IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IF80_LEIDO

TriTrypDb:

LdBPK_310790.1 , LdCL_310013700 , LDHU3_31.1170

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	214	220	PF00089	0.645
CLV_NRD_NRD_1	15	17	PF00675	0.641
CLV_NRD_NRD_1	153	155	PF00675	0.570
CLV_NRD_NRD_1	171	173	PF00675	0.351
CLV_NRD_NRD_1	243	245	PF00675	0.740
CLV_PCSK_KEX2_1	15	17	PF00082	0.641
CLV_PCSK_KEX2_1	176	178	PF00082	0.556
CLV_PCSK_KEX2_1	243	245	PF00082	0.740
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.602
CLV_PCSK_PC7_1	172	178	PF00082	0.558
CLV_PCSK_SKI1_1	145	149	PF00082	0.574
CLV_PCSK_SKI1_1	173	177	PF00082	0.610
DEG_APCC_DBOX_1	134	142	PF00400	0.519
DOC_MAPK_gen_1	15	25	PF00069	0.563
DOC_USP7_MATH_1	175	179	PF00917	0.589
DOC_USP7_MATH_1	189	193	PF00917	0.696
DOC_USP7_MATH_1	281	285	PF00917	0.696
DOC_USP7_MATH_1	296	300	PF00917	0.482
DOC_USP7_MATH_1	67	71	PF00917	0.614
DOC_USP7_UBL2_3	165	169	PF12436	0.628
DOC_USP7_UBL2_3	205	209	PF12436	0.659
DOC_WW_Pin1_4	216	221	PF00397	0.637
LIG_14-3-3_CanoR_1	154	163	PF00244	0.626
LIG_14-3-3_CanoR_1	243	249	PF00244	0.712
LIG_APCC_ABBA_1	139	144	PF00400	0.528
LIG_BIR_II_1	1	5	PF00653	0.776
LIG_BRCT_BRCA1_1	200	204	PF00533	0.622
LIG_FHA_1	113	119	PF00498	0.649
LIG_FHA_1	194	200	PF00498	0.634
LIG_FHA_1	237	243	PF00498	0.736
LIG_FHA_2	230	236	PF00498	0.746
LIG_FHA_2	46	52	PF00498	0.604
LIG_IRF3_LxIS_1	87	94	PF10401	0.531
LIG_LIR_Gen_1	70	78	PF02991	0.712
LIG_LIR_Nem_3	200	206	PF02991	0.609
LIG_LIR_Nem_3	59	63	PF02991	0.622
LIG_LIR_Nem_3	70	74	PF02991	0.513
LIG_MLH1_MIPbox_1	200	204	PF16413	0.657
LIG_REV1ctd_RIR_1	201	209	PF16727	0.658
LIG_SH2_STAP1	290	294	PF00017	0.701
LIG_SH2_STAT5	46	49	PF00017	0.481
LIG_SH2_STAT5	52	55	PF00017	0.474
LIG_SUMO_SIM_par_1	195	201	PF11976	0.560
LIG_UBA3_1	138	145	PF00899	0.527
LIG_WRC_WIRS_1	265	270	PF05994	0.716
MOD_CDC14_SPxK_1	219	222	PF00782	0.672
MOD_CDK_SPxK_1	216	222	PF00069	0.662
MOD_CK1_1	122	128	PF00069	0.600
MOD_CK1_1	198	204	PF00069	0.594
MOD_CK1_1	247	253	PF00069	0.704
MOD_CK2_1	45	51	PF00069	0.605
MOD_GlcNHglycan	144	148	PF01048	0.583
MOD_GlcNHglycan	257	260	PF01048	0.701
MOD_GlcNHglycan	283	286	PF01048	0.727
MOD_GlcNHglycan	34	37	PF01048	0.621
MOD_GlcNHglycan	64	67	PF01048	0.527
MOD_GSK3_1	119	126	PF00069	0.569
MOD_GSK3_1	189	196	PF00069	0.526
MOD_GSK3_1	247	254	PF00069	0.664
MOD_GSK3_1	264	271	PF00069	0.545
MOD_N-GLC_2	86	88	PF02516	0.512
MOD_NEK2_1	10	15	PF00069	0.505
MOD_NEK2_1	148	153	PF00069	0.515
MOD_NEK2_1	197	202	PF00069	0.563
MOD_NEK2_1	32	37	PF00069	0.533
MOD_NEK2_1	91	96	PF00069	0.588
MOD_PIKK_1	112	118	PF00454	0.630
MOD_PIKK_1	198	204	PF00454	0.581
MOD_PK_1	244	250	PF00069	0.723
MOD_PKA_1	154	160	PF00069	0.650
MOD_PKA_2	275	281	PF00069	0.735
MOD_Plk_1	143	149	PF00069	0.627
MOD_Plk_1	250	256	PF00069	0.716
MOD_Plk_2-3	231	237	PF00069	0.674
MOD_Plk_4	67	73	PF00069	0.692
MOD_ProDKin_1	216	222	PF00069	0.639
MOD_SUMO_rev_2	77	87	PF00179	0.647
TRG_DiLeu_BaEn_1	144	149	PF01217	0.578
TRG_ENDOCYTIC_2	265	268	PF00928	0.711
TRG_ENDOCYTIC_2	60	63	PF00928	0.551
TRG_ER_diArg_1	242	244	PF00400	0.732
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D2	Leptomonas seymouri	25%	100%
A0A0N1HUM2	Leptomonas seymouri	26%	100%
A4I6H0	Leishmania infantum	99%	100%
E9B1M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B1M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q6I7	Leishmania major	93%	100%