ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF68_LEIDO

TriTrypDb:

LdBPK_291570.1 , LdCL_290021300 , LDHU3_29.2280

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IF68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.531
CLV_C14_Caspase3-7	332	336	PF00656	0.656
CLV_C14_Caspase3-7	377	381	PF00656	0.618
CLV_C14_Caspase3-7	450	454	PF00656	0.438
CLV_C14_Caspase3-7	612	616	PF00656	0.639
CLV_NRD_NRD_1	480	482	PF00675	0.426
CLV_NRD_NRD_1	575	577	PF00675	0.596
CLV_NRD_NRD_1	607	609	PF00675	0.669
CLV_NRD_NRD_1	691	693	PF00675	0.713
CLV_PCSK_KEX2_1	231	233	PF00082	0.506
CLV_PCSK_KEX2_1	480	482	PF00082	0.426
CLV_PCSK_KEX2_1	575	577	PF00082	0.596
CLV_PCSK_KEX2_1	691	693	PF00082	0.713
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.506
CLV_PCSK_SKI1_1	11	15	PF00082	0.550
CLV_PCSK_SKI1_1	170	174	PF00082	0.492
CLV_PCSK_SKI1_1	200	204	PF00082	0.427
CLV_PCSK_SKI1_1	231	235	PF00082	0.448
CLV_PCSK_SKI1_1	358	362	PF00082	0.666
CLV_PCSK_SKI1_1	480	484	PF00082	0.441
CLV_PCSK_SKI1_1	653	657	PF00082	0.484
CLV_Separin_Metazoa	506	510	PF03568	0.633
DEG_SPOP_SBC_1	387	391	PF00917	0.548
DOC_ANK_TNKS_1	690	697	PF00023	0.626
DOC_CKS1_1	60	65	PF01111	0.617
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.568
DOC_MAPK_gen_1	231	238	PF00069	0.487
DOC_MAPK_gen_1	636	645	PF00069	0.431
DOC_MAPK_MEF2A_6	231	240	PF00069	0.500
DOC_PP1_RVXF_1	351	357	PF00149	0.632
DOC_PP2B_LxvP_1	222	225	PF13499	0.570
DOC_PP2B_LxvP_1	655	658	PF13499	0.458
DOC_PP2B_LxvP_1	705	708	PF13499	0.547
DOC_USP7_MATH_1	124	128	PF00917	0.761
DOC_USP7_MATH_1	136	140	PF00917	0.685
DOC_USP7_MATH_1	26	30	PF00917	0.684
DOC_USP7_MATH_1	260	264	PF00917	0.610
DOC_USP7_MATH_1	344	348	PF00917	0.580
DOC_USP7_MATH_1	374	378	PF00917	0.505
DOC_USP7_MATH_1	490	494	PF00917	0.614
DOC_USP7_MATH_1	592	596	PF00917	0.612
DOC_USP7_UBL2_3	298	302	PF12436	0.732
DOC_WW_Pin1_4	154	159	PF00397	0.701
DOC_WW_Pin1_4	231	236	PF00397	0.444
DOC_WW_Pin1_4	59	64	PF00397	0.845
DOC_WW_Pin1_4	684	689	PF00397	0.551
LIG_14-3-3_CanoR_1	338	348	PF00244	0.612
LIG_14-3-3_CanoR_1	575	579	PF00244	0.571
LIG_AP2alpha_1	105	109	PF02296	0.711
LIG_BH_BH3_1	163	179	PF00452	0.632
LIG_BIR_II_1	1	5	PF00653	0.742
LIG_EVH1_2	290	294	PF00568	0.673
LIG_FHA_1	158	164	PF00498	0.691
LIG_FHA_1	316	322	PF00498	0.638
LIG_FHA_1	388	394	PF00498	0.524
LIG_FHA_1	414	420	PF00498	0.592
LIG_FHA_1	595	601	PF00498	0.434
LIG_FHA_2	191	197	PF00498	0.584
LIG_FHA_2	232	238	PF00498	0.461
LIG_FHA_2	332	338	PF00498	0.670
LIG_FHA_2	448	454	PF00498	0.365
LIG_FHA_2	662	668	PF00498	0.494
LIG_FHA_2	688	694	PF00498	0.623
LIG_GBD_Chelix_1	434	442	PF00786	0.547
LIG_LIR_Gen_1	106	114	PF02991	0.630
LIG_LIR_Gen_1	165	174	PF02991	0.482
LIG_LIR_Gen_1	250	260	PF02991	0.596
LIG_LIR_Gen_1	492	502	PF02991	0.641
LIG_LIR_Gen_1	532	539	PF02991	0.505
LIG_LIR_Gen_1	624	634	PF02991	0.472
LIG_LIR_LC3C_4	597	601	PF02991	0.419
LIG_LIR_Nem_3	106	112	PF02991	0.713
LIG_LIR_Nem_3	165	169	PF02991	0.487
LIG_LIR_Nem_3	182	186	PF02991	0.417
LIG_LIR_Nem_3	250	256	PF02991	0.565
LIG_LIR_Nem_3	492	498	PF02991	0.556
LIG_LIR_Nem_3	500	504	PF02991	0.492
LIG_LIR_Nem_3	532	536	PF02991	0.461
LIG_LIR_Nem_3	624	630	PF02991	0.459
LIG_PCNA_yPIPBox_3	589	600	PF02747	0.523
LIG_PDZ_Class_2	707	712	PF00595	0.525
LIG_Pex14_2	105	109	PF04695	0.678
LIG_SH2_CRK	253	257	PF00017	0.584
LIG_SH2_SRC	487	490	PF00017	0.560
LIG_SH2_SRC	504	507	PF00017	0.591
LIG_SH2_SRC	682	685	PF00017	0.532
LIG_SH2_STAP1	205	209	PF00017	0.544
LIG_SH2_STAP1	253	257	PF00017	0.584
LIG_SH2_STAP1	504	508	PF00017	0.571
LIG_SH2_STAT5	226	229	PF00017	0.499
LIG_SH2_STAT5	403	406	PF00017	0.478
LIG_SH2_STAT5	487	490	PF00017	0.600
LIG_SH2_STAT5	578	581	PF00017	0.515
LIG_SH2_STAT5	587	590	PF00017	0.415
LIG_SH2_STAT5	682	685	PF00017	0.508
LIG_SH3_3	286	292	PF00018	0.589
LIG_SH3_3	74	80	PF00018	0.725
LIG_SH3_4	298	305	PF00018	0.726
LIG_SH3_CIN85_PxpxPR_1	63	68	PF14604	0.748
LIG_Sin3_3	510	517	PF02671	0.566
LIG_SUMO_SIM_anti_2	237	242	PF11976	0.504
LIG_SUMO_SIM_par_1	653	659	PF11976	0.483
LIG_UBA3_1	642	648	PF00899	0.526
LIG_WRC_WIRS_1	547	552	PF05994	0.523
MOD_CDK_SPxxK_3	154	161	PF00069	0.693
MOD_CDK_SPxxK_3	684	691	PF00069	0.617
MOD_CK1_1	139	145	PF00069	0.694
MOD_CK1_1	246	252	PF00069	0.545
MOD_CK1_1	315	321	PF00069	0.670
MOD_CK1_1	413	419	PF00069	0.614
MOD_CK1_1	429	435	PF00069	0.566
MOD_CK1_1	557	563	PF00069	0.573
MOD_CK1_1	610	616	PF00069	0.696
MOD_CK1_1	687	693	PF00069	0.628
MOD_CK2_1	123	129	PF00069	0.762
MOD_CK2_1	242	248	PF00069	0.613
MOD_CK2_1	268	274	PF00069	0.705
MOD_CK2_1	279	285	PF00069	0.602
MOD_CK2_1	28	34	PF00069	0.726
MOD_CK2_1	331	337	PF00069	0.599
MOD_CK2_1	661	667	PF00069	0.561
MOD_CK2_1	687	693	PF00069	0.577
MOD_GlcNHglycan	1	4	PF01048	0.706
MOD_GlcNHglycan	138	141	PF01048	0.738
MOD_GlcNHglycan	210	213	PF01048	0.470
MOD_GlcNHglycan	245	248	PF01048	0.668
MOD_GlcNHglycan	262	265	PF01048	0.562
MOD_GlcNHglycan	270	273	PF01048	0.701
MOD_GlcNHglycan	28	31	PF01048	0.656
MOD_GlcNHglycan	328	331	PF01048	0.557
MOD_GlcNHglycan	412	415	PF01048	0.551
MOD_GlcNHglycan	461	464	PF01048	0.614
MOD_GlcNHglycan	492	495	PF01048	0.629
MOD_GlcNHglycan	611	615	PF01048	0.663
MOD_GlcNHglycan	650	653	PF01048	0.558
MOD_GlcNHglycan	99	102	PF01048	0.754
MOD_GSK3_1	150	157	PF00069	0.706
MOD_GSK3_1	242	249	PF00069	0.616
MOD_GSK3_1	294	301	PF00069	0.721
MOD_GSK3_1	308	315	PF00069	0.612
MOD_GSK3_1	317	324	PF00069	0.560
MOD_GSK3_1	379	386	PF00069	0.647
MOD_GSK3_1	447	454	PF00069	0.434
MOD_GSK3_1	583	590	PF00069	0.552
MOD_NEK2_1	174	179	PF00069	0.570
MOD_NEK2_1	294	299	PF00069	0.604
MOD_NEK2_1	312	317	PF00069	0.403
MOD_NEK2_1	459	464	PF00069	0.602
MOD_NEK2_1	546	551	PF00069	0.440
MOD_NEK2_1	574	579	PF00069	0.507
MOD_NEK2_1	629	634	PF00069	0.474
MOD_NEK2_2	472	477	PF00069	0.591
MOD_PIKK_1	374	380	PF00454	0.533
MOD_PIKK_1	461	467	PF00454	0.684
MOD_PKA_1	410	416	PF00069	0.578
MOD_PKA_2	279	285	PF00069	0.689
MOD_PKA_2	429	435	PF00069	0.546
MOD_PKA_2	574	580	PF00069	0.559
MOD_PKA_2	604	610	PF00069	0.589
MOD_Plk_2-3	176	182	PF00069	0.496
MOD_Plk_2-3	537	543	PF00069	0.548
MOD_Plk_4	279	285	PF00069	0.637
MOD_Plk_4	518	524	PF00069	0.538
MOD_Plk_4	546	552	PF00069	0.500
MOD_Plk_4	656	662	PF00069	0.404
MOD_ProDKin_1	154	160	PF00069	0.700
MOD_ProDKin_1	231	237	PF00069	0.442
MOD_ProDKin_1	59	65	PF00069	0.843
MOD_ProDKin_1	684	690	PF00069	0.549
TRG_DiLeu_BaEn_1	108	113	PF01217	0.702
TRG_DiLeu_BaEn_1	542	547	PF01217	0.525
TRG_DiLeu_BaEn_4	93	99	PF01217	0.747
TRG_ENDOCYTIC_2	253	256	PF00928	0.531
TRG_ENDOCYTIC_2	495	498	PF00928	0.568
TRG_ENDOCYTIC_2	504	507	PF00928	0.500
TRG_ENDOCYTIC_2	627	630	PF00928	0.425
TRG_ER_diArg_1	442	445	PF00400	0.548
TRG_ER_diArg_1	479	481	PF00400	0.438
TRG_ER_diArg_1	574	576	PF00400	0.579
TRG_ER_diArg_1	602	605	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICE2	Leptomonas seymouri	57%	100%
A0A0S4KH65	Bodo saltans	27%	97%
A0A1X0P032	Trypanosomatidae	33%	100%
A4HHF9	Leishmania braziliensis	78%	99%
A4I4K9	Leishmania infantum	98%	100%
C9ZL94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AE06	Leishmania major	93%	99%
E9ALS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BH81	Trypanosoma cruzi	33%	100%