Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF74_LEIDO

TriTrypDb:

LdBPK_320090.1 , LdCL_320005800 , LDHU3_32.0140

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3Q8IF74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.524
CLV_NRD_NRD_1	22	24	PF00675	0.630
CLV_NRD_NRD_1	274	276	PF00675	0.341
CLV_NRD_NRD_1	87	89	PF00675	0.394
CLV_NRD_NRD_1	94	96	PF00675	0.348
CLV_PCSK_FUR_1	272	276	PF00082	0.387
CLV_PCSK_FUR_1	85	89	PF00082	0.384
CLV_PCSK_KEX2_1	169	171	PF00082	0.524
CLV_PCSK_KEX2_1	272	274	PF00082	0.342
CLV_PCSK_KEX2_1	87	89	PF00082	0.380
CLV_PCSK_KEX2_1	94	96	PF00082	0.388
CLV_PCSK_SKI1_1	207	211	PF00082	0.407
CLV_PCSK_SKI1_1	95	99	PF00082	0.393
DEG_MDM2_SWIB_1	276	284	PF02201	0.634
DOC_ANK_TNKS_1	254	261	PF00023	0.651
DOC_CYCLIN_RxL_1	92	101	PF00134	0.684
DOC_MAPK_gen_1	108	116	PF00069	0.528
DOC_MAPK_gen_1	169	176	PF00069	0.686
DOC_MAPK_gen_1	85	93	PF00069	0.603
DOC_PP4_FxxP_1	209	212	PF00568	0.647
DOC_PP4_FxxP_1	217	220	PF00568	0.709
DOC_SPAK_OSR1_1	170	174	PF12202	0.594
DOC_USP7_MATH_1	144	148	PF00917	0.731
DOC_USP7_MATH_1	182	186	PF00917	0.628
DOC_USP7_MATH_1	71	75	PF00917	0.355
DOC_WW_Pin1_4	130	135	PF00397	0.711
DOC_WW_Pin1_4	138	143	PF00397	0.698
DOC_WW_Pin1_4	178	183	PF00397	0.594
LIG_14-3-3_CanoR_1	235	245	PF00244	0.514
LIG_14-3-3_CanoR_1	85	93	PF00244	0.638
LIG_BRCT_BRCA1_1	213	217	PF00533	0.685
LIG_deltaCOP1_diTrp_1	259	265	PF00928	0.594
LIG_EH_1	34	38	PF12763	0.405
LIG_FHA_1	119	125	PF00498	0.721
LIG_FHA_1	144	150	PF00498	0.782
LIG_FHA_1	225	231	PF00498	0.678
LIG_FHA_1	5	11	PF00498	0.458
LIG_FHA_2	10	16	PF00498	0.429
LIG_FHA_2	37	43	PF00498	0.361
LIG_LIR_Apic_2	208	212	PF02991	0.644
LIG_LIR_Apic_2	214	220	PF02991	0.699
LIG_LIR_Gen_1	168	178	PF02991	0.691
LIG_LIR_Gen_1	74	83	PF02991	0.514
LIG_LIR_LC3C_4	121	126	PF02991	0.565
LIG_LIR_Nem_3	49	55	PF02991	0.444
LIG_LIR_Nem_3	67	72	PF02991	0.190
LIG_LIR_Nem_3	74	78	PF02991	0.512
LIG_Pex14_2	276	280	PF04695	0.636
LIG_SH2_SRC	55	58	PF00017	0.352
LIG_SH2_STAT5	50	53	PF00017	0.392
LIG_SH2_STAT5	55	58	PF00017	0.272
LIG_SH3_3	112	118	PF00018	0.559
LIG_SH3_3	131	137	PF00018	0.589
LIG_SH3_3	263	269	PF00018	0.563
LIG_SH3_3	294	300	PF00018	0.600
LIG_SUMO_SIM_anti_2	121	129	PF11976	0.606
LIG_SUMO_SIM_anti_2	146	153	PF11976	0.612
LIG_SUMO_SIM_par_1	121	129	PF11976	0.748
LIG_SUMO_SIM_par_1	243	249	PF11976	0.541
LIG_TRAF2_1	220	223	PF00917	0.615
LIG_WRC_WIRS_1	72	77	PF05994	0.421
LIG_WW_2	117	120	PF00397	0.555
MOD_CK1_1	143	149	PF00069	0.685
MOD_CK1_1	4	10	PF00069	0.636
MOD_CK2_1	253	259	PF00069	0.542
MOD_CK2_1	264	270	PF00069	0.303
MOD_CMANNOS	261	264	PF00535	0.497
MOD_GlcNHglycan	128	131	PF01048	0.602
MOD_GlcNHglycan	142	145	PF01048	0.733
MOD_GlcNHglycan	175	179	PF01048	0.537
MOD_GlcNHglycan	58	61	PF01048	0.298
MOD_GSK3_1	126	133	PF00069	0.633
MOD_GSK3_1	140	147	PF00069	0.562
MOD_GSK3_1	174	181	PF00069	0.463
MOD_N-GLC_1	147	152	PF02516	0.582
MOD_N-GLC_1	223	228	PF02516	0.419
MOD_NEK2_1	174	179	PF00069	0.630
MOD_NEK2_1	56	61	PF00069	0.278
MOD_NEK2_1	62	67	PF00069	0.269
MOD_PIKK_1	86	92	PF00454	0.573
MOD_PKA_2	86	92	PF00069	0.579
MOD_Plk_1	147	153	PF00069	0.577
MOD_Plk_4	135	141	PF00069	0.605
MOD_Plk_4	147	153	PF00069	0.741
MOD_Plk_4	36	42	PF00069	0.634
MOD_Plk_4	46	52	PF00069	0.503
MOD_Plk_4	64	70	PF00069	0.186
MOD_Plk_4	71	77	PF00069	0.376
MOD_ProDKin_1	130	136	PF00069	0.657
MOD_ProDKin_1	138	144	PF00069	0.636
MOD_ProDKin_1	178	184	PF00069	0.489
MOD_SUMO_rev_2	17	26	PF00179	0.534
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.570
TRG_ENDOCYTIC_2	72	75	PF00928	0.289
TRG_ER_diArg_1	169	171	PF00400	0.632
TRG_ER_diArg_1	230	233	PF00400	0.649
TRG_ER_diArg_1	272	275	PF00400	0.426
TRG_ER_diArg_1	86	88	PF00400	0.476
TRG_ER_diArg_1	93	95	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P876	Leptomonas seymouri	58%	97%
A0A1X0P6T9	Trypanosomatidae	38%	100%
A0A422NPR8	Trypanosoma rangeli	41%	100%
A4HJY9	Leishmania braziliensis	73%	100%
A4I7H2	Leishmania infantum	99%	100%
D0A004	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B2C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q5S7	Leishmania major	90%	100%
V5BWT8	Trypanosoma cruzi	38%	69%