LeishMANIAdb
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Ribosomal protein S19e family protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribosomal protein S19e family protein
Gene product:
40S ribosomal protein S19 protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IFE1_LEIDO
TriTrypDb:
LdBPK_342620.1 * , LdCL_290035800 , LDHU3_29.4330
Length:
161

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S19-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 35
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 21
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 16
GO:0032991 protein-containing complex 1 18
GO:0043226 organelle 2 16
GO:0043228 non-membrane-bounded organelle 3 16
GO:0043229 intracellular organelle 3 16
GO:0043232 intracellular non-membrane-bounded organelle 4 16
GO:0110165 cellular anatomical entity 1 16
GO:1990904 ribonucleoprotein complex 2 18
GO:0015935 small ribosomal subunit 4 2
GO:0022627 cytosolic small ribosomal subunit 5 2
GO:0044391 ribosomal subunit 3 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IFE1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFE1

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 18
GO:0006518 peptide metabolic process 4 18
GO:0006807 nitrogen compound metabolic process 2 18
GO:0008152 metabolic process 1 18
GO:0009058 biosynthetic process 2 18
GO:0009059 macromolecule biosynthetic process 4 18
GO:0009987 cellular process 1 18
GO:0019538 protein metabolic process 3 18
GO:0034641 cellular nitrogen compound metabolic process 3 18
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 18
GO:0043043 peptide biosynthetic process 5 18
GO:0043170 macromolecule metabolic process 3 18
GO:0043603 amide metabolic process 3 18
GO:0043604 amide biosynthetic process 4 18
GO:0044237 cellular metabolic process 2 18
GO:0044238 primary metabolic process 2 18
GO:0044249 cellular biosynthetic process 3 18
GO:0044260 obsolete cellular macromolecule metabolic process 3 18
GO:0044271 cellular nitrogen compound biosynthetic process 4 18
GO:0071704 organic substance metabolic process 2 18
GO:1901564 organonitrogen compound metabolic process 3 18
GO:1901566 organonitrogen compound biosynthetic process 4 18
GO:1901576 organic substance biosynthetic process 3 18
GO:0000028 ribosomal small subunit assembly 7 2
GO:0016043 cellular component organization 3 2
GO:0022607 cellular component assembly 4 2
GO:0022618 ribonucleoprotein complex assembly 6 2
GO:0043933 protein-containing complex organization 4 2
GO:0065003 protein-containing complex assembly 5 2
GO:0071826 ribonucleoprotein complex subunit organization 5 2
GO:0071840 cellular component organization or biogenesis 2 2
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 18
GO:0005198 structural molecule activity 1 18
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 88 94 PF00089 0.266
CLV_NRD_NRD_1 13 15 PF00675 0.427
CLV_NRD_NRD_1 137 139 PF00675 0.279
CLV_NRD_NRD_1 153 155 PF00675 0.312
CLV_PCSK_KEX2_1 13 15 PF00082 0.442
CLV_PCSK_KEX2_1 90 92 PF00082 0.266
CLV_PCSK_PC1ET2_1 13 15 PF00082 0.532
CLV_PCSK_PC1ET2_1 90 92 PF00082 0.266
CLV_PCSK_SKI1_1 118 122 PF00082 0.290
CLV_PCSK_SKI1_1 15 19 PF00082 0.361
CLV_PCSK_SKI1_1 26 30 PF00082 0.261
CLV_PCSK_SKI1_1 33 37 PF00082 0.241
DEG_SPOP_SBC_1 106 110 PF00917 0.414
DOC_MAPK_gen_1 138 149 PF00069 0.278
DOC_MAPK_gen_1 33 43 PF00069 0.322
DOC_USP7_MATH_1 116 120 PF00917 0.335
DOC_USP7_UBL2_3 118 122 PF12436 0.270
DOC_USP7_UBL2_3 36 40 PF12436 0.299
LIG_14-3-3_CanoR_1 14 20 PF00244 0.462
LIG_14-3-3_CanoR_1 26 35 PF00244 0.302
LIG_Actin_WH2_2 4 22 PF00022 0.481
LIG_BRCT_BRCA1_1 145 149 PF00533 0.362
LIG_BRCT_BRCA1_1 88 92 PF00533 0.266
LIG_FHA_1 108 114 PF00498 0.419
LIG_FHA_2 16 22 PF00498 0.261
LIG_LIR_Nem_3 23 28 PF02991 0.394
LIG_LIR_Nem_3 64 68 PF02991 0.266
LIG_PDZ_Class_1 156 161 PF00595 0.440
LIG_SH2_CRK 85 89 PF00017 0.318
LIG_SH2_STAT5 67 70 PF00017 0.262
LIG_SH2_STAT5 78 81 PF00017 0.240
LIG_SH3_3 57 63 PF00018 0.267
LIG_TYR_ITIM 83 88 PF00017 0.295
MOD_CK2_1 97 103 PF00069 0.261
MOD_Cter_Amidation 11 14 PF01082 0.432
MOD_GlcNHglycan 21 25 PF01048 0.394
MOD_GSK3_1 102 109 PF00069 0.276
MOD_N-GLC_1 44 49 PF02516 0.335
MOD_NEK2_1 143 148 PF00069 0.415
MOD_NEK2_1 156 161 PF00069 0.595
MOD_NEK2_1 50 55 PF00069 0.401
MOD_PKA_2 134 140 PF00069 0.280
MOD_Plk_1 102 108 PF00069 0.394
MOD_Plk_1 20 26 PF00069 0.368
MOD_SUMO_for_1 35 38 PF00179 0.280
TRG_DiLeu_BaEn_2 37 43 PF01217 0.362
TRG_ENDOCYTIC_2 85 88 PF00928 0.266
TRG_NLS_MonoExtN_4 10 17 PF00514 0.415

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IY51 Bodo saltans 66% 97%
A0A1D8PK61 Candida albicans (strain SC5314 / ATCC MYA-2876) 36% 100%
A0A1X0P9W6 Trypanosomatidae 68% 96%
A0A1X0P9X9 Trypanosomatidae 71% 98%
A0A3Q8INI0 Leishmania donovani 96% 90%
A0A3R7KIF6 Trypanosoma rangeli 69% 96%
A0A422NEU2 Trypanosoma rangeli 72% 97%
A4H3R3 Leishmania braziliensis 94% 100%
A4HAZ5 Leishmania braziliensis 94% 100%
A4I4Y2 Leishmania infantum 100% 100%
A4IA55 Leishmania infantum 97% 100%
C9ZM47 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 96%
E9AEE8 Leishmania major 99% 100%
E9ALD8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9B569 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O15631 Entamoeba histolytica 36% 100%
O18650 Caenorhabditis elegans 34% 100%
O27653 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 35% 100%
O28210 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 30% 100%
O59041 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 29% 100%
P07280 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 100%
P07281 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 100%
P17074 Rattus norvegicus 33% 100%
P19952 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 29% 100%
P24494 Ascaris suum 31% 100%
P27073 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 41% 100%
P39018 Drosophila melanogaster 33% 100%
P39019 Homo sapiens 32% 100%
P39698 Ascaris suum 32% 100%
P40978 Oryza sativa subsp. japonica 35% 100%
P54057 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 40% 100%
P58234 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 100%
P61155 Pagrus major 33% 100%
P79016 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 100%
Q29308 Sus scrofa 32% 100%
Q32PD5 Bos taurus 32% 100%
Q4Q2R6 Leishmania major 97% 100%
Q54X51 Dictyostelium discoideum 34% 100%
Q5R8M9 Pongo abelii 32% 100%
Q7KS38 Drosophila melanogaster 35% 100%
Q8ITC3 Argopecten irradians 35% 100%
Q8T5Z4 Branchiostoma belcheri 36% 100%
Q90YQ4 Ictalurus punctatus 36% 100%
Q94613 Mya arenaria 33% 100%
Q97CU4 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 28% 100%
Q9CZX8 Mus musculus 33% 100%
Q9DFR5 Gillichthys mirabilis 33% 100%
Q9FNP8 Arabidopsis thaliana 38% 100%
Q9HM21 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 29% 100%
Q9LF30 Arabidopsis thaliana 40% 100%
Q9SGA6 Arabidopsis thaliana 39% 100%
Q9V0G8 Pyrococcus abyssi (strain GE5 / Orsay) 31% 100%
Q9Y0H3 Myxine glutinosa 38% 100%
Q9YD22 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 27% 100%
V5DM12 Trypanosoma cruzi 69% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS