Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFB6_LEIDO

TriTrypDb:

LdBPK_251400.1 , LdCL_250019600 , LDHU3_25.1740

Length:

966

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.654
CLV_C14_Caspase3-7	495	499	PF00656	0.648
CLV_C14_Caspase3-7	865	869	PF00656	0.751
CLV_C14_Caspase3-7	945	949	PF00656	0.628
CLV_NRD_NRD_1	223	225	PF00675	0.593
CLV_NRD_NRD_1	229	231	PF00675	0.645
CLV_NRD_NRD_1	295	297	PF00675	0.655
CLV_NRD_NRD_1	355	357	PF00675	0.494
CLV_NRD_NRD_1	44	46	PF00675	0.565
CLV_NRD_NRD_1	635	637	PF00675	0.589
CLV_NRD_NRD_1	677	679	PF00675	0.655
CLV_NRD_NRD_1	718	720	PF00675	0.674
CLV_PCSK_FUR_1	110	114	PF00082	0.641
CLV_PCSK_FUR_1	220	224	PF00082	0.555
CLV_PCSK_FUR_1	636	640	PF00082	0.701
CLV_PCSK_FUR_1	675	679	PF00082	0.687
CLV_PCSK_KEX2_1	112	114	PF00082	0.618
CLV_PCSK_KEX2_1	222	224	PF00082	0.582
CLV_PCSK_KEX2_1	229	231	PF00082	0.640
CLV_PCSK_KEX2_1	236	238	PF00082	0.627
CLV_PCSK_KEX2_1	295	297	PF00082	0.655
CLV_PCSK_KEX2_1	355	357	PF00082	0.494
CLV_PCSK_KEX2_1	52	54	PF00082	0.557
CLV_PCSK_KEX2_1	635	637	PF00082	0.617
CLV_PCSK_KEX2_1	638	640	PF00082	0.603
CLV_PCSK_KEX2_1	674	676	PF00082	0.633
CLV_PCSK_KEX2_1	677	679	PF00082	0.647
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.571
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.715
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.557
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.702
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.520
CLV_PCSK_PC7_1	108	114	PF00082	0.575
CLV_PCSK_SKI1_1	356	360	PF00082	0.557
CLV_PCSK_SKI1_1	45	49	PF00082	0.570
CLV_PCSK_SKI1_1	468	472	PF00082	0.470
CLV_PCSK_SKI1_1	491	495	PF00082	0.675
CLV_PCSK_SKI1_1	542	546	PF00082	0.486
CLV_PCSK_SKI1_1	720	724	PF00082	0.652
CLV_PCSK_SKI1_1	818	822	PF00082	0.540
CLV_PCSK_SKI1_1	87	91	PF00082	0.580
CLV_Separin_Metazoa	349	353	PF03568	0.490
DEG_APCC_DBOX_1	166	174	PF00400	0.666
DEG_APCC_DBOX_1	307	315	PF00400	0.535
DEG_APCC_DBOX_1	718	726	PF00400	0.639
DEG_Nend_UBRbox_1	1	4	PF02207	0.725
DEG_SPOP_SBC_1	177	181	PF00917	0.719
DEG_SPOP_SBC_1	518	522	PF00917	0.777
DEG_SPOP_SBC_1	604	608	PF00917	0.593
DEG_SPOP_SBC_1	952	956	PF00917	0.664
DOC_CKS1_1	96	101	PF01111	0.685
DOC_CYCLIN_RxL_1	352	362	PF00134	0.548
DOC_CYCLIN_RxL_1	465	475	PF00134	0.458
DOC_CYCLIN_RxL_1	638	648	PF00134	0.688
DOC_MAPK_DCC_7	295	305	PF00069	0.646
DOC_MAPK_DCC_7	771	779	PF00069	0.503
DOC_MAPK_gen_1	195	204	PF00069	0.557
DOC_MAPK_gen_1	295	305	PF00069	0.655
DOC_MAPK_gen_1	635	644	PF00069	0.588
DOC_MAPK_HePTP_8	293	305	PF00069	0.651
DOC_MAPK_JIP1_4	542	548	PF00069	0.545
DOC_MAPK_MEF2A_6	296	305	PF00069	0.630
DOC_MAPK_MEF2A_6	635	644	PF00069	0.586
DOC_MAPK_MEF2A_6	771	779	PF00069	0.567
DOC_PP1_RVXF_1	466	473	PF00149	0.561
DOC_PP2B_LxvP_1	777	780	PF13499	0.666
DOC_PP4_FxxP_1	657	660	PF00568	0.656
DOC_USP7_MATH_1	177	181	PF00917	0.708
DOC_USP7_MATH_1	186	190	PF00917	0.749
DOC_USP7_MATH_1	375	379	PF00917	0.685
DOC_USP7_MATH_1	381	385	PF00917	0.690
DOC_USP7_MATH_1	421	425	PF00917	0.584
DOC_USP7_MATH_1	516	520	PF00917	0.774
DOC_USP7_MATH_1	604	608	PF00917	0.774
DOC_USP7_MATH_1	651	655	PF00917	0.683
DOC_USP7_MATH_1	712	716	PF00917	0.776
DOC_USP7_MATH_1	792	796	PF00917	0.687
DOC_USP7_MATH_1	809	813	PF00917	0.676
DOC_USP7_MATH_1	900	904	PF00917	0.698
DOC_USP7_MATH_1	92	96	PF00917	0.649
DOC_USP7_MATH_1	952	956	PF00917	0.693
DOC_USP7_UBL2_3	46	50	PF12436	0.563
DOC_WW_Pin1_4	117	122	PF00397	0.644
DOC_WW_Pin1_4	173	178	PF00397	0.719
DOC_WW_Pin1_4	182	187	PF00397	0.738
DOC_WW_Pin1_4	21	26	PF00397	0.651
DOC_WW_Pin1_4	214	219	PF00397	0.706
DOC_WW_Pin1_4	222	227	PF00397	0.683
DOC_WW_Pin1_4	264	269	PF00397	0.591
DOC_WW_Pin1_4	303	308	PF00397	0.645
DOC_WW_Pin1_4	383	388	PF00397	0.714
DOC_WW_Pin1_4	63	68	PF00397	0.554
DOC_WW_Pin1_4	733	738	PF00397	0.539
DOC_WW_Pin1_4	788	793	PF00397	0.705
DOC_WW_Pin1_4	95	100	PF00397	0.572
LIG_14-3-3_CanoR_1	167	177	PF00244	0.678
LIG_14-3-3_CanoR_1	195	204	PF00244	0.637
LIG_14-3-3_CanoR_1	241	245	PF00244	0.730
LIG_14-3-3_CanoR_1	308	312	PF00244	0.617
LIG_14-3-3_CanoR_1	473	477	PF00244	0.495
LIG_14-3-3_CanoR_1	491	501	PF00244	0.657
LIG_14-3-3_CanoR_1	652	660	PF00244	0.655
LIG_14-3-3_CanoR_1	7	16	PF00244	0.676
LIG_14-3-3_CanoR_1	824	834	PF00244	0.533
LIG_14-3-3_CanoR_1	87	92	PF00244	0.604
LIG_14-3-3_CanoR_1	916	922	PF00244	0.654
LIG_BIR_III_2	407	411	PF00653	0.522
LIG_BIR_III_4	868	872	PF00653	0.694
LIG_BRCT_BRCA1_1	653	657	PF00533	0.651
LIG_Clathr_ClatBox_1	644	648	PF01394	0.623
LIG_EH1_1	130	138	PF00400	0.484
LIG_eIF4E_1	465	471	PF01652	0.458
LIG_FHA_1	150	156	PF00498	0.660
LIG_FHA_1	223	229	PF00498	0.721
LIG_FHA_1	300	306	PF00498	0.612
LIG_FHA_1	317	323	PF00498	0.448
LIG_FHA_1	343	349	PF00498	0.508
LIG_FHA_1	371	377	PF00498	0.642
LIG_FHA_1	473	479	PF00498	0.471
LIG_FHA_1	74	80	PF00498	0.671
LIG_FHA_1	752	758	PF00498	0.414
LIG_FHA_1	853	859	PF00498	0.644
LIG_FHA_2	493	499	PF00498	0.721
LIG_FHA_2	586	592	PF00498	0.596
LIG_FHA_2	907	913	PF00498	0.611
LIG_FHA_2	96	102	PF00498	0.690
LIG_GBD_Chelix_1	327	335	PF00786	0.607
LIG_LIR_Apic_2	21	25	PF02991	0.657
LIG_LIR_Apic_2	654	660	PF02991	0.658
LIG_LIR_Apic_2	93	99	PF02991	0.685
LIG_LIR_Gen_1	435	444	PF02991	0.530
LIG_LIR_Gen_1	658	668	PF02991	0.652
LIG_LIR_Gen_1	726	737	PF02991	0.506
LIG_LIR_Gen_1	81	89	PF02991	0.552
LIG_LIR_Gen_1	835	846	PF02991	0.452
LIG_LIR_Nem_3	243	249	PF02991	0.705
LIG_LIR_Nem_3	337	342	PF02991	0.532
LIG_LIR_Nem_3	435	439	PF02991	0.529
LIG_LIR_Nem_3	538	544	PF02991	0.514
LIG_LIR_Nem_3	648	653	PF02991	0.554
LIG_LIR_Nem_3	658	664	PF02991	0.565
LIG_LIR_Nem_3	726	732	PF02991	0.510
LIG_LIR_Nem_3	81	86	PF02991	0.574
LIG_LIR_Nem_3	835	841	PF02991	0.449
LIG_NRBOX	308	314	PF00104	0.511
LIG_PCNA_yPIPBox_3	925	939	PF02747	0.471
LIG_PDZ_Class_3	961	966	PF00595	0.661
LIG_Pex14_2	18	22	PF04695	0.713
LIG_Pex14_2	55	59	PF04695	0.561
LIG_Pex14_2	657	661	PF04695	0.638
LIG_PTAP_UEV_1	267	272	PF05743	0.636
LIG_PTB_Apo_2	426	433	PF02174	0.608
LIG_PTB_Apo_2	623	630	PF02174	0.698
LIG_PTB_Phospho_1	426	432	PF10480	0.606
LIG_PTB_Phospho_1	623	629	PF10480	0.696
LIG_REV1ctd_RIR_1	469	477	PF16727	0.552
LIG_SH2_CRK	541	545	PF00017	0.542
LIG_SH2_CRK	823	827	PF00017	0.560
LIG_SH2_NCK_1	391	395	PF00017	0.639
LIG_SH2_STAP1	391	395	PF00017	0.620
LIG_SH2_STAP1	465	469	PF00017	0.452
LIG_SH2_STAP1	699	703	PF00017	0.577
LIG_SH2_STAT5	169	172	PF00017	0.667
LIG_SH2_STAT5	391	394	PF00017	0.586
LIG_SH2_STAT5	404	407	PF00017	0.423
LIG_SH2_STAT5	432	435	PF00017	0.607
LIG_SH2_STAT5	469	472	PF00017	0.448
LIG_SH2_STAT5	474	477	PF00017	0.487
LIG_SH2_STAT5	58	61	PF00017	0.559
LIG_SH3_1	13	19	PF00018	0.653
LIG_SH3_3	113	119	PF00018	0.611
LIG_SH3_3	13	19	PF00018	0.587
LIG_SH3_3	232	238	PF00018	0.726
LIG_SH3_3	265	271	PF00018	0.595
LIG_SH3_3	319	325	PF00018	0.519
LIG_SH3_3	363	369	PF00018	0.602
LIG_SH3_3	537	543	PF00018	0.596
LIG_SH3_3	767	773	PF00018	0.547
LIG_SH3_5	507	511	PF00018	0.570
LIG_SUMO_SIM_anti_2	310	315	PF11976	0.522
LIG_SUMO_SIM_anti_2	343	352	PF11976	0.522
LIG_SUMO_SIM_anti_2	435	441	PF11976	0.499
LIG_SUMO_SIM_par_1	210	215	PF11976	0.616
LIG_SUMO_SIM_par_1	254	260	PF11976	0.686
LIG_SUMO_SIM_par_1	318	324	PF11976	0.581
LIG_TRAF2_1	860	863	PF00917	0.716
LIG_TRAF2_2	121	126	PF00917	0.649
LIG_TRFH_1	63	67	PF08558	0.636
LIG_TYR_ITIM	821	826	PF00017	0.579
LIG_UBA3_1	272	278	PF00899	0.713
LIG_UBA3_1	311	315	PF00899	0.536
LIG_WW_2	773	776	PF00397	0.489
MOD_CDK_SPK_2	182	187	PF00069	0.686
MOD_CDK_SPK_2	303	308	PF00069	0.645
MOD_CDK_SPK_2	788	793	PF00069	0.561
MOD_CDK_SPxK_1	214	220	PF00069	0.591
MOD_CDK_SPxxK_3	222	229	PF00069	0.716
MOD_CDK_SPxxK_3	63	70	PF00069	0.668
MOD_CDK_SPxxK_3	95	102	PF00069	0.688
MOD_CK1_1	158	164	PF00069	0.539
MOD_CK1_1	176	182	PF00069	0.784
MOD_CK1_1	21	27	PF00069	0.659
MOD_CK1_1	286	292	PF00069	0.732
MOD_CK1_1	374	380	PF00069	0.706
MOD_CK1_1	386	392	PF00069	0.622
MOD_CK1_1	496	502	PF00069	0.696
MOD_CK1_1	519	525	PF00069	0.702
MOD_CK1_1	707	713	PF00069	0.777
MOD_CK1_1	778	784	PF00069	0.679
MOD_CK1_1	898	904	PF00069	0.661
MOD_CK1_1	906	912	PF00069	0.541
MOD_CK1_1	95	101	PF00069	0.664
MOD_CK1_1	954	960	PF00069	0.660
MOD_CK2_1	182	188	PF00069	0.821
MOD_CK2_1	340	346	PF00069	0.536
MOD_CK2_1	585	591	PF00069	0.590
MOD_CK2_1	712	718	PF00069	0.642
MOD_CK2_1	801	807	PF00069	0.696
MOD_CK2_1	845	851	PF00069	0.597
MOD_CK2_1	906	912	PF00069	0.606
MOD_GlcNHglycan	188	191	PF01048	0.724
MOD_GlcNHglycan	231	234	PF01048	0.712
MOD_GlcNHglycan	246	249	PF01048	0.530
MOD_GlcNHglycan	268	271	PF01048	0.755
MOD_GlcNHglycan	285	288	PF01048	0.614
MOD_GlcNHglycan	372	376	PF01048	0.701
MOD_GlcNHglycan	377	380	PF01048	0.677
MOD_GlcNHglycan	446	449	PF01048	0.544
MOD_GlcNHglycan	611	614	PF01048	0.697
MOD_GlcNHglycan	714	717	PF01048	0.753
MOD_GlcNHglycan	76	79	PF01048	0.644
MOD_GlcNHglycan	780	783	PF01048	0.645
MOD_GlcNHglycan	794	797	PF01048	0.728
MOD_GlcNHglycan	802	806	PF01048	0.732
MOD_GlcNHglycan	811	814	PF01048	0.415
MOD_GlcNHglycan	847	850	PF01048	0.548
MOD_GlcNHglycan	862	867	PF01048	0.708
MOD_GlcNHglycan	900	903	PF01048	0.633
MOD_GlcNHglycan	905	908	PF01048	0.604
MOD_GSK3_1	155	162	PF00069	0.680
MOD_GSK3_1	173	180	PF00069	0.703
MOD_GSK3_1	182	189	PF00069	0.695
MOD_GSK3_1	21	28	PF00069	0.669
MOD_GSK3_1	240	247	PF00069	0.641
MOD_GSK3_1	299	306	PF00069	0.707
MOD_GSK3_1	370	377	PF00069	0.700
MOD_GSK3_1	492	499	PF00069	0.597
MOD_GSK3_1	514	521	PF00069	0.681
MOD_GSK3_1	605	612	PF00069	0.742
MOD_GSK3_1	651	658	PF00069	0.650
MOD_GSK3_1	706	713	PF00069	0.767
MOD_GSK3_1	724	731	PF00069	0.476
MOD_GSK3_1	74	81	PF00069	0.593
MOD_GSK3_1	788	795	PF00069	0.667
MOD_LATS_1	489	495	PF00433	0.580
MOD_N-GLC_1	202	207	PF02516	0.744
MOD_N-GLC_1	707	712	PF02516	0.547
MOD_NEK2_1	1	6	PF00069	0.676
MOD_NEK2_1	150	155	PF00069	0.594
MOD_NEK2_1	159	164	PF00069	0.499
MOD_NEK2_1	178	183	PF00069	0.502
MOD_NEK2_1	244	249	PF00069	0.592
MOD_NEK2_1	257	262	PF00069	0.616
MOD_NEK2_1	327	332	PF00069	0.580
MOD_NEK2_1	472	477	PF00069	0.471
MOD_NEK2_1	48	53	PF00069	0.587
MOD_NEK2_1	501	506	PF00069	0.757
MOD_NEK2_1	685	690	PF00069	0.604
MOD_NEK2_1	750	755	PF00069	0.488
MOD_NEK2_1	825	830	PF00069	0.493
MOD_NEK2_2	271	276	PF00069	0.712
MOD_PIKK_1	119	125	PF00454	0.776
MOD_PIKK_1	585	591	PF00454	0.590
MOD_PIKK_1	651	657	PF00454	0.651
MOD_PIKK_1	895	901	PF00454	0.788
MOD_PKA_1	229	235	PF00069	0.723
MOD_PKA_2	186	192	PF00069	0.768
MOD_PKA_2	196	202	PF00069	0.591
MOD_PKA_2	229	235	PF00069	0.733
MOD_PKA_2	240	246	PF00069	0.742
MOD_PKA_2	307	313	PF00069	0.614
MOD_PKA_2	472	478	PF00069	0.480
MOD_PKA_2	6	12	PF00069	0.649
MOD_PKA_2	622	628	PF00069	0.579
MOD_PKA_2	651	657	PF00069	0.590
MOD_PKA_2	74	80	PF00069	0.658
MOD_PKA_2	792	798	PF00069	0.792
MOD_PKA_2	826	832	PF00069	0.554
MOD_PKA_2	917	923	PF00069	0.599
MOD_Plk_1	125	131	PF00069	0.620
MOD_Plk_1	371	377	PF00069	0.684
MOD_Plk_1	497	503	PF00069	0.737
MOD_Plk_1	590	596	PF00069	0.661
MOD_Plk_1	725	731	PF00069	0.592
MOD_Plk_1	942	948	PF00069	0.594
MOD_Plk_4	150	156	PF00069	0.576
MOD_Plk_4	18	24	PF00069	0.658
MOD_Plk_4	251	257	PF00069	0.583
MOD_Plk_4	307	313	PF00069	0.619
MOD_Plk_4	386	392	PF00069	0.621
MOD_Plk_4	590	596	PF00069	0.610
MOD_Plk_4	728	734	PF00069	0.530
MOD_Plk_4	751	757	PF00069	0.488
MOD_ProDKin_1	117	123	PF00069	0.644
MOD_ProDKin_1	173	179	PF00069	0.721
MOD_ProDKin_1	182	188	PF00069	0.737
MOD_ProDKin_1	21	27	PF00069	0.642
MOD_ProDKin_1	214	220	PF00069	0.704
MOD_ProDKin_1	222	228	PF00069	0.685
MOD_ProDKin_1	264	270	PF00069	0.589
MOD_ProDKin_1	303	309	PF00069	0.640
MOD_ProDKin_1	383	389	PF00069	0.709
MOD_ProDKin_1	63	69	PF00069	0.554
MOD_ProDKin_1	733	739	PF00069	0.530
MOD_ProDKin_1	788	794	PF00069	0.706
MOD_ProDKin_1	95	101	PF00069	0.574
MOD_SUMO_for_1	536	539	PF00179	0.630
MOD_SUMO_for_1	59	62	PF00179	0.683
MOD_SUMO_rev_2	713	722	PF00179	0.638
TRG_DiLeu_BaEn_1	346	351	PF01217	0.547
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.600
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.582
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.470
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.643
TRG_ENDOCYTIC_2	469	472	PF00928	0.448
TRG_ENDOCYTIC_2	541	544	PF00928	0.491
TRG_ENDOCYTIC_2	621	624	PF00928	0.617
TRG_ENDOCYTIC_2	629	632	PF00928	0.566
TRG_ENDOCYTIC_2	823	826	PF00928	0.565
TRG_ER_diArg_1	107	110	PF00400	0.604
TRG_ER_diArg_1	13	16	PF00400	0.589
TRG_ER_diArg_1	219	222	PF00400	0.542
TRG_ER_diArg_1	228	230	PF00400	0.668
TRG_ER_diArg_1	294	296	PF00400	0.647
TRG_ER_diArg_1	354	356	PF00400	0.489
TRG_ER_diArg_1	635	637	PF00400	0.615
TRG_ER_diArg_1	639	642	PF00400	0.596
TRG_ER_diArg_1	675	678	PF00400	0.694
TRG_NES_CRM1_1	349	362	PF08389	0.547
TRG_NES_CRM1_1	922	937	PF08389	0.518
TRG_NLS_MonoCore_2	673	678	PF00514	0.524
TRG_NLS_MonoExtC_3	48	53	PF00514	0.562
TRG_NLS_MonoExtC_3	673	678	PF00514	0.524
TRG_NLS_MonoExtN_4	46	53	PF00514	0.561
TRG_NLS_MonoExtN_4	635	642	PF00514	0.646
TRG_Pf-PMV_PEXEL_1	484	488	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	643	648	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	720	724	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ93	Leptomonas seymouri	61%	100%
A0A1X0NM18	Trypanosomatidae	36%	100%
A0A422P200	Trypanosoma rangeli	39%	100%
A4HE52	Leishmania braziliensis	81%	100%
A4I1I0	Leishmania infantum	100%	100%
C9ZJY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AXL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9V7	Leishmania major	93%	100%