DUF3778 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFD4_LEIDO

TriTrypDb:

LdBPK_291430.1 , LdCL_290019350

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IFD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	320	326	PF00089	0.235
CLV_NRD_NRD_1	265	267	PF00675	0.488
CLV_PCSK_SKI1_1	148	152	PF00082	0.653
CLV_PCSK_SKI1_1	314	318	PF00082	0.311
DOC_CDC14_PxL_1	229	237	PF14671	0.269
DOC_CKS1_1	258	263	PF01111	0.765
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.601
DOC_MAPK_FxFP_2	90	93	PF00069	0.563
DOC_MAPK_gen_1	189	197	PF00069	0.444
DOC_MAPK_gen_1	312	320	PF00069	0.425
DOC_MAPK_MEF2A_6	209	218	PF00069	0.477
DOC_MAPK_MEF2A_6	281	288	PF00069	0.622
DOC_MAPK_MEF2A_6	312	320	PF00069	0.425
DOC_PP1_RVXF_1	146	153	PF00149	0.419
DOC_PP4_FxxP_1	207	210	PF00568	0.483
DOC_PP4_FxxP_1	230	233	PF00568	0.339
DOC_PP4_FxxP_1	90	93	PF00568	0.580
DOC_WW_Pin1_4	11	16	PF00397	0.649
DOC_WW_Pin1_4	165	170	PF00397	0.488
DOC_WW_Pin1_4	182	187	PF00397	0.480
DOC_WW_Pin1_4	196	201	PF00397	0.508
DOC_WW_Pin1_4	252	257	PF00397	0.775
DOC_WW_Pin1_4	299	304	PF00397	0.641
LIG_14-3-3_CanoR_1	10	15	PF00244	0.647
LIG_14-3-3_CanoR_1	119	124	PF00244	0.661
LIG_14-3-3_CanoR_1	249	258	PF00244	0.654
LIG_14-3-3_CanoR_1	323	329	PF00244	0.250
LIG_14-3-3_CanoR_1	76	82	PF00244	0.506
LIG_Actin_WH2_2	48	65	PF00022	0.287
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BIR_III_1	1	5	PF00653	0.644
LIG_BIR_III_3	1	5	PF00653	0.644
LIG_BRCT_BRCA1_1	221	225	PF00533	0.462
LIG_BRCT_BRCA1_1	326	330	PF00533	0.235
LIG_BRCT_BRCA1_1	48	52	PF00533	0.269
LIG_EH1_1	279	287	PF00400	0.602
LIG_eIF4E_1	224	230	PF01652	0.269
LIG_eIF4E_1	311	317	PF01652	0.425
LIG_FHA_1	243	249	PF00498	0.656
LIG_FHA_1	277	283	PF00498	0.664
LIG_FHA_1	70	76	PF00498	0.300
LIG_FHA_1	96	102	PF00498	0.636
LIG_LIR_Apic_2	204	210	PF02991	0.596
LIG_LIR_Apic_2	88	93	PF02991	0.339
LIG_LIR_Gen_1	208	218	PF02991	0.454
LIG_LIR_Gen_1	49	59	PF02991	0.269
LIG_LIR_Nem_3	179	184	PF02991	0.489
LIG_LIR_Nem_3	208	214	PF02991	0.449
LIG_LIR_Nem_3	221	227	PF02991	0.224
LIG_LIR_Nem_3	299	304	PF02991	0.601
LIG_LIR_Nem_3	48	54	PF02991	0.269
LIG_LIR_Nem_3	88	92	PF02991	0.325
LIG_LYPXL_yS_3	181	184	PF13949	0.494
LIG_MLH1_MIPbox_1	221	225	PF16413	0.339
LIG_MLH1_MIPbox_1	48	52	PF16413	0.269
LIG_MYND_1	182	186	PF01753	0.491
LIG_Pex14_2	207	211	PF04695	0.482
LIG_Pex14_2	230	234	PF04695	0.269
LIG_Pex14_2	315	319	PF04695	0.235
LIG_Pex14_2	64	68	PF04695	0.414
LIG_SH2_STAT5	224	227	PF00017	0.339
LIG_SH2_STAT5	44	47	PF00017	0.269
LIG_SH3_2	261	266	PF14604	0.650
LIG_SH3_3	168	174	PF00018	0.486
LIG_SH3_3	197	203	PF00018	0.474
LIG_SH3_3	253	259	PF00018	0.771
LIG_SUMO_SIM_par_1	161	168	PF11976	0.481
LIG_UBA3_1	300	305	PF00899	0.602
LIG_WRC_WIRS_1	220	225	PF05994	0.339
LIG_WRC_WIRS_1	86	91	PF05994	0.339
MOD_CDC14_SPxK_1	302	305	PF00782	0.601
MOD_CDK_SPK_2	170	175	PF00069	0.434
MOD_CDK_SPxK_1	299	305	PF00069	0.601
MOD_CDK_SPxxK_3	182	189	PF00069	0.490
MOD_CK1_1	127	133	PF00069	0.308
MOD_CK1_1	13	19	PF00069	0.655
MOD_CK1_1	185	191	PF00069	0.501
MOD_CK1_1	198	204	PF00069	0.541
MOD_CK1_1	219	225	PF00069	0.390
MOD_CK1_1	252	258	PF00069	0.662
MOD_CK1_1	299	305	PF00069	0.601
MOD_CK1_1	66	72	PF00069	0.467
MOD_CK1_1	80	86	PF00069	0.427
MOD_CK1_1	88	94	PF00069	0.371
MOD_CK2_1	109	115	PF00069	0.785
MOD_GlcNHglycan	126	129	PF01048	0.296
MOD_GlcNHglycan	139	142	PF01048	0.580
MOD_GlcNHglycan	270	273	PF01048	0.491
MOD_GlcNHglycan	324	327	PF01048	0.368
MOD_GlcNHglycan	77	80	PF01048	0.339
MOD_GSK3_1	201	208	PF00069	0.500
MOD_GSK3_1	212	219	PF00069	0.446
MOD_GSK3_1	276	283	PF00069	0.607
MOD_GSK3_1	62	69	PF00069	0.537
MOD_GSK3_1	88	95	PF00069	0.594
MOD_GSK3_1	9	16	PF00069	0.650
MOD_LATS_1	106	112	PF00433	0.655
MOD_N-GLC_1	109	114	PF02516	0.491
MOD_N-GLC_1	119	124	PF02516	0.523
MOD_NEK2_1	109	114	PF00069	0.690
MOD_NEK2_1	139	144	PF00069	0.445
MOD_NEK2_1	214	219	PF00069	0.375
MOD_NEK2_1	275	280	PF00069	0.725
MOD_NEK2_1	45	50	PF00069	0.296
MOD_NEK2_1	62	67	PF00069	0.407
MOD_NEK2_1	75	80	PF00069	0.360
MOD_NEK2_1	85	90	PF00069	0.392
MOD_NEK2_2	296	301	PF00069	0.606
MOD_PIKK_1	139	145	PF00454	0.418
MOD_PIKK_1	92	98	PF00454	0.627
MOD_PKA_1	268	274	PF00069	0.644
MOD_PKA_2	322	328	PF00069	0.235
MOD_PKA_2	75	81	PF00069	0.444
MOD_PKA_2	9	15	PF00069	0.647
MOD_Plk_1	119	125	PF00069	0.549
MOD_Plk_4	219	225	PF00069	0.339
MOD_Plk_4	280	286	PF00069	0.608
MOD_Plk_4	296	302	PF00069	0.581
MOD_Plk_4	324	330	PF00069	0.235
MOD_Plk_4	46	52	PF00069	0.269
MOD_Plk_4	80	86	PF00069	0.471
MOD_Plk_4	96	102	PF00069	0.617
MOD_ProDKin_1	11	17	PF00069	0.650
MOD_ProDKin_1	165	171	PF00069	0.487
MOD_ProDKin_1	182	188	PF00069	0.480
MOD_ProDKin_1	196	202	PF00069	0.508
MOD_ProDKin_1	252	258	PF00069	0.776
MOD_ProDKin_1	299	305	PF00069	0.641
MOD_SUMO_for_1	304	307	PF00179	0.600
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.339
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.489
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.685
TRG_ENDOCYTIC_2	181	184	PF00928	0.494
TRG_ENDOCYTIC_2	224	227	PF00928	0.273
TRG_ER_diArg_1	311	314	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9ALT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	96%