Ankyrin repeats (3 copies), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF85_LEIDO

TriTrypDb:

LdBPK_290590.1 , LdCL_290010700 , LDHU3_29.0820

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	832	836	PF00656	0.566
CLV_NRD_NRD_1	445	447	PF00675	0.515
CLV_NRD_NRD_1	489	491	PF00675	0.620
CLV_NRD_NRD_1	5	7	PF00675	0.685
CLV_PCSK_KEX2_1	445	447	PF00082	0.515
CLV_PCSK_KEX2_1	468	470	PF00082	0.743
CLV_PCSK_KEX2_1	491	493	PF00082	0.557
CLV_PCSK_KEX2_1	5	7	PF00082	0.685
CLV_PCSK_KEX2_1	789	791	PF00082	0.594
CLV_PCSK_KEX2_1	833	835	PF00082	0.582
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.748
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.596
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.539
CLV_PCSK_PC1ET2_1	833	835	PF00082	0.614
CLV_PCSK_SKI1_1	182	186	PF00082	0.765
CLV_PCSK_SKI1_1	46	50	PF00082	0.556
CLV_PCSK_SKI1_1	492	496	PF00082	0.529
CLV_PCSK_SKI1_1	605	609	PF00082	0.382
CLV_PCSK_SKI1_1	61	65	PF00082	0.617
CLV_PCSK_SKI1_1	683	687	PF00082	0.367
DEG_APCC_DBOX_1	489	497	PF00400	0.677
DEG_APCC_DBOX_1	73	81	PF00400	0.614
DEG_APCC_DBOX_1	822	830	PF00400	0.546
DOC_CYCLIN_RxL_1	680	687	PF00134	0.424
DOC_CYCLIN_yClb5_NLxxxL_5	390	399	PF00134	0.624
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	551	557	PF00134	0.667
DOC_MAPK_gen_1	490	496	PF00069	0.528
DOC_PP2B_LxvP_1	110	113	PF13499	0.482
DOC_PP4_FxxP_1	531	534	PF00568	0.465
DOC_USP7_MATH_1	187	191	PF00917	0.734
DOC_USP7_MATH_1	192	196	PF00917	0.745
DOC_USP7_MATH_1	210	214	PF00917	0.724
DOC_USP7_MATH_1	218	222	PF00917	0.520
DOC_USP7_MATH_1	224	228	PF00917	0.623
DOC_USP7_MATH_1	237	241	PF00917	0.678
DOC_USP7_MATH_1	286	290	PF00917	0.434
DOC_USP7_MATH_1	418	422	PF00917	0.609
DOC_USP7_MATH_1	570	574	PF00917	0.773
DOC_USP7_MATH_1	623	627	PF00917	0.410
DOC_USP7_MATH_1	735	739	PF00917	0.500
DOC_USP7_MATH_1	744	748	PF00917	0.472
DOC_USP7_UBL2_3	753	757	PF12436	0.520
DOC_WW_Pin1_4	197	202	PF00397	0.637
DOC_WW_Pin1_4	228	233	PF00397	0.724
DOC_WW_Pin1_4	478	483	PF00397	0.713
DOC_WW_Pin1_4	574	579	PF00397	0.746
DOC_WW_Pin1_4	629	634	PF00397	0.376
DOC_WW_Pin1_4	692	697	PF00397	0.418
DOC_WW_Pin1_4	86	91	PF00397	0.520
LIG_14-3-3_CanoR_1	152	158	PF00244	0.489
LIG_14-3-3_CanoR_1	338	348	PF00244	0.513
LIG_14-3-3_CanoR_1	380	385	PF00244	0.488
LIG_14-3-3_CanoR_1	472	482	PF00244	0.755
LIG_14-3-3_CanoR_1	492	497	PF00244	0.555
LIG_14-3-3_CanoR_1	540	548	PF00244	0.559
LIG_14-3-3_CanoR_1	602	608	PF00244	0.376
LIG_14-3-3_CanoR_1	772	776	PF00244	0.535
LIG_Actin_WH2_2	105	122	PF00022	0.524
LIG_Actin_WH2_2	429	447	PF00022	0.541
LIG_BIR_III_4	827	831	PF00653	0.627
LIG_BRCT_BRCA1_1	406	410	PF00533	0.530
LIG_BRCT_BRCA1_1	625	629	PF00533	0.424
LIG_CtBP_PxDLS_1	10	14	PF00389	0.723
LIG_CtBP_PxDLS_1	645	649	PF00389	0.501
LIG_CtBP_PxDLS_1	839	843	PF00389	0.550
LIG_eIF4E_1	697	703	PF01652	0.467
LIG_FAT_LD_1	147	155	PF03623	0.411
LIG_FHA_1	122	128	PF00498	0.529
LIG_FHA_1	265	271	PF00498	0.628
LIG_FHA_1	355	361	PF00498	0.450
LIG_FHA_1	431	437	PF00498	0.543
LIG_FHA_1	47	53	PF00498	0.548
LIG_FHA_1	630	636	PF00498	0.395
LIG_FHA_1	679	685	PF00498	0.406
LIG_FHA_1	696	702	PF00498	0.344
LIG_FHA_1	724	730	PF00498	0.545
LIG_FHA_1	783	789	PF00498	0.544
LIG_FHA_1	79	85	PF00498	0.629
LIG_FHA_2	116	122	PF00498	0.460
LIG_FHA_2	171	177	PF00498	0.670
LIG_FHA_2	261	267	PF00498	0.804
LIG_FHA_2	340	346	PF00498	0.530
LIG_FHA_2	746	752	PF00498	0.541
LIG_FHA_2	779	785	PF00498	0.522
LIG_LIR_Apic_2	529	534	PF02991	0.471
LIG_LIR_Apic_2	694	700	PF02991	0.472
LIG_LIR_Gen_1	295	305	PF02991	0.487
LIG_LIR_Gen_1	407	418	PF02991	0.525
LIG_LIR_Gen_1	515	525	PF02991	0.543
LIG_LIR_Nem_3	25	31	PF02991	0.672
LIG_LIR_Nem_3	295	301	PF02991	0.439
LIG_LIR_Nem_3	343	349	PF02991	0.533
LIG_LIR_Nem_3	383	388	PF02991	0.540
LIG_LIR_Nem_3	407	413	PF02991	0.531
LIG_LIR_Nem_3	515	520	PF02991	0.549
LIG_LIR_Nem_3	62	66	PF02991	0.478
LIG_LIR_Nem_3	628	634	PF02991	0.433
LIG_LIR_Nem_3	668	674	PF02991	0.376
LIG_MYND_1	29	33	PF01753	0.682
LIG_Pex14_2	349	353	PF04695	0.499
LIG_Pex14_2	381	385	PF04695	0.388
LIG_Pex14_2	527	531	PF04695	0.480
LIG_SH2_CRK	697	701	PF00017	0.473
LIG_SH2_NCK_1	672	676	PF00017	0.376
LIG_SH2_NCK_1	780	784	PF00017	0.566
LIG_SH2_SRC	672	675	PF00017	0.402
LIG_SH2_STAP1	736	740	PF00017	0.495
LIG_SH2_STAP1	814	818	PF00017	0.474
LIG_SH2_STAT3	376	379	PF00017	0.598
LIG_SH2_STAT3	814	817	PF00017	0.566
LIG_SH2_STAT5	125	128	PF00017	0.444
LIG_SH2_STAT5	304	307	PF00017	0.447
LIG_SH2_STAT5	314	317	PF00017	0.481
LIG_SH2_STAT5	412	415	PF00017	0.507
LIG_SH2_STAT5	428	431	PF00017	0.294
LIG_SH2_STAT5	498	501	PF00017	0.509
LIG_SH2_STAT5	603	606	PF00017	0.341
LIG_SH2_STAT5	697	700	PF00017	0.423
LIG_SH2_STAT5	767	770	PF00017	0.521
LIG_SH2_STAT5	780	783	PF00017	0.543
LIG_SH3_1	229	235	PF00018	0.627
LIG_SH3_3	229	235	PF00018	0.627
LIG_SH3_3	345	351	PF00018	0.586
LIG_SH3_3	381	387	PF00018	0.540
LIG_SH3_3	483	489	PF00018	0.712
LIG_SH3_3	543	549	PF00018	0.698
LIG_SH3_3	553	559	PF00018	0.669
LIG_SH3_3	569	575	PF00018	0.716
LIG_SH3_3	635	641	PF00018	0.379
LIG_SH3_CIN85_PxpxPR_1	458	463	PF14604	0.680
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.711
LIG_SUMO_SIM_anti_2	643	650	PF11976	0.429
LIG_SUMO_SIM_anti_2	737	744	PF11976	0.529
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.494
LIG_SUMO_SIM_par_1	124	131	PF11976	0.530
LIG_SUMO_SIM_par_1	371	377	PF11976	0.463
LIG_SUMO_SIM_par_1	492	497	PF11976	0.431
LIG_SUMO_SIM_par_1	741	748	PF11976	0.471
LIG_SUMO_SIM_par_1	838	844	PF11976	0.552
LIG_TRAF2_1	342	345	PF00917	0.613
LIG_TRAF2_1	513	516	PF00917	0.585
LIG_TRAF2_1	69	72	PF00917	0.601
LIG_UBA3_1	361	368	PF00899	0.461
MOD_CDK_SPK_2	197	202	PF00069	0.698
MOD_CDK_SPK_2	228	233	PF00069	0.724
MOD_CK1_1	213	219	PF00069	0.612
MOD_CK1_1	374	380	PF00069	0.458
MOD_CK1_1	464	470	PF00069	0.816
MOD_CK1_1	474	480	PF00069	0.740
MOD_CK1_1	501	507	PF00069	0.556
MOD_CK1_1	573	579	PF00069	0.750
MOD_CK1_1	695	701	PF00069	0.419
MOD_CK1_1	760	766	PF00069	0.542
MOD_CK1_1	782	788	PF00069	0.518
MOD_CK2_1	115	121	PF00069	0.476
MOD_CK2_1	153	159	PF00069	0.424
MOD_CK2_1	197	203	PF00069	0.732
MOD_CK2_1	233	239	PF00069	0.707
MOD_CK2_1	339	345	PF00069	0.612
MOD_CK2_1	56	62	PF00069	0.576
MOD_CK2_1	745	751	PF00069	0.462
MOD_CK2_1	759	765	PF00069	0.539
MOD_CK2_1	778	784	PF00069	0.522
MOD_CK2_1	838	844	PF00069	0.705
MOD_CMANNOS	822	825	PF00535	0.532
MOD_GlcNHglycan	194	197	PF01048	0.744
MOD_GlcNHglycan	208	211	PF01048	0.504
MOD_GlcNHglycan	235	238	PF01048	0.749
MOD_GlcNHglycan	273	276	PF01048	0.648
MOD_GlcNHglycan	42	45	PF01048	0.719
MOD_GlcNHglycan	473	476	PF01048	0.567
MOD_GlcNHglycan	564	567	PF01048	0.600
MOD_GlcNHglycan	58	61	PF01048	0.500
MOD_GlcNHglycan	589	592	PF01048	0.511
MOD_GlcNHglycan	754	757	PF01048	0.578
MOD_GlcNHglycan	762	765	PF01048	0.516
MOD_GlcNHglycan	773	776	PF01048	0.330
MOD_GlcNHglycan	781	784	PF01048	0.574
MOD_GlcNHglycan	86	89	PF01048	0.553
MOD_GSK3_1	170	177	PF00069	0.638
MOD_GSK3_1	18	25	PF00069	0.733
MOD_GSK3_1	206	213	PF00069	0.692
MOD_GSK3_1	224	231	PF00069	0.710
MOD_GSK3_1	233	240	PF00069	0.683
MOD_GSK3_1	260	267	PF00069	0.652
MOD_GSK3_1	463	470	PF00069	0.774
MOD_GSK3_1	471	478	PF00069	0.710
MOD_GSK3_1	492	499	PF00069	0.392
MOD_GSK3_1	560	567	PF00069	0.688
MOD_GSK3_1	570	577	PF00069	0.772
MOD_GSK3_1	625	632	PF00069	0.487
MOD_GSK3_1	688	695	PF00069	0.486
MOD_GSK3_1	778	785	PF00069	0.647
MOD_N-GLC_1	587	592	PF02516	0.497
MOD_NEK2_1	108	113	PF00069	0.486
MOD_NEK2_1	153	158	PF00069	0.360
MOD_NEK2_1	413	418	PF00069	0.493
MOD_NEK2_1	539	544	PF00069	0.624
MOD_NEK2_1	560	565	PF00069	0.621
MOD_NEK2_1	745	750	PF00069	0.467
MOD_NEK2_2	210	215	PF00069	0.553
MOD_NEK2_2	224	229	PF00069	0.587
MOD_NEK2_2	371	376	PF00069	0.464
MOD_PIKK_1	170	176	PF00454	0.623
MOD_PIKK_1	264	270	PF00454	0.530
MOD_PIKK_1	793	799	PF00454	0.493
MOD_PK_1	380	386	PF00069	0.491
MOD_PK_1	757	763	PF00069	0.540
MOD_PKA_2	174	180	PF00069	0.707
MOD_PKA_2	251	257	PF00069	0.809
MOD_PKA_2	471	477	PF00069	0.721
MOD_PKA_2	539	545	PF00069	0.747
MOD_PKA_2	771	777	PF00069	0.619
MOD_PKB_1	490	498	PF00069	0.540
MOD_Plk_1	187	193	PF00069	0.718
MOD_Plk_1	238	244	PF00069	0.726
MOD_Plk_1	587	593	PF00069	0.486
MOD_Plk_1	665	671	PF00069	0.413
MOD_Plk_1	679	685	PF00069	0.452
MOD_Plk_1	736	742	PF00069	0.487
MOD_Plk_1	757	763	PF00069	0.561
MOD_Plk_2-3	167	173	PF00069	0.541
MOD_Plk_4	121	127	PF00069	0.578
MOD_Plk_4	153	159	PF00069	0.462
MOD_Plk_4	380	386	PF00069	0.551
MOD_Plk_4	611	617	PF00069	0.395
MOD_Plk_4	745	751	PF00069	0.514
MOD_ProDKin_1	197	203	PF00069	0.636
MOD_ProDKin_1	228	234	PF00069	0.725
MOD_ProDKin_1	478	484	PF00069	0.712
MOD_ProDKin_1	574	580	PF00069	0.745
MOD_ProDKin_1	629	635	PF00069	0.376
MOD_ProDKin_1	692	698	PF00069	0.415
MOD_ProDKin_1	86	92	PF00069	0.508
MOD_SUMO_for_1	185	188	PF00179	0.668
MOD_SUMO_rev_2	51	58	PF00179	0.664
MOD_SUMO_rev_2	59	66	PF00179	0.596
MOD_SUMO_rev_2	747	755	PF00179	0.495
TRG_DiLeu_BaEn_3	344	350	PF01217	0.522
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.584
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.547
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.376
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.470
TRG_ENDOCYTIC_2	412	415	PF00928	0.501
TRG_ENDOCYTIC_2	671	674	PF00928	0.376
TRG_ER_diArg_1	444	446	PF00400	0.526
TRG_ER_diArg_1	489	492	PF00400	0.577
TRG_ER_diArg_1	800	803	PF00400	0.504
TRG_ER_FFAT_2	774	786	PF00635	0.524
TRG_NES_CRM1_1	389	405	PF08389	0.506
TRG_NLS_MonoExtN_4	489	494	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G5	Leptomonas seymouri	57%	95%
A4HH65	Leishmania braziliensis	73%	99%
A4I4A9	Leishmania infantum	99%	100%
C9ZKL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ADQ9	Leishmania major	91%	100%
E9AM21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%