Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF73_LEIDO

TriTrypDb:

LdBPK_340260.1 , LdCL_340007700 , LDHU3_34.0400

Length:

1338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	2
GO:0042981	regulation of apoptotic process	6	2
GO:0043067	regulation of programmed cell death	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1054	1058	PF00656	0.520
CLV_C14_Caspase3-7	1165	1169	PF00656	0.612
CLV_C14_Caspase3-7	1201	1205	PF00656	0.549
CLV_C14_Caspase3-7	341	345	PF00656	0.569
CLV_C14_Caspase3-7	352	356	PF00656	0.530
CLV_C14_Caspase3-7	357	361	PF00656	0.569
CLV_C14_Caspase3-7	461	465	PF00656	0.555
CLV_C14_Caspase3-7	485	489	PF00656	0.634
CLV_NRD_NRD_1	1254	1256	PF00675	0.527
CLV_NRD_NRD_1	1304	1306	PF00675	0.490
CLV_NRD_NRD_1	296	298	PF00675	0.676
CLV_NRD_NRD_1	313	315	PF00675	0.534
CLV_NRD_NRD_1	346	348	PF00675	0.735
CLV_NRD_NRD_1	382	384	PF00675	0.680
CLV_NRD_NRD_1	477	479	PF00675	0.556
CLV_NRD_NRD_1	580	582	PF00675	0.583
CLV_NRD_NRD_1	654	656	PF00675	0.567
CLV_NRD_NRD_1	664	666	PF00675	0.455
CLV_NRD_NRD_1	670	672	PF00675	0.532
CLV_NRD_NRD_1	82	84	PF00675	0.566
CLV_NRD_NRD_1	952	954	PF00675	0.521
CLV_PCSK_KEX2_1	1075	1077	PF00082	0.673
CLV_PCSK_KEX2_1	1248	1250	PF00082	0.496
CLV_PCSK_KEX2_1	1254	1256	PF00082	0.492
CLV_PCSK_KEX2_1	158	160	PF00082	0.663
CLV_PCSK_KEX2_1	296	298	PF00082	0.676
CLV_PCSK_KEX2_1	313	315	PF00082	0.392
CLV_PCSK_KEX2_1	346	348	PF00082	0.735
CLV_PCSK_KEX2_1	382	384	PF00082	0.703
CLV_PCSK_KEX2_1	477	479	PF00082	0.571
CLV_PCSK_KEX2_1	579	581	PF00082	0.599
CLV_PCSK_KEX2_1	654	656	PF00082	0.634
CLV_PCSK_KEX2_1	81	83	PF00082	0.564
CLV_PCSK_KEX2_1	951	953	PF00082	0.523
CLV_PCSK_PC1ET2_1	1075	1077	PF00082	0.673
CLV_PCSK_PC1ET2_1	1248	1250	PF00082	0.480
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.663
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.554
CLV_PCSK_PC7_1	575	581	PF00082	0.546
CLV_PCSK_PC7_1	650	656	PF00082	0.632
CLV_PCSK_SKI1_1	1056	1060	PF00082	0.534
CLV_PCSK_SKI1_1	1267	1271	PF00082	0.604
CLV_PCSK_SKI1_1	205	209	PF00082	0.639
CLV_PCSK_SKI1_1	478	482	PF00082	0.516
CLV_PCSK_SKI1_1	50	54	PF00082	0.564
CLV_PCSK_SKI1_1	537	541	PF00082	0.544
CLV_PCSK_SKI1_1	560	564	PF00082	0.479
CLV_PCSK_SKI1_1	575	579	PF00082	0.528
CLV_PCSK_SKI1_1	901	905	PF00082	0.644
CLV_Separin_Metazoa	601	605	PF03568	0.504
CLV_Separin_Metazoa	62	66	PF03568	0.395
DEG_APCC_DBOX_1	1173	1181	PF00400	0.489
DEG_APCC_DBOX_1	1325	1333	PF00400	0.500
DEG_APCC_DBOX_1	373	381	PF00400	0.539
DEG_APCC_DBOX_1	712	720	PF00400	0.642
DEG_Nend_UBRbox_2	1	3	PF02207	0.561
DEG_SCF_FBW7_1	12	19	PF00400	0.485
DEG_SPOP_SBC_1	115	119	PF00917	0.700
DEG_SPOP_SBC_1	16	20	PF00917	0.498
DEG_SPOP_SBC_1	306	310	PF00917	0.664
DOC_CYCLIN_RxL_1	156	166	PF00134	0.663
DOC_MAPK_gen_1	158	165	PF00069	0.633
DOC_MAPK_gen_1	293	303	PF00069	0.566
DOC_MAPK_gen_1	556	564	PF00069	0.552
DOC_MAPK_gen_1	711	719	PF00069	0.462
DOC_MAPK_gen_1	729	738	PF00069	0.508
DOC_MAPK_MEF2A_6	158	165	PF00069	0.633
DOC_MAPK_MEF2A_6	504	511	PF00069	0.461
DOC_MAPK_MEF2A_6	937	946	PF00069	0.351
DOC_MAPK_NFAT4_5	158	166	PF00069	0.632
DOC_USP7_MATH_1	1010	1014	PF00917	0.529
DOC_USP7_MATH_1	1079	1083	PF00917	0.660
DOC_USP7_MATH_1	115	119	PF00917	0.647
DOC_USP7_MATH_1	1163	1167	PF00917	0.677
DOC_USP7_MATH_1	1240	1244	PF00917	0.644
DOC_USP7_MATH_1	16	20	PF00917	0.656
DOC_USP7_MATH_1	306	310	PF00917	0.688
DOC_USP7_MATH_1	322	326	PF00917	0.420
DOC_USP7_MATH_1	354	358	PF00917	0.674
DOC_USP7_MATH_1	541	545	PF00917	0.671
DOC_USP7_MATH_1	842	846	PF00917	0.593
DOC_USP7_MATH_1	97	101	PF00917	0.609
DOC_USP7_UBL2_3	53	57	PF12436	0.423
DOC_WW_Pin1_4	101	106	PF00397	0.621
DOC_WW_Pin1_4	12	17	PF00397	0.498
DOC_WW_Pin1_4	805	810	PF00397	0.742
LIG_14-3-3_CanoR_1	1211	1216	PF00244	0.522
LIG_14-3-3_CanoR_1	1222	1230	PF00244	0.482
LIG_14-3-3_CanoR_1	1267	1276	PF00244	0.593
LIG_14-3-3_CanoR_1	395	399	PF00244	0.543
LIG_14-3-3_CanoR_1	597	603	PF00244	0.621
LIG_14-3-3_CanoR_1	644	652	PF00244	0.575
LIG_14-3-3_CanoR_1	65	70	PF00244	0.555
LIG_14-3-3_CanoR_1	803	809	PF00244	0.625
LIG_14-3-3_CanoR_1	848	857	PF00244	0.449
LIG_14-3-3_CanoR_1	891	900	PF00244	0.642
LIG_14-3-3_CanoR_1	951	961	PF00244	0.405
LIG_Actin_WH2_2	1166	1183	PF00022	0.581
LIG_Actin_WH2_2	1234	1250	PF00022	0.652
LIG_Actin_WH2_2	997	1014	PF00022	0.523
LIG_BIR_III_4	355	359	PF00653	0.633
LIG_BIR_III_4	861	865	PF00653	0.586
LIG_CaM_IQ_9	1241	1257	PF13499	0.645
LIG_CaM_NSCaTE_8	1007	1014	PF13499	0.434
LIG_Clathr_ClatBox_1	857	861	PF01394	0.595
LIG_deltaCOP1_diTrp_1	1118	1123	PF00928	0.637
LIG_FHA_1	1017	1023	PF00498	0.488
LIG_FHA_1	1268	1274	PF00498	0.591
LIG_FHA_1	167	173	PF00498	0.513
LIG_FHA_1	18	24	PF00498	0.534
LIG_FHA_1	266	272	PF00498	0.433
LIG_FHA_1	450	456	PF00498	0.640
LIG_FHA_1	471	477	PF00498	0.585
LIG_FHA_1	806	812	PF00498	0.788
LIG_FHA_2	1049	1055	PF00498	0.634
LIG_FHA_2	1177	1183	PF00498	0.519
LIG_FHA_2	1266	1272	PF00498	0.579
LIG_FHA_2	133	139	PF00498	0.539
LIG_FHA_2	242	248	PF00498	0.639
LIG_FHA_2	280	286	PF00498	0.633
LIG_FHA_2	459	465	PF00498	0.612
LIG_FHA_2	610	616	PF00498	0.605
LIG_FHA_2	781	787	PF00498	0.581
LIG_FHA_2	831	837	PF00498	0.472
LIG_FHA_2	874	880	PF00498	0.606
LIG_FHA_2	969	975	PF00498	0.534
LIG_GBD_Chelix_1	1215	1223	PF00786	0.594
LIG_GBD_Chelix_1	416	424	PF00786	0.613
LIG_LIR_Gen_1	871	881	PF02991	0.605
LIG_LIR_Nem_3	34	38	PF02991	0.452
LIG_LIR_Nem_3	871	877	PF02991	0.611
LIG_LYPXL_SIV_4	44	52	PF13949	0.484
LIG_LYPXL_yS_3	35	38	PF13949	0.453
LIG_MYND_1	809	813	PF01753	0.733
LIG_NRBOX	1328	1334	PF00104	0.497
LIG_NRBOX	876	882	PF00104	0.598
LIG_Pex14_1	702	706	PF04695	0.543
LIG_SH2_NCK_1	1070	1074	PF00017	0.606
LIG_SH2_STAP1	1070	1074	PF00017	0.546
LIG_SH2_STAP1	334	338	PF00017	0.432
LIG_SH2_STAP1	45	49	PF00017	0.392
LIG_SH2_STAT3	1021	1024	PF00017	0.496
LIG_SH2_STAT3	193	196	PF00017	0.535
LIG_SH2_STAT5	1021	1024	PF00017	0.496
LIG_SH3_3	918	924	PF00018	0.437
LIG_Sin3_3	819	826	PF02671	0.513
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.453
LIG_SUMO_SIM_anti_2	586	594	PF11976	0.445
LIG_SUMO_SIM_anti_2	875	883	PF11976	0.598
LIG_SUMO_SIM_par_1	229	235	PF11976	0.466
LIG_SUMO_SIM_par_1	714	721	PF11976	0.644
LIG_TRAF2_1	1013	1016	PF00917	0.382
LIG_TRAF2_1	1051	1054	PF00917	0.630
LIG_TRAF2_1	1062	1065	PF00917	0.494
LIG_TRAF2_1	1150	1153	PF00917	0.666
LIG_TRAF2_1	1162	1165	PF00917	0.608
LIG_TRAF2_1	1243	1246	PF00917	0.548
LIG_TRAF2_1	195	198	PF00917	0.621
LIG_TRAF2_1	361	364	PF00917	0.622
LIG_TRAF2_1	482	485	PF00917	0.621
LIG_TRAF2_1	500	503	PF00917	0.422
LIG_TRAF2_1	775	778	PF00917	0.536
LIG_UBA3_1	716	720	PF00899	0.646
LIG_UBA3_1	73	81	PF00899	0.446
LIG_WRC_WIRS_1	1332	1337	PF05994	0.604
LIG_WRC_WIRS_1	522	527	PF05994	0.455
MOD_CDK_SPK_2	101	106	PF00069	0.621
MOD_CDK_SPxxK_3	805	812	PF00069	0.644
MOD_CK1_1	117	123	PF00069	0.674
MOD_CK1_1	1184	1190	PF00069	0.488
MOD_CK1_1	132	138	PF00069	0.403
MOD_CK1_1	1331	1337	PF00069	0.608
MOD_CK1_1	317	323	PF00069	0.610
MOD_CK1_1	544	550	PF00069	0.695
MOD_CK1_1	762	768	PF00069	0.672
MOD_CK1_1	804	810	PF00069	0.782
MOD_CK1_1	890	896	PF00069	0.637
MOD_CK2_1	101	107	PF00069	0.604
MOD_CK2_1	1010	1016	PF00069	0.359
MOD_CK2_1	1048	1054	PF00069	0.633
MOD_CK2_1	1079	1085	PF00069	0.659
MOD_CK2_1	1176	1182	PF00069	0.538
MOD_CK2_1	118	124	PF00069	0.385
MOD_CK2_1	1221	1227	PF00069	0.547
MOD_CK2_1	1240	1246	PF00069	0.452
MOD_CK2_1	1265	1271	PF00069	0.581
MOD_CK2_1	132	138	PF00069	0.433
MOD_CK2_1	1331	1337	PF00069	0.481
MOD_CK2_1	170	176	PF00069	0.539
MOD_CK2_1	241	247	PF00069	0.632
MOD_CK2_1	279	285	PF00069	0.602
MOD_CK2_1	65	71	PF00069	0.557
MOD_CK2_1	661	667	PF00069	0.636
MOD_CK2_1	694	700	PF00069	0.555
MOD_CK2_1	706	712	PF00069	0.572
MOD_CK2_1	734	740	PF00069	0.675
MOD_CK2_1	780	786	PF00069	0.558
MOD_CK2_1	830	836	PF00069	0.464
MOD_CK2_1	968	974	PF00069	0.520
MOD_GlcNHglycan	1001	1004	PF01048	0.499
MOD_GlcNHglycan	1012	1015	PF01048	0.376
MOD_GlcNHglycan	1165	1168	PF01048	0.684
MOD_GlcNHglycan	1184	1187	PF01048	0.379
MOD_GlcNHglycan	23	26	PF01048	0.560
MOD_GlcNHglycan	255	258	PF01048	0.672
MOD_GlcNHglycan	355	359	PF01048	0.616
MOD_GlcNHglycan	497	500	PF01048	0.556
MOD_GlcNHglycan	630	633	PF01048	0.630
MOD_GlcNHglycan	672	675	PF01048	0.546
MOD_GlcNHglycan	813	816	PF01048	0.556
MOD_GlcNHglycan	818	822	PF01048	0.436
MOD_GlcNHglycan	850	853	PF01048	0.518
MOD_GlcNHglycan	861	865	PF01048	0.530
MOD_GlcNHglycan	893	896	PF01048	0.639
MOD_GlcNHglycan	97	100	PF01048	0.657
MOD_GSK3_1	1064	1071	PF00069	0.660
MOD_GSK3_1	114	121	PF00069	0.578
MOD_GSK3_1	1176	1183	PF00069	0.499
MOD_GSK3_1	1193	1200	PF00069	0.458
MOD_GSK3_1	12	19	PF00069	0.526
MOD_GSK3_1	1207	1214	PF00069	0.478
MOD_GSK3_1	1222	1229	PF00069	0.541
MOD_GSK3_1	1236	1243	PF00069	0.462
MOD_GSK3_1	1289	1296	PF00069	0.628
MOD_GSK3_1	1331	1338	PF00069	0.469
MOD_GSK3_1	166	173	PF00069	0.535
MOD_GSK3_1	2	9	PF00069	0.563
MOD_GSK3_1	279	286	PF00069	0.581
MOD_GSK3_1	334	341	PF00069	0.583
MOD_GSK3_1	537	544	PF00069	0.634
MOD_GSK3_1	734	741	PF00069	0.644
MOD_GSK3_1	801	808	PF00069	0.544
MOD_GSK3_1	860	867	PF00069	0.441
MOD_GSK3_1	887	894	PF00069	0.627
MOD_GSK3_1	915	922	PF00069	0.471
MOD_GSK3_1	95	102	PF00069	0.579
MOD_N-GLC_1	1307	1312	PF02516	0.476
MOD_NEK2_1	1180	1185	PF00069	0.506
MOD_NEK2_1	1289	1294	PF00069	0.561
MOD_NEK2_1	165	170	PF00069	0.520
MOD_NEK2_1	241	246	PF00069	0.520
MOD_NEK2_1	265	270	PF00069	0.601
MOD_NEK2_1	283	288	PF00069	0.397
MOD_NEK2_1	333	338	PF00069	0.594
MOD_NEK2_1	734	739	PF00069	0.548
MOD_NEK2_1	759	764	PF00069	0.669
MOD_NEK2_1	780	785	PF00069	0.592
MOD_NEK2_1	873	878	PF00069	0.497
MOD_NEK2_1	95	100	PF00069	0.541
MOD_PIKK_1	1040	1046	PF00454	0.523
MOD_PIKK_1	1156	1162	PF00454	0.740
MOD_PIKK_1	1193	1199	PF00454	0.520
MOD_PIKK_1	167	173	PF00454	0.538
MOD_PIKK_1	241	247	PF00454	0.632
MOD_PIKK_1	314	320	PF00454	0.632
MOD_PIKK_1	596	602	PF00454	0.612
MOD_PIKK_1	644	650	PF00454	0.556
MOD_PIKK_1	743	749	PF00454	0.555
MOD_PK_1	1211	1217	PF00069	0.564
MOD_PK_1	65	71	PF00069	0.557
MOD_PK_1	694	700	PF00069	0.595
MOD_PKA_1	952	958	PF00069	0.465
MOD_PKA_2	1093	1099	PF00069	0.555
MOD_PKA_2	1180	1186	PF00069	0.566
MOD_PKA_2	1221	1227	PF00069	0.637
MOD_PKA_2	166	172	PF00069	0.557
MOD_PKA_2	2	8	PF00069	0.517
MOD_PKA_2	222	228	PF00069	0.625
MOD_PKA_2	394	400	PF00069	0.591
MOD_PKA_2	596	602	PF00069	0.612
MOD_PKA_2	607	613	PF00069	0.513
MOD_PKA_2	670	676	PF00069	0.475
MOD_PKA_2	743	749	PF00069	0.537
MOD_PKA_2	802	808	PF00069	0.634
MOD_PKA_2	811	817	PF00069	0.516
MOD_PKA_2	890	896	PF00069	0.637
MOD_PKA_2	952	958	PF00069	0.412
MOD_PKB_1	801	809	PF00069	0.708
MOD_PKB_1	846	854	PF00069	0.439
MOD_Plk_1	1226	1232	PF00069	0.674
MOD_Plk_1	1307	1313	PF00069	0.478
MOD_Plk_1	334	340	PF00069	0.542
MOD_Plk_1	457	463	PF00069	0.533
MOD_Plk_1	6	12	PF00069	0.665
MOD_Plk_1	694	700	PF00069	0.662
MOD_Plk_1	817	823	PF00069	0.527
MOD_Plk_2-3	1265	1271	PF00069	0.609
MOD_Plk_2-3	458	464	PF00069	0.637
MOD_Plk_2-3	969	975	PF00069	0.517
MOD_Plk_4	1211	1217	PF00069	0.475
MOD_Plk_4	1328	1334	PF00069	0.624
MOD_Plk_4	222	228	PF00069	0.625
MOD_Plk_4	338	344	PF00069	0.640
MOD_Plk_4	7	13	PF00069	0.658
MOD_Plk_4	873	879	PF00069	0.608
MOD_ProDKin_1	101	107	PF00069	0.621
MOD_ProDKin_1	12	18	PF00069	0.491
MOD_ProDKin_1	805	811	PF00069	0.740
MOD_SUMO_for_1	571	574	PF00179	0.440
MOD_SUMO_for_1	903	906	PF00179	0.651
MOD_SUMO_rev_2	1131	1137	PF00179	0.711
MOD_SUMO_rev_2	1243	1250	PF00179	0.504
MOD_SUMO_rev_2	474	483	PF00179	0.530
MOD_SUMO_rev_2	488	497	PF00179	0.551
MOD_SUMO_rev_2	565	573	PF00179	0.422
MOD_SUMO_rev_2	907	917	PF00179	0.719
TRG_DiLeu_BaEn_1	125	130	PF01217	0.496
TRG_DiLeu_BaEn_1	712	717	PF01217	0.641
TRG_DiLeu_BaEn_4	368	374	PF01217	0.526
TRG_DiLeu_BaEn_4	457	463	PF01217	0.633
TRG_DiLeu_LyEn_5	125	130	PF01217	0.469
TRG_ENDOCYTIC_2	35	38	PF00928	0.453
TRG_ENDOCYTIC_2	39	42	PF00928	0.455
TRG_ER_diArg_1	1230	1233	PF00400	0.687
TRG_ER_diArg_1	126	129	PF00400	0.506
TRG_ER_diArg_1	290	293	PF00400	0.616
TRG_ER_diArg_1	373	376	PF00400	0.563
TRG_ER_diArg_1	476	478	PF00400	0.551
TRG_ER_diArg_1	578	581	PF00400	0.570
TRG_ER_diArg_1	654	656	PF00400	0.634
TRG_ER_diArg_1	846	849	PF00400	0.448
TRG_ER_diArg_1	951	953	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	1267	1271	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	774	778	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	937	941	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H4	Leptomonas seymouri	42%	94%
A4HAE2	Leishmania braziliensis	76%	100%
A4I9J4	Leishmania infantum	100%	100%
E9B4J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3I4	Leishmania major	91%	100%