LeishMANIAdb
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Phospholipid methyltransferase family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phospholipid methyltransferase family protein
Gene product:
phosphatidylethanolaminen-methyltransferase-lik e protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IF60_LEIDO
TriTrypDb:
LdBPK_313250.1 , LdCL_310040800 , LDHU3_31.5510
Length:
582

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, Phosphatidylethanolaminen-methyltransferase-lik e

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3Q8IF60
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF60

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 9
GO:0006644 phospholipid metabolic process 4 9
GO:0006650 glycerophospholipid metabolic process 5 9
GO:0006656 phosphatidylcholine biosynthetic process 5 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0008610 lipid biosynthetic process 4 9
GO:0008654 phospholipid biosynthetic process 5 9
GO:0009058 biosynthetic process 2 9
GO:0009987 cellular process 1 9
GO:0019637 organophosphate metabolic process 3 9
GO:0032259 methylation 2 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044249 cellular biosynthetic process 3 9
GO:0044255 cellular lipid metabolic process 3 9
GO:0045017 glycerolipid biosynthetic process 4 9
GO:0046470 phosphatidylcholine metabolic process 4 9
GO:0046474 glycerophospholipid biosynthetic process 5 9
GO:0046486 glycerolipid metabolic process 4 9
GO:0071704 organic substance metabolic process 2 9
GO:0090407 organophosphate biosynthetic process 4 9
GO:1901564 organonitrogen compound metabolic process 3 9
GO:1901566 organonitrogen compound biosynthetic process 4 9
GO:1901576 organic substance biosynthetic process 3 9
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0004608 phosphatidylethanolamine N-methyltransferase activity 6 6
GO:0008168 methyltransferase activity 4 9
GO:0008170 N-methyltransferase activity 5 6
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 6
GO:0016740 transferase activity 2 9
GO:0016741 transferase activity, transferring one-carbon groups 3 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 39 43 PF00656 0.535
CLV_NRD_NRD_1 115 117 PF00675 0.297
CLV_NRD_NRD_1 125 127 PF00675 0.305
CLV_NRD_NRD_1 536 538 PF00675 0.223
CLV_NRD_NRD_1 556 558 PF00675 0.316
CLV_NRD_NRD_1 578 580 PF00675 0.402
CLV_PCSK_KEX2_1 115 117 PF00082 0.297
CLV_PCSK_KEX2_1 125 127 PF00082 0.305
CLV_PCSK_KEX2_1 378 380 PF00082 0.398
CLV_PCSK_KEX2_1 401 403 PF00082 0.280
CLV_PCSK_KEX2_1 538 540 PF00082 0.213
CLV_PCSK_KEX2_1 556 558 PF00082 0.326
CLV_PCSK_PC1ET2_1 378 380 PF00082 0.297
CLV_PCSK_PC1ET2_1 401 403 PF00082 0.280
CLV_PCSK_PC1ET2_1 538 540 PF00082 0.234
CLV_PCSK_SKI1_1 125 129 PF00082 0.296
CLV_PCSK_SKI1_1 229 233 PF00082 0.486
CLV_PCSK_SKI1_1 421 425 PF00082 0.348
CLV_PCSK_SKI1_1 556 560 PF00082 0.379
CLV_PCSK_SKI1_1 570 574 PF00082 0.384
DOC_CKS1_1 44 49 PF01111 0.539
DOC_CYCLIN_RxL_1 122 131 PF00134 0.485
DOC_CYCLIN_yClb5_NLxxxL_5 408 417 PF00134 0.348
DOC_CYCLIN_yCln2_LP_2 183 189 PF00134 0.486
DOC_CYCLIN_yCln2_LP_2 349 355 PF00134 0.292
DOC_MAPK_gen_1 31 40 PF00069 0.529
DOC_MAPK_MEF2A_6 332 340 PF00069 0.442
DOC_PIKK_1 159 167 PF02985 0.510
DOC_PP1_RVXF_1 227 234 PF00149 0.219
DOC_PP2B_LxvP_1 349 352 PF13499 0.292
DOC_PP4_FxxP_1 240 243 PF00568 0.219
DOC_PP4_FxxP_1 32 35 PF00568 0.485
DOC_SPAK_OSR1_1 31 35 PF12202 0.490
DOC_USP7_MATH_1 451 455 PF00917 0.337
DOC_USP7_MATH_1 492 496 PF00917 0.436
DOC_USP7_MATH_1 517 521 PF00917 0.396
DOC_USP7_MATH_1 6 10 PF00917 0.570
DOC_WW_Pin1_4 182 187 PF00397 0.543
DOC_WW_Pin1_4 293 298 PF00397 0.618
DOC_WW_Pin1_4 389 394 PF00397 0.544
DOC_WW_Pin1_4 43 48 PF00397 0.522
DOC_WW_Pin1_4 49 54 PF00397 0.469
DOC_WW_Pin1_4 507 512 PF00397 0.288
LIG_14-3-3_CanoR_1 332 340 PF00244 0.444
LIG_14-3-3_CanoR_1 51 57 PF00244 0.515
LIG_AP2alpha_1 145 149 PF02296 0.481
LIG_APCC_ABBA_1 324 329 PF00400 0.512
LIG_BIR_II_1 1 5 PF00653 0.662
LIG_BRCT_BRCA1_1 130 134 PF00533 0.480
LIG_BRCT_BRCA1_1 197 201 PF00533 0.348
LIG_Clathr_ClatBox_1 325 329 PF01394 0.472
LIG_deltaCOP1_diTrp_1 215 225 PF00928 0.219
LIG_eIF4E_1 344 350 PF01652 0.343
LIG_eIF4E_1 501 507 PF01652 0.254
LIG_FHA_1 122 128 PF00498 0.547
LIG_FHA_1 288 294 PF00498 0.421
LIG_FHA_1 346 352 PF00498 0.348
LIG_FHA_1 35 41 PF00498 0.511
LIG_FHA_1 442 448 PF00498 0.313
LIG_FHA_1 66 72 PF00498 0.262
LIG_FHA_2 13 19 PF00498 0.640
LIG_FHA_2 296 302 PF00498 0.538
LIG_GBD_Chelix_1 338 346 PF00786 0.348
LIG_LIR_Apic_2 30 35 PF02991 0.495
LIG_LIR_Apic_2 387 393 PF02991 0.545
LIG_LIR_Apic_2 424 428 PF02991 0.441
LIG_LIR_Apic_2 49 53 PF02991 0.473
LIG_LIR_Gen_1 109 118 PF02991 0.483
LIG_LIR_Gen_1 169 176 PF02991 0.412
LIG_LIR_Gen_1 234 245 PF02991 0.219
LIG_LIR_Gen_1 246 257 PF02991 0.219
LIG_LIR_Gen_1 261 270 PF02991 0.254
LIG_LIR_Gen_1 288 299 PF02991 0.547
LIG_LIR_Gen_1 456 466 PF02991 0.449
LIG_LIR_LC3C_4 321 324 PF02991 0.470
LIG_LIR_Nem_3 105 110 PF02991 0.468
LIG_LIR_Nem_3 169 173 PF02991 0.444
LIG_LIR_Nem_3 21 26 PF02991 0.546
LIG_LIR_Nem_3 215 219 PF02991 0.219
LIG_LIR_Nem_3 222 227 PF02991 0.219
LIG_LIR_Nem_3 232 236 PF02991 0.219
LIG_LIR_Nem_3 261 265 PF02991 0.254
LIG_LIR_Nem_3 268 273 PF02991 0.254
LIG_LIR_Nem_3 288 294 PF02991 0.364
LIG_LIR_Nem_3 454 458 PF02991 0.286
LIG_LIR_Nem_3 463 467 PF02991 0.409
LIG_LIR_Nem_3 483 489 PF02991 0.421
LIG_LIR_Nem_3 499 504 PF02991 0.259
LIG_LIR_Nem_3 61 65 PF02991 0.321
LIG_NRBOX 345 351 PF00104 0.305
LIG_NRBOX 372 378 PF00104 0.319
LIG_Pex14_1 220 224 PF04695 0.219
LIG_Pex14_1 400 404 PF04695 0.446
LIG_Pex14_1 89 93 PF04695 0.254
LIG_Pex14_2 145 149 PF04695 0.481
LIG_Pex14_2 216 220 PF04695 0.270
LIG_Pex14_2 233 237 PF04695 0.158
LIG_Pex14_2 368 372 PF04695 0.302
LIG_Pex14_2 467 471 PF04695 0.426
LIG_Pex14_2 82 86 PF04695 0.269
LIG_PTB_Apo_2 409 416 PF02174 0.254
LIG_PTB_Phospho_1 409 415 PF10480 0.254
LIG_SH2_CRK 114 118 PF00017 0.564
LIG_SH2_CRK 170 174 PF00017 0.495
LIG_SH2_CRK 23 27 PF00017 0.550
LIG_SH2_CRK 253 257 PF00017 0.219
LIG_SH2_CRK 266 270 PF00017 0.254
LIG_SH2_CRK 291 295 PF00017 0.612
LIG_SH2_CRK 390 394 PF00017 0.460
LIG_SH2_CRK 482 486 PF00017 0.428
LIG_SH2_GRB2like 488 491 PF00017 0.444
LIG_SH2_NCK_1 390 394 PF00017 0.525
LIG_SH2_NCK_1 458 462 PF00017 0.427
LIG_SH2_SRC 316 319 PF00017 0.499
LIG_SH2_STAP1 249 253 PF00017 0.219
LIG_SH2_STAP1 262 266 PF00017 0.254
LIG_SH2_STAP1 358 362 PF00017 0.305
LIG_SH2_STAP1 565 569 PF00017 0.497
LIG_SH2_STAT3 540 543 PF00017 0.486
LIG_SH2_STAT5 170 173 PF00017 0.410
LIG_SH2_STAT5 245 248 PF00017 0.248
LIG_SH2_STAT5 262 265 PF00017 0.341
LIG_SH2_STAT5 316 319 PF00017 0.494
LIG_SH2_STAT5 344 347 PF00017 0.288
LIG_SH2_STAT5 375 378 PF00017 0.348
LIG_SH2_STAT5 415 418 PF00017 0.288
LIG_SH2_STAT5 422 425 PF00017 0.288
LIG_SH2_STAT5 452 455 PF00017 0.254
LIG_SH2_STAT5 466 469 PF00017 0.444
LIG_SH2_STAT5 488 491 PF00017 0.444
LIG_SH2_STAT5 72 75 PF00017 0.272
LIG_SH3_3 279 285 PF00018 0.425
LIG_SH3_3 528 534 PF00018 0.419
LIG_SUMO_SIM_anti_2 321 327 PF11976 0.482
LIG_SUMO_SIM_anti_2 510 516 PF11976 0.293
LIG_SUMO_SIM_par_1 334 341 PF11976 0.306
LIG_TRAF2_1 298 301 PF00917 0.530
LIG_TYR_ITIM 168 173 PF00017 0.459
LIG_TYR_ITIM 264 269 PF00017 0.254
LIG_TYR_ITIM 480 485 PF00017 0.419
LIG_WRC_WIRS_1 107 112 PF05994 0.486
MOD_CDK_SPK_2 43 48 PF00069 0.542
MOD_CK1_1 13 19 PF00069 0.577
MOD_CK1_1 182 188 PF00069 0.487
MOD_CK1_1 2 8 PF00069 0.638
MOD_CK1_1 295 301 PF00069 0.616
MOD_CK1_1 49 55 PF00069 0.524
MOD_CK2_1 12 18 PF00069 0.696
MOD_CK2_1 295 301 PF00069 0.585
MOD_CK2_1 428 434 PF00069 0.351
MOD_CK2_1 453 459 PF00069 0.369
MOD_CK2_1 558 564 PF00069 0.553
MOD_GlcNHglycan 4 7 PF01048 0.443
MOD_GlcNHglycan 431 434 PF01048 0.562
MOD_GlcNHglycan 482 485 PF01048 0.244
MOD_GlcNHglycan 498 501 PF01048 0.254
MOD_GlcNHglycan 507 510 PF01048 0.254
MOD_GlcNHglycan 8 11 PF01048 0.449
MOD_GSK3_1 10 17 PF00069 0.641
MOD_GSK3_1 102 109 PF00069 0.484
MOD_GSK3_1 2 9 PF00069 0.675
MOD_GSK3_1 404 411 PF00069 0.267
MOD_GSK3_1 492 499 PF00069 0.428
MOD_LATS_1 104 110 PF00433 0.501
MOD_N-GLC_1 229 234 PF02516 0.466
MOD_N-GLC_1 310 315 PF02516 0.278
MOD_N-GLC_1 404 409 PF02516 0.264
MOD_N-GLC_1 411 416 PF02516 0.241
MOD_N-GLC_1 480 485 PF02516 0.244
MOD_NEK2_1 12 17 PF00069 0.649
MOD_NEK2_1 128 133 PF00069 0.456
MOD_NEK2_1 258 263 PF00069 0.261
MOD_NEK2_1 265 270 PF00069 0.272
MOD_NEK2_1 338 343 PF00069 0.348
MOD_NEK2_1 345 350 PF00069 0.311
MOD_NEK2_1 480 485 PF00069 0.428
MOD_NEK2_1 496 501 PF00069 0.254
MOD_NEK2_1 558 563 PF00069 0.637
MOD_NEK2_1 71 76 PF00069 0.292
MOD_PKA_1 378 384 PF00069 0.545
MOD_PKA_2 331 337 PF00069 0.444
MOD_PKA_2 378 384 PF00069 0.504
MOD_Plk_1 128 134 PF00069 0.453
MOD_Plk_1 229 235 PF00069 0.293
MOD_Plk_1 287 293 PF00069 0.419
MOD_Plk_1 404 410 PF00069 0.264
MOD_Plk_1 411 417 PF00069 0.241
MOD_Plk_1 492 498 PF00069 0.419
MOD_Plk_2-3 36 42 PF00069 0.531
MOD_Plk_4 106 112 PF00069 0.509
MOD_Plk_4 128 134 PF00069 0.492
MOD_Plk_4 171 177 PF00069 0.472
MOD_Plk_4 260 266 PF00069 0.277
MOD_Plk_4 338 344 PF00069 0.316
MOD_Plk_4 345 351 PF00069 0.258
MOD_Plk_4 36 42 PF00069 0.509
MOD_Plk_4 441 447 PF00069 0.443
MOD_Plk_4 52 58 PF00069 0.407
MOD_ProDKin_1 182 188 PF00069 0.479
MOD_ProDKin_1 293 299 PF00069 0.614
MOD_ProDKin_1 389 395 PF00069 0.541
MOD_ProDKin_1 43 49 PF00069 0.516
MOD_ProDKin_1 507 513 PF00069 0.288
MOD_SUMO_for_1 377 380 PF00179 0.511
MOD_SUMO_for_1 574 577 PF00179 0.579
MOD_SUMO_rev_2 136 143 PF00179 0.524
MOD_SUMO_rev_2 561 569 PF00179 0.566
TRG_DiLeu_BaEn_1 21 26 PF01217 0.494
TRG_DiLeu_BaEn_1 318 323 PF01217 0.533
TRG_DiLeu_BaEn_2 433 439 PF01217 0.244
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.523
TRG_ENDOCYTIC_2 107 110 PF00928 0.486
TRG_ENDOCYTIC_2 114 117 PF00928 0.495
TRG_ENDOCYTIC_2 170 173 PF00928 0.437
TRG_ENDOCYTIC_2 23 26 PF00928 0.537
TRG_ENDOCYTIC_2 249 252 PF00928 0.219
TRG_ENDOCYTIC_2 262 265 PF00928 0.254
TRG_ENDOCYTIC_2 266 269 PF00928 0.254
TRG_ENDOCYTIC_2 291 294 PF00928 0.542
TRG_ENDOCYTIC_2 458 461 PF00928 0.454
TRG_ENDOCYTIC_2 464 467 PF00928 0.478
TRG_ENDOCYTIC_2 468 471 PF00928 0.419
TRG_ENDOCYTIC_2 482 485 PF00928 0.412
TRG_ENDOCYTIC_2 486 489 PF00928 0.416
TRG_ENDOCYTIC_2 501 504 PF00928 0.294
TRG_ER_diArg_1 114 116 PF00400 0.485
TRG_ER_diArg_1 125 127 PF00400 0.505
TRG_ER_diArg_1 536 539 PF00400 0.414
TRG_ER_diArg_1 555 557 PF00400 0.543
TRG_NLS_MonoExtC_3 536 542 PF00514 0.395
TRG_NLS_MonoExtN_4 534 541 PF00514 0.434
TRG_Pf-PMV_PEXEL_1 125 129 PF00026 0.318
TRG_Pf-PMV_PEXEL_1 211 215 PF00026 0.444

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1S1 Leptomonas seymouri 80% 100%
A0A0S4ITN2 Bodo saltans 53% 100%
A0A1X0NK27 Trypanosomatidae 58% 97%
A3LQW6 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 30% 68%
A4HJV7 Leishmania braziliensis 87% 100%
A4I7B9 Leishmania infantum 100% 100%
A5DL79 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 31% 67%
A6ZUG8 Saccharomyces cerevisiae (strain YJM789) 30% 67%
A7TLA7 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 32% 69%
A7TNI7 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 32% 69%
B3LI73 Saccharomyces cerevisiae (strain RM11-1a) 30% 67%
B5VJA0 Saccharomyces cerevisiae (strain AWRI1631) 30% 67%
C4Y206 Clavispora lusitaniae (strain ATCC 42720) 29% 68%
C5DGB6 Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) 34% 69%
C5DZU3 Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) 32% 70%
C5M4D4 Candida tropicalis (strain ATCC MYA-3404 / T1) 29% 67%
C7GQ65 Saccharomyces cerevisiae (strain JAY291) 30% 67%
C8Z951 Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) 30% 67%
E9B2B2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P05374 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 67%
Q4Q5U4 Leishmania major 97% 100%
Q6BY28 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 31% 67%
Q6CJI9 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 29% 69%
Q6FVB6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 33% 68%
Q754G0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 32% 69%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS