Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF59_LEIDO

TriTrypDb:

LdBPK_250400.1 , LdCL_250009100 , LDHU3_25.0470

Length:

201

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0008180	COP9 signalosome	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IF59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.408
CLV_C14_Caspase3-7	81	85	PF00656	0.340
CLV_NRD_NRD_1	50	52	PF00675	0.452
CLV_PCSK_KEX2_1	50	52	PF00082	0.388
CLV_PCSK_SKI1_1	140	144	PF00082	0.431
CLV_PCSK_SKI1_1	170	174	PF00082	0.641
CLV_PCSK_SKI1_1	69	73	PF00082	0.369
CLV_PCSK_SKI1_1	87	91	PF00082	0.567
DEG_APCC_DBOX_1	139	147	PF00400	0.557
DOC_CYCLIN_RxL_1	66	75	PF00134	0.416
DOC_PP1_RVXF_1	67	74	PF00149	0.414
DOC_USP7_MATH_1	25	29	PF00917	0.474
DOC_USP7_MATH_1	31	35	PF00917	0.513
DOC_USP7_MATH_1	59	63	PF00917	0.478
DOC_WW_Pin1_4	112	117	PF00397	0.482
DOC_WW_Pin1_4	170	175	PF00397	0.490
LIG_14-3-3_CanoR_1	163	168	PF00244	0.473
LIG_14-3-3_CanoR_1	60	68	PF00244	0.359
LIG_BRCT_BRCA1_1	33	37	PF00533	0.413
LIG_FHA_1	133	139	PF00498	0.456
LIG_FHA_1	62	68	PF00498	0.523
LIG_FHA_2	16	22	PF00498	0.531
LIG_FHA_2	171	177	PF00498	0.499
LIG_FHA_2	73	79	PF00498	0.489
LIG_LIR_Gen_1	104	113	PF02991	0.490
LIG_LIR_Gen_1	122	130	PF02991	0.357
LIG_LIR_Gen_1	72	79	PF02991	0.531
LIG_LIR_Nem_3	104	108	PF02991	0.479
LIG_LIR_Nem_3	122	126	PF02991	0.416
LIG_LIR_Nem_3	72	76	PF02991	0.491
LIG_MLH1_MIPbox_1	33	37	PF16413	0.413
LIG_NRBOX	66	72	PF00104	0.406
LIG_SH2_CRK	38	42	PF00017	0.371
LIG_SH2_NCK_1	123	127	PF00017	0.351
LIG_SH2_SRC	123	126	PF00017	0.291
LIG_SH2_SRC	190	193	PF00017	0.379
LIG_SH2_STAT5	9	12	PF00017	0.456
LIG_SUMO_SIM_anti_2	61	69	PF11976	0.422
LIG_TYR_ITIM	121	126	PF00017	0.363
LIG_WRC_WIRS_1	102	107	PF05994	0.391
LIG_WRC_WIRS_1	70	75	PF05994	0.412
MOD_CK1_1	104	110	PF00069	0.394
MOD_CK1_1	166	172	PF00069	0.492
MOD_GlcNHglycan	27	30	PF01048	0.485
MOD_GlcNHglycan	42	45	PF01048	0.424
MOD_GSK3_1	134	141	PF00069	0.527
MOD_GSK3_1	166	173	PF00069	0.541
MOD_GSK3_1	40	47	PF00069	0.367
MOD_N-GLC_1	170	175	PF02516	0.490
MOD_N-GLC_1	52	57	PF02516	0.416
MOD_NEK2_2	31	36	PF00069	0.421
MOD_NMyristoyl	1	7	PF02799	0.422
MOD_PKA_2	59	65	PF00069	0.427
MOD_Plk_1	31	37	PF00069	0.419
MOD_Plk_1	52	58	PF00069	0.411
MOD_Plk_4	101	107	PF00069	0.334
MOD_Plk_4	31	37	PF00069	0.419
MOD_Plk_4	5	11	PF00069	0.359
MOD_ProDKin_1	112	118	PF00069	0.472
MOD_ProDKin_1	170	176	PF00069	0.490
TRG_ENDOCYTIC_2	123	126	PF00928	0.413
TRG_ENDOCYTIC_2	38	41	PF00928	0.377
TRG_ER_diArg_1	49	51	PF00400	0.372
TRG_Pf-PMV_PEXEL_1	128	133	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8M2	Leptomonas seymouri	45%	85%
A0A3R7KB37	Trypanosoma rangeli	23%	96%
A4H4A3	Leishmania braziliensis	82%	100%
A4I182	Leishmania infantum	100%	100%
D0A5G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	99%
E9AXB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA56	Leishmania major	93%	100%