Inositol 5-phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFD8_LEIDO

TriTrypDb:

LdBPK_341320.1 , LdCL_340019200 , LDHU3_34.2070

Length:

764

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IFD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFD8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0030258	lipid modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0046839	phospholipid dephosphorylation	5	7
GO:0046856	phosphatidylinositol dephosphorylation	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0009056	catabolic process	2	1
GO:0019751	polyol metabolic process	4	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.326
CLV_C14_Caspase3-7	99	103	PF00656	0.460
CLV_NRD_NRD_1	121	123	PF00675	0.640
CLV_NRD_NRD_1	210	212	PF00675	0.699
CLV_NRD_NRD_1	378	380	PF00675	0.545
CLV_NRD_NRD_1	532	534	PF00675	0.584
CLV_NRD_NRD_1	535	537	PF00675	0.548
CLV_NRD_NRD_1	59	61	PF00675	0.687
CLV_NRD_NRD_1	679	681	PF00675	0.668
CLV_NRD_NRD_1	689	691	PF00675	0.637
CLV_NRD_NRD_1	81	83	PF00675	0.633
CLV_PCSK_FUR_1	533	537	PF00082	0.567
CLV_PCSK_KEX2_1	120	122	PF00082	0.643
CLV_PCSK_KEX2_1	180	182	PF00082	0.531
CLV_PCSK_KEX2_1	227	229	PF00082	0.744
CLV_PCSK_KEX2_1	360	362	PF00082	0.478
CLV_PCSK_KEX2_1	377	379	PF00082	0.526
CLV_PCSK_KEX2_1	44	46	PF00082	0.648
CLV_PCSK_KEX2_1	534	536	PF00082	0.571
CLV_PCSK_KEX2_1	61	63	PF00082	0.651
CLV_PCSK_KEX2_1	679	681	PF00082	0.682
CLV_PCSK_KEX2_1	689	691	PF00082	0.624
CLV_PCSK_KEX2_1	81	83	PF00082	0.531
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.636
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.531
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.655
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.478
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.526
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.648
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.571
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.651
CLV_PCSK_PC7_1	116	122	PF00082	0.586
CLV_PCSK_SKI1_1	360	364	PF00082	0.468
CLV_PCSK_SKI1_1	412	416	PF00082	0.639
CLV_PCSK_SKI1_1	44	48	PF00082	0.719
CLV_PCSK_SKI1_1	543	547	PF00082	0.472
CLV_PCSK_SKI1_1	692	696	PF00082	0.688
CLV_PCSK_SKI1_1	70	74	PF00082	0.622
CLV_PCSK_SKI1_1	754	758	PF00082	0.564
CLV_PCSK_SKI1_1	85	89	PF00082	0.579
DEG_APCC_DBOX_1	129	137	PF00400	0.395
DEG_Kelch_Keap1_1	697	702	PF01344	0.467
DEG_Nend_UBRbox_3	1	3	PF02207	0.692
DEG_SCF_TRCP1_1	102	108	PF00400	0.447
DEG_SPOP_SBC_1	620	624	PF00917	0.493
DOC_CKS1_1	106	111	PF01111	0.421
DOC_CKS1_1	18	23	PF01111	0.544
DOC_CYCLIN_RxL_1	689	699	PF00134	0.468
DOC_CYCLIN_RxL_1	81	92	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.338
DOC_MAPK_FxFP_2	659	662	PF00069	0.429
DOC_MAPK_gen_1	305	312	PF00069	0.286
DOC_MAPK_gen_1	388	396	PF00069	0.350
DOC_MAPK_gen_1	44	53	PF00069	0.427
DOC_MAPK_gen_1	734	744	PF00069	0.327
DOC_MAPK_gen_1	81	90	PF00069	0.451
DOC_MAPK_HePTP_8	345	357	PF00069	0.329
DOC_MAPK_MEF2A_6	25	33	PF00069	0.309
DOC_MAPK_MEF2A_6	348	357	PF00069	0.312
DOC_MAPK_MEF2A_6	44	53	PF00069	0.519
DOC_MAPK_MEF2A_6	81	90	PF00069	0.455
DOC_MIT_MIM_1	465	473	PF04212	0.322
DOC_PP1_RVXF_1	386	393	PF00149	0.328
DOC_PP1_RVXF_1	541	547	PF00149	0.270
DOC_PP2B_LxvP_1	141	144	PF13499	0.357
DOC_PP2B_LxvP_1	704	707	PF13499	0.482
DOC_PP4_FxxP_1	392	395	PF00568	0.364
DOC_PP4_FxxP_1	573	576	PF00568	0.504
DOC_PP4_FxxP_1	659	662	PF00568	0.538
DOC_SPAK_OSR1_1	739	743	PF12202	0.333
DOC_USP7_MATH_1	202	206	PF00917	0.488
DOC_USP7_MATH_1	295	299	PF00917	0.322
DOC_USP7_MATH_1	567	571	PF00917	0.542
DOC_USP7_MATH_1	620	624	PF00917	0.573
DOC_USP7_MATH_1	65	69	PF00917	0.441
DOC_USP7_MATH_1	662	666	PF00917	0.574
DOC_USP7_MATH_1	750	754	PF00917	0.385
DOC_USP7_UBL2_3	373	377	PF12436	0.361
DOC_WW_Pin1_4	105	110	PF00397	0.471
DOC_WW_Pin1_4	17	22	PF00397	0.548
DOC_WW_Pin1_4	222	227	PF00397	0.496
DOC_WW_Pin1_4	472	477	PF00397	0.366
DOC_WW_Pin1_4	53	58	PF00397	0.451
DOC_WW_Pin1_4	605	610	PF00397	0.459
LIG_14-3-3_CanoR_1	128	137	PF00244	0.390
LIG_14-3-3_CanoR_1	211	219	PF00244	0.475
LIG_14-3-3_CanoR_1	228	236	PF00244	0.379
LIG_14-3-3_CanoR_1	333	337	PF00244	0.306
LIG_14-3-3_CanoR_1	432	437	PF00244	0.441
LIG_14-3-3_CanoR_1	442	446	PF00244	0.391
LIG_14-3-3_CanoR_1	616	625	PF00244	0.541
LIG_14-3-3_CanoR_1	729	736	PF00244	0.289
LIG_AP2alpha_1	257	261	PF02296	0.295
LIG_BRCT_BRCA1_1	365	369	PF00533	0.297
LIG_BRCT_BRCA1_1	569	573	PF00533	0.512
LIG_Clathr_ClatBox_1	87	91	PF01394	0.465
LIG_deltaCOP1_diTrp_1	247	257	PF00928	0.343
LIG_deltaCOP1_diTrp_1	511	516	PF00928	0.338
LIG_deltaCOP1_diTrp_1	537	546	PF00928	0.268
LIG_eIF4E_1	358	364	PF01652	0.277
LIG_FHA_1	149	155	PF00498	0.306
LIG_FHA_1	174	180	PF00498	0.335
LIG_FHA_1	271	277	PF00498	0.455
LIG_FHA_1	337	343	PF00498	0.388
LIG_FHA_1	400	406	PF00498	0.443
LIG_FHA_1	590	596	PF00498	0.503
LIG_FHA_1	613	619	PF00498	0.530
LIG_FHA_1	670	676	PF00498	0.592
LIG_FHA_1	712	718	PF00498	0.376
LIG_FHA_2	227	233	PF00498	0.437
LIG_FHA_2	445	451	PF00498	0.363
LIG_FHA_2	555	561	PF00498	0.518
LIG_FHA_2	624	630	PF00498	0.491
LIG_HCF-1_HBM_1	456	459	PF13415	0.328
LIG_LIR_Apic_2	389	395	PF02991	0.352
LIG_LIR_Apic_2	570	576	PF02991	0.508
LIG_LIR_Apic_2	656	662	PF02991	0.524
LIG_LIR_Gen_1	247	258	PF02991	0.328
LIG_LIR_Gen_1	428	436	PF02991	0.458
LIG_LIR_Gen_1	456	466	PF02991	0.269
LIG_LIR_Gen_1	486	491	PF02991	0.309
LIG_LIR_Gen_1	511	520	PF02991	0.328
LIG_LIR_Gen_1	593	602	PF02991	0.485
LIG_LIR_Gen_1	721	728	PF02991	0.301
LIG_LIR_Nem_3	247	253	PF02991	0.321
LIG_LIR_Nem_3	254	260	PF02991	0.258
LIG_LIR_Nem_3	301	307	PF02991	0.333
LIG_LIR_Nem_3	428	433	PF02991	0.453
LIG_LIR_Nem_3	456	462	PF02991	0.275
LIG_LIR_Nem_3	486	490	PF02991	0.314
LIG_LIR_Nem_3	504	509	PF02991	0.320
LIG_LIR_Nem_3	511	516	PF02991	0.297
LIG_LIR_Nem_3	593	599	PF02991	0.484
LIG_LIR_Nem_3	708	713	PF02991	0.472
LIG_LIR_Nem_3	721	725	PF02991	0.262
LIG_Pex14_1	430	434	PF04695	0.457
LIG_Pex14_2	257	261	PF04695	0.295
LIG_Pex14_2	441	445	PF04695	0.458
LIG_Pex14_2	509	513	PF04695	0.342
LIG_SH2_CRK	304	308	PF00017	0.293
LIG_SH2_CRK	487	491	PF00017	0.347
LIG_SH2_CRK	722	726	PF00017	0.328
LIG_SH2_GRB2like	487	490	PF00017	0.349
LIG_SH2_NCK_1	162	166	PF00017	0.306
LIG_SH2_SRC	162	165	PF00017	0.317
LIG_SH2_SRC	182	185	PF00017	0.281
LIG_SH2_STAP1	162	166	PF00017	0.373
LIG_SH2_STAP1	487	491	PF00017	0.347
LIG_SH2_STAT5	328	331	PF00017	0.314
LIG_SH2_STAT5	459	462	PF00017	0.258
LIG_SH2_STAT5	722	725	PF00017	0.336
LIG_SH3_2	223	228	PF14604	0.402
LIG_SH3_3	103	109	PF00018	0.428
LIG_SH3_3	15	21	PF00018	0.648
LIG_SH3_3	196	202	PF00018	0.469
LIG_SH3_3	220	226	PF00018	0.465
LIG_SUMO_SIM_anti_2	341	346	PF11976	0.357
LIG_SUMO_SIM_par_1	261	267	PF11976	0.263
LIG_SUMO_SIM_par_1	27	32	PF11976	0.338
LIG_SUMO_SIM_par_1	36	42	PF11976	0.351
LIG_SUMO_SIM_par_1	743	748	PF11976	0.370
LIG_TRAF2_1	264	267	PF00917	0.264
LIG_TRAF2_1	557	560	PF00917	0.519
LIG_TRAF2_1	598	601	PF00917	0.473
LIG_TYR_ITIM	302	307	PF00017	0.290
LIG_TYR_ITIM	720	725	PF00017	0.301
LIG_UBA3_1	317	324	PF00899	0.308
LIG_WRC_WIRS_1	405	410	PF05994	0.375
LIG_WRC_WIRS_1	433	438	PF05994	0.458
LIG_WW_1	159	162	PF00397	0.353
LIG_WW_1	517	520	PF00397	0.273
MOD_CDC14_SPxK_1	225	228	PF00782	0.442
MOD_CDK_SPK_2	222	227	PF00069	0.447
MOD_CDK_SPxK_1	222	228	PF00069	0.446
MOD_CDK_SPxxK_3	472	479	PF00069	0.359
MOD_CDK_SPxxK_3	53	60	PF00069	0.446
MOD_CK1_1	298	304	PF00069	0.324
MOD_CK1_1	444	450	PF00069	0.381
MOD_CK1_1	569	575	PF00069	0.494
MOD_CK1_1	590	596	PF00069	0.469
MOD_CK1_1	619	625	PF00069	0.480
MOD_CK1_1	697	703	PF00069	0.569
MOD_CK1_1	95	101	PF00069	0.500
MOD_CK2_1	226	232	PF00069	0.471
MOD_CK2_1	261	267	PF00069	0.260
MOD_CK2_1	395	401	PF00069	0.401
MOD_CK2_1	444	450	PF00069	0.381
MOD_CK2_1	554	560	PF00069	0.512
MOD_CK2_1	595	601	PF00069	0.548
MOD_CK2_1	623	629	PF00069	0.445
MOD_CK2_1	696	702	PF00069	0.484
MOD_Cter_Amidation	358	361	PF01082	0.493
MOD_GlcNHglycan	213	216	PF01048	0.689
MOD_GlcNHglycan	365	368	PF01048	0.496
MOD_GlcNHglycan	427	430	PF01048	0.627
MOD_GlcNHglycan	438	441	PF01048	0.671
MOD_GlcNHglycan	501	504	PF01048	0.530
MOD_GlcNHglycan	560	565	PF01048	0.707
MOD_GlcNHglycan	568	572	PF01048	0.673
MOD_GlcNHglycan	592	595	PF01048	0.781
MOD_GlcNHglycan	618	621	PF01048	0.691
MOD_GlcNHglycan	653	656	PF01048	0.683
MOD_GlcNHglycan	662	665	PF01048	0.725
MOD_GlcNHglycan	699	702	PF01048	0.716
MOD_GlcNHglycan	99	102	PF01048	0.657
MOD_GSK3_1	200	207	PF00069	0.579
MOD_GSK3_1	222	229	PF00069	0.476
MOD_GSK3_1	276	283	PF00069	0.381
MOD_GSK3_1	332	339	PF00069	0.312
MOD_GSK3_1	395	402	PF00069	0.419
MOD_GSK3_1	415	422	PF00069	0.369
MOD_GSK3_1	432	439	PF00069	0.486
MOD_GSK3_1	440	447	PF00069	0.434
MOD_GSK3_1	512	519	PF00069	0.330
MOD_GSK3_1	550	557	PF00069	0.445
MOD_GSK3_1	601	608	PF00069	0.472
MOD_GSK3_1	612	619	PF00069	0.469
MOD_GSK3_1	620	627	PF00069	0.414
MOD_GSK3_1	720	727	PF00069	0.354
MOD_GSK3_1	89	96	PF00069	0.452
MOD_N-GLC_1	415	420	PF02516	0.646
MOD_N-GLC_1	550	555	PF02516	0.626
MOD_N-GLC_2	148	150	PF02516	0.510
MOD_NEK2_1	1	6	PF00069	0.687
MOD_NEK2_1	110	115	PF00069	0.516
MOD_NEK2_1	261	266	PF00069	0.296
MOD_NEK2_1	270	275	PF00069	0.396
MOD_NEK2_1	334	339	PF00069	0.312
MOD_NEK2_1	353	358	PF00069	0.199
MOD_NEK2_1	363	368	PF00069	0.254
MOD_NEK2_1	415	420	PF00069	0.432
MOD_NEK2_1	436	441	PF00069	0.474
MOD_NEK2_1	529	534	PF00069	0.373
MOD_NEK2_1	580	585	PF00069	0.459
MOD_NEK2_1	694	699	PF00069	0.468
MOD_NEK2_1	720	725	PF00069	0.341
MOD_NEK2_2	115	120	PF00069	0.430
MOD_NEK2_2	204	209	PF00069	0.448
MOD_NEK2_2	65	70	PF00069	0.442
MOD_NEK2_2	724	729	PF00069	0.352
MOD_PIKK_1	277	283	PF00454	0.377
MOD_PIKK_1	555	561	PF00454	0.484
MOD_PKA_1	211	217	PF00069	0.494
MOD_PKA_1	227	233	PF00069	0.442
MOD_PKA_1	377	383	PF00069	0.355
MOD_PKA_2	115	121	PF00069	0.408
MOD_PKA_2	227	233	PF00069	0.437
MOD_PKA_2	276	282	PF00069	0.385
MOD_PKA_2	332	338	PF00069	0.311
MOD_PKA_2	353	359	PF00069	0.282
MOD_PKA_2	377	383	PF00069	0.351
MOD_PKA_2	441	447	PF00069	0.417
MOD_PKA_2	523	529	PF00069	0.363
MOD_PKA_2	728	734	PF00069	0.292
MOD_PKB_1	209	217	PF00069	0.490
MOD_Plk_1	298	304	PF00069	0.324
MOD_Plk_1	415	421	PF00069	0.479
MOD_Plk_1	550	556	PF00069	0.433
MOD_Plk_1	633	639	PF00069	0.505
MOD_Plk_1	65	71	PF00069	0.442
MOD_Plk_1	720	726	PF00069	0.343
MOD_Plk_4	165	171	PF00069	0.301
MOD_Plk_4	340	346	PF00069	0.399
MOD_Plk_4	353	359	PF00069	0.247
MOD_Plk_4	404	410	PF00069	0.415
MOD_Plk_4	581	587	PF00069	0.483
MOD_Plk_4	720	726	PF00069	0.287
MOD_ProDKin_1	105	111	PF00069	0.465
MOD_ProDKin_1	17	23	PF00069	0.546
MOD_ProDKin_1	222	228	PF00069	0.495
MOD_ProDKin_1	472	478	PF00069	0.359
MOD_ProDKin_1	53	59	PF00069	0.450
MOD_ProDKin_1	605	611	PF00069	0.460
MOD_SUMO_rev_2	178	188	PF00179	0.351
MOD_SUMO_rev_2	249	258	PF00179	0.321
MOD_SUMO_rev_2	298	307	PF00179	0.336
MOD_SUMO_rev_2	598	607	PF00179	0.477
TRG_DiLeu_BaEn_1	486	491	PF01217	0.308
TRG_DiLeu_BaEn_1	495	500	PF01217	0.289
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.356
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.449
TRG_ENDOCYTIC_2	304	307	PF00928	0.290
TRG_ENDOCYTIC_2	459	462	PF00928	0.261
TRG_ENDOCYTIC_2	487	490	PF00928	0.321
TRG_ENDOCYTIC_2	722	725	PF00928	0.296
TRG_ER_diArg_1	208	211	PF00400	0.509
TRG_ER_diArg_1	533	536	PF00400	0.374
TRG_ER_diArg_1	59	62	PF00400	0.562
TRG_ER_diArg_1	689	692	PF00400	0.497
TRG_ER_diArg_1	736	739	PF00400	0.321
TRG_ER_diArg_1	81	83	PF00400	0.458
TRG_ER_FFAT_2	439	450	PF00635	0.435
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	635	640	PF00026	0.699
TRG_Pf-PMV_PEXEL_1	692	696	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ6	Leptomonas seymouri	57%	100%
A0A422NU02	Trypanosoma rangeli	36%	99%
A4I9T4	Leishmania infantum	100%	100%
E9B4U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q381	Leishmania major	94%	100%