Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF78_LEIDO

TriTrypDb:

LdBPK_250790.1 , LdCL_250013200 , LDHU3_25.1000

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF78

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.545
CLV_NRD_NRD_1	15	17	PF00675	0.597
CLV_NRD_NRD_1	276	278	PF00675	0.494
CLV_PCSK_KEX2_1	15	17	PF00082	0.597
CLV_PCSK_KEX2_1	275	277	PF00082	0.506
CLV_PCSK_SKI1_1	141	145	PF00082	0.518
CLV_PCSK_SKI1_1	252	256	PF00082	0.560
CLV_PCSK_SKI1_1	88	92	PF00082	0.578
DEG_Nend_UBRbox_2	1	3	PF02207	0.557
DOC_CYCLIN_RxL_1	186	195	PF00134	0.555
DOC_CYCLIN_RxL_1	85	93	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.442
DOC_MAPK_MEF2A_6	127	136	PF00069	0.537
DOC_MAPK_MEF2A_6	291	299	PF00069	0.366
DOC_PP1_RVXF_1	187	194	PF00149	0.565
DOC_PP2B_LxvP_1	292	295	PF13499	0.411
DOC_USP7_MATH_1	117	121	PF00917	0.632
DOC_USP7_MATH_1	169	173	PF00917	0.580
DOC_USP7_MATH_1	29	33	PF00917	0.615
DOC_USP7_MATH_1	59	63	PF00917	0.692
DOC_WW_Pin1_4	126	131	PF00397	0.752
DOC_WW_Pin1_4	170	175	PF00397	0.696
DOC_WW_Pin1_4	176	181	PF00397	0.660
DOC_WW_Pin1_4	349	354	PF00397	0.659
DOC_WW_Pin1_4	64	69	PF00397	0.646
LIG_14-3-3_CanoR_1	182	188	PF00244	0.629
LIG_14-3-3_CanoR_1	252	257	PF00244	0.565
LIG_Actin_WH2_2	207	225	PF00022	0.454
LIG_APCC_ABBA_1	147	152	PF00400	0.372
LIG_BIR_III_4	93	97	PF00653	0.470
LIG_BRCT_BRCA1_1	172	176	PF00533	0.592
LIG_CaM_NSCaTE_8	230	237	PF13499	0.461
LIG_Clathr_ClatBox_1	211	215	PF01394	0.446
LIG_Clathr_ClatBox_1	309	313	PF01394	0.450
LIG_eIF4E_1	206	212	PF01652	0.427
LIG_eIF4E_1	42	48	PF01652	0.538
LIG_FHA_1	41	47	PF00498	0.607
LIG_HCF-1_HBM_1	203	206	PF13415	0.436
LIG_LIR_Gen_1	152	159	PF02991	0.523
LIG_LIR_Nem_3	152	157	PF02991	0.447
LIG_LIR_Nem_3	200	205	PF02991	0.548
LIG_LIR_Nem_3	346	351	PF02991	0.521
LIG_MYND_1	349	353	PF01753	0.543
LIG_NRBOX	207	213	PF00104	0.443
LIG_NRBOX	86	92	PF00104	0.507
LIG_Pex14_1	202	206	PF04695	0.356
LIG_SH2_CRK	73	77	PF00017	0.556
LIG_SH2_SRC	150	153	PF00017	0.432
LIG_SH2_STAP1	159	163	PF00017	0.544
LIG_SH2_STAP1	42	46	PF00017	0.694
LIG_SH2_STAT3	78	81	PF00017	0.538
LIG_SH2_STAT5	150	153	PF00017	0.452
LIG_SH2_STAT5	159	162	PF00017	0.561
LIG_SH2_STAT5	206	209	PF00017	0.526
LIG_SH2_STAT5	42	45	PF00017	0.654
LIG_SH2_STAT5	78	81	PF00017	0.538
LIG_SH3_3	125	131	PF00018	0.571
LIG_SH3_3	237	243	PF00018	0.549
LIG_SH3_3	47	53	PF00018	0.673
LIG_SUMO_SIM_par_1	307	314	PF11976	0.439
LIG_SxIP_EBH_1	329	339	PF03271	0.466
MOD_CDC14_SPxK_1	179	182	PF00782	0.579
MOD_CDK_SPK_2	349	354	PF00069	0.479
MOD_CDK_SPxK_1	176	182	PF00069	0.581
MOD_CK1_1	172	178	PF00069	0.574
MOD_CK1_1	37	43	PF00069	0.692
MOD_CK1_1	5	11	PF00069	0.546
MOD_CK1_1	62	68	PF00069	0.633
MOD_CK2_1	182	188	PF00069	0.620
MOD_CK2_1	197	203	PF00069	0.423
MOD_GlcNHglycan	112	115	PF01048	0.730
MOD_GlcNHglycan	119	122	PF01048	0.687
MOD_GlcNHglycan	161	164	PF01048	0.682
MOD_GlcNHglycan	323	326	PF01048	0.619
MOD_GlcNHglycan	330	333	PF01048	0.686
MOD_GlcNHglycan	62	65	PF01048	0.712
MOD_GSK3_1	157	164	PF00069	0.560
MOD_GSK3_1	172	179	PF00069	0.616
MOD_GSK3_1	214	221	PF00069	0.473
MOD_GSK3_1	23	30	PF00069	0.687
MOD_GSK3_1	31	38	PF00069	0.726
MOD_GSK3_1	60	67	PF00069	0.733
MOD_NEK2_1	157	162	PF00069	0.710
MOD_NEK2_1	214	219	PF00069	0.485
MOD_NEK2_1	300	305	PF00069	0.440
MOD_PIKK_1	214	220	PF00454	0.470
MOD_PIKK_1	23	29	PF00454	0.703
MOD_PIKK_1	244	250	PF00454	0.679
MOD_PIKK_1	260	266	PF00454	0.492
MOD_PIKK_1	66	72	PF00454	0.623
MOD_PKA_2	328	334	PF00069	0.509
MOD_PKB_1	275	283	PF00069	0.461
MOD_Plk_1	214	220	PF00069	0.470
MOD_Plk_1	38	44	PF00069	0.682
MOD_Plk_4	172	178	PF00069	0.693
MOD_Plk_4	5	11	PF00069	0.582
MOD_ProDKin_1	126	132	PF00069	0.743
MOD_ProDKin_1	170	176	PF00069	0.699
MOD_ProDKin_1	64	70	PF00069	0.642
MOD_SUMO_for_1	243	246	PF00179	0.605
MOD_SUMO_rev_2	20	25	PF00179	0.549
TRG_DiLeu_BaEn_1	6	11	PF01217	0.525
TRG_ENDOCYTIC_2	205	208	PF00928	0.428
TRG_ER_diArg_1	14	16	PF00400	0.590
TRG_ER_diArg_1	275	277	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T2	Leptomonas seymouri	34%	99%
A0A3R7K7C7	Trypanosoma rangeli	30%	100%
A4HE11	Leishmania braziliensis	70%	98%
A4I1B8	Leishmania infantum	97%	98%
D0A5L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AXF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4QA18	Leishmania major	90%	98%