Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IF83_LEIDO

TriTrypDb:

LdBPK_340400.1 , LdCL_340009100 , LDHU3_34.0570

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 6
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IF83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.541
CLV_NRD_NRD_1	138	140	PF00675	0.680
CLV_NRD_NRD_1	317	319	PF00675	0.671
CLV_NRD_NRD_1	7	9	PF00675	0.535
CLV_PCSK_KEX2_1	138	140	PF00082	0.680
CLV_PCSK_KEX2_1	7	9	PF00082	0.535
CLV_PCSK_PC7_1	3	9	PF00082	0.534
CLV_PCSK_SKI1_1	132	136	PF00082	0.766
CLV_PCSK_SKI1_1	30	34	PF00082	0.706
CLV_PCSK_SKI1_1	308	312	PF00082	0.668
CLV_PCSK_SKI1_1	476	480	PF00082	0.721
DEG_APCC_DBOX_1	299	307	PF00400	0.516
DEG_APCC_DBOX_1	7	15	PF00400	0.576
DEG_COP1_1	250	259	PF00400	0.582
DEG_Nend_UBRbox_4	1	3	PF02207	0.790
DEG_ODPH_VHL_1	11	22	PF01847	0.426
DOC_MAPK_DCC_7	255	265	PF00069	0.537
DOC_MAPK_DCC_7	7	16	PF00069	0.612
DOC_MAPK_gen_1	337	343	PF00069	0.504
DOC_MAPK_gen_1	7	16	PF00069	0.587
DOC_MAPK_MEF2A_6	10	18	PF00069	0.629
DOC_PP1_RVXF_1	306	312	PF00149	0.493
DOC_PP4_FxxP_1	228	231	PF00568	0.564
DOC_USP7_MATH_1	112	116	PF00917	0.456
DOC_USP7_MATH_1	23	27	PF00917	0.463
DOC_USP7_MATH_1	231	235	PF00917	0.575
DOC_USP7_MATH_1	362	366	PF00917	0.530
DOC_USP7_MATH_1	430	434	PF00917	0.559
DOC_USP7_MATH_1	441	445	PF00917	0.471
DOC_USP7_MATH_1	560	564	PF00917	0.542
DOC_USP7_MATH_1	567	571	PF00917	0.552
DOC_USP7_MATH_1	68	72	PF00917	0.543
DOC_WW_Pin1_4	154	159	PF00397	0.535
DOC_WW_Pin1_4	250	255	PF00397	0.617
DOC_WW_Pin1_4	258	263	PF00397	0.506
DOC_WW_Pin1_4	47	52	PF00397	0.583
DOC_WW_Pin1_4	484	489	PF00397	0.533
LIG_14-3-3_CanoR_1	141	146	PF00244	0.446
LIG_14-3-3_CanoR_1	285	294	PF00244	0.582
LIG_14-3-3_CanoR_1	30	35	PF00244	0.533
LIG_14-3-3_CanoR_1	557	567	PF00244	0.493
LIG_14-3-3_CterR_2	569	572	PF00244	0.593
LIG_BIR_III_4	44	48	PF00653	0.587
LIG_BRCT_BRCA1_1	432	436	PF00533	0.465
LIG_BRCT_BRCA1_1	549	553	PF00533	0.437
LIG_BRCT_BRCA1_1	69	73	PF00533	0.489
LIG_CtBP_PxDLS_1	262	266	PF00389	0.481
LIG_EH1_1	110	118	PF00400	0.436
LIG_FHA_1	117	123	PF00498	0.456
LIG_FHA_1	129	135	PF00498	0.473
LIG_FHA_1	187	193	PF00498	0.622
LIG_FHA_1	271	277	PF00498	0.465
LIG_FHA_1	281	287	PF00498	0.498
LIG_FHA_1	393	399	PF00498	0.509
LIG_FHA_1	420	426	PF00498	0.518
LIG_FHA_1	544	550	PF00498	0.426
LIG_FHA_1	87	93	PF00498	0.446
LIG_FHA_1	97	103	PF00498	0.394
LIG_FHA_2	369	375	PF00498	0.485
LIG_FHA_2	380	386	PF00498	0.548
LIG_FHA_2	443	449	PF00498	0.487
LIG_Integrin_isoDGR_2	46	48	PF01839	0.794
LIG_LIR_Gen_1	144	151	PF02991	0.412
LIG_LIR_LC3C_4	115	118	PF02991	0.412
LIG_LIR_Nem_3	70	76	PF02991	0.512
LIG_MLH1_MIPbox_1	549	553	PF16413	0.437
LIG_NBox_RRM_1	538	548	PF00076	0.410
LIG_NRBOX	17	23	PF00104	0.440
LIG_PTB_Apo_2	532	539	PF02174	0.551
LIG_PTB_Apo_2	548	555	PF02174	0.391
LIG_REV1ctd_RIR_1	551	561	PF16727	0.491
LIG_SH2_PTP2	469	472	PF00017	0.501
LIG_SH2_SRC	469	472	PF00017	0.496
LIG_SH2_STAP1	143	147	PF00017	0.456
LIG_SH2_STAT5	104	107	PF00017	0.446
LIG_SH2_STAT5	124	127	PF00017	0.476
LIG_SH2_STAT5	143	146	PF00017	0.352
LIG_SH2_STAT5	275	278	PF00017	0.489
LIG_SH2_STAT5	388	391	PF00017	0.544
LIG_SH2_STAT5	469	472	PF00017	0.493
LIG_SH2_STAT5	516	519	PF00017	0.561
LIG_SH2_STAT5	552	555	PF00017	0.459
LIG_SH2_STAT5	96	99	PF00017	0.515
LIG_SH3_1	327	333	PF00018	0.508
LIG_SH3_1	361	367	PF00018	0.558
LIG_SH3_1	412	418	PF00018	0.564
LIG_SH3_2	197	202	PF14604	0.534
LIG_SH3_3	194	200	PF00018	0.577
LIG_SH3_3	251	257	PF00018	0.584
LIG_SH3_3	327	333	PF00018	0.508
LIG_SH3_3	361	367	PF00018	0.556
LIG_SH3_3	412	418	PF00018	0.579
LIG_SH3_3	465	471	PF00018	0.491
LIG_SUMO_SIM_par_1	261	267	PF11976	0.486
LIG_TRAF2_1	177	180	PF00917	0.626
LIG_TRAF2_1	414	417	PF00917	0.561
LIG_TRAF2_1	85	88	PF00917	0.466
MOD_CDK_SPK_2	250	255	PF00069	0.588
MOD_CDK_SPK_2	484	489	PF00069	0.527
MOD_CK1_1	154	160	PF00069	0.529
MOD_CK1_1	174	180	PF00069	0.562
MOD_CK1_1	258	264	PF00069	0.517
MOD_CK1_1	289	295	PF00069	0.663
MOD_CK1_1	298	304	PF00069	0.567
MOD_CK1_1	365	371	PF00069	0.513
MOD_CK1_1	71	77	PF00069	0.443
MOD_CK2_1	174	180	PF00069	0.588
MOD_CK2_1	368	374	PF00069	0.488
MOD_CK2_1	379	385	PF00069	0.551
MOD_CK2_1	436	442	PF00069	0.448
MOD_CK2_1	523	529	PF00069	0.544
MOD_GlcNHglycan	153	156	PF01048	0.658
MOD_GlcNHglycan	257	260	PF01048	0.813
MOD_GlcNHglycan	34	37	PF01048	0.700
MOD_GlcNHglycan	364	367	PF01048	0.698
MOD_GlcNHglycan	476	479	PF01048	0.695
MOD_GlcNHglycan	510	513	PF01048	0.735
MOD_GlcNHglycan	54	57	PF01048	0.876
MOD_GlcNHglycan	560	563	PF01048	0.762
MOD_GlcNHglycan	72	76	PF01048	0.762
MOD_GSK3_1	112	119	PF00069	0.471
MOD_GSK3_1	124	131	PF00069	0.523
MOD_GSK3_1	150	157	PF00069	0.502
MOD_GSK3_1	163	170	PF00069	0.598
MOD_GSK3_1	264	271	PF00069	0.488
MOD_GSK3_1	276	283	PF00069	0.561
MOD_GSK3_1	294	301	PF00069	0.598
MOD_GSK3_1	543	550	PF00069	0.497
MOD_GSK3_1	67	74	PF00069	0.508
MOD_GSK3_1	86	93	PF00069	0.477
MOD_N-GLC_1	166	171	PF02516	0.792
MOD_N-GLC_1	534	539	PF02516	0.666
MOD_NEK2_1	116	121	PF00069	0.462
MOD_NEK2_1	150	155	PF00069	0.448
MOD_NEK2_1	276	281	PF00069	0.486
MOD_NEK2_1	32	37	PF00069	0.538
MOD_NEK2_1	436	441	PF00069	0.469
MOD_NEK2_1	508	513	PF00069	0.539
MOD_NEK2_1	547	552	PF00069	0.461
MOD_NEK2_1	86	91	PF00069	0.532
MOD_PIKK_1	231	237	PF00454	0.571
MOD_PIKK_1	286	292	PF00454	0.574
MOD_PIKK_1	392	398	PF00454	0.451
MOD_PIKK_1	419	425	PF00454	0.530
MOD_PIKK_1	86	92	PF00454	0.476
MOD_PKA_2	286	292	PF00069	0.574
MOD_PKA_2	508	514	PF00069	0.536
MOD_PKB_1	139	147	PF00069	0.431
MOD_Plk_1	166	172	PF00069	0.594
MOD_Plk_1	534	540	PF00069	0.461
MOD_Plk_1	86	92	PF00069	0.446
MOD_Plk_4	23	29	PF00069	0.382
MOD_Plk_4	365	371	PF00069	0.468
MOD_Plk_4	543	549	PF00069	0.515
MOD_Plk_4	60	66	PF00069	0.507
MOD_ProDKin_1	154	160	PF00069	0.544
MOD_ProDKin_1	250	256	PF00069	0.614
MOD_ProDKin_1	258	264	PF00069	0.495
MOD_ProDKin_1	47	53	PF00069	0.583
MOD_ProDKin_1	484	490	PF00069	0.528
MOD_SUMO_for_1	183	186	PF00179	0.601
MOD_SUMO_for_1	494	497	PF00179	0.514
MOD_SUMO_rev_2	407	414	PF00179	0.551
TRG_DiLeu_BaEn_1	78	83	PF01217	0.494
TRG_DiLeu_BaEn_2	431	437	PF01217	0.468
TRG_DiLeu_BaEn_2	528	534	PF01217	0.455
TRG_DiLeu_BaEn_2	542	548	PF01217	0.347
TRG_DiLeu_BaEn_4	87	93	PF01217	0.462
TRG_ENDOCYTIC_2	145	148	PF00928	0.449
TRG_ER_diArg_1	137	139	PF00400	0.463
TRG_ER_diArg_1	7	10	PF00400	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P8	Leptomonas seymouri	54%	100%
A0A3S7X7F2	Leishmania donovani	26%	99%
A4HAF2	Leishmania braziliensis	78%	100%
A4HAF3	Leishmania braziliensis	26%	99%
A4I9K8	Leishmania infantum	100%	100%
A4I9K9	Leishmania infantum	27%	99%
E9B4K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3H0	Leishmania major	91%	100%