
MOD_GSK3_1	253	260	PF00069	0.684
MOD_GSK3_1	27	34	PF00069	0.650
MOD_GSK3_1	337	344	PF00069	0.775
MOD_GSK3_1	480	487	PF00069	0.644
MOD_GSK3_1	541	548	PF00069	0.714
MOD_GSK3_1	552	559	PF00069	0.730
MOD_GSK3_1	563	570	PF00069	0.486
MOD_GSK3_1	61	68	PF00069	0.514
MOD_N-GLC_1	105	110	PF02516	0.691
MOD_NEK2_1	233	238	PF00069	0.773
MOD_NEK2_1	28	33	PF00069	0.706
MOD_NEK2_1	288	293	PF00069	0.485
MOD_NEK2_1	506	511	PF00069	0.504
MOD_NEK2_1	551	556	PF00069	0.793
MOD_NEK2_1	561	566	PF00069	0.465
MOD_NEK2_1	568	573	PF00069	0.353
MOD_NEK2_1	6	11	PF00069	0.489
MOD_PIKK_1	105	111	PF00454	0.689
MOD_PIKK_1	440	446	PF00454	0.750
MOD_PIKK_1	568	574	PF00454	0.537
MOD_PIKK_1	61	67	PF00454	0.627
MOD_PKA_1	545	551	PF00069	0.740
MOD_PKA_2	18	24	PF00069	0.782
MOD_PKA_2	207	213	PF00069	0.782
MOD_PKA_2	265	271	PF00069	0.715
MOD_PKA_2	286	292	PF00069	0.547
MOD_PKA_2	295	301	PF00069	0.553
MOD_PKA_2	528	534	PF00069	0.818
MOD_PKA_2	541	547	PF00069	0.712
MOD_PKA_2	568	574	PF00069	0.537
MOD_Plk_1	105	111	PF00069	0.694
MOD_Plk_2-3	97	103	PF00069	0.603
MOD_Plk_4	461	467	PF00069	0.429
MOD_Plk_4	563	569	PF00069	0.515
MOD_ProDKin_1	116	122	PF00069	0.674
MOD_ProDKin_1	190	196	PF00069	0.739
MOD_ProDKin_1	258	264	PF00069	0.746
MOD_ProDKin_1	31	37	PF00069	0.469
MOD_ProDKin_1	339	345	PF00069	0.701
MOD_ProDKin_1	367	373	PF00069	0.568
MOD_ProDKin_1	383	389	PF00069	0.670
MOD_ProDKin_1	529	535	PF00069	0.604
MOD_ProDKin_1	554	560	PF00069	0.770
MOD_SUMO_rev_2	214	221	PF00179	0.731
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.547
TRG_ER_diArg_1	141	144	PF00400	0.541
TRG_ER_diArg_1	152	154	PF00400	0.527
TRG_ER_diArg_1	314	316	PF00400	0.509
TRG_ER_diArg_1	545	547	PF00400	0.717
TRG_ER_diArg_1	85	87	PF00400	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL6	Leptomonas seymouri	32%	100%
A4HC97	Leishmania braziliensis	65%	100%
A4HZS9	Leishmania infantum	99%	100%
E9AVN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
Q4QBU5	Leishmania major	85%	100%