Probable eukaryotic initiation factor 4A

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase HEL67

Species:

Leishmania donovani

UniProt:

A0A3Q8IF94_LEIDO

TriTrypDb:

LdBPK_320410.1 , LdCL_320009000 , LDHU3_32.0510

Length:

614

Annotations

Annotations by Jardim et al.

Helicases, ATP-dependent RNA helicase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0034399	nuclear periphery	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Phosphorylation

Amastigote: 56
Promastigote/Amastigote: 609

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IF94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF94

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	1
GO:0003724	RNA helicase activity	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	231	233	PF00675	0.222
CLV_PCSK_KEX2_1	374	376	PF00082	0.222
CLV_PCSK_KEX2_1	397	399	PF00082	0.222
CLV_PCSK_KEX2_1	483	485	PF00082	0.464
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.222
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.222
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.464
CLV_PCSK_SKI1_1	232	236	PF00082	0.222
CLV_PCSK_SKI1_1	341	345	PF00082	0.340
DEG_APCC_DBOX_1	374	382	PF00400	0.447

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J1	Leptomonas seymouri	30%	68%
A0A0N0P942	Leptomonas seymouri	32%	71%
A0A0N1I5R1	Leptomonas seymouri	23%	77%
A0A0N1I7N1	Leptomonas seymouri	85%	98%
A0A0N1PCW9	Leptomonas seymouri	50%	69%
A0A0N1PDY8	Leptomonas seymouri	39%	100%
A0A0S4IKX9	Bodo saltans	25%	81%
A0A0S4IX79	Bodo saltans	30%	84%
A0A0S4J192	Bodo saltans	77%	100%
A0A0S4JDN6	Bodo saltans	52%	74%

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