LeishMANIAdb
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Histone RNA hairpin-binding protein RNA-binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Histone RNA hairpin-binding protein RNA-binding domain containing protein, putative
Gene product:
Histone RNA hairpin-binding protein RNA-binding domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IF88_LEIDO
TriTrypDb:
LdBPK_250950.1 * , LdCL_250014800 , LDHU3_25.1220
Length:
851

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0032991 protein-containing complex 1 1
GO:0071204 histone pre-mRNA 3'end processing complex 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A0A3Q8IF88
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF88

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage 8 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0008152 metabolic process 1 1
GO:0008334 histone mRNA metabolic process 7 1
GO:0009987 cellular process 1 1
GO:0015931 nucleobase-containing compound transport 5 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0031123 RNA 3'-end processing 7 1
GO:0031124 mRNA 3'-end processing 8 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050657 nucleic acid transport 6 1
GO:0050658 RNA transport 4 1
GO:0051028 mRNA transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051236 establishment of RNA localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 6
GO:0003723 RNA binding 4 6
GO:0003729 mRNA binding 5 6
GO:0005488 binding 1 6
GO:0097159 organic cyclic compound binding 2 6
GO:1901363 heterocyclic compound binding 2 6
GO:0036002 pre-mRNA binding 5 1
GO:0071207 histone pre-mRNA stem-loop binding 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 150 152 PF00675 0.835
CLV_NRD_NRD_1 165 167 PF00675 0.433
CLV_NRD_NRD_1 220 222 PF00675 0.435
CLV_NRD_NRD_1 224 226 PF00675 0.388
CLV_NRD_NRD_1 252 254 PF00675 0.600
CLV_NRD_NRD_1 411 413 PF00675 0.700
CLV_NRD_NRD_1 691 693 PF00675 0.710
CLV_NRD_NRD_1 793 795 PF00675 0.632
CLV_NRD_NRD_1 94 96 PF00675 0.775
CLV_PCSK_KEX2_1 164 166 PF00082 0.435
CLV_PCSK_KEX2_1 186 188 PF00082 0.435
CLV_PCSK_KEX2_1 213 215 PF00082 0.321
CLV_PCSK_KEX2_1 224 226 PF00082 0.339
CLV_PCSK_KEX2_1 252 254 PF00082 0.576
CLV_PCSK_KEX2_1 411 413 PF00082 0.700
CLV_PCSK_KEX2_1 691 693 PF00082 0.710
CLV_PCSK_KEX2_1 94 96 PF00082 0.775
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.435
CLV_PCSK_PC1ET2_1 213 215 PF00082 0.321
CLV_PCSK_PC7_1 687 693 PF00082 0.628
CLV_PCSK_SKI1_1 224 228 PF00082 0.343
CLV_PCSK_SKI1_1 296 300 PF00082 0.714
CLV_PCSK_SKI1_1 794 798 PF00082 0.806
CLV_Separin_Metazoa 262 266 PF03568 0.662
DEG_COP1_1 379 387 PF00400 0.754
DEG_Nend_UBRbox_3 1 3 PF02207 0.816
DOC_CKS1_1 824 829 PF01111 0.844
DOC_CYCLIN_RxL_1 473 484 PF00134 0.733
DOC_CYCLIN_RxL_1 791 799 PF00134 0.729
DOC_MAPK_gen_1 164 175 PF00069 0.636
DOC_MAPK_gen_1 210 220 PF00069 0.519
DOC_MAPK_gen_1 265 273 PF00069 0.705
DOC_MAPK_gen_1 411 417 PF00069 0.855
DOC_MAPK_gen_1 780 790 PF00069 0.745
DOC_MAPK_MEF2A_6 265 273 PF00069 0.705
DOC_PP1_RVXF_1 169 176 PF00149 0.636
DOC_PP2B_LxvP_1 203 206 PF13499 0.636
DOC_PP2B_LxvP_1 415 418 PF13499 0.738
DOC_PP2B_LxvP_1 492 495 PF13499 0.742
DOC_PP2B_LxvP_1 504 507 PF13499 0.669
DOC_PP2B_LxvP_1 552 555 PF13499 0.776
DOC_PP2B_LxvP_1 635 638 PF13499 0.716
DOC_PP4_FxxP_1 510 513 PF00568 0.734
DOC_PP4_MxPP_1 599 602 PF00568 0.591
DOC_USP7_MATH_1 136 140 PF00917 0.735
DOC_USP7_MATH_1 143 147 PF00917 0.677
DOC_USP7_MATH_1 284 288 PF00917 0.639
DOC_USP7_MATH_1 4 8 PF00917 0.630
DOC_USP7_MATH_1 416 420 PF00917 0.741
DOC_USP7_MATH_1 421 425 PF00917 0.680
DOC_USP7_MATH_1 460 464 PF00917 0.784
DOC_USP7_MATH_1 495 499 PF00917 0.656
DOC_USP7_MATH_1 538 542 PF00917 0.707
DOC_USP7_MATH_1 611 615 PF00917 0.754
DOC_USP7_MATH_1 616 620 PF00917 0.736
DOC_USP7_MATH_1 681 685 PF00917 0.778
DOC_WW_Pin1_4 102 107 PF00397 0.863
DOC_WW_Pin1_4 132 137 PF00397 0.677
DOC_WW_Pin1_4 139 144 PF00397 0.684
DOC_WW_Pin1_4 151 156 PF00397 0.774
DOC_WW_Pin1_4 201 206 PF00397 0.636
DOC_WW_Pin1_4 28 33 PF00397 0.833
DOC_WW_Pin1_4 323 328 PF00397 0.713
DOC_WW_Pin1_4 404 409 PF00397 0.843
DOC_WW_Pin1_4 417 422 PF00397 0.618
DOC_WW_Pin1_4 427 432 PF00397 0.693
DOC_WW_Pin1_4 43 48 PF00397 0.571
DOC_WW_Pin1_4 436 441 PF00397 0.534
DOC_WW_Pin1_4 444 449 PF00397 0.587
DOC_WW_Pin1_4 511 516 PF00397 0.805
DOC_WW_Pin1_4 526 531 PF00397 0.560
DOC_WW_Pin1_4 54 59 PF00397 0.677
DOC_WW_Pin1_4 566 571 PF00397 0.619
DOC_WW_Pin1_4 625 630 PF00397 0.785
DOC_WW_Pin1_4 70 75 PF00397 0.589
DOC_WW_Pin1_4 702 707 PF00397 0.753
DOC_WW_Pin1_4 716 721 PF00397 0.589
DOC_WW_Pin1_4 788 793 PF00397 0.815
DOC_WW_Pin1_4 819 824 PF00397 0.840
LIG_14-3-3_CanoR_1 164 173 PF00244 0.580
LIG_14-3-3_CanoR_1 253 263 PF00244 0.631
LIG_14-3-3_CanoR_1 355 360 PF00244 0.703
LIG_14-3-3_CanoR_1 451 458 PF00244 0.667
LIG_14-3-3_CanoR_1 476 481 PF00244 0.834
LIG_14-3-3_CanoR_1 537 543 PF00244 0.561
LIG_14-3-3_CanoR_1 61 70 PF00244 0.751
LIG_14-3-3_CanoR_1 675 681 PF00244 0.722
LIG_14-3-3_CanoR_1 691 697 PF00244 0.584
LIG_14-3-3_CanoR_1 715 720 PF00244 0.755
LIG_14-3-3_CanoR_1 728 734 PF00244 0.636
LIG_14-3-3_CanoR_1 766 772 PF00244 0.617
LIG_14-3-3_CanoR_1 79 85 PF00244 0.586
LIG_Actin_WH2_2 181 198 PF00022 0.636
LIG_Actin_WH2_2 282 298 PF00022 0.714
LIG_BRCT_BRCA1_1 104 108 PF00533 0.654
LIG_BRCT_BRCA1_1 256 260 PF00533 0.642
LIG_BRCT_BRCA1_1 602 606 PF00533 0.640
LIG_BRCT_BRCA1_1 768 772 PF00533 0.654
LIG_CSL_BTD_1 521 524 PF09270 0.714
LIG_CtBP_PxDLS_1 403 407 PF00389 0.764
LIG_EVH1_2 205 209 PF00568 0.483
LIG_EVH1_2 506 510 PF00568 0.810
LIG_FHA_1 132 138 PF00498 0.615
LIG_FHA_1 498 504 PF00498 0.824
LIG_FHA_1 512 518 PF00498 0.545
LIG_FHA_1 625 631 PF00498 0.784
LIG_FHA_1 746 752 PF00498 0.788
LIG_FHA_1 797 803 PF00498 0.738
LIG_FHA_1 832 838 PF00498 0.744
LIG_Integrin_RGD_1 114 116 PF01839 0.778
LIG_LIR_Gen_1 179 190 PF02991 0.636
LIG_LIR_Gen_1 231 239 PF02991 0.534
LIG_LIR_Gen_1 257 267 PF02991 0.571
LIG_LIR_Gen_1 302 313 PF02991 0.690
LIG_LIR_Gen_1 668 678 PF02991 0.789
LIG_LIR_Gen_1 7 15 PF02991 0.771
LIG_LIR_Nem_3 231 235 PF02991 0.502
LIG_LIR_Nem_3 302 308 PF02991 0.682
LIG_LIR_Nem_3 7 11 PF02991 0.742
LIG_Pex14_2 230 234 PF04695 0.720
LIG_PTAP_UEV_1 384 389 PF05743 0.737
LIG_SH2_GRB2like 182 185 PF00017 0.636
LIG_SH2_PTP2 232 235 PF00017 0.672
LIG_SH2_STAT5 177 180 PF00017 0.636
LIG_SH2_STAT5 182 185 PF00017 0.577
LIG_SH2_STAT5 232 235 PF00017 0.672
LIG_SH3_3 199 205 PF00018 0.636
LIG_SH3_3 382 388 PF00018 0.750
LIG_SH3_3 407 413 PF00018 0.824
LIG_SH3_3 415 421 PF00018 0.697
LIG_SH3_3 423 429 PF00018 0.594
LIG_SH3_3 46 52 PF00018 0.832
LIG_SH3_3 500 506 PF00018 0.783
LIG_SH3_3 573 579 PF00018 0.839
LIG_SH3_3 623 629 PF00018 0.660
LIG_SH3_3 744 750 PF00018 0.646
LIG_SH3_3 82 88 PF00018 0.751
LIG_SH3_3 838 844 PF00018 0.774
LIG_SUMO_SIM_par_1 401 407 PF11976 0.765
LIG_TRAF2_1 290 293 PF00917 0.710
LIG_WW_2 413 416 PF00397 0.844
MOD_CDC14_SPxK_1 409 412 PF00782 0.857
MOD_CDK_SPK_2 406 411 PF00069 0.844
MOD_CDK_SPxK_1 406 412 PF00069 0.848
MOD_CDK_SPxK_1 436 442 PF00069 0.748
MOD_CDK_SPxK_1 70 76 PF00069 0.791
MOD_CDK_SPxK_1 788 794 PF00069 0.814
MOD_CDK_SPxxK_3 404 411 PF00069 0.845
MOD_CDK_SPxxK_3 427 434 PF00069 0.654
MOD_CDK_SPxxK_3 444 451 PF00069 0.595
MOD_CDK_SPxxK_3 54 61 PF00069 0.783
MOD_CDK_SPxxK_3 566 573 PF00069 0.601
MOD_CDK_SPxxK_3 788 795 PF00069 0.638
MOD_CDK_SPxxK_3 823 830 PF00069 0.846
MOD_CK1_1 139 145 PF00069 0.687
MOD_CK1_1 156 162 PF00069 0.710
MOD_CK1_1 307 313 PF00069 0.685
MOD_CK1_1 315 321 PF00069 0.599
MOD_CK1_1 419 425 PF00069 0.773
MOD_CK1_1 427 433 PF00069 0.674
MOD_CK1_1 463 469 PF00069 0.777
MOD_CK1_1 481 487 PF00069 0.709
MOD_CK1_1 511 517 PF00069 0.677
MOD_CK1_1 541 547 PF00069 0.636
MOD_CK1_1 614 620 PF00069 0.743
MOD_CK1_1 676 682 PF00069 0.724
MOD_CK1_1 7 13 PF00069 0.646
MOD_CK2_1 156 162 PF00069 0.787
MOD_CK2_1 164 170 PF00069 0.452
MOD_CK2_1 323 329 PF00069 0.715
MOD_CK2_1 716 722 PF00069 0.755
MOD_Cter_Amidation 162 165 PF01082 0.316
MOD_DYRK1A_RPxSP_1 43 47 PF00069 0.737
MOD_GlcNHglycan 121 124 PF01048 0.853
MOD_GlcNHglycan 155 158 PF01048 0.733
MOD_GlcNHglycan 196 199 PF01048 0.530
MOD_GlcNHglycan 282 285 PF01048 0.670
MOD_GlcNHglycan 314 317 PF01048 0.738
MOD_GlcNHglycan 338 341 PF01048 0.705
MOD_GlcNHglycan 385 388 PF01048 0.715
MOD_GlcNHglycan 462 465 PF01048 0.723
MOD_GlcNHglycan 470 473 PF01048 0.839
MOD_GlcNHglycan 480 483 PF01048 0.741
MOD_GlcNHglycan 497 500 PF01048 0.547
MOD_GlcNHglycan 510 513 PF01048 0.622
MOD_GlcNHglycan 58 61 PF01048 0.778
MOD_GlcNHglycan 595 598 PF01048 0.649
MOD_GlcNHglycan 675 678 PF01048 0.833
MOD_GlcNHglycan 693 696 PF01048 0.535
MOD_GlcNHglycan 729 732 PF01048 0.804
MOD_GlcNHglycan 735 738 PF01048 0.688
MOD_GlcNHglycan 740 743 PF01048 0.614
MOD_GlcNHglycan 785 788 PF01048 0.661
MOD_GlcNHglycan 827 830 PF01048 0.759
MOD_GSK3_1 131 138 PF00069 0.664
MOD_GSK3_1 139 146 PF00069 0.616
MOD_GSK3_1 176 183 PF00069 0.389
MOD_GSK3_1 19 26 PF00069 0.647
MOD_GSK3_1 280 287 PF00069 0.631
MOD_GSK3_1 379 386 PF00069 0.678
MOD_GSK3_1 39 46 PF00069 0.706
MOD_GSK3_1 417 424 PF00069 0.768
MOD_GSK3_1 476 483 PF00069 0.741
MOD_GSK3_1 524 531 PF00069 0.658
MOD_GSK3_1 669 676 PF00069 0.708
MOD_GSK3_1 819 826 PF00069 0.830
MOD_LATS_1 653 659 PF00433 0.544
MOD_NEK2_1 194 199 PF00069 0.530
MOD_NEK2_1 209 214 PF00069 0.232
MOD_NEK2_1 39 44 PF00069 0.828
MOD_NEK2_1 478 483 PF00069 0.706
MOD_NEK2_1 497 502 PF00069 0.571
MOD_NEK2_1 781 786 PF00069 0.818
MOD_NEK2_1 796 801 PF00069 0.567
MOD_NEK2_2 304 309 PF00069 0.673
MOD_PIKK_1 164 170 PF00454 0.452
MOD_PIKK_1 470 476 PF00454 0.832
MOD_PIKK_1 61 67 PF00454 0.818
MOD_PIKK_1 655 661 PF00454 0.858
MOD_PIKK_1 781 787 PF00454 0.819
MOD_PIKK_1 80 86 PF00454 0.575
MOD_PKA_1 164 170 PF00069 0.452
MOD_PKA_1 691 697 PF00069 0.726
MOD_PKA_2 164 170 PF00069 0.452
MOD_PKA_2 354 360 PF00069 0.704
MOD_PKA_2 435 441 PF00069 0.631
MOD_PKA_2 450 456 PF00069 0.719
MOD_PKA_2 660 666 PF00069 0.776
MOD_PKA_2 690 696 PF00069 0.837
MOD_PKA_2 714 720 PF00069 0.807
MOD_PKA_2 727 733 PF00069 0.662
MOD_PKA_2 831 837 PF00069 0.763
MOD_Plk_4 767 773 PF00069 0.631
MOD_ProDKin_1 102 108 PF00069 0.867
MOD_ProDKin_1 132 138 PF00069 0.678
MOD_ProDKin_1 139 145 PF00069 0.685
MOD_ProDKin_1 151 157 PF00069 0.771
MOD_ProDKin_1 201 207 PF00069 0.530
MOD_ProDKin_1 28 34 PF00069 0.833
MOD_ProDKin_1 323 329 PF00069 0.715
MOD_ProDKin_1 404 410 PF00069 0.841
MOD_ProDKin_1 417 423 PF00069 0.618
MOD_ProDKin_1 427 433 PF00069 0.692
MOD_ProDKin_1 43 49 PF00069 0.570
MOD_ProDKin_1 436 442 PF00069 0.535
MOD_ProDKin_1 444 450 PF00069 0.579
MOD_ProDKin_1 511 517 PF00069 0.807
MOD_ProDKin_1 526 532 PF00069 0.558
MOD_ProDKin_1 54 60 PF00069 0.677
MOD_ProDKin_1 566 572 PF00069 0.619
MOD_ProDKin_1 625 631 PF00069 0.784
MOD_ProDKin_1 70 76 PF00069 0.589
MOD_ProDKin_1 702 708 PF00069 0.752
MOD_ProDKin_1 716 722 PF00069 0.590
MOD_ProDKin_1 788 794 PF00069 0.814
MOD_ProDKin_1 819 825 PF00069 0.839
TRG_DiLeu_BaLyEn_6 184 189 PF01217 0.530
TRG_DiLeu_BaLyEn_6 190 195 PF01217 0.431
TRG_ENDOCYTIC_2 182 185 PF00928 0.530
TRG_ENDOCYTIC_2 232 235 PF00928 0.511
TRG_ENDOCYTIC_2 305 308 PF00928 0.659
TRG_ENDOCYTIC_2 562 565 PF00928 0.820
TRG_ENDOCYTIC_2 631 634 PF00928 0.711
TRG_ER_diArg_1 164 166 PF00400 0.530
TRG_ER_diArg_1 223 225 PF00400 0.530
TRG_ER_diArg_1 410 412 PF00400 0.701
TRG_NLS_MonoExtC_3 220 225 PF00514 0.530
TRG_Pf-PMV_PEXEL_1 246 250 PF00026 0.585
TRG_Pf-PMV_PEXEL_1 749 754 PF00026 0.615

Homologs

Protein Taxonomy Sequence identity Coverage
A4HE27 Leishmania braziliensis 63% 97%
A4I1D3 Leishmania infantum 99% 100%
E9AXH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4QA02 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS