Ribosomal protein L13e family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L13, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IFC5_LEIDO

TriTrypDb:

LdBPK_292570.1 , LdCL_290031900 , LDHU3_29.3820 , LDHU3_29.3830

Length:

220

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L13

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	16
GO:0043228	non-membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043232	intracellular non-membrane-bounded organelle	4	16
GO:0110165	cellular anatomical entity	1	16
GO:1990904	ribonucleoprotein complex	2	16
GO:0005730	nucleolus	5	2
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

A0A3Q8IFC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFC5

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	16
GO:0006518	peptide metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009058	biosynthetic process	2	16
GO:0009059	macromolecule biosynthetic process	4	16
GO:0009987	cellular process	1	16
GO:0019538	protein metabolic process	3	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	16
GO:0043043	peptide biosynthetic process	5	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043603	amide metabolic process	3	16
GO:0043604	amide biosynthetic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0044271	cellular nitrogen compound biosynthetic process	4	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	16
GO:0005198	structural molecule activity	1	16
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.318
CLV_NRD_NRD_1	208	210	PF00675	0.524
CLV_NRD_NRD_1	41	43	PF00675	0.306
CLV_NRD_NRD_1	74	76	PF00675	0.388
CLV_PCSK_FUR_1	39	43	PF00082	0.306
CLV_PCSK_KEX2_1	105	107	PF00082	0.315
CLV_PCSK_KEX2_1	39	41	PF00082	0.317
CLV_PCSK_KEX2_1	73	75	PF00082	0.316
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.316
CLV_PCSK_PC7_1	101	107	PF00082	0.306
CLV_PCSK_PC7_1	69	75	PF00082	0.388
CLV_PCSK_SKI1_1	127	131	PF00082	0.314
CLV_PCSK_SKI1_1	149	153	PF00082	0.316
CLV_PCSK_SKI1_1	28	32	PF00082	0.306
CLV_PCSK_SKI1_1	44	48	PF00082	0.314
CLV_PCSK_SKI1_1	49	53	PF00082	0.312
CLV_PCSK_SKI1_1	54	58	PF00082	0.306
DEG_APCC_DBOX_1	39	47	PF00400	0.514
DOC_MAPK_gen_1	105	116	PF00069	0.524
DOC_MAPK_gen_1	191	199	PF00069	0.594
DOC_MAPK_gen_1	37	45	PF00069	0.516
DOC_MAPK_MEF2A_6	109	118	PF00069	0.517
DOC_MAPK_MEF2A_6	24	31	PF00069	0.526
DOC_PP1_RVXF_1	125	132	PF00149	0.506
DOC_PP4_FxxP_1	52	55	PF00568	0.506
DOC_USP7_MATH_1	19	23	PF00917	0.506
DOC_USP7_UBL2_3	136	140	PF12436	0.514
DOC_USP7_UBL2_3	210	214	PF12436	0.521
DOC_USP7_UBL2_3	24	28	PF12436	0.506
DOC_WW_Pin1_4	170	175	PF00397	0.465
DOC_WW_Pin1_4	78	83	PF00397	0.588
LIG_14-3-3_CanoR_1	106	116	PF00244	0.506
LIG_14-3-3_CanoR_1	120	125	PF00244	0.506
LIG_14-3-3_CanoR_1	175	184	PF00244	0.530
LIG_ActinCP_TwfCPI_2	52	60	PF01115	0.514
LIG_FHA_1	95	101	PF00498	0.506
LIG_PTB_Apo_2	88	95	PF02174	0.566
LIG_PTB_Phospho_1	88	94	PF10480	0.616
LIG_REV1ctd_RIR_1	197	207	PF16727	0.474
LIG_SH2_CRK	187	191	PF00017	0.506
LIG_SH2_STAP1	94	98	PF00017	0.549
LIG_SH3_3	126	132	PF00018	0.506
LIG_SH3_3	163	169	PF00018	0.561
LIG_SH3_3	60	66	PF00018	0.513
LIG_TRAF2_1	143	146	PF00917	0.514
LIG_TRAF2_1	178	181	PF00917	0.506
LIG_TRAF2_1	213	216	PF00917	0.696
LIG_UBA3_1	130	137	PF00899	0.515
MOD_CDK_SPK_2	170	175	PF00069	0.449
MOD_CK1_1	170	176	PF00069	0.449
MOD_CK2_1	141	147	PF00069	0.506
MOD_CK2_1	175	181	PF00069	0.506
MOD_CK2_1	78	84	PF00069	0.506
MOD_GlcNHglycan	169	172	PF01048	0.430
MOD_GlcNHglycan	177	180	PF01048	0.358
MOD_GlcNHglycan	194	197	PF01048	0.373
MOD_GlcNHglycan	203	206	PF01048	0.468
MOD_GSK3_1	149	156	PF00069	0.500
MOD_N-GLC_1	107	112	PF02516	0.306
MOD_N-GLC_1	192	197	PF02516	0.372
MOD_PIKK_1	149	155	PF00454	0.516
MOD_PIKK_1	19	25	PF00454	0.506
MOD_Plk_1	153	159	PF00069	0.514
MOD_Plk_1	180	186	PF00069	0.569
MOD_Plk_1	192	198	PF00069	0.559
MOD_Plk_4	120	126	PF00069	0.530
MOD_ProDKin_1	170	176	PF00069	0.465
MOD_ProDKin_1	78	84	PF00069	0.588
MOD_SUMO_for_1	213	216	PF00179	0.617
MOD_SUMO_rev_2	142	151	PF00179	0.514
MOD_SUMO_rev_2	178	184	PF00179	0.615
MOD_SUMO_rev_2	211	218	PF00179	0.679
MOD_SUMO_rev_2	81	88	PF00179	0.510
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.535
TRG_ENDOCYTIC_2	187	190	PF00928	0.506
TRG_ER_diArg_1	155	158	PF00400	0.506
TRG_ER_diArg_1	39	42	PF00400	0.507
TRG_ER_diArg_1	74	76	PF00400	0.588
TRG_NLS_MonoExtC_3	105	111	PF00514	0.514
TRG_NLS_MonoExtN_4	105	110	PF00514	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T3	Leptomonas seymouri	90%	100%
A0A0S4IPY1	Bodo saltans	77%	100%
A0A1X0P9D4	Trypanosomatidae	82%	100%
A0A3Q8IFI6	Leishmania donovani	100%	100%
A0A422N0S6	Trypanosoma rangeli	73%	93%
A0A422N0S7	Trypanosoma rangeli	79%	100%
A4HHP5	Leishmania braziliensis	95%	100%
A4I4W0	Leishmania infantum	100%	100%
C9ZL00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	96%
C9ZL01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AEA8	Leishmania major	100%	100%
E9AEA9	Leishmania major	99%	100%
E9ALH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O46157	Lumbricus rubellus	45%	100%
O48513	Chlamydomonas sp. (strain W80)	41%	100%
O59931	Candida albicans (strain SC5314 / ATCC MYA-2876)	49%	100%
O74175	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
P0DJ58	Tetrahymena thermophila (strain SB210)	41%	100%
P26373	Homo sapiens	45%	100%
P41123	Rattus norvegicus	45%	100%
P41125	Gallus gallus	44%	100%
P41126	Drosophila melanogaster	48%	100%
P41127	Arabidopsis thaliana	53%	100%
P41128	Brassica napus	45%	100%
P41129	Brassica napus	45%	100%
P47963	Mus musculus	44%	100%
P91128	Caenorhabditis elegans	42%	100%
Q54E20	Dictyostelium discoideum	46%	100%
Q56JZ1	Bos taurus	44%	100%
Q876B2	Saccharomyces exiguus	43%	100%
Q90YV5	Ictalurus punctatus	45%	100%
Q90Z10	Danio rerio	43%	100%
Q95043	Schistosoma mansoni	53%	100%
Q962U1	Spodoptera frugiperda	49%	100%
Q9FF90	Arabidopsis thaliana	51%	100%
Q9SMT4	Arabidopsis thaliana	50%	100%
Q9Z313	Cricetulus griseus	44%	100%
V5BX72	Trypanosoma cruzi	82%	100%