Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF64_LEIDO

TriTrypDb:

LdBPK_340100.1 , LdCL_340006100 , LDHU3_34.0150

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	447	451	PF00656	0.538
CLV_NRD_NRD_1	252	254	PF00675	0.647
CLV_NRD_NRD_1	491	493	PF00675	0.585
CLV_NRD_NRD_1	502	504	PF00675	0.566
CLV_NRD_NRD_1	58	60	PF00675	0.605
CLV_NRD_NRD_1	80	82	PF00675	0.674
CLV_PCSK_FUR_1	500	504	PF00082	0.648
CLV_PCSK_KEX2_1	252	254	PF00082	0.647
CLV_PCSK_KEX2_1	491	493	PF00082	0.499
CLV_PCSK_KEX2_1	502	504	PF00082	0.548
CLV_PCSK_KEX2_1	79	81	PF00082	0.681
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.681
CLV_PCSK_SKI1_1	166	170	PF00082	0.631
CLV_PCSK_SKI1_1	290	294	PF00082	0.556
CLV_PCSK_SKI1_1	318	322	PF00082	0.696
CLV_PCSK_SKI1_1	462	466	PF00082	0.473
CLV_PCSK_SKI1_1	484	488	PF00082	0.588
CLV_PCSK_SKI1_1	503	507	PF00082	0.283
CLV_PCSK_SKI1_1	80	84	PF00082	0.624
DEG_ODPH_VHL_1	402	414	PF01847	0.533
DEG_SCF_TRCP1_1	120	126	PF00400	0.661
DEG_SPOP_SBC_1	345	349	PF00917	0.551
DEG_SPOP_SBC_1	376	380	PF00917	0.631
DOC_CYCLIN_RxL_1	312	325	PF00134	0.707
DOC_MAPK_MEF2A_6	222	229	PF00069	0.495
DOC_MAPK_NFAT4_5	222	230	PF00069	0.626
DOC_MIT_MIM_1	573	583	PF04212	0.607
DOC_PP1_RVXF_1	202	208	PF00149	0.542
DOC_PP1_RVXF_1	490	497	PF00149	0.482
DOC_PP1_RVXF_1	568	574	PF00149	0.571
DOC_PP4_FxxP_1	22	25	PF00568	0.506
DOC_PP4_FxxP_1	342	345	PF00568	0.635
DOC_USP7_MATH_1	118	122	PF00917	0.700
DOC_USP7_MATH_1	145	149	PF00917	0.721
DOC_USP7_MATH_1	275	279	PF00917	0.777
DOC_USP7_MATH_1	280	284	PF00917	0.652
DOC_USP7_MATH_1	376	380	PF00917	0.611
DOC_USP7_MATH_1	384	388	PF00917	0.580
DOC_USP7_MATH_1	404	408	PF00917	0.341
DOC_USP7_MATH_1	545	549	PF00917	0.479
DOC_WW_Pin1_4	21	26	PF00397	0.602
DOC_WW_Pin1_4	270	275	PF00397	0.714
LIG_14-3-3_CanoR_1	154	163	PF00244	0.520
LIG_14-3-3_CanoR_1	16	22	PF00244	0.714
LIG_14-3-3_CanoR_1	204	208	PF00244	0.668
LIG_14-3-3_CanoR_1	290	296	PF00244	0.628
LIG_14-3-3_CanoR_1	383	391	PF00244	0.721
LIG_14-3-3_CanoR_1	491	495	PF00244	0.571
LIG_14-3-3_CanoR_1	80	89	PF00244	0.693
LIG_Actin_WH2_2	422	438	PF00022	0.609
LIG_AP2alpha_2	139	141	PF02296	0.710
LIG_APCC_ABBA_1	172	177	PF00400	0.635
LIG_BIR_III_2	355	359	PF00653	0.676
LIG_BRCT_BRCA1_1	191	195	PF00533	0.567
LIG_BRCT_BRCA1_1	295	299	PF00533	0.525
LIG_BRCT_BRCA1_1	492	496	PF00533	0.593
LIG_deltaCOP1_diTrp_1	137	143	PF00928	0.735
LIG_deltaCOP1_diTrp_1	187	195	PF00928	0.584
LIG_FHA_1	124	130	PF00498	0.760
LIG_FHA_1	197	203	PF00498	0.528
LIG_FHA_1	266	272	PF00498	0.698
LIG_FHA_1	346	352	PF00498	0.669
LIG_FHA_1	397	403	PF00498	0.598
LIG_FHA_1	408	414	PF00498	0.520
LIG_FHA_1	417	423	PF00498	0.315
LIG_FHA_1	444	450	PF00498	0.580
LIG_FHA_1	46	52	PF00498	0.571
LIG_FHA_1	502	508	PF00498	0.398
LIG_FHA_1	525	531	PF00498	0.517
LIG_FHA_1	73	79	PF00498	0.646
LIG_FHA_2	429	435	PF00498	0.660
LIG_LIR_Apic_2	20	25	PF02991	0.510
LIG_LIR_Gen_1	185	196	PF02991	0.416
LIG_LIR_Gen_1	294	303	PF02991	0.532
LIG_LIR_Gen_1	406	416	PF02991	0.528
LIG_LIR_Gen_1	493	501	PF02991	0.515
LIG_LIR_Gen_1	572	581	PF02991	0.677
LIG_LIR_LC3C_4	409	413	PF02991	0.619
LIG_LIR_Nem_3	157	163	PF02991	0.631
LIG_LIR_Nem_3	185	191	PF02991	0.642
LIG_LIR_Nem_3	294	298	PF02991	0.531
LIG_LIR_Nem_3	392	397	PF02991	0.620
LIG_LIR_Nem_3	406	411	PF02991	0.529
LIG_LIR_Nem_3	493	499	PF02991	0.499
LIG_LIR_Nem_3	572	576	PF02991	0.670
LIG_LYPXL_yS_3	337	340	PF13949	0.727
LIG_MLH1_MIPbox_1	295	299	PF16413	0.525
LIG_MYND_1	372	376	PF01753	0.644
LIG_NRBOX	33	39	PF00104	0.604
LIG_NRBOX	444	450	PF00104	0.449
LIG_Pex14_1	156	160	PF04695	0.534
LIG_PTB_Apo_2	336	343	PF02174	0.589
LIG_SH2_CRK	14	18	PF00017	0.664
LIG_SH2_CRK	160	164	PF00017	0.700
LIG_SH2_GRB2like	201	204	PF00017	0.554
LIG_SH2_GRB2like	471	474	PF00017	0.591
LIG_SH2_SRC	305	308	PF00017	0.549
LIG_SH2_SRC	534	537	PF00017	0.523
LIG_SH2_STAP1	295	299	PF00017	0.525
LIG_SH2_STAT5	175	178	PF00017	0.619
LIG_SH2_STAT5	201	204	PF00017	0.537
LIG_SH2_STAT5	305	308	PF00017	0.549
LIG_SH2_STAT5	390	393	PF00017	0.645
LIG_SH2_STAT5	40	43	PF00017	0.542
LIG_SH2_STAT5	471	474	PF00017	0.544
LIG_SH2_STAT5	489	492	PF00017	0.558
LIG_SH2_STAT5	498	501	PF00017	0.467
LIG_SH2_STAT5	534	537	PF00017	0.523
LIG_SH3_3	348	354	PF00018	0.740
LIG_SH3_3	355	361	PF00018	0.644
LIG_SH3_3	370	376	PF00018	0.478
LIG_SH3_3	398	404	PF00018	0.538
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.637
LIG_SUMO_SIM_anti_2	409	415	PF11976	0.530
LIG_SUMO_SIM_par_1	409	415	PF11976	0.522
LIG_TRAF2_1	518	521	PF00917	0.504
LIG_TYR_ITIM	38	43	PF00017	0.567
LIG_WRC_WIRS_1	295	300	PF05994	0.552
MOD_CK1_1	121	127	PF00069	0.758
MOD_CK1_1	150	156	PF00069	0.691
MOD_CK1_1	278	284	PF00069	0.635
MOD_CK1_1	294	300	PF00069	0.531
MOD_CK1_1	406	412	PF00069	0.620
MOD_CK1_1	42	48	PF00069	0.650
MOD_CK1_1	443	449	PF00069	0.505
MOD_CK2_1	428	434	PF00069	0.655
MOD_CK2_1	46	52	PF00069	0.649
MOD_CK2_1	515	521	PF00069	0.504
MOD_GlcNHglycan	114	117	PF01048	0.748
MOD_GlcNHglycan	120	123	PF01048	0.781
MOD_GlcNHglycan	145	148	PF01048	0.646
MOD_GlcNHglycan	17	20	PF01048	0.647
MOD_GlcNHglycan	277	280	PF01048	0.682
MOD_GlcNHglycan	364	367	PF01048	0.633
MOD_GlcNHglycan	384	387	PF01048	0.608
MOD_GlcNHglycan	414	417	PF01048	0.465
MOD_GlcNHglycan	573	576	PF01048	0.619
MOD_GlcNHglycan	583	586	PF01048	0.528
MOD_GSK3_1	121	128	PF00069	0.770
MOD_GSK3_1	141	148	PF00069	0.536
MOD_GSK3_1	150	157	PF00069	0.662
MOD_GSK3_1	17	24	PF00069	0.714
MOD_GSK3_1	214	221	PF00069	0.587
MOD_GSK3_1	294	301	PF00069	0.563
MOD_GSK3_1	362	369	PF00069	0.731
MOD_GSK3_1	403	410	PF00069	0.584
MOD_GSK3_1	412	419	PF00069	0.474
MOD_GSK3_1	42	49	PF00069	0.655
MOD_GSK3_1	424	431	PF00069	0.543
MOD_GSK3_1	440	447	PF00069	0.560
MOD_GSK3_1	501	508	PF00069	0.607
MOD_GSK3_1	524	531	PF00069	0.527
MOD_GSK3_1	99	106	PF00069	0.668
MOD_N-GLC_1	141	146	PF02516	0.524
MOD_N-GLC_1	275	280	PF02516	0.614
MOD_N-GLC_1	46	51	PF02516	0.565
MOD_NEK2_1	143	148	PF00069	0.625
MOD_NEK2_1	17	22	PF00069	0.684
MOD_NEK2_1	218	223	PF00069	0.497
MOD_NEK2_1	225	230	PF00069	0.527
MOD_NEK2_1	291	296	PF00069	0.521
MOD_NEK2_1	298	303	PF00069	0.536
MOD_NEK2_1	571	576	PF00069	0.577
MOD_PIKK_1	147	153	PF00454	0.664
MOD_PIKK_1	27	33	PF00454	0.638
MOD_PIKK_1	360	366	PF00454	0.650
MOD_PIKK_1	424	430	PF00454	0.539
MOD_PIKK_1	80	86	PF00454	0.681
MOD_PKA_1	80	86	PF00069	0.681
MOD_PKA_2	104	110	PF00069	0.691
MOD_PKA_2	15	21	PF00069	0.718
MOD_PKA_2	203	209	PF00069	0.556
MOD_PKA_2	265	271	PF00069	0.765
MOD_PKA_2	382	388	PF00069	0.766
MOD_PKA_2	490	496	PF00069	0.593
MOD_PKA_2	501	507	PF00069	0.431
MOD_PKA_2	80	86	PF00069	0.681
MOD_PKB_1	85	93	PF00069	0.705
MOD_Plk_1	196	202	PF00069	0.502
MOD_Plk_1	218	224	PF00069	0.590
MOD_Plk_1	443	449	PF00069	0.583
MOD_Plk_1	563	569	PF00069	0.628
MOD_Plk_1	72	78	PF00069	0.598
MOD_Plk_2-3	444	450	PF00069	0.541
MOD_Plk_4	125	131	PF00069	0.657
MOD_Plk_4	167	173	PF00069	0.559
MOD_Plk_4	17	23	PF00069	0.630
MOD_Plk_4	197	203	PF00069	0.489
MOD_Plk_4	294	300	PF00069	0.513
MOD_Plk_4	32	38	PF00069	0.403
MOD_Plk_4	366	372	PF00069	0.713
MOD_Plk_4	407	413	PF00069	0.622
MOD_Plk_4	444	450	PF00069	0.478
MOD_ProDKin_1	21	27	PF00069	0.599
MOD_ProDKin_1	270	276	PF00069	0.714
MOD_SUMO_for_1	561	564	PF00179	0.733
MOD_SUMO_rev_2	555	563	PF00179	0.733
TRG_DiLeu_BaEn_1	167	172	PF01217	0.636
TRG_DiLeu_BaEn_1	444	449	PF01217	0.445
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.554
TRG_ENDOCYTIC_2	14	17	PF00928	0.673
TRG_ENDOCYTIC_2	160	163	PF00928	0.714
TRG_ENDOCYTIC_2	175	178	PF00928	0.392
TRG_ENDOCYTIC_2	288	291	PF00928	0.532
TRG_ENDOCYTIC_2	295	298	PF00928	0.530
TRG_ENDOCYTIC_2	337	340	PF00928	0.727
TRG_ENDOCYTIC_2	40	43	PF00928	0.566
TRG_ENDOCYTIC_2	498	501	PF00928	0.514
TRG_ER_diArg_1	251	253	PF00400	0.650
TRG_ER_diArg_1	490	492	PF00400	0.585
TRG_ER_diArg_1	499	502	PF00400	0.504
TRG_ER_diArg_1	80	82	PF00400	0.674
TRG_ER_diArg_1	85	88	PF00400	0.616
TRG_NLS_Bipartite_1	68	83	PF00514	0.603
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU5	Leptomonas seymouri	42%	99%
A4HAC5	Leishmania braziliensis	78%	100%
A4I9H8	Leishmania infantum	100%	100%
E9B4H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3J9	Leishmania major	93%	100%