Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFC4_LEIDO

TriTrypDb:

LdBPK_291300.1 , LdCL_290018100 , LDHU3_29.1790

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.432
CLV_C14_Caspase3-7	182	186	PF00656	0.500
CLV_C14_Caspase3-7	344	348	PF00656	0.630
CLV_NRD_NRD_1	142	144	PF00675	0.478
CLV_NRD_NRD_1	282	284	PF00675	0.630
CLV_NRD_NRD_1	333	335	PF00675	0.626
CLV_NRD_NRD_1	350	352	PF00675	0.584
CLV_PCSK_KEX2_1	142	144	PF00082	0.526
CLV_PCSK_KEX2_1	281	283	PF00082	0.613
CLV_PCSK_KEX2_1	333	335	PF00082	0.735
CLV_PCSK_KEX2_1	350	352	PF00082	0.577
CLV_PCSK_SKI1_1	160	164	PF00082	0.489
CLV_PCSK_SKI1_1	189	193	PF00082	0.463
CLV_PCSK_SKI1_1	300	304	PF00082	0.550
DEG_MDM2_SWIB_1	118	126	PF02201	0.567
DEG_MDM2_SWIB_1	362	369	PF02201	0.583
DEG_SPOP_SBC_1	155	159	PF00917	0.567
DOC_CKS1_1	249	254	PF01111	0.604
DOC_CYCLIN_yCln2_LP_2	254	257	PF00134	0.725
DOC_MAPK_FxFP_2	191	194	PF00069	0.458
DOC_MAPK_gen_1	142	150	PF00069	0.457
DOC_MAPK_gen_1	333	340	PF00069	0.619
DOC_MAPK_gen_1	9	19	PF00069	0.504
DOC_MAPK_HePTP_8	140	152	PF00069	0.580
DOC_MAPK_MEF2A_6	142	150	PF00069	0.424
DOC_MAPK_MEF2A_6	333	340	PF00069	0.531
DOC_MAPK_MEF2A_6	9	17	PF00069	0.502
DOC_PP1_RVXF_1	265	272	PF00149	0.460
DOC_PP2B_LxvP_1	254	257	PF13499	0.674
DOC_PP2B_LxvP_1	367	370	PF13499	0.519
DOC_PP4_FxxP_1	191	194	PF00568	0.458
DOC_USP7_MATH_1	155	159	PF00917	0.667
DOC_USP7_MATH_1	161	165	PF00917	0.564
DOC_USP7_MATH_1	2	6	PF00917	0.542
DOC_USP7_MATH_1	204	208	PF00917	0.680
DOC_USP7_MATH_1	223	227	PF00917	0.673
DOC_USP7_MATH_1	69	73	PF00917	0.787
DOC_WW_Pin1_4	248	253	PF00397	0.581
DOC_WW_Pin1_4	71	76	PF00397	0.725
LIG_14-3-3_CanoR_1	12	16	PF00244	0.509
LIG_14-3-3_CanoR_1	160	170	PF00244	0.601
LIG_14-3-3_CanoR_1	189	194	PF00244	0.440
LIG_14-3-3_CanoR_1	216	222	PF00244	0.801
LIG_APCC_ABBA_1	13	18	PF00400	0.422
LIG_APCC_ABBAyCdc20_2	12	18	PF00400	0.510
LIG_BIR_III_2	211	215	PF00653	0.564
LIG_Clathr_ClatBox_1	54	58	PF01394	0.579
LIG_CSL_BTD_1	249	252	PF09270	0.591
LIG_CtBP_PxDLS_1	194	198	PF00389	0.524
LIG_deltaCOP1_diTrp_1	329	335	PF00928	0.626
LIG_eIF4E_1	297	303	PF01652	0.561
LIG_EVH1_1	255	259	PF00568	0.639
LIG_EVH1_2	258	262	PF00568	0.632
LIG_FHA_1	107	113	PF00498	0.649
LIG_FHA_1	12	18	PF00498	0.476
LIG_FHA_1	135	141	PF00498	0.545
LIG_FHA_1	157	163	PF00498	0.517
LIG_FHA_1	232	238	PF00498	0.463
LIG_FHA_1	249	255	PF00498	0.724
LIG_FHA_1	49	55	PF00498	0.496
LIG_FHA_1	91	97	PF00498	0.531
LIG_FHA_2	177	183	PF00498	0.552
LIG_FHA_2	339	345	PF00498	0.643
LIG_FHA_2	363	369	PF00498	0.604
LIG_FHA_2	79	85	PF00498	0.652
LIG_LIR_Gen_1	168	178	PF02991	0.604
LIG_LIR_Gen_1	363	372	PF02991	0.631
LIG_LIR_Gen_1	8	17	PF02991	0.510
LIG_LIR_LC3C_4	51	56	PF02991	0.512
LIG_LIR_Nem_3	14	19	PF02991	0.450
LIG_LIR_Nem_3	168	174	PF02991	0.582
LIG_LIR_Nem_3	260	265	PF02991	0.485
LIG_LIR_Nem_3	363	369	PF02991	0.580
LIG_LIR_Nem_3	8	13	PF02991	0.518
LIG_MYND_1	252	256	PF01753	0.618
LIG_MYND_1	71	75	PF01753	0.761
LIG_NRBOX	165	171	PF00104	0.463
LIG_Pex14_1	331	335	PF04695	0.636
LIG_Pex14_2	118	122	PF04695	0.585
LIG_Pex14_2	362	366	PF04695	0.569
LIG_SH2_CRK	171	175	PF00017	0.602
LIG_SH2_NCK_1	171	175	PF00017	0.602
LIG_SH2_NCK_1	217	221	PF00017	0.674
LIG_SH2_PTP2	16	19	PF00017	0.499
LIG_SH2_SRC	16	19	PF00017	0.499
LIG_SH2_STAP1	108	112	PF00017	0.638
LIG_SH2_STAT5	108	111	PF00017	0.637
LIG_SH2_STAT5	16	19	PF00017	0.468
LIG_SH2_STAT5	171	174	PF00017	0.426
LIG_SH2_STAT5	200	203	PF00017	0.582
LIG_SH3_1	282	288	PF00018	0.660
LIG_SH3_2	256	261	PF14604	0.697
LIG_SH3_3	198	204	PF00018	0.590
LIG_SH3_3	243	249	PF00018	0.602
LIG_SH3_3	253	259	PF00018	0.378
LIG_SH3_3	282	288	PF00018	0.612
LIG_SUMO_SIM_par_1	53	59	PF11976	0.587
LIG_TRAF2_1	165	168	PF00917	0.580
LIG_TRAF2_1	25	28	PF00917	0.713
LIG_TRAF2_1	64	67	PF00917	0.629
LIG_TYR_ITIM	169	174	PF00017	0.583
LIG_TYR_ITSM	12	19	PF00017	0.497
MOD_CK1_1	128	134	PF00069	0.537
MOD_CK1_1	176	182	PF00069	0.584
MOD_CK1_1	224	230	PF00069	0.724
MOD_CK1_1	61	67	PF00069	0.604
MOD_CK1_1	87	93	PF00069	0.594
MOD_CK2_1	161	167	PF00069	0.619
MOD_CK2_1	2	8	PF00069	0.728
MOD_CK2_1	61	67	PF00069	0.611
MOD_CK2_1	78	84	PF00069	0.520
MOD_GlcNHglycan	163	166	PF01048	0.630
MOD_GlcNHglycan	175	178	PF01048	0.648
MOD_GlcNHglycan	206	209	PF01048	0.647
MOD_GlcNHglycan	223	226	PF01048	0.548
MOD_GlcNHglycan	273	276	PF01048	0.676
MOD_GlcNHglycan	304	307	PF01048	0.564
MOD_GlcNHglycan	326	329	PF01048	0.698
MOD_GlcNHglycan	45	48	PF01048	0.565
MOD_GlcNHglycan	63	66	PF01048	0.489
MOD_GSK3_1	124	131	PF00069	0.490
MOD_GSK3_1	169	176	PF00069	0.589
MOD_GSK3_1	80	87	PF00069	0.730
MOD_N-GLC_1	112	117	PF02516	0.611
MOD_NEK2_1	125	130	PF00069	0.486
MOD_NEK2_1	169	174	PF00069	0.492
MOD_NEK2_1	271	276	PF00069	0.590
MOD_NEK2_1	302	307	PF00069	0.582
MOD_NEK2_1	362	367	PF00069	0.668
MOD_NEK2_1	88	93	PF00069	0.559
MOD_NEK2_2	355	360	PF00069	0.721
MOD_PIKK_1	345	351	PF00454	0.652
MOD_PKA_2	11	17	PF00069	0.516
MOD_PKA_2	215	221	PF00069	0.762
MOD_PKA_2	69	75	PF00069	0.790
MOD_Plk_1	112	118	PF00069	0.602
MOD_Plk_1	336	342	PF00069	0.759
MOD_Plk_1	362	368	PF00069	0.646
MOD_Plk_4	11	17	PF00069	0.516
MOD_Plk_4	250	256	PF00069	0.714
MOD_Plk_4	362	368	PF00069	0.664
MOD_ProDKin_1	248	254	PF00069	0.590
MOD_ProDKin_1	71	77	PF00069	0.725
MOD_SUMO_rev_2	176	184	PF00179	0.500
MOD_SUMO_rev_2	205	214	PF00179	0.748
TRG_DiLeu_BaEn_1	35	40	PF01217	0.607
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.659
TRG_ENDOCYTIC_2	16	19	PF00928	0.434
TRG_ENDOCYTIC_2	171	174	PF00928	0.587
TRG_ER_diArg_1	280	283	PF00400	0.608
TRG_ER_diArg_1	332	334	PF00400	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E7	Leptomonas seymouri	42%	100%
A0A1X0NZS1	Trypanosomatidae	27%	91%
A0A3R7LZ67	Trypanosoma rangeli	29%	93%
A4HHD3	Leishmania braziliensis	74%	100%
A4I4H8	Leishmania infantum	99%	100%
E9ADX9	Leishmania major	89%	100%
E9ALV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%