Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFE5_LEIDO

TriTrypDb:

LdBPK_251990.1 , LdCL_250025700 , LDHU3_25.2460

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.775
CLV_NRD_NRD_1	291	293	PF00675	0.715
CLV_PCSK_KEX2_1	165	167	PF00082	0.583
CLV_PCSK_KEX2_1	192	194	PF00082	0.628
CLV_PCSK_KEX2_1	291	293	PF00082	0.700
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.549
CLV_PCSK_SKI1_1	174	178	PF00082	0.595
CLV_PCSK_SKI1_1	34	38	PF00082	0.385
CLV_PCSK_SKI1_1	69	73	PF00082	0.461
DEG_APCC_DBOX_1	227	235	PF00400	0.484
DEG_APCC_DBOX_1	239	247	PF00400	0.485
DOC_CKS1_1	216	221	PF01111	0.454
DOC_CYCLIN_yCln2_LP_2	234	237	PF00134	0.473
DOC_MAPK_gen_1	238	245	PF00069	0.377
DOC_MAPK_MEF2A_6	121	130	PF00069	0.432
DOC_PP2B_LxvP_1	234	237	PF13499	0.473
DOC_USP7_MATH_1	179	183	PF00917	0.628
DOC_USP7_MATH_1	202	206	PF00917	0.693
DOC_USP7_MATH_1	207	211	PF00917	0.679
DOC_USP7_MATH_1	259	263	PF00917	0.623
DOC_USP7_MATH_1	284	288	PF00917	0.647
DOC_USP7_MATH_1	3	7	PF00917	0.468
DOC_USP7_MATH_1	316	320	PF00917	0.493
DOC_USP7_UBL2_3	174	178	PF12436	0.595
DOC_WW_Pin1_4	136	141	PF00397	0.509
DOC_WW_Pin1_4	160	165	PF00397	0.636
DOC_WW_Pin1_4	197	202	PF00397	0.716
DOC_WW_Pin1_4	215	220	PF00397	0.445
DOC_WW_Pin1_4	84	89	PF00397	0.636
LIG_14-3-3_CanoR_1	102	112	PF00244	0.443
LIG_14-3-3_CanoR_1	21	26	PF00244	0.464
LIG_14-3-3_CanoR_1	228	232	PF00244	0.557
LIG_14-3-3_CanoR_1	238	246	PF00244	0.368
LIG_14-3-3_CanoR_1	59	67	PF00244	0.443
LIG_Actin_WH2_2	219	235	PF00022	0.445
LIG_Actin_WH2_2	313	330	PF00022	0.410
LIG_DLG_GKlike_1	323	331	PF00625	0.354
LIG_eIF4E_1	25	31	PF01652	0.391
LIG_FHA_1	123	129	PF00498	0.530
LIG_FHA_1	137	143	PF00498	0.488
LIG_FHA_1	216	222	PF00498	0.573
LIG_FHA_1	273	279	PF00498	0.576
LIG_FHA_1	35	41	PF00498	0.390
LIG_FHA_2	150	156	PF00498	0.655
LIG_FHA_2	39	45	PF00498	0.511
LIG_FHA_2	72	78	PF00498	0.612
LIG_LIR_Gen_1	184	194	PF02991	0.621
LIG_LIR_Gen_1	56	64	PF02991	0.389
LIG_LIR_Nem_3	184	190	PF02991	0.642
LIG_LIR_Nem_3	56	60	PF02991	0.356
LIG_PDZ_Class_3	341	346	PF00595	0.494
LIG_Pex14_1	28	32	PF04695	0.357
LIG_SH2_NCK_1	187	191	PF00017	0.622
LIG_SH2_SRC	301	304	PF00017	0.432
LIG_SH2_STAP1	124	128	PF00017	0.433
LIG_SH2_STAT5	124	127	PF00017	0.434
LIG_SH2_STAT5	244	247	PF00017	0.492
LIG_SH3_3	198	204	PF00018	0.607
LIG_SH3_3	213	219	PF00018	0.463
LIG_SH3_3	280	286	PF00018	0.589
LIG_SH3_3	85	91	PF00018	0.629
LIG_SH3_3	92	98	PF00018	0.552
LIG_SUMO_SIM_par_1	124	129	PF11976	0.437
LIG_SUMO_SIM_par_1	279	287	PF11976	0.498
LIG_WW_1	236	239	PF00397	0.487
LIG_WW_3	235	239	PF00397	0.477
MOD_CDK_SPK_2	160	165	PF00069	0.580
MOD_CDK_SPxK_1	160	166	PF00069	0.558
MOD_CDK_SPxxK_3	215	222	PF00069	0.447
MOD_CK1_1	148	154	PF00069	0.686
MOD_CK1_1	87	93	PF00069	0.643
MOD_CK2_1	143	149	PF00069	0.559
MOD_CK2_1	179	185	PF00069	0.628
MOD_CK2_1	38	44	PF00069	0.490
MOD_CK2_1	71	77	PF00069	0.539
MOD_CK2_1	87	93	PF00069	0.628
MOD_GlcNHglycan	106	109	PF01048	0.412
MOD_GlcNHglycan	209	212	PF01048	0.709
MOD_GlcNHglycan	260	264	PF01048	0.750
MOD_GlcNHglycan	303	306	PF01048	0.481
MOD_GlcNHglycan	314	317	PF01048	0.313
MOD_GSK3_1	122	129	PF00069	0.487
MOD_GSK3_1	145	152	PF00069	0.576
MOD_GSK3_1	160	167	PF00069	0.690
MOD_GSK3_1	268	275	PF00069	0.618
MOD_GSK3_1	312	319	PF00069	0.430
MOD_GSK3_1	34	41	PF00069	0.436
MOD_GSK3_1	59	66	PF00069	0.508
MOD_GSK3_1	71	78	PF00069	0.631
MOD_N-GLC_1	268	273	PF02516	0.706
MOD_N-GLC_2	141	143	PF02516	0.498
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	71	76	PF00069	0.542
MOD_PIKK_1	59	65	PF00454	0.424
MOD_PKA_2	20	26	PF00069	0.333
MOD_PKA_2	227	233	PF00069	0.377
MOD_PKA_2	58	64	PF00069	0.456
MOD_PKB_1	19	27	PF00069	0.459
MOD_Plk_4	172	178	PF00069	0.664
MOD_Plk_4	227	233	PF00069	0.554
MOD_Plk_4	316	322	PF00069	0.378
MOD_ProDKin_1	136	142	PF00069	0.511
MOD_ProDKin_1	160	166	PF00069	0.637
MOD_ProDKin_1	197	203	PF00069	0.716
MOD_ProDKin_1	215	221	PF00069	0.427
MOD_ProDKin_1	84	90	PF00069	0.638
MOD_SUMO_rev_2	169	176	PF00179	0.614
TRG_DiLeu_BaEn_1	185	190	PF01217	0.652
TRG_DiLeu_BaEn_1	227	232	PF01217	0.425
TRG_DiLeu_BaEn_4	280	286	PF01217	0.550
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.426
TRG_ENDOCYTIC_2	187	190	PF00928	0.627
TRG_ER_diArg_1	192	194	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I869	Leptomonas seymouri	48%	100%
A0A3S5ISQ2	Trypanosoma rangeli	28%	100%
A4HE93	Leishmania braziliensis	67%	100%
A4I1N9	Leishmania infantum	100%	100%
C9ZK88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AXS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9P8	Leishmania major	90%	99%
V5BHX9	Trypanosoma cruzi	27%	100%