C2 domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFD2_LEIDO

TriTrypDb:

LdBPK_310710.1 , LdCL_310012800 , LDHU3_31.1010

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFD2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.438
CLV_PCSK_KEX2_1	142	144	PF00082	0.543
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.543
CLV_PCSK_PC7_1	138	144	PF00082	0.532
DOC_CKS1_1	209	214	PF01111	0.657
DOC_MAPK_gen_1	104	113	PF00069	0.492
DOC_MAPK_MEF2A_6	106	115	PF00069	0.481
DOC_PP2B_LxvP_1	168	171	PF13499	0.615
DOC_PP4_FxxP_1	55	58	PF00568	0.388
DOC_SPAK_OSR1_1	54	58	PF12202	0.416
DOC_USP7_MATH_1	236	240	PF00917	0.679
DOC_USP7_MATH_1	248	252	PF00917	0.638
DOC_USP7_MATH_1	258	262	PF00917	0.612
DOC_USP7_UBL2_3	92	96	PF12436	0.416
DOC_WW_Pin1_4	185	190	PF00397	0.634
DOC_WW_Pin1_4	208	213	PF00397	0.672
DOC_WW_Pin1_4	244	249	PF00397	0.726
LIG_AP2alpha_2	24	26	PF02296	0.416
LIG_Clathr_ClatBox_1	115	119	PF01394	0.468
LIG_deltaCOP1_diTrp_1	48	55	PF00928	0.373
LIG_FHA_1	131	137	PF00498	0.570
LIG_FHA_1	36	42	PF00498	0.460
LIG_FHA_1	82	88	PF00498	0.568
LIG_FHA_1	89	95	PF00498	0.510
LIG_FHA_2	105	111	PF00498	0.463
LIG_FHA_2	72	78	PF00498	0.458
LIG_LIR_Apic_2	239	243	PF02991	0.770
LIG_LIR_Apic_2	52	58	PF02991	0.388
LIG_LIR_Gen_1	24	31	PF02991	0.615
LIG_LIR_Nem_3	119	123	PF02991	0.500
LIG_LIR_Nem_3	24	29	PF02991	0.615
LIG_LIR_Nem_3	97	102	PF02991	0.578
LIG_Pex14_1	49	53	PF04695	0.519
LIG_SH2_CRK	166	170	PF00017	0.625
LIG_SH2_CRK	266	270	PF00017	0.673
LIG_SH2_NCK_1	166	170	PF00017	0.625
LIG_SH2_PTP2	194	197	PF00017	0.598
LIG_SH2_PTP2	202	205	PF00017	0.602
LIG_SH2_STAP1	75	79	PF00017	0.503
LIG_SH2_STAP1	83	87	PF00017	0.557
LIG_SH2_STAT3	210	213	PF00017	0.670
LIG_SH2_STAT3	219	222	PF00017	0.754
LIG_SH2_STAT3	253	256	PF00017	0.707
LIG_SH2_STAT3	265	268	PF00017	0.621
LIG_SH2_STAT3	274	277	PF00017	0.589
LIG_SH2_STAT3	36	39	PF00017	0.416
LIG_SH2_STAT5	100	103	PF00017	0.427
LIG_SH2_STAT5	194	197	PF00017	0.669
LIG_SH2_STAT5	202	205	PF00017	0.643
LIG_SH2_STAT5	210	213	PF00017	0.664
LIG_SH2_STAT5	219	222	PF00017	0.720
LIG_SH2_STAT5	266	269	PF00017	0.650
LIG_SH2_STAT5	83	86	PF00017	0.375
LIG_SH3_1	155	161	PF00018	0.562
LIG_SH3_1	228	234	PF00018	0.796
LIG_SH3_1	240	246	PF00018	0.752
LIG_SH3_3	155	161	PF00018	0.682
LIG_SH3_3	190	196	PF00018	0.670
LIG_SH3_3	200	206	PF00018	0.660
LIG_SH3_3	228	234	PF00018	0.809
LIG_SH3_3	239	245	PF00018	0.762
LIG_SH3_3	254	260	PF00018	0.657
LIG_SUMO_SIM_par_1	114	119	PF11976	0.620
LIG_TRAF2_1	124	127	PF00917	0.557
LIG_TYR_ITIM	192	197	PF00017	0.582
LIG_TYR_ITIM	200	205	PF00017	0.602
LIG_TYR_ITIM	264	269	PF00017	0.604
LIG_WW_2	233	236	PF00397	0.657
MOD_CK2_1	104	110	PF00069	0.559
MOD_GlcNHglycan	250	253	PF01048	0.683
MOD_GSK3_1	244	251	PF00069	0.628
MOD_GSK3_1	264	271	PF00069	0.592
MOD_N-GLC_2	71	73	PF02516	0.388
MOD_NEK2_1	102	107	PF00069	0.711
MOD_NEK2_2	49	54	PF00069	0.453
MOD_PIKK_1	104	110	PF00454	0.495
MOD_PIKK_1	258	264	PF00454	0.641
MOD_PIKK_1	268	274	PF00454	0.599
MOD_PIKK_1	35	41	PF00454	0.527
MOD_PIKK_1	60	66	PF00454	0.545
MOD_Plk_1	4	10	PF00069	0.416
MOD_Plk_4	236	242	PF00069	0.708
MOD_ProDKin_1	185	191	PF00069	0.633
MOD_ProDKin_1	208	214	PF00069	0.673
MOD_ProDKin_1	244	250	PF00069	0.653
MOD_SUMO_for_1	124	127	PF00179	0.523
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.451
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.610
TRG_ENDOCYTIC_2	194	197	PF00928	0.590
TRG_ENDOCYTIC_2	202	205	PF00928	0.589
TRG_ENDOCYTIC_2	266	269	PF00928	0.613
TRG_ENDOCYTIC_2	82	85	PF00928	0.416
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X485	Leishmania donovani	35%	98%
A0A3S7X4C0	Leishmania donovani	37%	100%
A4HJ46	Leishmania braziliensis	66%	93%
A4HJ57	Leishmania braziliensis	40%	100%
A4HJ58	Leishmania braziliensis	37%	100%
A4I6G2	Leishmania infantum	99%	100%
A4I6H2	Leishmania infantum	36%	100%
A4I6H3	Leishmania infantum	35%	98%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q9BHE7	Leishmania major	35%	100%
Q9BHF8	Leishmania major	87%	95%