LeishMANIAdb
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Proteophosphoglycan ppg4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proteophosphoglycan ppg4
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3Q8IFC2_LEIDO
TriTrypDb:
LdBPK_311480.1 * , LdCL_310021700 , LDHU3_31.2540
Length:
436

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 29, no: 1
NetGPI no yes: 0, no: 30
Cellular components
Term Name Level Count
GO:0005929 cilium 4 31
GO:0042995 cell projection 2 31
GO:0043226 organelle 2 31
GO:0043227 membrane-bounded organelle 3 31
GO:0110165 cellular anatomical entity 1 31
GO:0120025 plasma membrane bounded cell projection 3 31
GO:0016020 membrane 2 10
GO:0005886 plasma membrane 3 2

Expansion

Sequence features

A0A3Q8IFC2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFC2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004672 protein kinase activity 3 1
GO:0004674 protein serine/threonine kinase activity 4 1
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.275
CLV_NRD_NRD_1 246 248 PF00675 0.478
CLV_NRD_NRD_1 264 266 PF00675 0.509
CLV_NRD_NRD_1 3 5 PF00675 0.651
CLV_PCSK_KEX2_1 246 248 PF00082 0.478
CLV_PCSK_KEX2_1 264 266 PF00082 0.506
CLV_PCSK_KEX2_1 3 5 PF00082 0.651
CLV_PCSK_KEX2_1 405 407 PF00082 0.552
CLV_PCSK_PC1ET2_1 405 407 PF00082 0.553
CLV_PCSK_SKI1_1 171 175 PF00082 0.531
DEG_Nend_Nbox_1 1 3 PF02207 0.471
DEG_SPOP_SBC_1 289 293 PF00917 0.481
DEG_SPOP_SBC_1 296 300 PF00917 0.468
DEG_SPOP_SBC_1 304 308 PF00917 0.449
DEG_SPOP_SBC_1 312 316 PF00917 0.467
DEG_SPOP_SBC_1 320 324 PF00917 0.465
DEG_SPOP_SBC_1 328 332 PF00917 0.460
DEG_SPOP_SBC_1 336 340 PF00917 0.468
DEG_SPOP_SBC_1 344 348 PF00917 0.473
DEG_SPOP_SBC_1 352 356 PF00917 0.468
DEG_SPOP_SBC_1 360 364 PF00917 0.460
DOC_MAPK_gen_1 264 272 PF00069 0.337
DOC_MAPK_MEF2A_6 145 154 PF00069 0.266
DOC_PP1_RVXF_1 169 176 PF00149 0.252
DOC_USP7_MATH_1 179 183 PF00917 0.243
DOC_USP7_MATH_1 422 426 PF00917 0.279
DOC_USP7_MATH_1 72 76 PF00917 0.265
DOC_USP7_MATH_2 212 218 PF00917 0.285
DOC_WW_Pin1_4 411 416 PF00397 0.433
LIG_14-3-3_CanoR_1 171 176 PF00244 0.300
LIG_14-3-3_CanoR_1 192 198 PF00244 0.314
LIG_14-3-3_CanoR_1 246 251 PF00244 0.335
LIG_14-3-3_CanoR_1 264 269 PF00244 0.297
LIG_14-3-3_CanoR_1 44 52 PF00244 0.347
LIG_Actin_WH2_2 156 173 PF00022 0.255
LIG_BIR_III_2 47 51 PF00653 0.335
LIG_deltaCOP1_diTrp_1 261 268 PF00928 0.298
LIG_eIF4E_1 92 98 PF01652 0.246
LIG_FHA_1 123 129 PF00498 0.251
LIG_FHA_1 197 203 PF00498 0.290
LIG_FHA_1 230 236 PF00498 0.335
LIG_FHA_1 60 66 PF00498 0.380
LIG_FHA_1 9 15 PF00498 0.435
LIG_FHA_2 106 112 PF00498 0.450
LIG_FHA_2 290 296 PF00498 0.445
LIG_FHA_2 298 304 PF00498 0.443
LIG_FHA_2 306 312 PF00498 0.431
LIG_FHA_2 314 320 PF00498 0.449
LIG_FHA_2 322 328 PF00498 0.460
LIG_FHA_2 330 336 PF00498 0.455
LIG_FHA_2 338 344 PF00498 0.462
LIG_FHA_2 346 352 PF00498 0.459
LIG_FHA_2 354 360 PF00498 0.458
LIG_FHA_2 362 368 PF00498 0.460
LIG_FHA_2 384 390 PF00498 0.306
LIG_LIR_Gen_1 117 126 PF02991 0.290
LIG_LIR_Gen_1 174 183 PF02991 0.374
LIG_LIR_Gen_1 214 223 PF02991 0.291
LIG_LIR_Gen_1 238 245 PF02991 0.306
LIG_LIR_Gen_1 53 60 PF02991 0.295
LIG_LIR_Nem_3 117 121 PF02991 0.347
LIG_LIR_Nem_3 141 146 PF02991 0.317
LIG_LIR_Nem_3 166 170 PF02991 0.298
LIG_LIR_Nem_3 174 178 PF02991 0.318
LIG_LIR_Nem_3 53 57 PF02991 0.318
LIG_SH2_STAP1 118 122 PF00017 0.272
LIG_SH2_STAP1 203 207 PF00017 0.259
LIG_SH2_STAT3 203 206 PF00017 0.270
LIG_SH3_3 107 113 PF00018 0.344
LIG_SUMO_SIM_par_1 198 205 PF11976 0.259
LIG_TYR_ITIM 116 121 PF00017 0.360
MOD_CK1_1 101 107 PF00069 0.329
MOD_CK1_1 133 139 PF00069 0.303
MOD_CK1_1 166 172 PF00069 0.415
MOD_CK1_1 190 196 PF00069 0.383
MOD_CK1_1 217 223 PF00069 0.351
MOD_CK1_1 274 280 PF00069 0.383
MOD_CK1_1 413 419 PF00069 0.430
MOD_CK1_1 53 59 PF00069 0.365
MOD_CK2_1 289 295 PF00069 0.450
MOD_CK2_1 297 303 PF00069 0.451
MOD_CK2_1 305 311 PF00069 0.436
MOD_CK2_1 313 319 PF00069 0.449
MOD_CK2_1 321 327 PF00069 0.458
MOD_CK2_1 329 335 PF00069 0.445
MOD_CK2_1 337 343 PF00069 0.461
MOD_CK2_1 345 351 PF00069 0.464
MOD_CK2_1 353 359 PF00069 0.463
MOD_CK2_1 361 367 PF00069 0.476
MOD_CK2_1 43 49 PF00069 0.355
MOD_GlcNHglycan 100 103 PF01048 0.550
MOD_GlcNHglycan 135 138 PF01048 0.546
MOD_GlcNHglycan 159 162 PF01048 0.524
MOD_GlcNHglycan 183 186 PF01048 0.524
MOD_GlcNHglycan 207 210 PF01048 0.512
MOD_GlcNHglycan 276 279 PF01048 0.556
MOD_GlcNHglycan 392 395 PF01048 0.544
MOD_GlcNHglycan 407 410 PF01048 0.609
MOD_GSK3_1 101 108 PF00069 0.334
MOD_GSK3_1 131 138 PF00069 0.368
MOD_GSK3_1 153 160 PF00069 0.350
MOD_GSK3_1 174 181 PF00069 0.286
MOD_GSK3_1 183 190 PF00069 0.335
MOD_GSK3_1 192 199 PF00069 0.388
MOD_GSK3_1 213 220 PF00069 0.341
MOD_GSK3_1 231 238 PF00069 0.335
MOD_GSK3_1 264 271 PF00069 0.330
MOD_GSK3_1 283 290 PF00069 0.421
MOD_GSK3_1 291 298 PF00069 0.477
MOD_GSK3_1 299 306 PF00069 0.487
MOD_GSK3_1 307 314 PF00069 0.561
MOD_GSK3_1 315 322 PF00069 0.553
MOD_GSK3_1 323 330 PF00069 0.467
MOD_GSK3_1 331 338 PF00069 0.467
MOD_GSK3_1 339 346 PF00069 0.473
MOD_GSK3_1 347 354 PF00069 0.475
MOD_GSK3_1 355 362 PF00069 0.497
MOD_GSK3_1 363 370 PF00069 0.452
MOD_GSK3_1 410 417 PF00069 0.537
MOD_GSK3_1 87 94 PF00069 0.373
MOD_N-GLC_2 254 256 PF02516 0.517
MOD_N-GLC_2 285 287 PF02516 0.578
MOD_NEK2_1 122 127 PF00069 0.351
MOD_NEK2_1 154 159 PF00069 0.262
MOD_NEK2_1 202 207 PF00069 0.271
MOD_NEK2_1 231 236 PF00069 0.318
MOD_NEK2_1 98 103 PF00069 0.312
MOD_NEK2_2 87 92 PF00069 0.248
MOD_OFUCOSY 281 287 PF10250 0.508
MOD_OFUCOSY 84 91 PF10250 0.483
MOD_PIKK_1 202 208 PF00454 0.266
MOD_PIKK_1 271 277 PF00454 0.280
MOD_PK_1 85 91 PF00069 0.287
MOD_PKA_1 246 252 PF00069 0.271
MOD_PKA_1 264 270 PF00069 0.289
MOD_PKA_1 405 411 PF00069 0.378
MOD_PKA_2 246 252 PF00069 0.340
MOD_PKA_2 264 270 PF00069 0.290
MOD_PKA_2 405 411 PF00069 0.378
MOD_PKA_2 43 49 PF00069 0.366
MOD_PKA_2 50 56 PF00069 0.304
MOD_Plk_1 116 122 PF00069 0.349
MOD_Plk_1 213 219 PF00069 0.283
MOD_Plk_2-3 367 373 PF00069 0.381
MOD_Plk_4 171 177 PF00069 0.270
MOD_Plk_4 196 202 PF00069 0.300
MOD_Plk_4 246 252 PF00069 0.311
MOD_Plk_4 92 98 PF00069 0.298
MOD_ProDKin_1 411 417 PF00069 0.434
TRG_ENDOCYTIC_2 118 121 PF00928 0.403
TRG_ER_diArg_1 2 4 PF00400 0.561
TRG_ER_diArg_1 245 247 PF00400 0.367
TRG_ER_diArg_1 263 265 PF00400 0.288

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I121 Leptomonas seymouri 27% 87%
A0A3Q8IIJ9 Leishmania donovani 33% 100%
A0A3S7X4J4 Leishmania donovani 33% 100%
A4H4D2 Leishmania braziliensis 26% 100%
A4HJC8 Leishmania braziliensis 32% 100%
A4HJX1 Leishmania braziliensis 66% 100%
A4HVB0 Leishmania infantum 36% 100%
A4I6S4 Leishmania infantum 33% 100%
D1GJ51 Leishmania infantum 32% 94%
E8NHG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E8NHP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AEF4 Leishmania major 86% 100%
E9AGG5 Leishmania infantum 38% 100%
E9AGH0 Leishmania infantum 38% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9B1U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 96%
E9B1U6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
Q25331 Leishmania major 40% 100%
Q4Q6B6 Leishmania major 32% 100%
Q4Q6B7 Leishmania major 32% 100%
Q4QGI2 Leishmania major 32% 78%
Q4QGI4 Leishmania major 32% 81%
Q4QGJ4 Leishmania major 40% 100%
Q4QGJ6 Leishmania major 36% 76%
Q4QGK6 Leishmania major 40% 100%
Q4QGL4 Leishmania major 40% 100%
Q4QGL5 Leishmania major 34% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS