Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF59_LEIDO

TriTrypDb:

LdBPK_250400.1 , LdCL_250009100 , LDHU3_25.0470

Length:

201

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0008180	COP9 signalosome	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

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Expansion

Sequence features

A0A3Q8IF59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF59

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.408
CLV_C14_Caspase3-7	81	85	PF00656	0.340
CLV_NRD_NRD_1	50	52	PF00675	0.452
CLV_PCSK_KEX2_1	50	52	PF00082	0.388
CLV_PCSK_SKI1_1	140	144	PF00082	0.431
CLV_PCSK_SKI1_1	170	174	PF00082	0.641
CLV_PCSK_SKI1_1	69	73	PF00082	0.369
CLV_PCSK_SKI1_1	87	91	PF00082	0.567
DEG_APCC_DBOX_1	139	147	PF00400	0.557
DOC_CYCLIN_RxL_1	66	75	PF00134	0.416

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8M2	Leptomonas seymouri	45%	85%
A0A3R7KB37	Trypanosoma rangeli	23%	96%
A4H4A3	Leishmania braziliensis	82%	100%
A4I182	Leishmania infantum	100%	100%
D0A5G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	99%
E9AXB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA56	Leishmania major	93%	100%

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