RNA-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF58_LEIDO

TriTrypDb:

LdBPK_291440.1 , LdCL_290019400 , LDHU3_29.1940

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IF58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF58

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.546
CLV_C14_Caspase3-7	359	363	PF00656	0.594
CLV_C14_Caspase3-7	543	547	PF00656	0.766
CLV_NRD_NRD_1	155	157	PF00675	0.539
CLV_NRD_NRD_1	260	262	PF00675	0.621
CLV_NRD_NRD_1	70	72	PF00675	0.360
CLV_NRD_NRD_1	82	84	PF00675	0.214
CLV_PCSK_KEX2_1	143	145	PF00082	0.576
CLV_PCSK_KEX2_1	155	157	PF00082	0.412
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.576
CLV_PCSK_SKI1_1	176	180	PF00082	0.237
CLV_PCSK_SKI1_1	501	505	PF00082	0.576
CLV_PCSK_SKI1_1	83	87	PF00082	0.351
DEG_Nend_Nbox_1	1	3	PF02207	0.655
DEG_SPOP_SBC_1	348	352	PF00917	0.585
DOC_CKS1_1	25	30	PF01111	0.667
DOC_CKS1_1	301	306	PF01111	0.697
DOC_CKS1_1	470	475	PF01111	0.654
DOC_CYCLIN_yCln2_LP_2	301	307	PF00134	0.646
DOC_CYCLIN_yCln2_LP_2	563	569	PF00134	0.682
DOC_MAPK_gen_1	155	163	PF00069	0.500
DOC_MAPK_gen_1	60	70	PF00069	0.541
DOC_PP1_RVXF_1	211	218	PF00149	0.551
DOC_PP2B_LxvP_1	297	300	PF13499	0.643
DOC_PP2B_LxvP_1	309	312	PF13499	0.629
DOC_PP2B_LxvP_1	563	566	PF13499	0.676
DOC_PP4_FxxP_1	25	28	PF00568	0.613
DOC_USP7_MATH_1	238	242	PF00917	0.511
DOC_USP7_MATH_1	412	416	PF00917	0.592
DOC_USP7_MATH_1	466	470	PF00917	0.580
DOC_USP7_MATH_1	6	10	PF00917	0.583
DOC_USP7_MATH_1	607	611	PF00917	0.639
DOC_USP7_MATH_1	633	637	PF00917	0.629
DOC_WW_Pin1_4	146	151	PF00397	0.674
DOC_WW_Pin1_4	24	29	PF00397	0.470
DOC_WW_Pin1_4	292	297	PF00397	0.696
DOC_WW_Pin1_4	300	305	PF00397	0.691
DOC_WW_Pin1_4	307	312	PF00397	0.611
DOC_WW_Pin1_4	319	324	PF00397	0.671
DOC_WW_Pin1_4	351	356	PF00397	0.703
DOC_WW_Pin1_4	370	375	PF00397	0.474
DOC_WW_Pin1_4	460	465	PF00397	0.680
DOC_WW_Pin1_4	469	474	PF00397	0.618
DOC_WW_Pin1_4	505	510	PF00397	0.713
DOC_WW_Pin1_4	521	526	PF00397	0.637
DOC_WW_Pin1_4	544	549	PF00397	0.685
DOC_WW_Pin1_4	626	631	PF00397	0.628
DOC_WW_Pin1_4	9	14	PF00397	0.692
LIG_14-3-3_CanoR_1	207	215	PF00244	0.551
LIG_14-3-3_CanoR_1	491	497	PF00244	0.577
LIG_14-3-3_CanoR_1	585	591	PF00244	0.688
LIG_Actin_WH2_2	163	178	PF00022	0.595
LIG_APCC_ABBA_1	188	193	PF00400	0.551
LIG_APCC_ABBA_1	217	222	PF00400	0.551
LIG_BIR_III_4	362	366	PF00653	0.565
LIG_BIR_III_4	442	446	PF00653	0.639
LIG_BRCT_BRCA1_1	32	36	PF00533	0.625
LIG_BRCT_BRCA1_1	321	325	PF00533	0.629
LIG_BRCT_BRCA1_1	38	42	PF00533	0.563
LIG_BRCT_BRCA1_1	414	418	PF00533	0.631
LIG_FHA_1	107	113	PF00498	0.551
LIG_FHA_1	296	302	PF00498	0.691
LIG_FHA_1	352	358	PF00498	0.698
LIG_FHA_1	365	371	PF00498	0.499
LIG_FHA_1	431	437	PF00498	0.682
LIG_FHA_1	485	491	PF00498	0.693
LIG_FHA_1	554	560	PF00498	0.749
LIG_FHA_2	114	120	PF00498	0.551
LIG_FHA_2	357	363	PF00498	0.668
LIG_FHA_2	76	82	PF00498	0.569
LIG_LIR_Apic_2	131	136	PF02991	0.551
LIG_LIR_Gen_1	367	376	PF02991	0.596
LIG_LIR_Gen_1	39	50	PF02991	0.576
LIG_LIR_Gen_1	51	59	PF02991	0.613
LIG_LIR_Gen_1	94	101	PF02991	0.551
LIG_LIR_Nem_3	109	114	PF02991	0.551
LIG_LIR_Nem_3	180	185	PF02991	0.551
LIG_LIR_Nem_3	367	372	PF02991	0.651
LIG_LIR_Nem_3	39	45	PF02991	0.579
LIG_LIR_Nem_3	51	55	PF02991	0.611
LIG_LIR_Nem_3	619	625	PF02991	0.655
LIG_LIR_Nem_3	87	92	PF02991	0.516
LIG_MYND_1	332	336	PF01753	0.569
LIG_PTB_Apo_2	211	218	PF02174	0.551
LIG_SH2_CRK	133	137	PF00017	0.551
LIG_SH2_CRK	431	435	PF00017	0.687
LIG_SH2_CRK	89	93	PF00017	0.551
LIG_SH2_NCK_1	419	423	PF00017	0.700
LIG_SH2_NCK_1	52	56	PF00017	0.658
LIG_SH2_PTP2	369	372	PF00017	0.660
LIG_SH2_SRC	369	372	PF00017	0.660
LIG_SH2_STAP1	419	423	PF00017	0.700
LIG_SH2_STAP1	52	56	PF00017	0.703
LIG_SH2_STAT5	2	5	PF00017	0.652
LIG_SH2_STAT5	369	372	PF00017	0.667
LIG_SH3_3	329	335	PF00018	0.749
LIG_SH3_3	343	349	PF00018	0.618
LIG_SH3_3	411	417	PF00018	0.690
LIG_SH3_3	431	437	PF00018	0.556
LIG_SH3_3	444	450	PF00018	0.569
LIG_SH3_3	451	457	PF00018	0.539
LIG_SH3_3	56	62	PF00018	0.646
LIG_SH3_3	603	609	PF00018	0.609
LIG_SH3_3	8	14	PF00018	0.698
LIG_SUMO_SIM_par_1	166	171	PF11976	0.551
LIG_TYR_ITSM	365	372	PF00017	0.643
LIG_WRC_WIRS_1	92	97	PF05994	0.551
LIG_WW_1	49	52	PF00397	0.653
MOD_CDK_SPxK_1	24	30	PF00069	0.663
MOD_CK1_1	106	112	PF00069	0.597
MOD_CK1_1	186	192	PF00069	0.602
MOD_CK1_1	268	274	PF00069	0.504
MOD_CK1_1	295	301	PF00069	0.740
MOD_CK1_1	310	316	PF00069	0.719
MOD_CK1_1	319	325	PF00069	0.702
MOD_CK1_1	347	353	PF00069	0.667
MOD_CK1_1	465	471	PF00069	0.702
MOD_CK1_1	626	632	PF00069	0.639
MOD_CK1_1	75	81	PF00069	0.620
MOD_CK1_1	9	15	PF00069	0.592
MOD_CK2_1	113	119	PF00069	0.586
MOD_GlcNHglycan	19	22	PF01048	0.631
MOD_GlcNHglycan	230	233	PF01048	0.253
MOD_GlcNHglycan	267	271	PF01048	0.531
MOD_GlcNHglycan	305	308	PF01048	0.649
MOD_GlcNHglycan	336	339	PF01048	0.704
MOD_GlcNHglycan	346	349	PF01048	0.601
MOD_GlcNHglycan	387	390	PF01048	0.680
MOD_GlcNHglycan	45	48	PF01048	0.763
MOD_GlcNHglycan	542	545	PF01048	0.721
MOD_GlcNHglycan	572	575	PF01048	0.695
MOD_GlcNHglycan	578	581	PF01048	0.676
MOD_GlcNHglycan	625	628	PF01048	0.636
MOD_GlcNHglycan	74	77	PF01048	0.351
MOD_GSK3_1	177	184	PF00069	0.608
MOD_GSK3_1	203	210	PF00069	0.530
MOD_GSK3_1	266	273	PF00069	0.599
MOD_GSK3_1	282	289	PF00069	0.592
MOD_GSK3_1	295	302	PF00069	0.645
MOD_GSK3_1	30	37	PF00069	0.625
MOD_GSK3_1	303	310	PF00069	0.698
MOD_GSK3_1	312	319	PF00069	0.492
MOD_GSK3_1	330	337	PF00069	0.482
MOD_GSK3_1	338	345	PF00069	0.632
MOD_GSK3_1	347	354	PF00069	0.523
MOD_GSK3_1	458	465	PF00069	0.663
MOD_GSK3_1	521	528	PF00069	0.654
MOD_GSK3_1	533	540	PF00069	0.568
MOD_GSK3_1	549	556	PF00069	0.556
MOD_GSK3_1	586	593	PF00069	0.634
MOD_N-GLC_1	186	191	PF02516	0.351
MOD_N-GLC_1	505	510	PF02516	0.708
MOD_N-GLC_1	549	554	PF02516	0.624
MOD_N-GLC_1	623	628	PF02516	0.673
MOD_N-GLC_2	235	237	PF02516	0.351
MOD_NEK2_1	168	173	PF00069	0.551
MOD_NEK2_1	233	238	PF00069	0.551
MOD_NEK2_1	265	270	PF00069	0.624
MOD_NEK2_1	282	287	PF00069	0.523
MOD_NEK2_1	316	321	PF00069	0.696
MOD_NEK2_1	32	37	PF00069	0.624
MOD_NEK2_1	344	349	PF00069	0.713
MOD_NEK2_1	356	361	PF00069	0.545
MOD_OFUCOSY	237	242	PF10250	0.514
MOD_PIKK_1	207	213	PF00454	0.551
MOD_PIKK_1	412	418	PF00454	0.617
MOD_PIKK_1	466	472	PF00454	0.676
MOD_PIKK_1	61	67	PF00454	0.582
MOD_PK_1	135	141	PF00069	0.618
MOD_PK_1	181	187	PF00069	0.551
MOD_PK_1	30	36	PF00069	0.626
MOD_PKA_2	112	118	PF00069	0.551
MOD_PKA_2	533	539	PF00069	0.565
MOD_Plk_1	186	192	PF00069	0.551
MOD_Plk_1	30	36	PF00069	0.682
MOD_Plk_1	618	624	PF00069	0.694
MOD_Plk_4	537	543	PF00069	0.708
MOD_Plk_4	598	604	PF00069	0.606
MOD_Plk_4	607	613	PF00069	0.631
MOD_Plk_4	88	94	PF00069	0.582
MOD_ProDKin_1	146	152	PF00069	0.673
MOD_ProDKin_1	24	30	PF00069	0.473
MOD_ProDKin_1	292	298	PF00069	0.697
MOD_ProDKin_1	300	306	PF00069	0.692
MOD_ProDKin_1	307	313	PF00069	0.614
MOD_ProDKin_1	319	325	PF00069	0.672
MOD_ProDKin_1	351	357	PF00069	0.700
MOD_ProDKin_1	370	376	PF00069	0.468
MOD_ProDKin_1	460	466	PF00069	0.677
MOD_ProDKin_1	469	475	PF00069	0.621
MOD_ProDKin_1	505	511	PF00069	0.714
MOD_ProDKin_1	521	527	PF00069	0.638
MOD_ProDKin_1	544	550	PF00069	0.687
MOD_ProDKin_1	626	632	PF00069	0.629
MOD_ProDKin_1	9	15	PF00069	0.695
MOD_SUMO_for_1	142	145	PF00179	0.553
MOD_SUMO_rev_2	53	62	PF00179	0.652
MOD_SUMO_rev_2	579	584	PF00179	0.587
TRG_ENDOCYTIC_2	369	372	PF00928	0.667
TRG_ENDOCYTIC_2	431	434	PF00928	0.690
TRG_ENDOCYTIC_2	52	55	PF00928	0.660
TRG_ENDOCYTIC_2	89	92	PF00928	0.551
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHE7	Leishmania braziliensis	71%	100%
A4I4J0	Leishmania infantum	99%	100%
E9ADZ3	Leishmania major	92%	100%
E9ALT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%