LeishMANIAdb
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VIT family, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
VIT family, putative
Gene product:
VIT family, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IFA4_LEIDO
TriTrypDb:
LdCL_290028400 , LDHU3_29.3200
Length:
296

Annotations

LeishMANIAdb annotations

Part of a conserved family of eukaryotic iron transporters.. Localization: Endosomal (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13
GO:0005739 mitochondrion 5 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A0A3Q8IFA4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFA4

Function

Biological processes
Term Name Level Count
GO:0006873 intracellular monoatomic ion homeostasis 4 13
GO:0006875 obsolete intracellular metal ion homeostasis 6 13
GO:0009987 cellular process 1 13
GO:0019725 cellular homeostasis 2 13
GO:0030003 intracellular monoatomic cation homeostasis 5 13
GO:0030026 intracellular manganese ion homeostasis 8 13
GO:0042592 homeostatic process 3 13
GO:0046916 obsolete intracellular transition metal ion homeostasis 7 13
GO:0048878 chemical homeostasis 4 13
GO:0050801 monoatomic ion homeostasis 5 13
GO:0055065 obsolete metal ion homeostasis 7 13
GO:0055071 manganese ion homeostasis 9 13
GO:0055076 obsolete transition metal ion homeostasis 8 13
GO:0055080 monoatomic cation homeostasis 6 13
GO:0055082 intracellular chemical homeostasis 3 13
GO:0065007 biological regulation 1 13
GO:0065008 regulation of biological quality 2 13
GO:0098771 inorganic ion homeostasis 6 13
GO:0006880 intracellular sequestering of iron ion 4 1
GO:0051179 localization 1 1
GO:0051235 maintenance of location 2 1
GO:0051238 sequestering of metal ion 3 1
GO:0051651 maintenance of location in cell 2 1
GO:0097577 sequestering of iron ion 3 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 13
GO:0005384 manganese ion transmembrane transporter activity 7 13
GO:0008324 monoatomic cation transmembrane transporter activity 4 13
GO:0015075 monoatomic ion transmembrane transporter activity 3 13
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 13
GO:0022857 transmembrane transporter activity 2 13
GO:0022890 inorganic cation transmembrane transporter activity 4 13
GO:0046873 metal ion transmembrane transporter activity 5 13
GO:0046915 transition metal ion transmembrane transporter activity 6 13
GO:0005381 iron ion transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 116 118 PF00675 0.303
CLV_NRD_NRD_1 37 39 PF00675 0.380
CLV_PCSK_KEX2_1 116 118 PF00082 0.269
CLV_PCSK_SKI1_1 158 162 PF00082 0.279
DEG_SPOP_SBC_1 177 181 PF00917 0.538
DEG_SPOP_SBC_1 99 103 PF00917 0.417
DOC_CDC14_PxL_1 265 273 PF14671 0.287
DOC_CKS1_1 199 204 PF01111 0.417
DOC_MAPK_gen_1 77 87 PF00069 0.358
DOC_PP2B_LxvP_1 175 178 PF13499 0.448
DOC_USP7_MATH_1 178 182 PF00917 0.519
DOC_USP7_MATH_1 19 23 PF00917 0.543
DOC_USP7_MATH_1 97 101 PF00917 0.442
DOC_WW_Pin1_4 198 203 PF00397 0.398
LIG_14-3-3_CanoR_1 156 161 PF00244 0.457
LIG_14-3-3_CanoR_1 211 220 PF00244 0.440
LIG_14-3-3_CanoR_1 273 277 PF00244 0.240
LIG_BRCT_BRCA1_1 102 106 PF00533 0.369
LIG_Clathr_ClatBox_1 164 168 PF01394 0.463
LIG_FHA_1 199 205 PF00498 0.407
LIG_FHA_1 248 254 PF00498 0.293
LIG_FHA_1 30 36 PF00498 0.706
LIG_FHA_1 60 66 PF00498 0.336
LIG_FHA_2 141 147 PF00498 0.457
LIG_FHA_2 177 183 PF00498 0.538
LIG_LIR_Gen_1 159 167 PF02991 0.490
LIG_LIR_Gen_1 169 178 PF02991 0.465
LIG_LIR_Nem_3 159 164 PF02991 0.490
LIG_LIR_Nem_3 169 175 PF02991 0.465
LIG_LIR_Nem_3 259 265 PF02991 0.310
LIG_PCNA_PIPBox_1 119 128 PF02747 0.457
LIG_PDZ_Wminus1_1 294 296 PF00595 0.534
LIG_SH2_NCK_1 265 269 PF00017 0.353
LIG_SH2_SRC 265 268 PF00017 0.392
LIG_SH2_STAP1 111 115 PF00017 0.466
LIG_SH2_STAT3 137 140 PF00017 0.437
LIG_SH2_STAT5 255 258 PF00017 0.442
LIG_SH2_STAT5 290 293 PF00017 0.385
LIG_SH2_STAT5 98 101 PF00017 0.346
LIG_SH3_3 184 190 PF00018 0.519
LIG_SH3_3 196 202 PF00018 0.220
LIG_SH3_3 225 231 PF00018 0.191
LIG_SH3_3 64 70 PF00018 0.304
LIG_SUMO_SIM_par_1 268 275 PF11976 0.159
LIG_TRAF2_1 143 146 PF00917 0.457
LIG_TYR_ITIM 170 175 PF00017 0.448
LIG_UBA3_1 133 138 PF00899 0.554
LIG_WRC_WIRS_1 30 35 PF05994 0.664
MOD_CK1_1 100 106 PF00069 0.390
MOD_CK1_1 232 238 PF00069 0.480
MOD_CK2_1 140 146 PF00069 0.457
MOD_CK2_1 170 176 PF00069 0.448
MOD_GlcNHglycan 126 129 PF01048 0.338
MOD_GlcNHglycan 220 223 PF01048 0.429
MOD_GlcNHglycan 231 234 PF01048 0.192
MOD_GlcNHglycan 50 53 PF01048 0.364
MOD_GSK3_1 132 139 PF00069 0.532
MOD_GSK3_1 178 185 PF00069 0.501
MOD_GSK3_1 229 236 PF00069 0.390
MOD_GSK3_1 247 254 PF00069 0.276
MOD_GSK3_1 55 62 PF00069 0.223
MOD_GSK3_1 98 105 PF00069 0.319
MOD_NEK2_1 148 153 PF00069 0.461
MOD_NEK2_1 170 175 PF00069 0.434
MOD_NEK2_1 210 215 PF00069 0.318
MOD_NEK2_1 241 246 PF00069 0.298
MOD_NEK2_1 271 276 PF00069 0.368
MOD_NEK2_1 286 291 PF00069 0.324
MOD_NEK2_1 48 53 PF00069 0.289
MOD_NEK2_2 281 286 PF00069 0.304
MOD_PIKK_1 136 142 PF00454 0.482
MOD_PIKK_1 233 239 PF00454 0.418
MOD_PKA_2 210 216 PF00069 0.448
MOD_PKA_2 272 278 PF00069 0.268
MOD_Plk_1 19 25 PF00069 0.585
MOD_Plk_4 132 138 PF00069 0.572
MOD_Plk_4 156 162 PF00069 0.570
MOD_Plk_4 241 247 PF00069 0.387
MOD_Plk_4 251 257 PF00069 0.368
MOD_Plk_4 281 287 PF00069 0.401
MOD_ProDKin_1 198 204 PF00069 0.398
MOD_SUMO_for_1 28 31 PF00179 0.658
TRG_DiLeu_BaEn_1 144 149 PF01217 0.479
TRG_DiLeu_BaEn_3 144 150 PF01217 0.504
TRG_DiLeu_BaLyEn_6 199 204 PF01217 0.341
TRG_ENDOCYTIC_2 172 175 PF00928 0.445
TRG_ER_diArg_1 115 117 PF00400 0.521
TRG_ER_diArg_1 43 46 PF00400 0.516
TRG_Pf-PMV_PEXEL_1 108 112 PF00026 0.272

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYN3 Leptomonas seymouri 65% 100%
A0A0S4J089 Bodo saltans 30% 100%
A0A1X0P039 Trypanosomatidae 42% 100%
A0A3R7L265 Trypanosoma rangeli 42% 100%
A4HFD9 Leishmania braziliensis 29% 100%
A4HHL2 Leishmania braziliensis 80% 100%
C9ZKW1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
C9ZLG6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AE74 Leishmania major 94% 100%
E9ALL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5BGJ1 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS