Cyclin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cyclin

Gene product:

CYC2-like cyclin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFC8_LEIDO

TriTrypDb:

LdBPK_320870.1 , LdCL_320014200 , LDHU3_32.1100

Length:

164

Annotations

Annotations by Jardim et al.

Cell Cycle, CYC2-like cyclin CYC2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFC8

Function

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Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	10
GO:0001932	regulation of protein phosphorylation	7	10
GO:0019220	regulation of phosphate metabolic process	6	10
GO:0019222	regulation of metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031399	regulation of protein modification process	6	10
GO:0042325	regulation of phosphorylation	7	10
GO:0043549	regulation of kinase activity	5	10
GO:0045859	regulation of protein kinase activity	6	10
GO:0050789	regulation of biological process	2	10

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0019899	enzyme binding	3	10
GO:0019900	kinase binding	4	10
GO:0019901	protein kinase binding	5	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	45	47	PF00675	0.334
CLV_PCSK_KEX2_1	156	158	PF00082	0.617
CLV_PCSK_KEX2_1	45	47	PF00082	0.299
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.543
CLV_PCSK_SKI1_1	46	50	PF00082	0.306
DOC_MAPK_gen_1	71	78	PF00069	0.336
DOC_MAPK_MEF2A_6	71	78	PF00069	0.375
DOC_WW_Pin1_4	158	163	PF00397	0.585
LIG_14-3-3_CanoR_1	73	79	PF00244	0.293
LIG_14-3-3_CanoR_1	83	93	PF00244	0.265

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRS5	Leptomonas seymouri	34%	70%
A0A0S4J0V7	Bodo saltans	58%	95%
A0A1X0NV96	Trypanosomatidae	56%	87%
A0A1X0P2T0	Trypanosomatidae	36%	75%
A0A3R7RLR0	Trypanosoma rangeli	39%	74%
A0A422N8W7	Trypanosoma rangeli	53%	85%
A4HK63	Leishmania braziliensis	95%	100%
A4I7P8	Leishmania infantum	100%	100%
C9ZRH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	77%
D0A9V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	78%

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