Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFA7_LEIDO

TriTrypDb:

LdBPK_320630.1 , LdCL_320011800 , LDHU3_32.0780

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFA7

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.545
CLV_C14_Caspase3-7	675	679	PF00656	0.491
CLV_NRD_NRD_1	160	162	PF00675	0.610
CLV_NRD_NRD_1	201	203	PF00675	0.469
CLV_NRD_NRD_1	208	210	PF00675	0.492
CLV_NRD_NRD_1	282	284	PF00675	0.398
CLV_NRD_NRD_1	351	353	PF00675	0.642
CLV_NRD_NRD_1	363	365	PF00675	0.508
CLV_NRD_NRD_1	610	612	PF00675	0.489
CLV_NRD_NRD_1	693	695	PF00675	0.557
CLV_PCSK_FUR_1	205	209	PF00082	0.599
CLV_PCSK_KEX2_1	160	162	PF00082	0.610
CLV_PCSK_KEX2_1	207	209	PF00082	0.497
CLV_PCSK_KEX2_1	281	283	PF00082	0.447
CLV_PCSK_KEX2_1	351	353	PF00082	0.599
CLV_PCSK_KEX2_1	363	365	PF00082	0.581
CLV_PCSK_KEX2_1	610	612	PF00082	0.489
CLV_PCSK_KEX2_1	693	695	PF00082	0.557
CLV_PCSK_PC7_1	359	365	PF00082	0.511
CLV_PCSK_SKI1_1	146	150	PF00082	0.503
CLV_PCSK_SKI1_1	208	212	PF00082	0.577
CLV_PCSK_SKI1_1	317	321	PF00082	0.563
DEG_APCC_DBOX_1	145	153	PF00400	0.504
DEG_APCC_DBOX_1	206	214	PF00400	0.504
DEG_APCC_DBOX_1	358	366	PF00400	0.593
DEG_SPOP_SBC_1	120	124	PF00917	0.614
DOC_CKS1_1	474	479	PF01111	0.687
DOC_CKS1_1	631	636	PF01111	0.524
DOC_CYCLIN_RxL_1	202	214	PF00134	0.600
DOC_MAPK_gen_1	205	213	PF00069	0.537
DOC_MAPK_gen_1	354	362	PF00069	0.716
DOC_MAPK_gen_1	363	371	PF00069	0.584
DOC_MAPK_gen_1	431	440	PF00069	0.703
DOC_PP1_RVXF_1	315	321	PF00149	0.608
DOC_PP2B_LxvP_1	509	512	PF13499	0.571
DOC_PP2B_LxvP_1	525	528	PF13499	0.623
DOC_PP4_FxxP_1	771	774	PF00568	0.373
DOC_USP7_MATH_1	127	131	PF00917	0.665
DOC_USP7_MATH_1	15	19	PF00917	0.586
DOC_USP7_MATH_1	237	241	PF00917	0.583
DOC_USP7_MATH_1	277	281	PF00917	0.433
DOC_USP7_MATH_1	408	412	PF00917	0.547
DOC_USP7_MATH_1	526	530	PF00917	0.758
DOC_USP7_MATH_1	720	724	PF00917	0.542
DOC_USP7_MATH_1	780	784	PF00917	0.587
DOC_USP7_UBL2_3	288	292	PF12436	0.493
DOC_WW_Pin1_4	116	121	PF00397	0.554
DOC_WW_Pin1_4	473	478	PF00397	0.598
DOC_WW_Pin1_4	50	55	PF00397	0.454
DOC_WW_Pin1_4	534	539	PF00397	0.725
DOC_WW_Pin1_4	630	635	PF00397	0.547
DOC_WW_Pin1_4	776	781	PF00397	0.477
DOC_WW_Pin1_4	793	798	PF00397	0.427
LIG_14-3-3_CanoR_1	212	220	PF00244	0.481
LIG_14-3-3_CanoR_1	241	245	PF00244	0.481
LIG_14-3-3_CanoR_1	4	9	PF00244	0.572
LIG_14-3-3_CanoR_1	414	419	PF00244	0.567
LIG_14-3-3_CanoR_1	447	452	PF00244	0.553
LIG_14-3-3_CanoR_1	66	75	PF00244	0.606
LIG_14-3-3_CanoR_1	693	701	PF00244	0.557
LIG_14-3-3_CanoR_1	77	87	PF00244	0.418
LIG_APCC_ABBA_1	21	26	PF00400	0.685
LIG_BRCT_BRCA1_1	529	533	PF00533	0.727
LIG_BRCT_BRCA1_2	529	535	PF00533	0.661
LIG_CaM_IQ_9	562	578	PF13499	0.657
LIG_deltaCOP1_diTrp_1	181	189	PF00928	0.512
LIG_deltaCOP1_diTrp_1	307	312	PF00928	0.464
LIG_deltaCOP1_diTrp_1	763	771	PF00928	0.493
LIG_FHA_1	230	236	PF00498	0.502
LIG_FHA_1	334	340	PF00498	0.584
LIG_FHA_1	379	385	PF00498	0.723
LIG_FHA_1	423	429	PF00498	0.751
LIG_FHA_1	651	657	PF00498	0.562
LIG_FHA_1	709	715	PF00498	0.484
LIG_FHA_1	780	786	PF00498	0.461
LIG_FHA_1	96	102	PF00498	0.606
LIG_FHA_2	121	127	PF00498	0.520
LIG_FHA_2	212	218	PF00498	0.485
LIG_FHA_2	309	315	PF00498	0.574
LIG_FHA_2	683	689	PF00498	0.394
LIG_FHA_2	739	745	PF00498	0.450
LIG_LIR_Apic_2	402	408	PF02991	0.699
LIG_LIR_Apic_2	772	778	PF02991	0.430
LIG_LIR_Gen_1	181	190	PF02991	0.625
LIG_LIR_Gen_1	261	270	PF02991	0.563
LIG_LIR_Gen_1	650	660	PF02991	0.437
LIG_LIR_Gen_1	680	691	PF02991	0.506
LIG_LIR_Gen_1	764	775	PF02991	0.388
LIG_LIR_Gen_1	779	789	PF02991	0.451
LIG_LIR_Gen_1	796	806	PF02991	0.359
LIG_LIR_Nem_3	191	195	PF02991	0.491
LIG_LIR_Nem_3	261	266	PF02991	0.566
LIG_LIR_Nem_3	38	44	PF02991	0.441
LIG_LIR_Nem_3	462	467	PF02991	0.522
LIG_LIR_Nem_3	530	536	PF02991	0.667
LIG_LIR_Nem_3	557	563	PF02991	0.581
LIG_LIR_Nem_3	625	631	PF02991	0.628
LIG_LIR_Nem_3	650	655	PF02991	0.438
LIG_LIR_Nem_3	680	686	PF02991	0.466
LIG_LIR_Nem_3	764	770	PF02991	0.379
LIG_LIR_Nem_3	779	784	PF02991	0.480
LIG_LIR_Nem_3	796	802	PF02991	0.341
LIG_MYND_1	473	477	PF01753	0.594
LIG_NRBOX	708	714	PF00104	0.457
LIG_NRBOX	729	735	PF00104	0.414
LIG_PCNA_PIPBox_1	246	255	PF02747	0.462
LIG_PCNA_PIPBox_1	302	311	PF02747	0.460
LIG_PCNA_yPIPBox_3	241	253	PF02747	0.472
LIG_PCNA_yPIPBox_3	34	42	PF02747	0.577
LIG_PCNA_yPIPBox_3	96	110	PF02747	0.575
LIG_Pex14_1	767	771	PF04695	0.492
LIG_Pex14_2	222	226	PF04695	0.538
LIG_SH2_CRK	51	55	PF00017	0.452
LIG_SH2_PTP2	13	16	PF00017	0.584
LIG_SH2_PTP2	775	778	PF00017	0.445
LIG_SH2_SRC	13	16	PF00017	0.584
LIG_SH2_SRC	24	27	PF00017	0.578
LIG_SH2_SRC	43	46	PF00017	0.365
LIG_SH2_SRC	775	778	PF00017	0.445
LIG_SH2_STAT5	115	118	PF00017	0.550
LIG_SH2_STAT5	13	16	PF00017	0.584
LIG_SH2_STAT5	338	341	PF00017	0.592
LIG_SH2_STAT5	43	46	PF00017	0.548
LIG_SH2_STAT5	585	588	PF00017	0.541
LIG_SH2_STAT5	604	607	PF00017	0.439
LIG_SH2_STAT5	658	661	PF00017	0.430
LIG_SH2_STAT5	715	718	PF00017	0.455
LIG_SH2_STAT5	775	778	PF00017	0.432
LIG_SH2_STAT5	79	82	PF00017	0.452
LIG_SH3_2	442	447	PF14604	0.568
LIG_SH3_3	426	432	PF00018	0.649
LIG_SH3_3	439	445	PF00018	0.675
LIG_SH3_3	467	473	PF00018	0.555
LIG_SH3_3	624	630	PF00018	0.449
LIG_SH3_3	9	15	PF00018	0.669
LIG_Sin3_3	145	152	PF02671	0.419
LIG_SUMO_SIM_anti_2	596	602	PF11976	0.508
LIG_SUMO_SIM_anti_2	728	735	PF11976	0.394
LIG_SUMO_SIM_par_1	231	236	PF11976	0.477
LIG_TRAF2_1	23	26	PF00917	0.625
LIG_UBA3_1	712	719	PF00899	0.426
MOD_CDK_SPxK_1	630	636	PF00069	0.524
MOD_CK1_1	125	131	PF00069	0.713
MOD_CK1_1	191	197	PF00069	0.599
MOD_CK1_1	240	246	PF00069	0.593
MOD_CK1_1	347	353	PF00069	0.717
MOD_CK1_1	392	398	PF00069	0.721
MOD_CK1_1	399	405	PF00069	0.659
MOD_CK1_1	417	423	PF00069	0.581
MOD_CK1_1	449	455	PF00069	0.694
MOD_CK1_1	496	502	PF00069	0.476
MOD_CK1_1	666	672	PF00069	0.496
MOD_CK1_1	779	785	PF00069	0.462
MOD_CK1_1	95	101	PF00069	0.492
MOD_CK2_1	120	126	PF00069	0.514
MOD_CK2_1	211	217	PF00069	0.481
MOD_CK2_1	308	314	PF00069	0.576
MOD_CK2_1	440	446	PF00069	0.573
MOD_CK2_1	593	599	PF00069	0.529
MOD_CK2_1	682	688	PF00069	0.517
MOD_CK2_1	738	744	PF00069	0.439
MOD_CK2_1	780	786	PF00069	0.428
MOD_CMANNOS	309	312	PF00535	0.460
MOD_GlcNHglycan	17	20	PF01048	0.581
MOD_GlcNHglycan	346	349	PF01048	0.672
MOD_GlcNHglycan	391	394	PF01048	0.634
MOD_GlcNHglycan	410	413	PF01048	0.597
MOD_GlcNHglycan	451	454	PF01048	0.637
MOD_GlcNHglycan	502	505	PF01048	0.509
MOD_GlcNHglycan	664	668	PF01048	0.486
MOD_GlcNHglycan	741	744	PF01048	0.377
MOD_GlcNHglycan	771	774	PF01048	0.435
MOD_GlcNHglycan	806	809	PF01048	0.550
MOD_GSK3_1	116	123	PF00069	0.564
MOD_GSK3_1	236	243	PF00069	0.670
MOD_GSK3_1	340	347	PF00069	0.566
MOD_GSK3_1	392	399	PF00069	0.674
MOD_GSK3_1	447	454	PF00069	0.651
MOD_GSK3_1	493	500	PF00069	0.536
MOD_GSK3_1	692	699	PF00069	0.452
MOD_GSK3_1	776	783	PF00069	0.468
MOD_N-GLC_1	330	335	PF02516	0.593
MOD_N-GLC_1	340	345	PF02516	0.590
MOD_N-GLC_1	491	496	PF02516	0.541
MOD_N-GLC_1	720	725	PF02516	0.581
MOD_NEK2_1	113	118	PF00069	0.531
MOD_NEK2_1	211	216	PF00069	0.499
MOD_NEK2_1	222	227	PF00069	0.571
MOD_NEK2_1	284	289	PF00069	0.561
MOD_NEK2_1	387	392	PF00069	0.775
MOD_NEK2_1	416	421	PF00069	0.598
MOD_NEK2_1	491	496	PF00069	0.515
MOD_NEK2_1	497	502	PF00069	0.519
MOD_NEK2_1	677	682	PF00069	0.445
MOD_NEK2_1	738	743	PF00069	0.358
MOD_NEK2_1	769	774	PF00069	0.492
MOD_NEK2_1	78	83	PF00069	0.561
MOD_NEK2_2	505	510	PF00069	0.548
MOD_NEK2_2	585	590	PF00069	0.585
MOD_PIKK_1	134	140	PF00454	0.533
MOD_PIKK_1	154	160	PF00454	0.328
MOD_PIKK_1	298	304	PF00454	0.534
MOD_PIKK_1	378	384	PF00454	0.666
MOD_PIKK_1	527	533	PF00454	0.634
MOD_PIKK_1	617	623	PF00454	0.462
MOD_PIKK_1	720	726	PF00454	0.577
MOD_PK_1	414	420	PF00069	0.561
MOD_PK_1	623	629	PF00069	0.437
MOD_PKA_2	211	217	PF00069	0.481
MOD_PKA_2	240	246	PF00069	0.480
MOD_PKA_2	446	452	PF00069	0.561
MOD_PKA_2	692	698	PF00069	0.562
MOD_Plk_1	313	319	PF00069	0.603
MOD_Plk_1	330	336	PF00069	0.533
MOD_Plk_1	491	497	PF00069	0.599
MOD_Plk_1	677	683	PF00069	0.468
MOD_Plk_1	720	726	PF00069	0.577
MOD_Plk_1	746	752	PF00069	0.569
MOD_Plk_4	240	246	PF00069	0.593
MOD_Plk_4	26	32	PF00069	0.686
MOD_Plk_4	36	42	PF00069	0.440
MOD_Plk_4	466	472	PF00069	0.539
MOD_Plk_4	493	499	PF00069	0.524
MOD_Plk_4	505	511	PF00069	0.544
MOD_Plk_4	623	629	PF00069	0.440
MOD_Plk_4	708	714	PF00069	0.392
MOD_Plk_4	728	734	PF00069	0.331
MOD_Plk_4	780	786	PF00069	0.502
MOD_ProDKin_1	116	122	PF00069	0.560
MOD_ProDKin_1	473	479	PF00069	0.595
MOD_ProDKin_1	50	56	PF00069	0.455
MOD_ProDKin_1	534	540	PF00069	0.727
MOD_ProDKin_1	630	636	PF00069	0.548
MOD_ProDKin_1	776	782	PF00069	0.471
MOD_ProDKin_1	793	799	PF00069	0.422
MOD_SUMO_rev_2	163	173	PF00179	0.453
MOD_SUMO_rev_2	256	261	PF00179	0.448
TRG_DiLeu_BaEn_1	314	319	PF01217	0.589
TRG_DiLeu_BaEn_3	25	31	PF01217	0.566
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.619
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.600
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.508
TRG_ENDOCYTIC_2	13	16	PF00928	0.584
TRG_ENDOCYTIC_2	263	266	PF00928	0.570
TRG_ENDOCYTIC_2	464	467	PF00928	0.630
TRG_ENDOCYTIC_2	683	686	PF00928	0.485
TRG_ER_diArg_1	159	161	PF00400	0.602
TRG_ER_diArg_1	205	208	PF00400	0.481
TRG_ER_diArg_1	281	283	PF00400	0.404
TRG_ER_diArg_1	351	354	PF00400	0.764
TRG_ER_diArg_1	362	364	PF00400	0.583
TRG_ER_diArg_1	609	611	PF00400	0.491
TRG_ER_diArg_1	65	68	PF00400	0.517
TRG_ER_diArg_1	692	694	PF00400	0.563
TRG_NES_CRM1_1	361	374	PF08389	0.503
TRG_NES_CRM1_1	728	744	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	790	794	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Y4	Leptomonas seymouri	54%	97%
A4I7M2	Leishmania infantum	100%	100%
E9AIU9	Leishmania braziliensis	78%	100%
E9B2I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q5M3	Leishmania major	94%	100%