LEM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF96_LEIDO

TriTrypDb:

LdBPK_290760.1 , LdCL_290012300 , LDHU3_29.1030

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.701
CLV_NRD_NRD_1	147	149	PF00675	0.526
CLV_NRD_NRD_1	16	18	PF00675	0.732
CLV_NRD_NRD_1	36	38	PF00675	0.539
CLV_NRD_NRD_1	48	50	PF00675	0.632
CLV_NRD_NRD_1	99	101	PF00675	0.618
CLV_PCSK_KEX2_1	147	149	PF00082	0.596
CLV_PCSK_KEX2_1	16	18	PF00082	0.732
CLV_PCSK_KEX2_1	36	38	PF00082	0.529
CLV_PCSK_KEX2_1	48	50	PF00082	0.542
CLV_PCSK_SKI1_1	100	104	PF00082	0.630
CLV_PCSK_SKI1_1	211	215	PF00082	0.552
CLV_PCSK_SKI1_1	41	45	PF00082	0.649
CLV_PCSK_SKI1_1	94	98	PF00082	0.735
DEG_COP1_1	165	176	PF00400	0.583
DEG_Nend_Nbox_1	1	3	PF02207	0.750
DOC_USP7_MATH_1	12	16	PF00917	0.693
DOC_USP7_MATH_1	124	128	PF00917	0.691
DOC_USP7_MATH_1	178	182	PF00917	0.663
DOC_USP7_MATH_1	191	195	PF00917	0.477
DOC_USP7_MATH_1	3	7	PF00917	0.821
DOC_USP7_UBL2_3	217	221	PF12436	0.605
DOC_WW_Pin1_4	100	105	PF00397	0.636
DOC_WW_Pin1_4	113	118	PF00397	0.738
DOC_WW_Pin1_4	159	164	PF00397	0.710
LIG_14-3-3_CanoR_1	177	183	PF00244	0.591
LIG_14-3-3_CanoR_1	4	8	PF00244	0.704
LIG_14-3-3_CanoR_1	67	71	PF00244	0.626
LIG_14-3-3_CterR_2	223	226	PF00244	0.679
LIG_APCC_ABBA_1	118	123	PF00400	0.710
LIG_FHA_1	168	174	PF00498	0.652
LIG_FHA_1	38	44	PF00498	0.570
LIG_FHA_2	104	110	PF00498	0.686
LIG_FHA_2	55	61	PF00498	0.644
LIG_LIR_Gen_1	133	143	PF02991	0.644
LIG_LIR_Gen_1	192	203	PF02991	0.582
LIG_LIR_Nem_3	133	138	PF02991	0.660
LIG_LIR_Nem_3	192	198	PF02991	0.579
LIG_LIR_Nem_3	201	207	PF02991	0.531
LIG_SH2_CRK	135	139	PF00017	0.651
LIG_SH2_CRK	68	72	PF00017	0.702
LIG_SH2_NCK_1	68	72	PF00017	0.702
LIG_SH2_STAP1	182	186	PF00017	0.623
LIG_SH2_STAT5	68	71	PF00017	0.650
LIG_SH3_3	111	117	PF00018	0.639
LIG_SH3_3	200	206	PF00018	0.672
LIG_SH3_3	22	28	PF00018	0.696
LIG_TRAF2_1	181	184	PF00917	0.599
MOD_CK1_1	112	118	PF00069	0.665
MOD_CK1_1	127	133	PF00069	0.700
MOD_CK1_1	159	165	PF00069	0.708
MOD_CK1_1	172	178	PF00069	0.609
MOD_CK2_1	127	133	PF00069	0.571
MOD_CK2_1	159	165	PF00069	0.789
MOD_CK2_1	178	184	PF00069	0.611
MOD_GlcNHglycan	111	114	PF01048	0.751
MOD_GlcNHglycan	12	15	PF01048	0.680
MOD_GlcNHglycan	186	189	PF01048	0.710
MOD_GlcNHglycan	88	91	PF01048	0.808
MOD_GlcNHglycan	94	97	PF01048	0.675
MOD_GSK3_1	109	116	PF00069	0.694
MOD_GSK3_1	124	131	PF00069	0.654
MOD_GSK3_1	172	179	PF00069	0.607
MOD_GSK3_1	189	196	PF00069	0.650
MOD_GSK3_1	66	73	PF00069	0.705
MOD_GSK3_1	86	93	PF00069	0.751
MOD_LATS_1	92	98	PF00433	0.677
MOD_N-GLC_1	157	162	PF02516	0.694
MOD_N-GLC_1	18	23	PF02516	0.747
MOD_N-GLC_1	29	34	PF02516	0.627
MOD_NEK2_1	157	162	PF00069	0.578
MOD_NEK2_1	2	7	PF00069	0.752
MOD_NEK2_1	29	34	PF00069	0.737
MOD_NEK2_1	43	48	PF00069	0.556
MOD_NEK2_1	54	59	PF00069	0.595
MOD_PIKK_1	43	49	PF00454	0.567
MOD_PK_1	169	175	PF00069	0.728
MOD_PKA_1	149	155	PF00069	0.598
MOD_PKA_2	131	137	PF00069	0.696
MOD_PKA_2	176	182	PF00069	0.537
MOD_PKA_2	3	9	PF00069	0.705
MOD_PKA_2	66	72	PF00069	0.633
MOD_Plk_1	29	35	PF00069	0.594
MOD_Plk_4	20	26	PF00069	0.611
MOD_Plk_4	71	77	PF00069	0.798
MOD_ProDKin_1	100	106	PF00069	0.634
MOD_ProDKin_1	113	119	PF00069	0.741
MOD_ProDKin_1	159	165	PF00069	0.709
TRG_DiLeu_BaEn_1	210	215	PF01217	0.664
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.635
TRG_ENDOCYTIC_2	135	138	PF00928	0.717
TRG_ENDOCYTIC_2	204	207	PF00928	0.607
TRG_ER_diArg_1	146	148	PF00400	0.594
TRG_ER_diArg_1	36	38	PF00400	0.762
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I154	Leptomonas seymouri	41%	99%
A4HH80	Leishmania braziliensis	62%	100%
A4I4C6	Leishmania infantum	98%	100%
E9ADS5	Leishmania major	86%	100%
E9AM05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%