Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFB4_LEIDO

TriTrypDb:

LdCL_290029500 , LDHU3_29.3450

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

A0A3Q8IFB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFB4

Function

Biological processes
Term	Name	Level	Count
GO:0006072	glycerol-3-phosphate metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0046168	glycerol-3-phosphate catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0052646	alditol phosphate metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0036094	small molecule binding	2	2
GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	5	1
GO:0051287	NAD binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.564
CLV_NRD_NRD_1	105	107	PF00675	0.468
CLV_NRD_NRD_1	414	416	PF00675	0.593
CLV_NRD_NRD_1	421	423	PF00675	0.548
CLV_PCSK_KEX2_1	107	109	PF00082	0.555
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.555
CLV_PCSK_SKI1_1	131	135	PF00082	0.555
CLV_PCSK_SKI1_1	2	6	PF00082	0.536
CLV_PCSK_SKI1_1	271	275	PF00082	0.687
CLV_PCSK_SKI1_1	315	319	PF00082	0.507
CLV_PCSK_SKI1_1	501	505	PF00082	0.460
CLV_PCSK_SKI1_1	524	528	PF00082	0.528
CLV_Separin_Metazoa	498	502	PF03568	0.536
DEG_Nend_UBRbox_1	1	4	PF02207	0.491
DEG_SCF_FBW7_1	115	121	PF00400	0.536
DEG_SCF_FBW7_1	229	236	PF00400	0.657
DEG_SCF_FBW7_1	79	86	PF00400	0.584
DOC_CKS1_1	115	120	PF01111	0.510
DOC_CKS1_1	211	216	PF01111	0.585
DOC_CKS1_1	230	235	PF01111	0.478
DOC_MAPK_gen_1	106	115	PF00069	0.466
DOC_PP1_RVXF_1	313	319	PF00149	0.549
DOC_PP1_RVXF_1	413	420	PF00149	0.643
DOC_PP2B_LxvP_1	326	329	PF13499	0.565
DOC_PP2B_LxvP_1	391	394	PF13499	0.536
DOC_USP7_MATH_1	118	122	PF00917	0.479
DOC_USP7_MATH_1	155	159	PF00917	0.682
DOC_USP7_MATH_1	163	167	PF00917	0.579
DOC_USP7_MATH_1	22	26	PF00917	0.569
DOC_USP7_MATH_1	233	237	PF00917	0.592
DOC_USP7_MATH_1	273	277	PF00917	0.745
DOC_USP7_MATH_1	319	323	PF00917	0.552
DOC_USP7_MATH_1	343	347	PF00917	0.448
DOC_USP7_MATH_1	394	398	PF00917	0.460
DOC_USP7_MATH_1	62	66	PF00917	0.767
DOC_USP7_MATH_1	74	78	PF00917	0.658
DOC_USP7_MATH_1	83	87	PF00917	0.560
DOC_WW_Pin1_4	114	119	PF00397	0.474
DOC_WW_Pin1_4	149	154	PF00397	0.540
DOC_WW_Pin1_4	210	215	PF00397	0.611
DOC_WW_Pin1_4	229	234	PF00397	0.351
DOC_WW_Pin1_4	294	299	PF00397	0.487
DOC_WW_Pin1_4	386	391	PF00397	0.455
DOC_WW_Pin1_4	454	459	PF00397	0.437
DOC_WW_Pin1_4	69	74	PF00397	0.742
DOC_WW_Pin1_4	79	84	PF00397	0.642
LIG_14-3-3_CanoR_1	148	153	PF00244	0.560
LIG_14-3-3_CanoR_1	2	7	PF00244	0.426
LIG_14-3-3_CanoR_1	449	458	PF00244	0.346
LIG_14-3-3_CanoR_1	517	525	PF00244	0.536
LIG_BRCT_BRCA1_1	165	169	PF00533	0.596
LIG_BRCT_BRCA1_1	407	411	PF00533	0.490
LIG_CSL_BTD_1	295	298	PF09270	0.472
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.593
LIG_FHA_1	1	7	PF00498	0.579
LIG_FHA_1	140	146	PF00498	0.473
LIG_FHA_1	211	217	PF00498	0.564
LIG_FHA_1	295	301	PF00498	0.479
LIG_FHA_1	373	379	PF00498	0.380
LIG_FHA_1	402	408	PF00498	0.536
LIG_FHA_1	450	456	PF00498	0.338
LIG_FHA_2	325	331	PF00498	0.550
LIG_FHA_2	489	495	PF00498	0.642
LIG_FHA_2	502	508	PF00498	0.554
LIG_LIR_Gen_1	166	177	PF02991	0.441
LIG_LIR_Gen_1	457	467	PF02991	0.411
LIG_LIR_Nem_3	166	172	PF02991	0.546
LIG_LIR_Nem_3	457	463	PF02991	0.397
LIG_LIR_Nem_3	483	488	PF02991	0.549
LIG_LIR_Nem_3	82	87	PF02991	0.569
LIG_PDZ_Class_1	529	534	PF00595	0.626
LIG_Pex14_2	169	173	PF04695	0.466
LIG_SH2_SRC	122	125	PF00017	0.452
LIG_SH2_STAP1	367	371	PF00017	0.497
LIG_SH2_STAP1	460	464	PF00017	0.380
LIG_SH2_STAT5	122	125	PF00017	0.525
LIG_SH2_STAT5	325	328	PF00017	0.512
LIG_SH2_STAT5	356	359	PF00017	0.645
LIG_SH2_STAT5	420	423	PF00017	0.600
LIG_SH3_3	452	458	PF00018	0.546
LIG_SH3_3	70	76	PF00018	0.730
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.537
LIG_SUMO_SIM_par_1	212	219	PF11976	0.476
LIG_TRAF2_2	184	189	PF00917	0.460
LIG_WRC_WIRS_1	344	349	PF05994	0.508
MOD_CK1_1	158	164	PF00069	0.649
MOD_CK1_1	228	234	PF00069	0.587
MOD_CK1_1	245	251	PF00069	0.686
MOD_CK1_1	25	31	PF00069	0.553
MOD_CK1_1	275	281	PF00069	0.571
MOD_CK1_1	354	360	PF00069	0.566
MOD_CK1_1	50	56	PF00069	0.721
MOD_CK1_1	77	83	PF00069	0.611
MOD_CK2_1	204	210	PF00069	0.759
MOD_CK2_1	275	281	PF00069	0.706
MOD_CK2_1	488	494	PF00069	0.576
MOD_CK2_1	509	515	PF00069	0.572
MOD_CK2_1	57	63	PF00069	0.681
MOD_Cter_Amidation	413	416	PF01082	0.608
MOD_GlcNHglycan	101	104	PF01048	0.654
MOD_GlcNHglycan	201	204	PF01048	0.713
MOD_GlcNHglycan	218	221	PF01048	0.246
MOD_GlcNHglycan	236	239	PF01048	0.638
MOD_GlcNHglycan	252	255	PF01048	0.595
MOD_GlcNHglycan	275	278	PF01048	0.702
MOD_GlcNHglycan	286	289	PF01048	0.429
MOD_GlcNHglycan	452	455	PF01048	0.481
MOD_GlcNHglycan	494	498	PF01048	0.652
MOD_GlcNHglycan	511	514	PF01048	0.490
MOD_GlcNHglycan	52	55	PF01048	0.746
MOD_GlcNHglycan	59	62	PF01048	0.781
MOD_GSK3_1	114	121	PF00069	0.481
MOD_GSK3_1	144	151	PF00069	0.608
MOD_GSK3_1	206	213	PF00069	0.691
MOD_GSK3_1	225	232	PF00069	0.276
MOD_GSK3_1	241	248	PF00069	0.565
MOD_GSK3_1	350	357	PF00069	0.533
MOD_GSK3_1	401	408	PF00069	0.459
MOD_GSK3_1	44	51	PF00069	0.754
MOD_GSK3_1	450	457	PF00069	0.487
MOD_GSK3_1	63	70	PF00069	0.791
MOD_GSK3_1	75	82	PF00069	0.673
MOD_LATS_1	447	453	PF00433	0.334
MOD_N-GLC_1	22	27	PF02516	0.595
MOD_N-GLC_1	44	49	PF02516	0.570
MOD_N-GLC_1	57	62	PF02516	0.621
MOD_N-GLC_2	339	341	PF02516	0.373
MOD_NEK2_1	216	221	PF00069	0.507
MOD_NEK2_1	234	239	PF00069	0.429
MOD_NEK2_1	246	251	PF00069	0.507
MOD_NEK2_1	351	356	PF00069	0.500
MOD_NEK2_1	450	455	PF00069	0.481
MOD_NEK2_1	463	468	PF00069	0.419
MOD_NEK2_1	48	53	PF00069	0.560
MOD_NEK2_1	529	534	PF00069	0.605
MOD_PKA_2	319	325	PF00069	0.426
MOD_PKA_2	471	477	PF00069	0.519
MOD_PKA_2	488	494	PF00069	0.335
MOD_PKA_2	516	522	PF00069	0.619
MOD_Plk_1	22	28	PF00069	0.579
MOD_Plk_1	225	231	PF00069	0.517
MOD_Plk_1	44	50	PF00069	0.689
MOD_Plk_2-3	206	212	PF00069	0.644
MOD_Plk_4	118	124	PF00069	0.478
MOD_Plk_4	2	8	PF00069	0.491
MOD_Plk_4	242	248	PF00069	0.678
MOD_Plk_4	27	33	PF00069	0.487
MOD_Plk_4	321	327	PF00069	0.468
MOD_Plk_4	351	357	PF00069	0.567
MOD_Plk_4	395	401	PF00069	0.475
MOD_Plk_4	466	472	PF00069	0.473
MOD_Plk_4	83	89	PF00069	0.543
MOD_ProDKin_1	114	120	PF00069	0.474
MOD_ProDKin_1	149	155	PF00069	0.546
MOD_ProDKin_1	210	216	PF00069	0.599
MOD_ProDKin_1	229	235	PF00069	0.360
MOD_ProDKin_1	294	300	PF00069	0.486
MOD_ProDKin_1	386	392	PF00069	0.447
MOD_ProDKin_1	454	460	PF00069	0.430
MOD_ProDKin_1	69	75	PF00069	0.740
MOD_ProDKin_1	79	85	PF00069	0.628
MOD_SUMO_rev_2	86	96	PF00179	0.563
TRG_DiLeu_BaEn_1	212	217	PF01217	0.548
TRG_ENDOCYTIC_2	460	463	PF00928	0.381
TRG_ENDOCYTIC_2	467	470	PF00928	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P658	Leptomonas seymouri	55%	100%
A0A0S4ITH1	Bodo saltans	23%	100%
A0A1X0P970	Trypanosomatidae	34%	100%
A0A422NEK6	Trypanosoma rangeli	32%	100%
A4HHM3	Leishmania braziliensis	79%	100%
A4I4T2	Leishmania infantum	100%	100%
C9ZLH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AE85	Leishmania major	93%	100%
E9ALK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%