Ribosome biogenesis protein NOP53

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nop53 (60S ribosomal biogenesis), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF61_LEIDO

TriTrypDb:

LdBPK_352520.1 , LdCL_350030100 , LDHU3_35.3270

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	11
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IF61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF61

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	10
GO:0042254	ribosome biogenesis	5	10
GO:0044085	cellular component biogenesis	3	10
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000027	ribosomal large subunit assembly	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0008097	5S rRNA binding	6	1
GO:0019843	rRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.347
CLV_NRD_NRD_1	244	246	PF00675	0.354
CLV_NRD_NRD_1	313	315	PF00675	0.568
CLV_NRD_NRD_1	47	49	PF00675	0.324
CLV_NRD_NRD_1	92	94	PF00675	0.304
CLV_PCSK_FUR_1	241	245	PF00082	0.363
CLV_PCSK_FUR_1	324	328	PF00082	0.592
CLV_PCSK_KEX2_1	202	204	PF00082	0.379
CLV_PCSK_KEX2_1	208	210	PF00082	0.350
CLV_PCSK_KEX2_1	212	214	PF00082	0.348
CLV_PCSK_KEX2_1	236	238	PF00082	0.347
CLV_PCSK_KEX2_1	243	245	PF00082	0.355
CLV_PCSK_KEX2_1	313	315	PF00082	0.568
CLV_PCSK_KEX2_1	326	328	PF00082	0.572
CLV_PCSK_KEX2_1	46	48	PF00082	0.323
CLV_PCSK_KEX2_1	92	94	PF00082	0.362
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.434
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.324
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.340
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.364
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.568
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.572
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.371
CLV_PCSK_PC7_1	208	214	PF00082	0.356
CLV_PCSK_SKI1_1	185	189	PF00082	0.388
CLV_PCSK_SKI1_1	194	198	PF00082	0.269
CLV_PCSK_SKI1_1	203	207	PF00082	0.331
CLV_PCSK_SKI1_1	245	249	PF00082	0.395
CLV_PCSK_SKI1_1	314	318	PF00082	0.578
CLV_PCSK_SKI1_1	97	101	PF00082	0.436
DOC_CKS1_1	261	266	PF01111	0.447
DOC_MAPK_gen_1	243	254	PF00069	0.369
DOC_MAPK_gen_1	313	325	PF00069	0.568
DOC_MAPK_HePTP_8	215	227	PF00069	0.363
DOC_MAPK_MEF2A_6	218	227	PF00069	0.363
DOC_MAPK_MEF2A_6	58	65	PF00069	0.480
DOC_USP7_MATH_1	149	153	PF00917	0.414
DOC_USP7_MATH_1	334	338	PF00917	0.574
DOC_USP7_UBL2_3	133	137	PF12436	0.391
DOC_USP7_UBL2_3	185	189	PF12436	0.346
DOC_USP7_UBL2_3	191	195	PF12436	0.341
DOC_USP7_UBL2_3	90	94	PF12436	0.349
DOC_WW_Pin1_4	131	136	PF00397	0.462
DOC_WW_Pin1_4	156	161	PF00397	0.486
DOC_WW_Pin1_4	260	265	PF00397	0.335
DOC_WW_Pin1_4	267	272	PF00397	0.335
DOC_WW_Pin1_4	31	36	PF00397	0.424
LIG_14-3-3_CanoR_1	203	211	PF00244	0.363
LIG_14-3-3_CanoR_1	293	298	PF00244	0.450
LIG_14-3-3_CanoR_1	306	312	PF00244	0.527
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_eIF4E_1	311	317	PF01652	0.399
LIG_FHA_1	14	20	PF00498	0.447
LIG_FHA_1	218	224	PF00498	0.447
LIG_FHA_1	261	267	PF00498	0.381
LIG_FHA_1	32	38	PF00498	0.371
LIG_FHA_2	117	123	PF00498	0.335
LIG_FHA_2	195	201	PF00498	0.445
LIG_FHA_2	268	274	PF00498	0.447
LIG_LIR_Apic_2	283	289	PF02991	0.562
LIG_LIR_Gen_1	95	104	PF02991	0.336
LIG_LIR_Nem_3	69	73	PF02991	0.378
LIG_MYND_1	35	39	PF01753	0.480
LIG_NRBOX	222	228	PF00104	0.447
LIG_PDZ_Class_1	333	338	PF00595	0.578
LIG_SH2_CRK	261	265	PF00017	0.447
LIG_SH2_CRK	50	54	PF00017	0.408
LIG_SH2_PTP2	286	289	PF00017	0.502
LIG_SH2_SRC	286	289	PF00017	0.502
LIG_SH2_SRC	50	53	PF00017	0.355
LIG_SH2_STAT5	110	113	PF00017	0.480
LIG_SH2_STAT5	286	289	PF00017	0.502
LIG_SH3_1	49	55	PF00018	0.408
LIG_SH3_2	42	47	PF14604	0.355
LIG_SH3_3	16	22	PF00018	0.355
LIG_SH3_3	36	42	PF00018	0.329
LIG_SH3_3	49	55	PF00018	0.296
LIG_SH3_3	58	64	PF00018	0.300
LIG_SUMO_SIM_anti_2	219	227	PF11976	0.363
LIG_SUMO_SIM_par_1	263	268	PF11976	0.335
LIG_TRAF2_1	119	122	PF00917	0.335
LIG_TRAF2_1	197	200	PF00917	0.424
LIG_TRAF2_1	296	299	PF00917	0.461
LIG_UBA3_1	101	108	PF00899	0.447
MOD_CDK_SPK_2	131	136	PF00069	0.363
MOD_CDK_SPxK_1	131	137	PF00069	0.363
MOD_CDK_SPxxK_3	267	274	PF00069	0.447
MOD_CK1_1	152	158	PF00069	0.439
MOD_CK1_1	159	165	PF00069	0.405
MOD_CK2_1	116	122	PF00069	0.335
MOD_CK2_1	194	200	PF00069	0.445
MOD_CK2_1	293	299	PF00069	0.464
MOD_GlcNHglycan	114	117	PF01048	0.346
MOD_GlcNHglycan	151	154	PF01048	0.475
MOD_GlcNHglycan	155	158	PF01048	0.490
MOD_GlcNHglycan	282	285	PF01048	0.596
MOD_GSK3_1	108	115	PF00069	0.342
MOD_GSK3_1	124	131	PF00069	0.306
MOD_GSK3_1	139	146	PF00069	0.306
MOD_GSK3_1	148	155	PF00069	0.414
MOD_GSK3_1	190	197	PF00069	0.429
MOD_N-GLC_1	108	113	PF02516	0.343
MOD_NEK2_1	275	280	PF00069	0.355
MOD_NEK2_1	307	312	PF00069	0.549
MOD_PIKK_1	159	165	PF00454	0.266
MOD_PKA_1	194	200	PF00069	0.361
MOD_PKA_2	307	313	PF00069	0.551
MOD_Plk_1	116	122	PF00069	0.335
MOD_ProDKin_1	131	137	PF00069	0.462
MOD_ProDKin_1	156	162	PF00069	0.486
MOD_ProDKin_1	260	266	PF00069	0.335
MOD_ProDKin_1	267	273	PF00069	0.335
MOD_ProDKin_1	31	37	PF00069	0.424
MOD_SUMO_for_1	168	171	PF00179	0.363
MOD_SUMO_for_1	319	322	PF00179	0.559
MOD_SUMO_for_1	325	328	PF00179	0.571
MOD_SUMO_rev_2	199	204	PF00179	0.441
TRG_DiLeu_BaEn_1	222	227	PF01217	0.447
TRG_DiLeu_BaEn_1	298	303	PF01217	0.496
TRG_ENDOCYTIC_2	50	53	PF00928	0.355
TRG_ENDOCYTIC_2	70	73	PF00928	0.150
TRG_ER_diArg_1	45	48	PF00400	0.319
TRG_NLS_MonoCore_2	89	94	PF00514	0.266
TRG_NLS_MonoExtC_3	187	192	PF00514	0.341
TRG_NLS_MonoExtC_3	89	94	PF00514	0.480
TRG_NLS_MonoExtN_4	185	192	PF00514	0.337
TRG_NLS_MonoExtN_4	241	247	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R6	Leptomonas seymouri	68%	100%
A0A0S4KHQ3	Bodo saltans	48%	100%
A0A1X0P5V5	Trypanosomatidae	54%	97%
A0A422NEC3	Trypanosoma rangeli	54%	100%
A4HMS1	Leishmania braziliensis	79%	100%
A4IBF7	Leishmania infantum	100%	100%
E9AF71	Leishmania major	91%	100%
E9B6C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B3S8	Trypanosoma cruzi	54%	100%