Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFE4_LEIDO

TriTrypDb:

LdBPK_353770.1 , LdCL_350042700 , LDHU3_35.4930

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.551
CLV_C14_Caspase3-7	68	72	PF00656	0.599
CLV_NRD_NRD_1	184	186	PF00675	0.506
CLV_NRD_NRD_1	258	260	PF00675	0.463
CLV_NRD_NRD_1	276	278	PF00675	0.565
CLV_NRD_NRD_1	345	347	PF00675	0.477
CLV_NRD_NRD_1	431	433	PF00675	0.694
CLV_NRD_NRD_1	438	440	PF00675	0.746
CLV_NRD_NRD_1	85	87	PF00675	0.445
CLV_PCSK_KEX2_1	128	130	PF00082	0.636
CLV_PCSK_KEX2_1	184	186	PF00082	0.510
CLV_PCSK_KEX2_1	258	260	PF00082	0.463
CLV_PCSK_KEX2_1	276	278	PF00082	0.653
CLV_PCSK_KEX2_1	394	396	PF00082	0.533
CLV_PCSK_KEX2_1	438	440	PF00082	0.545
CLV_PCSK_KEX2_1	85	87	PF00082	0.447
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.636
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.533
CLV_PCSK_SKI1_1	169	173	PF00082	0.508
CLV_PCSK_SKI1_1	243	247	PF00082	0.515
CLV_PCSK_SKI1_1	300	304	PF00082	0.588
CLV_PCSK_SKI1_1	347	351	PF00082	0.482
CLV_PCSK_SKI1_1	391	395	PF00082	0.482
CLV_Separin_Metazoa	338	342	PF03568	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.712
DOC_MAPK_gen_1	166	174	PF00069	0.472
DOC_MAPK_gen_1	184	191	PF00069	0.437
DOC_MAPK_gen_1	346	352	PF00069	0.467
DOC_PP1_RVXF_1	127	134	PF00149	0.608
DOC_USP7_MATH_1	305	309	PF00917	0.575
LIG_Actin_WH2_2	66	83	PF00022	0.454
LIG_CaM_IQ_9	363	379	PF13499	0.427
LIG_CaM_IQ_9	73	88	PF13499	0.477
LIG_FHA_1	16	22	PF00498	0.605
LIG_FHA_1	280	286	PF00498	0.599
LIG_FHA_1	327	333	PF00498	0.455
LIG_FHA_2	109	115	PF00498	0.535
LIG_FHA_2	223	229	PF00498	0.558
LIG_LIR_Gen_1	130	141	PF02991	0.585
LIG_LIR_Gen_1	186	194	PF02991	0.566
LIG_LIR_Nem_3	130	136	PF02991	0.602
LIG_LIR_Nem_3	186	191	PF02991	0.523
LIG_LIR_Nem_3	322	327	PF02991	0.472
LIG_LIR_Nem_3	328	333	PF02991	0.439
LIG_Rb_LxCxE_1	233	252	PF01857	0.616
LIG_SH2_CRK	188	192	PF00017	0.484
LIG_SH2_NCK_1	54	58	PF00017	0.640
LIG_SH2_PTP2	324	327	PF00017	0.565
LIG_SH2_SRC	324	327	PF00017	0.579
LIG_SH2_STAP1	24	28	PF00017	0.463
LIG_SH2_STAT5	324	327	PF00017	0.496
LIG_SUMO_SIM_par_1	170	175	PF11976	0.517
LIG_SUMO_SIM_par_1	348	353	PF11976	0.476
LIG_TRAF2_1	10	13	PF00917	0.543
LIG_TRAF2_1	20	23	PF00917	0.521
LIG_TRAF2_1	308	311	PF00917	0.578
LIG_TRAF2_1	60	63	PF00917	0.506
LIG_TRAF2_1	95	98	PF00917	0.566
LIG_UBA3_1	349	354	PF00899	0.485
LIG_WRC_WIRS_1	327	332	PF05994	0.559
MOD_CK1_1	160	166	PF00069	0.538
MOD_CK1_1	227	233	PF00069	0.529
MOD_CK2_1	108	114	PF00069	0.620
MOD_CK2_1	131	137	PF00069	0.535
MOD_CK2_1	144	150	PF00069	0.369
MOD_CK2_1	227	233	PF00069	0.552
MOD_CK2_1	238	244	PF00069	0.586
MOD_CK2_1	281	287	PF00069	0.503
MOD_CK2_1	305	311	PF00069	0.589
MOD_Cter_Amidation	126	129	PF01082	0.626
MOD_Cter_Amidation	436	439	PF01082	0.525
MOD_GlcNHglycan	174	177	PF01048	0.602
MOD_GlcNHglycan	300	303	PF01048	0.573
MOD_GlcNHglycan	305	308	PF01048	0.556
MOD_GlcNHglycan	384	387	PF01048	0.627
MOD_GlcNHglycan	435	438	PF01048	0.734
MOD_GSK3_1	156	163	PF00069	0.396
MOD_GSK3_1	222	229	PF00069	0.576
MOD_GSK3_1	277	284	PF00069	0.495
MOD_GSK3_1	353	360	PF00069	0.554
MOD_GSK3_1	378	385	PF00069	0.557
MOD_N-GLC_2	193	195	PF02516	0.526
MOD_NEK2_1	108	113	PF00069	0.493
MOD_NEK2_1	119	124	PF00069	0.565
MOD_NEK2_1	167	172	PF00069	0.558
MOD_NEK2_1	339	344	PF00069	0.521
MOD_NEK2_1	378	383	PF00069	0.555
MOD_NEK2_1	411	416	PF00069	0.506
MOD_NEK2_2	326	331	PF00069	0.555
MOD_NEK2_2	386	391	PF00069	0.533
MOD_PIKK_1	426	432	PF00454	0.477
MOD_PKA_2	15	21	PF00069	0.638
MOD_PKA_2	183	189	PF00069	0.568
MOD_PKA_2	411	417	PF00069	0.570
MOD_Plk_1	144	150	PF00069	0.487
MOD_Plk_1	167	173	PF00069	0.593
MOD_Plk_1	227	233	PF00069	0.598
MOD_Plk_1	378	384	PF00069	0.624
MOD_Plk_1	386	392	PF00069	0.563
MOD_Plk_1	55	61	PF00069	0.460
MOD_Plk_2-3	2	8	PF00069	0.600
MOD_Plk_2-3	34	40	PF00069	0.581
MOD_Plk_4	144	150	PF00069	0.529
MOD_Plk_4	167	173	PF00069	0.486
MOD_Plk_4	227	233	PF00069	0.609
MOD_Plk_4	353	359	PF00069	0.581
MOD_SUMO_for_1	223	226	PF00179	0.540
MOD_SUMO_rev_2	150	160	PF00179	0.525
MOD_SUMO_rev_2	247	256	PF00179	0.515
MOD_SUMO_rev_2	398	405	PF00179	0.626
TRG_DiLeu_BaEn_1	400	405	PF01217	0.538
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.483
TRG_ENDOCYTIC_2	188	191	PF00928	0.450
TRG_ENDOCYTIC_2	324	327	PF00928	0.445
TRG_ER_diArg_1	184	187	PF00400	0.521
TRG_ER_diArg_1	276	278	PF00400	0.611
TRG_NES_CRM1_1	71	84	PF08389	0.512
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ51	Leptomonas seymouri	70%	100%
A0A0S4JDF0	Bodo saltans	40%	99%
A0A1X0P5H1	Trypanosomatidae	43%	100%
A0A3R7N172	Trypanosoma rangeli	43%	100%
A4HN43	Leishmania braziliensis	81%	100%
A4IBR1	Leishmania infantum	100%	100%
C9ZYW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AFJ6	Leishmania major	93%	100%
E9B6Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BXZ9	Trypanosoma cruzi	41%	100%