C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3451), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF75_LEIDO

TriTrypDb:

LdBPK_290390.1 , LdCL_290008700 , LDHU3_29.0530

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005638	lamin filament	7	1
GO:0005815	microtubule organizing center	2	1
GO:0005882	intermediate filament	6	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IF75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF75

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1
GO:0030527	structural constituent of chromatin	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	543	547	PF00656	0.598
CLV_C14_Caspase3-7	654	658	PF00656	0.592
CLV_NRD_NRD_1	311	313	PF00675	0.595
CLV_NRD_NRD_1	384	386	PF00675	0.478
CLV_NRD_NRD_1	437	439	PF00675	0.460
CLV_NRD_NRD_1	441	443	PF00675	0.466
CLV_NRD_NRD_1	456	458	PF00675	0.461
CLV_NRD_NRD_1	611	613	PF00675	0.677
CLV_NRD_NRD_1	64	66	PF00675	0.571
CLV_NRD_NRD_1	71	73	PF00675	0.609
CLV_PCSK_FUR_1	435	439	PF00082	0.605
CLV_PCSK_KEX2_1	356	358	PF00082	0.514
CLV_PCSK_KEX2_1	437	439	PF00082	0.462
CLV_PCSK_KEX2_1	455	457	PF00082	0.488
CLV_PCSK_KEX2_1	519	521	PF00082	0.596
CLV_PCSK_KEX2_1	526	528	PF00082	0.639
CLV_PCSK_KEX2_1	64	66	PF00082	0.536
CLV_PCSK_KEX2_1	71	73	PF00082	0.499
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.514
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.679
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.727
CLV_PCSK_SKI1_1	115	119	PF00082	0.695
CLV_PCSK_SKI1_1	139	143	PF00082	0.676
CLV_PCSK_SKI1_1	166	170	PF00082	0.484
CLV_PCSK_SKI1_1	287	291	PF00082	0.640
CLV_PCSK_SKI1_1	356	360	PF00082	0.466
CLV_PCSK_SKI1_1	442	446	PF00082	0.549
CLV_PCSK_SKI1_1	559	563	PF00082	0.626
CLV_PCSK_SKI1_1	580	584	PF00082	0.483
CLV_PCSK_SKI1_1	608	612	PF00082	0.590
CLV_PCSK_SKI1_1	618	622	PF00082	0.485
CLV_PCSK_SKI1_1	798	802	PF00082	0.611
CLV_PCSK_SKI1_1	887	891	PF00082	0.425
CLV_PCSK_SKI1_1	943	947	PF00082	0.396
CLV_Separin_Metazoa	609	613	PF03568	0.613
DEG_APCC_DBOX_1	114	122	PF00400	0.734
DEG_APCC_DBOX_1	222	230	PF00400	0.579
DEG_APCC_DBOX_1	607	615	PF00400	0.555
DEG_APCC_DBOX_1	797	805	PF00400	0.558
DOC_CYCLIN_RxL_1	352	363	PF00134	0.450
DOC_CYCLIN_RxL_1	940	948	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	117	120	PF00134	0.725
DOC_CYCLIN_yCln2_LP_2	685	691	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	799	805	PF00134	0.451
DOC_MAPK_gen_1	271	280	PF00069	0.469
DOC_MAPK_gen_1	556	564	PF00069	0.615
DOC_MAPK_HePTP_8	831	843	PF00069	0.378
DOC_MAPK_MEF2A_6	271	280	PF00069	0.456
DOC_MAPK_MEF2A_6	786	794	PF00069	0.369
DOC_MAPK_MEF2A_6	798	805	PF00069	0.488
DOC_MAPK_MEF2A_6	834	843	PF00069	0.359
DOC_MAPK_NFAT4_5	273	281	PF00069	0.464
DOC_PP1_RVXF_1	414	420	PF00149	0.572
DOC_PP1_RVXF_1	910	917	PF00149	0.488
DOC_PP1_SILK_1	42	47	PF00149	0.513
DOC_PP2B_LxvP_1	117	120	PF13499	0.780
DOC_PP2B_LxvP_1	685	688	PF13499	0.537
DOC_PP2B_LxvP_1	799	802	PF13499	0.440
DOC_PP2B_LxvP_1	805	808	PF13499	0.510
DOC_PP2B_LxvP_1	821	824	PF13499	0.474
DOC_USP7_MATH_1	110	114	PF00917	0.670
DOC_USP7_MATH_1	155	159	PF00917	0.661
DOC_USP7_MATH_1	195	199	PF00917	0.651
DOC_USP7_MATH_1	205	209	PF00917	0.608
DOC_USP7_MATH_1	245	249	PF00917	0.587
DOC_USP7_MATH_1	289	293	PF00917	0.638
DOC_USP7_MATH_1	540	544	PF00917	0.789
DOC_USP7_MATH_1	651	655	PF00917	0.615
DOC_USP7_MATH_1	73	77	PF00917	0.725
DOC_USP7_MATH_1	761	765	PF00917	0.538
DOC_USP7_UBL2_3	139	143	PF12436	0.676
DOC_WW_Pin1_4	108	113	PF00397	0.696
DOC_WW_Pin1_4	144	149	PF00397	0.773
DOC_WW_Pin1_4	23	28	PF00397	0.641
DOC_WW_Pin1_4	78	83	PF00397	0.661
DOC_WW_Pin1_4	84	89	PF00397	0.696
DOC_WW_Pin1_4	866	871	PF00397	0.507
DOC_WW_Pin1_4	945	950	PF00397	0.407
LIG_14-3-3_CanoR_1	106	114	PF00244	0.595
LIG_14-3-3_CanoR_1	18	27	PF00244	0.656
LIG_14-3-3_CanoR_1	312	320	PF00244	0.557
LIG_14-3-3_CanoR_1	357	363	PF00244	0.593
LIG_14-3-3_CanoR_1	385	393	PF00244	0.460
LIG_14-3-3_CanoR_1	422	429	PF00244	0.580
LIG_14-3-3_CanoR_1	612	621	PF00244	0.641
LIG_14-3-3_CanoR_1	629	639	PF00244	0.396
LIG_14-3-3_CanoR_1	648	656	PF00244	0.659
LIG_14-3-3_CanoR_1	667	676	PF00244	0.525
LIG_14-3-3_CanoR_1	813	821	PF00244	0.668
LIG_14-3-3_CanoR_1	887	893	PF00244	0.560
LIG_14-3-3_CanoR_1	954	961	PF00244	0.472
LIG_14-3-3_CanoR_1	96	105	PF00244	0.598
LIG_Actin_WH2_2	597	614	PF00022	0.611
LIG_APCC_ABBA_1	921	926	PF00400	0.388
LIG_BIR_III_2	896	900	PF00653	0.499
LIG_BIR_III_4	548	552	PF00653	0.554
LIG_BIR_III_4	657	661	PF00653	0.421
LIG_BRCT_BRCA1_1	689	693	PF00533	0.437
LIG_BRCT_BRCA1_1	885	889	PF00533	0.534
LIG_Clathr_ClatBox_1	359	363	PF01394	0.508
LIG_CtBP_PxDLS_1	300	304	PF00389	0.634
LIG_DLG_GKlike_1	372	379	PF00625	0.499
LIG_FHA_1	109	115	PF00498	0.620
LIG_FHA_1	189	195	PF00498	0.638
LIG_FHA_1	20	26	PF00498	0.641
LIG_FHA_1	288	294	PF00498	0.706
LIG_FHA_1	661	667	PF00498	0.415
LIG_FHA_1	749	755	PF00498	0.518
LIG_FHA_1	774	780	PF00498	0.518
LIG_FHA_1	866	872	PF00498	0.555
LIG_FHA_1	889	895	PF00498	0.437
LIG_FHA_1	950	956	PF00498	0.449
LIG_FHA_1	962	968	PF00498	0.360
LIG_FHA_2	131	137	PF00498	0.766
LIG_FHA_2	389	395	PF00498	0.530
LIG_FHA_2	459	465	PF00498	0.565
LIG_FHA_2	502	508	PF00498	0.619
LIG_Integrin_RGD_1	544	546	PF01839	0.593
LIG_LIR_Gen_1	563	571	PF02991	0.513
LIG_LIR_Gen_1	700	709	PF02991	0.408
LIG_LIR_Gen_1	892	900	PF02991	0.528
LIG_LIR_Gen_1	920	928	PF02991	0.442
LIG_LIR_Nem_3	563	568	PF02991	0.515
LIG_LIR_Nem_3	61	66	PF02991	0.564
LIG_LIR_Nem_3	690	695	PF02991	0.386
LIG_LIR_Nem_3	920	924	PF02991	0.419
LIG_MLH1_MIPbox_1	689	693	PF16413	0.471
LIG_MYND_1	119	123	PF01753	0.733
LIG_PDZ_Class_1	970	975	PF00595	0.511
LIG_SH2_STAP1	701	705	PF00017	0.404
LIG_SH2_STAT3	468	471	PF00017	0.471
LIG_SH2_STAT5	862	865	PF00017	0.369
LIG_SH3_3	117	123	PF00018	0.739
LIG_SH3_3	76	82	PF00018	0.743
LIG_SH3_3	878	884	PF00018	0.461
LIG_SH3_3	91	97	PF00018	0.757
LIG_SUMO_SIM_par_1	829	835	PF11976	0.456
LIG_SxIP_EBH_1	517	527	PF03271	0.607
LIG_TRAF2_1	215	218	PF00917	0.615
LIG_UBA3_1	341	346	PF00899	0.576
LIG_UBA3_1	44	49	PF00899	0.514
LIG_WRC_WIRS_1	661	666	PF05994	0.415
LIG_WRC_WIRS_1	918	923	PF05994	0.497
MOD_CDK_SPxK_1	23	29	PF00069	0.606
MOD_CDK_SPxxK_3	108	115	PF00069	0.708
MOD_CK1_1	108	114	PF00069	0.703
MOD_CK1_1	134	140	PF00069	0.751
MOD_CK1_1	198	204	PF00069	0.635
MOD_CK1_1	208	214	PF00069	0.513
MOD_CK1_1	265	271	PF00069	0.559
MOD_CK1_1	315	321	PF00069	0.560
MOD_CK1_1	368	374	PF00069	0.586
MOD_CK1_1	421	427	PF00069	0.577
MOD_CK1_1	480	486	PF00069	0.535
MOD_CK1_1	87	93	PF00069	0.661
MOD_CK2_1	155	161	PF00069	0.596
MOD_CK2_1	372	378	PF00069	0.534
MOD_CK2_1	388	394	PF00069	0.416
MOD_CK2_1	819	825	PF00069	0.582
MOD_CK2_1	96	102	PF00069	0.762
MOD_GlcNHglycan	108	111	PF01048	0.538
MOD_GlcNHglycan	203	206	PF01048	0.637
MOD_GlcNHglycan	207	210	PF01048	0.589
MOD_GlcNHglycan	478	482	PF01048	0.556
MOD_GlcNHglycan	653	656	PF01048	0.644
MOD_GlcNHglycan	75	78	PF01048	0.689
MOD_GlcNHglycan	821	824	PF01048	0.603
MOD_GlcNHglycan	851	854	PF01048	0.600
MOD_GlcNHglycan	89	92	PF01048	0.722
MOD_GlcNHglycan	972	975	PF01048	0.534
MOD_GlcNHglycan	98	101	PF01048	0.615
MOD_GSK3_1	106	113	PF00069	0.644
MOD_GSK3_1	128	135	PF00069	0.743
MOD_GSK3_1	19	26	PF00069	0.701
MOD_GSK3_1	194	201	PF00069	0.574
MOD_GSK3_1	315	322	PF00069	0.460
MOD_GSK3_1	368	375	PF00069	0.582
MOD_GSK3_1	384	391	PF00069	0.498
MOD_GSK3_1	630	637	PF00069	0.475
MOD_GSK3_1	687	694	PF00069	0.389
MOD_GSK3_1	815	822	PF00069	0.663
MOD_GSK3_1	83	90	PF00069	0.624
MOD_GSK3_1	883	890	PF00069	0.454
MOD_GSK3_1	926	933	PF00069	0.521
MOD_GSK3_1	945	952	PF00069	0.452
MOD_GSK3_1	963	970	PF00069	0.291
MOD_N-GLC_1	198	203	PF02516	0.700
MOD_NEK2_1	194	199	PF00069	0.631
MOD_NEK2_1	319	324	PF00069	0.538
MOD_NEK2_1	400	405	PF00069	0.442
MOD_NEK2_1	592	597	PF00069	0.481
MOD_NEK2_1	622	627	PF00069	0.609
MOD_NEK2_1	676	681	PF00069	0.453
MOD_NEK2_1	819	824	PF00069	0.630
MOD_NEK2_2	949	954	PF00069	0.512
MOD_PIKK_1	221	227	PF00454	0.567
MOD_PIKK_1	245	251	PF00454	0.612
MOD_PIKK_1	458	464	PF00454	0.608
MOD_PIKK_1	58	64	PF00454	0.638
MOD_PIKK_1	668	674	PF00454	0.578
MOD_PK_1	786	792	PF00069	0.526
MOD_PKA_1	312	318	PF00069	0.579
MOD_PKA_1	519	525	PF00069	0.645
MOD_PKA_1	612	618	PF00069	0.650
MOD_PKA_2	105	111	PF00069	0.627
MOD_PKA_2	189	195	PF00069	0.653
MOD_PKA_2	262	268	PF00069	0.555
MOD_PKA_2	384	390	PF00069	0.513
MOD_PKA_2	408	414	PF00069	0.432
MOD_PKA_2	421	427	PF00069	0.466
MOD_PKA_2	429	435	PF00069	0.453
MOD_PKA_2	519	525	PF00069	0.618
MOD_PKA_2	630	636	PF00069	0.512
MOD_PKA_2	877	883	PF00069	0.417
MOD_PKA_2	926	932	PF00069	0.567
MOD_PKA_2	953	959	PF00069	0.459
MOD_PKB_1	370	378	PF00069	0.501
MOD_Plk_1	274	280	PF00069	0.626
MOD_Plk_1	315	321	PF00069	0.609
MOD_Plk_1	40	46	PF00069	0.515
MOD_Plk_1	477	483	PF00069	0.631
MOD_Plk_1	622	628	PF00069	0.630
MOD_Plk_1	735	741	PF00069	0.412
MOD_Plk_1	749	755	PF00069	0.421
MOD_Plk_1	773	779	PF00069	0.432
MOD_Plk_2-3	566	572	PF00069	0.551
MOD_Plk_4	315	321	PF00069	0.532
MOD_Plk_4	40	46	PF00069	0.515
MOD_Plk_4	634	640	PF00069	0.530
MOD_Plk_4	687	693	PF00069	0.384
MOD_Plk_4	761	767	PF00069	0.544
MOD_Plk_4	786	792	PF00069	0.506
MOD_Plk_4	877	883	PF00069	0.417
MOD_Plk_4	917	923	PF00069	0.431
MOD_Plk_4	967	973	PF00069	0.404
MOD_ProDKin_1	108	114	PF00069	0.697
MOD_ProDKin_1	144	150	PF00069	0.773
MOD_ProDKin_1	23	29	PF00069	0.638
MOD_ProDKin_1	78	84	PF00069	0.663
MOD_ProDKin_1	866	872	PF00069	0.518
MOD_ProDKin_1	945	951	PF00069	0.405
MOD_SUMO_for_1	215	218	PF00179	0.534
MOD_SUMO_for_1	334	337	PF00179	0.430
MOD_SUMO_for_1	473	476	PF00179	0.596
MOD_SUMO_for_1	525	528	PF00179	0.639
MOD_SUMO_rev_2	343	348	PF00179	0.517
MOD_SUMO_rev_2	436	445	PF00179	0.585
MOD_SUMO_rev_2	51	56	PF00179	0.573
MOD_SUMO_rev_2	822	829	PF00179	0.538
TRG_DiLeu_BaEn_1	337	342	PF01217	0.435
TRG_DiLeu_BaEn_1	396	401	PF01217	0.553
TRG_DiLeu_BaEn_1	617	622	PF01217	0.482
TRG_DiLeu_BaEn_1	750	755	PF01217	0.529
TRG_DiLeu_BaEn_4	623	629	PF01217	0.610
TRG_DiLeu_BaLyEn_6	941	946	PF01217	0.418
TRG_DiLeu_LyEn_5	337	342	PF01217	0.571
TRG_ENDOCYTIC_2	701	704	PF00928	0.402
TRG_ENDOCYTIC_2	722	725	PF00928	0.416
TRG_ER_diArg_1	369	372	PF00400	0.624
TRG_ER_diArg_1	454	457	PF00400	0.502
TRG_ER_diArg_1	628	631	PF00400	0.494
TRG_ER_diArg_1	63	65	PF00400	0.609
TRG_ER_diArg_1	70	72	PF00400	0.644
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	667	672	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	710	714	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	903	907	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE6	Leptomonas seymouri	62%	99%
A0A0S4IU72	Bodo saltans	29%	93%
A0A1X0NZR4	Trypanosomatidae	45%	100%
A0A3R7KK73	Trypanosoma rangeli	45%	100%
A4HH39	Leishmania braziliensis	82%	100%
A4I490	Leishmania infantum	100%	100%
C9ZKP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ADN9	Leishmania major	96%	100%
E9AM41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BPY2	Trypanosoma cruzi	44%	97%