Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IFA6_LEIDO

TriTrypDb:

LdBPK_291050.1 , LdCL_290014300 , LDHU3_29.1430

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.690
CLV_C14_Caspase3-7	265	269	PF00656	0.685
CLV_C14_Caspase3-7	273	277	PF00656	0.685
CLV_C14_Caspase3-7	405	409	PF00656	0.662
CLV_NRD_NRD_1	189	191	PF00675	0.629
CLV_NRD_NRD_1	228	230	PF00675	0.656
CLV_NRD_NRD_1	67	69	PF00675	0.600
CLV_PCSK_KEX2_1	123	125	PF00082	0.604
CLV_PCSK_KEX2_1	228	230	PF00082	0.656
CLV_PCSK_KEX2_1	67	69	PF00082	0.600
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.594
CLV_PCSK_SKI1_1	151	155	PF00082	0.742
CLV_PCSK_SKI1_1	328	332	PF00082	0.663
CLV_PCSK_SKI1_1	401	405	PF00082	0.727
CLV_PCSK_SKI1_1	49	53	PF00082	0.683
CLV_PCSK_SKI1_1	61	65	PF00082	0.575
DOC_CKS1_1	309	314	PF01111	0.680
DOC_CKS1_1	410	415	PF01111	0.664
DOC_MAPK_gen_1	35	45	PF00069	0.593
DOC_MAPK_MEF2A_6	141	149	PF00069	0.557
DOC_PP1_RVXF_1	304	311	PF00149	0.666
DOC_PP1_RVXF_1	39	46	PF00149	0.594
DOC_PP2B_LxvP_1	176	179	PF13499	0.680
DOC_PP2B_LxvP_1	347	350	PF13499	0.677
DOC_USP7_MATH_1	155	159	PF00917	0.747
DOC_USP7_MATH_1	179	183	PF00917	0.622
DOC_USP7_MATH_1	19	23	PF00917	0.723
DOC_USP7_MATH_1	284	288	PF00917	0.701
DOC_USP7_MATH_1	375	379	PF00917	0.612
DOC_WW_Pin1_4	114	119	PF00397	0.660
DOC_WW_Pin1_4	163	168	PF00397	0.633
DOC_WW_Pin1_4	182	187	PF00397	0.672
DOC_WW_Pin1_4	214	219	PF00397	0.594
DOC_WW_Pin1_4	267	272	PF00397	0.673
DOC_WW_Pin1_4	280	285	PF00397	0.649
DOC_WW_Pin1_4	308	313	PF00397	0.781
DOC_WW_Pin1_4	315	320	PF00397	0.550
DOC_WW_Pin1_4	328	333	PF00397	0.676
DOC_WW_Pin1_4	409	414	PF00397	0.657
LIG_14-3-3_CanoR_1	124	133	PF00244	0.643
LIG_14-3-3_CanoR_1	156	164	PF00244	0.703
LIG_14-3-3_CanoR_1	200	205	PF00244	0.628
LIG_14-3-3_CanoR_1	228	236	PF00244	0.679
LIG_14-3-3_CanoR_1	401	410	PF00244	0.727
LIG_14-3-3_CanoR_1	416	424	PF00244	0.563
LIG_14-3-3_CanoR_1	74	82	PF00244	0.573
LIG_Actin_WH2_2	36	54	PF00022	0.639
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_BRCT_BRCA1_1	184	188	PF00533	0.651
LIG_BRCT_BRCA1_1	353	357	PF00533	0.708
LIG_deltaCOP1_diTrp_1	77	82	PF00928	0.645
LIG_FHA_1	117	123	PF00498	0.577
LIG_FHA_1	157	163	PF00498	0.619
LIG_FHA_1	171	177	PF00498	0.710
LIG_FHA_1	303	309	PF00498	0.657
LIG_FHA_1	342	348	PF00498	0.697
LIG_FHA_1	405	411	PF00498	0.673
LIG_FHA_1	425	431	PF00498	0.488
LIG_FHA_1	54	60	PF00498	0.709
LIG_FHA_2	416	422	PF00498	0.629
LIG_FHA_2	52	58	PF00498	0.634
LIG_GBD_Chelix_1	43	51	PF00786	0.685
LIG_LIR_Gen_1	100	109	PF02991	0.619
LIG_LIR_Nem_3	100	105	PF02991	0.618
LIG_LIR_Nem_3	388	392	PF02991	0.673
LIG_MYND_1	214	218	PF01753	0.617
LIG_SH2_CRK	254	258	PF00017	0.708
LIG_SH2_NCK_1	111	115	PF00017	0.550
LIG_SH2_STAP1	111	115	PF00017	0.612
LIG_SH3_2	186	191	PF14604	0.555
LIG_SH3_3	133	139	PF00018	0.627
LIG_SH3_3	183	189	PF00018	0.600
LIG_SH3_3	212	218	PF00018	0.625
LIG_SH3_3	238	244	PF00018	0.646
LIG_SxIP_EBH_1	328	342	PF03271	0.588
LIG_TRAF2_1	75	78	PF00917	0.640
LIG_TRAF2_2	350	355	PF00917	0.655
LIG_TYR_ITIM	109	114	PF00017	0.552
MOD_CDC14_SPxK_1	283	286	PF00782	0.680
MOD_CDC14_SPxK_1	318	321	PF00782	0.692
MOD_CDK_SPK_2	328	333	PF00069	0.699
MOD_CDK_SPxK_1	280	286	PF00069	0.687
MOD_CDK_SPxK_1	315	321	PF00069	0.738
MOD_CDK_SPxxK_3	308	315	PF00069	0.667
MOD_CDK_SPxxK_3	409	416	PF00069	0.723
MOD_CK1_1	127	133	PF00069	0.549
MOD_CK1_1	165	171	PF00069	0.628
MOD_CK1_1	182	188	PF00069	0.699
MOD_CK1_1	196	202	PF00069	0.593
MOD_CK1_1	203	209	PF00069	0.643
MOD_CK1_1	22	28	PF00069	0.605
MOD_CK1_1	262	268	PF00069	0.580
MOD_CK1_1	287	293	PF00069	0.729
MOD_CK1_1	323	329	PF00069	0.726
MOD_CK1_1	368	374	PF00069	0.639
MOD_CK1_1	395	401	PF00069	0.574
MOD_CK1_1	9	15	PF00069	0.743
MOD_CK2_1	165	171	PF00069	0.712
MOD_CK2_1	22	28	PF00069	0.722
MOD_CK2_1	415	421	PF00069	0.630
MOD_CK2_1	51	57	PF00069	0.629
MOD_CK2_1	72	78	PF00069	0.547
MOD_Cter_Amidation	65	68	PF01082	0.660
MOD_DYRK1A_RPxSP_1	328	332	PF00069	0.668
MOD_GlcNHglycan	1	4	PF01048	0.657
MOD_GlcNHglycan	106	109	PF01048	0.524
MOD_GlcNHglycan	15	18	PF01048	0.564
MOD_GlcNHglycan	151	154	PF01048	0.662
MOD_GlcNHglycan	167	170	PF01048	0.565
MOD_GlcNHglycan	181	184	PF01048	0.614
MOD_GlcNHglycan	24	27	PF01048	0.628
MOD_GlcNHglycan	379	382	PF01048	0.618
MOD_GlcNHglycan	82	85	PF01048	0.681
MOD_GSK3_1	151	158	PF00069	0.711
MOD_GSK3_1	165	172	PF00069	0.518
MOD_GSK3_1	195	202	PF00069	0.606
MOD_GSK3_1	20	27	PF00069	0.562
MOD_GSK3_1	228	235	PF00069	0.798
MOD_GSK3_1	262	269	PF00069	0.750
MOD_GSK3_1	280	287	PF00069	0.721
MOD_GSK3_1	311	318	PF00069	0.718
MOD_GSK3_1	331	338	PF00069	0.697
MOD_GSK3_1	364	371	PF00069	0.627
MOD_GSK3_1	9	16	PF00069	0.660
MOD_N-GLC_1	302	307	PF02516	0.668
MOD_N-GLC_1	375	380	PF02516	0.647
MOD_NEK2_1	266	271	PF00069	0.655
MOD_NEK2_1	364	369	PF00069	0.710
MOD_NEK2_1	402	407	PF00069	0.688
MOD_NEK2_1	6	11	PF00069	0.610
MOD_PIKK_1	392	398	PF00454	0.625
MOD_PKA_1	228	234	PF00069	0.651
MOD_PKA_2	155	161	PF00069	0.662
MOD_PKA_2	199	205	PF00069	0.632
MOD_PKA_2	228	234	PF00069	0.668
MOD_PKA_2	244	250	PF00069	0.582
MOD_PKA_2	285	291	PF00069	0.696
MOD_PKA_2	359	365	PF00069	0.683
MOD_PKA_2	415	421	PF00069	0.630
MOD_PKA_2	424	430	PF00069	0.623
MOD_PKA_2	73	79	PF00069	0.644
MOD_Plk_1	170	176	PF00069	0.660
MOD_Plk_1	20	26	PF00069	0.630
MOD_Plk_1	232	238	PF00069	0.639
MOD_Plk_1	302	308	PF00069	0.597
MOD_Plk_1	375	381	PF00069	0.646
MOD_Plk_4	343	349	PF00069	0.787
MOD_Plk_4	359	365	PF00069	0.529
MOD_ProDKin_1	114	120	PF00069	0.659
MOD_ProDKin_1	163	169	PF00069	0.631
MOD_ProDKin_1	182	188	PF00069	0.674
MOD_ProDKin_1	214	220	PF00069	0.594
MOD_ProDKin_1	267	273	PF00069	0.675
MOD_ProDKin_1	280	286	PF00069	0.651
MOD_ProDKin_1	308	314	PF00069	0.780
MOD_ProDKin_1	315	321	PF00069	0.553
MOD_ProDKin_1	328	334	PF00069	0.676
MOD_ProDKin_1	409	415	PF00069	0.660
MOD_SUMO_rev_2	48	54	PF00179	0.682
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.624
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.662
TRG_ENDOCYTIC_2	111	114	PF00928	0.546
TRG_ER_diArg_1	228	230	PF00400	0.656
TRG_ER_diArg_1	91	94	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D7	Leptomonas seymouri	41%	100%
A4HHA8	Leishmania braziliensis	70%	99%
A4I4F4	Leishmania infantum	99%	100%
E9ADV4	Leishmania major	91%	100%
E9ALX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%