DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF92_LEIDO

TriTrypDb:

LdBPK_352950.1 , LdCL_350034400 , LDHU3_35.3790

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	369	373	PF00656	0.524
CLV_C14_Caspase3-7	583	587	PF00656	0.603
CLV_C14_Caspase3-7	717	721	PF00656	0.722
CLV_NRD_NRD_1	242	244	PF00675	0.433
CLV_NRD_NRD_1	256	258	PF00675	0.469
CLV_NRD_NRD_1	345	347	PF00675	0.637
CLV_NRD_NRD_1	485	487	PF00675	0.428
CLV_NRD_NRD_1	634	636	PF00675	0.582
CLV_NRD_NRD_1	69	71	PF00675	0.499
CLV_NRD_NRD_1	704	706	PF00675	0.582
CLV_PCSK_KEX2_1	242	244	PF00082	0.448
CLV_PCSK_KEX2_1	255	257	PF00082	0.470
CLV_PCSK_KEX2_1	334	336	PF00082	0.614
CLV_PCSK_KEX2_1	345	347	PF00082	0.638
CLV_PCSK_KEX2_1	485	487	PF00082	0.428
CLV_PCSK_KEX2_1	634	636	PF00082	0.585
CLV_PCSK_KEX2_1	69	71	PF00082	0.499
CLV_PCSK_KEX2_1	704	706	PF00082	0.582
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.614
CLV_PCSK_SKI1_1	279	283	PF00082	0.474
CLV_PCSK_SKI1_1	543	547	PF00082	0.378
CLV_Separin_Metazoa	393	397	PF03568	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.418
DEG_SPOP_SBC_1	467	471	PF00917	0.587
DOC_CDC14_PxL_1	233	241	PF14671	0.426
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	548	554	PF00134	0.373
DOC_MAPK_gen_1	21	30	PF00069	0.429
DOC_MAPK_HePTP_8	544	556	PF00069	0.474
DOC_MAPK_MEF2A_6	21	30	PF00069	0.429
DOC_MAPK_MEF2A_6	41	49	PF00069	0.427
DOC_MAPK_MEF2A_6	547	556	PF00069	0.479
DOC_MAPK_MEF2A_6	705	714	PF00069	0.571
DOC_MAPK_NFAT4_5	23	31	PF00069	0.427
DOC_PP1_RVXF_1	404	410	PF00149	0.424
DOC_PP1_RVXF_1	428	434	PF00149	0.501
DOC_PP2B_LxvP_1	282	285	PF13499	0.483
DOC_PP2B_LxvP_1	35	38	PF13499	0.422
DOC_PP2B_LxvP_1	658	661	PF13499	0.486
DOC_PP4_FxxP_1	108	111	PF00568	0.502
DOC_PP4_FxxP_1	154	157	PF00568	0.351
DOC_PP4_FxxP_1	210	213	PF00568	0.520
DOC_PP4_FxxP_1	261	264	PF00568	0.429
DOC_PP4_FxxP_1	329	332	PF00568	0.651
DOC_PP4_FxxP_1	43	46	PF00568	0.432
DOC_PP4_FxxP_1	442	445	PF00568	0.497
DOC_PP4_FxxP_1	91	94	PF00568	0.477
DOC_SPAK_OSR1_1	685	689	PF12202	0.477
DOC_USP7_MATH_1	379	383	PF00917	0.548
DOC_USP7_MATH_1	398	402	PF00917	0.297
DOC_USP7_MATH_1	533	537	PF00917	0.323
DOC_USP7_MATH_1	58	62	PF00917	0.663
DOC_USP7_MATH_1	661	665	PF00917	0.696
DOC_WW_Pin1_4	10	15	PF00397	0.501
DOC_WW_Pin1_4	33	38	PF00397	0.424
DOC_WW_Pin1_4	41	46	PF00397	0.523
DOC_WW_Pin1_4	412	417	PF00397	0.484
DOC_WW_Pin1_4	468	473	PF00397	0.603
DOC_WW_Pin1_4	641	646	PF00397	0.643
DOC_WW_Pin1_4	97	102	PF00397	0.501
LIG_14-3-3_CanoR_1	279	285	PF00244	0.483
LIG_14-3-3_CanoR_1	320	329	PF00244	0.576
LIG_14-3-3_CanoR_1	335	341	PF00244	0.652
LIG_14-3-3_CanoR_1	349	357	PF00244	0.634
LIG_14-3-3_CanoR_1	456	460	PF00244	0.498
LIG_14-3-3_CanoR_1	466	472	PF00244	0.510
LIG_14-3-3_CanoR_1	503	507	PF00244	0.380
LIG_14-3-3_CanoR_1	557	567	PF00244	0.515
LIG_14-3-3_CanoR_1	581	585	PF00244	0.552
LIG_14-3-3_CanoR_1	70	76	PF00244	0.495
LIG_14-3-3_CanoR_1	704	712	PF00244	0.694
LIG_Actin_WH2_2	553	568	PF00022	0.508
LIG_AP2alpha_1	420	424	PF02296	0.512
LIG_AP2alpha_2	327	329	PF02296	0.629
LIG_APCC_ABBA_1	409	414	PF00400	0.406
LIG_BRCT_BRCA1_1	174	178	PF00533	0.360
LIG_BRCT_BRCA1_1	282	286	PF00533	0.449
LIG_BRCT_BRCA1_1	456	460	PF00533	0.409
LIG_BRCT_BRCA1_1	536	540	PF00533	0.376
LIG_Clathr_ClatBox_1	683	687	PF01394	0.481
LIG_CtBP_PxDLS_1	37	41	PF00389	0.420
LIG_eIF4E_1	48	54	PF01652	0.420
LIG_FHA_1	111	117	PF00498	0.502
LIG_FHA_1	160	166	PF00498	0.424
LIG_FHA_1	270	276	PF00498	0.439
LIG_FHA_1	389	395	PF00498	0.541
LIG_FHA_1	459	465	PF00498	0.471
LIG_FHA_1	529	535	PF00498	0.340
LIG_FHA_1	58	64	PF00498	0.557
LIG_FHA_1	615	621	PF00498	0.705
LIG_FHA_1	720	726	PF00498	0.541
LIG_FHA_1	772	778	PF00498	0.511
LIG_FHA_2	120	126	PF00498	0.443
LIG_FHA_2	427	433	PF00498	0.504
LIG_FHA_2	608	614	PF00498	0.667
LIG_FHA_2	620	626	PF00498	0.695
LIG_FHA_2	711	717	PF00498	0.693
LIG_GSK3_LRP6_1	10	15	PF00069	0.394
LIG_HP1_1	398	402	PF01393	0.343
LIG_IBAR_NPY_1	436	438	PF08397	0.494
LIG_Integrin_isoDGR_2	277	279	PF01839	0.360
LIG_IRF3_LxIS_1	758	765	PF10401	0.421
LIG_LIR_Apic_2	106	111	PF02991	0.446
LIG_LIR_Apic_2	207	213	PF02991	0.509
LIG_LIR_Apic_2	259	264	PF02991	0.439
LIG_LIR_Apic_2	327	332	PF02991	0.640
LIG_LIR_Apic_2	42	46	PF02991	0.430
LIG_LIR_Apic_2	640	645	PF02991	0.637
LIG_LIR_Apic_2	89	94	PF02991	0.365
LIG_LIR_Gen_1	172	180	PF02991	0.380
LIG_LIR_Gen_1	418	427	PF02991	0.415
LIG_LIR_Nem_3	106	110	PF02991	0.463
LIG_LIR_Nem_3	143	148	PF02991	0.342
LIG_LIR_Nem_3	172	176	PF02991	0.387
LIG_LIR_Nem_3	418	423	PF02991	0.419
LIG_LIR_Nem_3	507	513	PF02991	0.566
LIG_LIR_Nem_3	653	658	PF02991	0.563
LIG_LYPXL_yS_3	438	441	PF13949	0.532
LIG_MAD2	543	551	PF02301	0.371
LIG_MLH1_MIPbox_1	174	178	PF16413	0.410
LIG_MLH1_MIPbox_1	456	460	PF16413	0.416
LIG_PCNA_TLS_4	255	262	PF02747	0.445
LIG_Pex14_1	173	177	PF04695	0.333
LIG_Pex14_2	138	142	PF04695	0.407
LIG_Pex14_2	200	204	PF04695	0.536
LIG_Pex14_2	286	290	PF04695	0.505
LIG_Pex14_2	420	424	PF04695	0.512
LIG_Pex14_2	523	527	PF04695	0.369
LIG_Pex14_2	91	95	PF04695	0.462
LIG_PTB_Apo_2	274	281	PF02174	0.345
LIG_PTB_Phospho_1	274	280	PF10480	0.344
LIG_Rb_LxCxE_1	603	624	PF01857	0.575
LIG_REV1ctd_RIR_1	538	547	PF16727	0.455
LIG_SH2_CRK	244	248	PF00017	0.412
LIG_SH2_CRK	510	514	PF00017	0.462
LIG_SH2_CRK	642	646	PF00017	0.640
LIG_SH2_CRK	759	763	PF00017	0.551
LIG_SH2_STAP1	249	253	PF00017	0.510
LIG_SH2_STAP1	656	660	PF00017	0.573
LIG_SH2_STAP1	773	777	PF00017	0.494
LIG_SH2_STAT3	570	573	PF00017	0.655
LIG_SH2_STAT5	177	180	PF00017	0.332
LIG_SH2_STAT5	249	252	PF00017	0.592
LIG_SH2_STAT5	280	283	PF00017	0.460
LIG_SH2_STAT5	308	311	PF00017	0.440
LIG_SH2_STAT5	318	321	PF00017	0.490
LIG_SH2_STAT5	477	480	PF00017	0.429
LIG_SH2_STAT5	48	51	PF00017	0.545
LIG_SH2_STAT5	606	609	PF00017	0.663
LIG_SH2_STAT5	728	731	PF00017	0.394
LIG_SH2_STAT5	773	776	PF00017	0.513
LIG_SH3_2	341	346	PF14604	0.542
LIG_SH3_3	338	344	PF00018	0.539
LIG_SH3_3	392	398	PF00018	0.462
LIG_SH3_3	462	468	PF00018	0.451
LIG_SH3_3	609	615	PF00018	0.643
LIG_SH3_3	748	754	PF00018	0.341
LIG_SH3_3	8	14	PF00018	0.455
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.546
LIG_SUMO_SIM_anti_2	29	34	PF11976	0.426
LIG_SUMO_SIM_par_1	156	162	PF11976	0.478
LIG_SUMO_SIM_par_1	26	31	PF11976	0.427
LIG_TRAF2_1	676	679	PF00917	0.562
LIG_TRAF2_1	713	716	PF00917	0.531
LIG_WRC_WIRS_1	201	206	PF05994	0.553
LIG_WRC_WIRS_1	258	263	PF05994	0.530
LIG_WW_1	45	48	PF00397	0.428
MOD_CK1_1	172	178	PF00069	0.359
MOD_CK1_1	351	357	PF00069	0.579
MOD_CK1_1	36	42	PF00069	0.635
MOD_CK1_1	366	372	PF00069	0.554
MOD_CK1_1	458	464	PF00069	0.593
MOD_CK1_1	522	528	PF00069	0.408
MOD_CK1_1	664	670	PF00069	0.570
MOD_CK1_1	719	725	PF00069	0.559
MOD_CK2_1	426	432	PF00069	0.517
MOD_CK2_1	556	562	PF00069	0.426
MOD_CK2_1	607	613	PF00069	0.686
MOD_CK2_1	673	679	PF00069	0.694
MOD_CK2_1	710	716	PF00069	0.760
MOD_CK2_1	738	744	PF00069	0.556
MOD_Cter_Amidation	253	256	PF01082	0.442
MOD_Cter_Amidation	627	630	PF01082	0.536
MOD_GlcNHglycan	282	285	PF01048	0.428
MOD_GlcNHglycan	296	300	PF01048	0.449
MOD_GlcNHglycan	324	327	PF01048	0.513
MOD_GlcNHglycan	350	353	PF01048	0.513
MOD_GlcNHglycan	417	420	PF01048	0.544
MOD_GlcNHglycan	432	436	PF01048	0.586
MOD_GlcNHglycan	657	661	PF01048	0.488
MOD_GlcNHglycan	706	709	PF01048	0.649
MOD_GSK3_1	106	113	PF00069	0.487
MOD_GSK3_1	196	203	PF00069	0.389
MOD_GSK3_1	291	298	PF00069	0.399
MOD_GSK3_1	454	461	PF00069	0.519
MOD_GSK3_1	466	473	PF00069	0.499
MOD_GSK3_1	519	526	PF00069	0.373
MOD_GSK3_1	696	703	PF00069	0.510
MOD_N-GLC_1	322	327	PF02516	0.470
MOD_N-GLC_1	412	417	PF02516	0.398
MOD_N-GLC_1	574	579	PF02516	0.517
MOD_N-GLC_1	651	656	PF02516	0.516
MOD_N-GLC_1	667	672	PF02516	0.488
MOD_NEK2_1	178	183	PF00069	0.343
MOD_NEK2_1	200	205	PF00069	0.430
MOD_NEK2_1	269	274	PF00069	0.457
MOD_NEK2_1	28	33	PF00069	0.428
MOD_NEK2_1	321	326	PF00069	0.546
MOD_NEK2_1	348	353	PF00069	0.497
MOD_NEK2_1	455	460	PF00069	0.502
MOD_NEK2_1	523	528	PF00069	0.422
MOD_NEK2_1	534	539	PF00069	0.325
MOD_NEK2_1	556	561	PF00069	0.388
MOD_NEK2_1	589	594	PF00069	0.673
MOD_NEK2_1	71	76	PF00069	0.505
MOD_NEK2_1	762	767	PF00069	0.442
MOD_NEK2_1	95	100	PF00069	0.510
MOD_NEK2_2	398	403	PF00069	0.488
MOD_OFUCOSY	92	99	PF10250	0.379
MOD_PIKK_1	363	369	PF00454	0.498
MOD_PIKK_1	673	679	PF00454	0.574
MOD_PKA_1	334	340	PF00069	0.611
MOD_PKA_1	704	710	PF00069	0.574
MOD_PKA_2	334	340	PF00069	0.611
MOD_PKA_2	348	354	PF00069	0.643
MOD_PKA_2	455	461	PF00069	0.487
MOD_PKA_2	502	508	PF00069	0.381
MOD_PKA_2	556	562	PF00069	0.459
MOD_PKA_2	580	586	PF00069	0.555
MOD_PKA_2	704	710	PF00069	0.641
MOD_PKB_1	255	263	PF00069	0.468
MOD_Plk_1	119	125	PF00069	0.569
MOD_Plk_1	196	202	PF00069	0.467
MOD_Plk_1	291	297	PF00069	0.393
MOD_Plk_1	523	529	PF00069	0.400
MOD_Plk_1	650	656	PF00069	0.558
MOD_Plk_2-3	119	125	PF00069	0.445
MOD_Plk_2-3	651	657	PF00069	0.560
MOD_Plk_2-3	738	744	PF00069	0.423
MOD_Plk_4	103	109	PF00069	0.532
MOD_Plk_4	119	125	PF00069	0.389
MOD_Plk_4	169	175	PF00069	0.388
MOD_Plk_4	257	263	PF00069	0.425
MOD_Plk_4	28	34	PF00069	0.427
MOD_Plk_4	455	461	PF00069	0.521
MOD_Plk_4	523	529	PF00069	0.387
MOD_Plk_4	589	595	PF00069	0.722
MOD_Plk_4	651	657	PF00069	0.560
MOD_Plk_4	690	696	PF00069	0.648
MOD_ProDKin_1	10	16	PF00069	0.504
MOD_ProDKin_1	33	39	PF00069	0.423
MOD_ProDKin_1	41	47	PF00069	0.523
MOD_ProDKin_1	412	418	PF00069	0.490
MOD_ProDKin_1	468	474	PF00069	0.606
MOD_ProDKin_1	641	647	PF00069	0.641
MOD_ProDKin_1	97	103	PF00069	0.502
MOD_SUMO_for_1	742	745	PF00179	0.506
MOD_SUMO_rev_2	310	317	PF00179	0.446
TRG_DiLeu_BaEn_1	119	124	PF01217	0.447
TRG_DiLeu_BaEn_1	679	684	PF01217	0.484
TRG_DiLeu_BaEn_1	745	750	PF01217	0.390
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.407
TRG_ENDOCYTIC_2	139	142	PF00928	0.420
TRG_ENDOCYTIC_2	177	180	PF00928	0.383
TRG_ENDOCYTIC_2	244	247	PF00928	0.407
TRG_ENDOCYTIC_2	318	321	PF00928	0.423
TRG_ENDOCYTIC_2	438	441	PF00928	0.517
TRG_ENDOCYTIC_2	510	513	PF00928	0.460
TRG_ENDOCYTIC_2	655	658	PF00928	0.571
TRG_ENDOCYTIC_2	759	762	PF00928	0.545
TRG_ER_diArg_1	242	244	PF00400	0.449
TRG_ER_diArg_1	255	257	PF00400	0.473
TRG_ER_diArg_1	344	346	PF00400	0.577
TRG_ER_diArg_1	484	486	PF00400	0.401
TRG_ER_diArg_1	634	636	PF00400	0.585
TRG_ER_diArg_1	68	70	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q5	Leptomonas seymouri	69%	100%
A0A1X0P6X0	Trypanosomatidae	37%	100%
A0A3S5ISL4	Trypanosoma rangeli	41%	100%
A4HMV7	Leishmania braziliensis	77%	100%
A4IBH8	Leishmania infantum	99%	100%
C9ZZ63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AFB4	Leishmania major	93%	100%
E9B6G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%